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https://www.readbyqxmd.com/read/29053913/morphological-changes-of-the-internal-carotid-artery-prevalence-and-characteristics-a-clinic-and-ultrasonographic-study-in-a-series-of-19-804-patients-over-25-years-old
#1
Hugo F G Martins, Alexandra Mayer, Paulo Batista, Fátima Soares, Vanessa Almeida, Ana Júlia Pedro, Victor Oliveira
BACKGROUND: Morphological changes of the internal carotid arteries (McICA) are frequently found during cervical ultrasound studies. However, McICA's etiology remains controversial. During this study, the prevalence and demographic characteristics of McICA such as kinking, coiling or looping, identified by Doppler ultrasound, were analysed and its relationship with vascular risk factors and stroke was assessed. METHODS: A retrospective study was performed by analysing 19,804 patients between Jan 2000 and Jun 2012 who were submitted to cervical ultrasonographic study...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053805/longitudinal-measures-of-deformation-are-associated-with-a-composite-measure-of-contractility-derived-from-pressure-volume-loop-analysis-in-children
#2
Shahryar M Chowdhury, Ryan J Butts, Carolyn L Taylor, Varsha M Bandisode, Karen S Chessa, Anthony M Hlavacek, Arni Nutting, Girish S Shirali, G Hamilton Baker
Aims: The relationship between echocardiographic measures of left ventricular (LV) systolic function and reference-standard measures have not been assessed in children. The objective of this study was to assess the validity of echocardiographic indices of LV systolic function via direct comparison to a novel composite measure of contractility derived from pressure-volume loop (PVL) analysis. Methods and results: Children with normal loading conditions undergoing routine left heart catheterization were prospectively enrolled...
June 29, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29053623/transfer-efficient-face-routing-using-the-planar-graphs-of-neighbors-in-high-density-wsns
#3
Eun-Seok Cho, Yongbin Yim, Sang-Ha Kim
Face routing has been adopted in wireless sensor networks (WSNs) where topological changes occur frequently or maintaining full network information is difficult. For message forwarding in networks, a planar graph is used to prevent looping, and because long edges are removed by planarization and the resulting planar graph is composed of short edges, and messages are forwarded along multiple nodes connected by them even though they can be forwarded directly. To solve this, face routing using information on all nodes within 2-hop range was adopted to forward messages directly to the farthest node within radio range...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053578/treatment-with-synthetic-glucocorticoids-and-the-hypothalamus-pituitary-adrenal-axis
#4
REVIEW
Rosa Maria Paragliola, Giampaolo Papi, Alfredo Pontecorvi, Salvatore Maria Corsello
Chronic glucocorticoid (GC) treatment represents a widely-prescribed therapy for several diseases in consideration of both anti-inflammatory and immunosuppressive activity but, if used at high doses for prolonged periods, it can determine the systemic effects characteristic of Cushing's syndrome. In addition to signs and symptoms of hypercortisolism, patients on chronic GC therapy are at risk to develop tertiary adrenal insufficiency after the reduction or the withdrawal of corticosteroids or during acute stress...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053378/genetic-diversity-of-jiangsu-native-chicken-breeds-assessed-with-the-mitochondrial-dna-d-loop-region
#5
X X Jia, J X Lu, X J Tang, Y F Fan, S H Huang, Q L Ge, Y S Gao
1. The objective of this study was to determine the origin and evolution of chickens from 5 native breeds that are traditionally raised in Jiangsu Province. 2. The sequence of the mitochondrial D-loop has proven to be useful for studying population genetics and trace the origins of domestic animals. 3. To address this question, we analysed the complete mitochondrial DNA D-loop sequence of 149 chickens from 5 native breeds of Jiangsu Province. 4. Sequences read lengths of the native breeds were 1231 to 1232 bp, with a single-base deletion from the 859 bp site in the 1231 bp haplotype...
October 20, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29053317/supercoiling-dna-locates-mismatches
#6
Andrew Dittmore, Sumitabha Brahmachari, Yasuharu Takagi, John F Marko, Keir C Neuman
We present a method of detecting sequence defects by supercoiling DNA with magnetic tweezers. The method is sensitive to a single mismatched base pair in a DNA sequence of several thousand base pairs. We systematically compare DNA molecules with 0 to 16 adjacent mismatches at 1 M monovalent salt and 3.6 pN force and show that under these conditions, a single plectoneme forms and is stably pinned at the defect. We use these measurements to estimate the energy and degree of end-loop kinking at defects. From this, we calculate the relative probability of plectoneme pinning at the mismatch under physiologically relevant conditions...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053299/two-loop-four-gluon-amplitudes-from-numerical-unitarity
#7
S Abreu, F Febres Cordero, H Ita, M Jaquier, B Page, M Zeng
We present the first numerical computation of two-loop amplitudes based on the unitarity method. As a proof of principle, we compute the four-gluon process in the leading-color approximation. We discuss the new method, analyze its numerical properties, and apply it to reconstruct the analytic form of the amplitudes. The numerical method is universal, and can be automated to provide multiscale two-loop computations for phenomenologically relevant signatures at hadron colliders.
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053291/double-helix-nodal-line-superconductor
#8
Xiao-Qi Sun, Biao Lian, Shou-Cheng Zhang
Time-reversal invariant superconductors in three dimensions may contain nodal lines in the Brillouin zone, which behave as Wilson loops of 3D momentum-space Chern-Simons theory of the Berry connection. Here we study the conditions of realizing linked nodal lines (Wilson loops), which yield a topological contribution to the thermal magnetoelectric coefficient that is given by the Chern-Simons action. We find the essential conditions are the existence of torus or higher genus Fermi surfaces and spiral spin textures...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053272/cardiotoxins-functional-role-of-local-conformational-changes
#9
Anastasia G Konshina, Nikolay A Krylov, Roman G Efremov
Cardiotoxins (CTs) from snake venoms are a family of homologous highly basic proteins that have extended hydrophobic patterns on their molecular surfaces. CTs are folded into three β-structured loops stabilized by four disulfide bridges. Being well-structured in aqueous solution, most of these proteins are membrane-active, although the exact molecular mechanisms of CT-induced cell damage are still poorly understood. To elucidate the structure-function relationships in CTs, a detailed knowledge of their spatial organization and local conformational dynamics is required...
October 20, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29053169/whole-body-physiologically-based-modelling-of-beta-blockers-in-the-rat-events-in-tissues-and-plasma-following-an-intravenous-bolus-dose
#10
S Y A Cheung, T Rodgers, L Aarons, I Gueorguieva, G L Dickinson, S Murby, C Brown, B Collins, M Rowland
BACKGROUND AND PURPOSE: Whole body physiologically based pharmacokinetic (PBPK) models have been increasingly applied in drug development to describe kinetic events of therapeutic agents in animals and human. The advantage of such modelling is the ability to incorporate vast amounts of physiological information, such as organ blood flow and volume, to ensure that the model is as close to reality as possible. EXPERIMENTAL APPROACH: Prior PBPK model development of enantiomers of a series of seven racemic betablockers, namely acebutolol, betaxolol, bisoprolol, metoprolol, oxprenolol, pindolol and propranolol, together with S-timolol in rat was based on tissue and blood concentration data at steady state...
October 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29052998/3d-imaging-of-a-dislocation-loop-at-the-onset-of-plasticity-in-an-indented-nanocrystal
#11
M Dupraz, G Beutier, T W Cornelius, G Parry, Z Ren, S Labat, M-I Richard, G A Chahine, O Kovalenko, M De Boissieu, E Rabkin, M Verdier, O Thomas
Structural quality and stability of nanocrystals are fundamental problems that bear important consequences for the performances of small-scale devices. Indeed, at the nanoscale, their functional properties are largely influenced by elastic strain and depend critically on the presence of crystal defects. It is thus of prime importance to be able to monitor, by noninvasive means, the stability of the microstructure of nano-objects against external stimuli such as mechanical load. Here we demonstrate the potential of Bragg coherent diffraction imaging for such measurements, by imaging in 3D the evolution of the microstructure of a nanocrystal exposed to in situ mechanical loading...
October 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/29052991/transition-metal-single-molecule-magnets-a-mn31-nano-sized-cluster-with-a-large-energy-barrier-of-60-k-and-magnetic-hysteresis-at-5-k
#12
Parisa Abbasi, Kevan Quinn, Dimitris I Alexandropoulos, Marko Damjanović, Wolfgang Wernsdorfer, Albert Escuer, Julia Mayans, Melanie Pilkington, Theocharis C Stamatatos
The first {Mn31} cluster (1) has been prepared from carboxylate ions and the chelating/bridging ligand α-methyl-2-pyridine-methanol. Compound 1 possesses a unique nano-sized structural topology with one of the largest energy barriers reported to-date for high-nuclearity 3d-metal clusters. Single-crystal magnetic hysteresis studies reveal the presence of hysteresis loops below 5 K, one of the highest temperatures below which molecular hysteresis has been observed for 3d-based SMMs.
October 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29052509/a-yin-yang-1-mir-30a-regulatory-circuit-modulates-autophagy-in-pancreatic-cancer-cells
#13
Chuang Yang, Jing-Jing Zhang, Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Ji-Shu Wei, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao
BACKGROUND: Autophagy is a highly regulated biological process that mediates the degradation of intracellular components. It is required for tumor cell metabolism and homeostasis. Yin-Yang 1 (YY1) has been reported to be involved in autophagy in several carcinomas. However, its role in autophagy in pancreatic cancer, one of the deadliest human malignancies, is unknown. Here, we investigated the function of YY1 in pancreatic cancer cells autophagy and its mechanisms of action. METHODS: The activity of cells undergoing autophagy was assessed using transmission electron microscopy, immunofluorescence, and Western blotting...
October 19, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29052271/living-with-a-resected-rectum-after-rectal-cancer-surgery-struggling-not-to-let-bowel-function-control-life
#14
Maria Reinwalds, Andrea Blixter, Eva Carlsson
AIMS AND OBJECTIVE: To illuminate what it means to live with a resected rectum due to rectal cancer, after reversal of a temporary loop-ileostomy. BACKGROUND: Today, treatment for rectal cancer is performed with increasing emphasis on sphincter-saving surgery, meaning that an anterior resection often includes construction of a temporary loop-ileostomy that is later reversed. The majority of patients will subsequently have disordered bowel function, with symptoms ranging from urgency to fecal incontinence...
October 20, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29052270/crystal-structure-of-the-human-dual-specificity-phosphatase-1-catalytic-domain
#15
Rajesh Gumpena, George T Lountos, Sreejith Raran-Kurussi, Joseph E Tropea, Scott Cherry, David S Waugh
The dual specificity phosphatase DUSP1 was the first mitogen activated protein kinase phosphatase (MKP) to be identified. It dephosphorylates conserved tyrosine and threonine residues in the activation loops of mitogen activated protein kinases ERK2, JNK1 and p38-alpha. Here, we report the crystal structure of the human DUSP1 catalytic domain at 2.49 Å resolution. Uniquely, the protein was crystallized as an MBP fusion protein in complex with a monobody that binds to MBP. Sulfate ions occupy the phosphotyrosine and putative phosphothreonine binding sites in the DUSP1 catalytic domain...
October 20, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29052200/rna-immunoprecipitation-protocol-to-identify-protein-rna-interactions-in-arabidopsis-thaliana
#16
Benoit Mermaz, Fuquan Liu, Jie Song
The role of RNA-binding proteins in the regulation of epigenetic processes has received increasing attention in the past decades. In particular noncoding RNAs have been shown to play a role in chromatin loop formation, recruitment of chromatin modifiers and RNA-dependent DNA methylation. In plants, the identification of specific RNA-protein interactions is now rising, facilitated by the development of specific approaches for plant tissues. Here, we present a simple one-day RNA immunoprecipitation (RIP) protocol adapted for Arabidopsis, suited for the identification of RNAs that are associated with a protein-of-interest in planta...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29051884/curettage-using-soft-wire-for-enchondroma-in-the-hand-a-technical-note
#17
Akio Sakamoto, Shuichi Matsuda
INTRODUCTION: Enchondromas are benign bone cartilaginous lesions predominantly seen in the hand, possibly leading to a pathological fracture. When the lesion expands to the whole phalanx, curettage through a small fenestration is difficult. To overcome the problem, soft-wire (cerclage wire) was used as a curette. Soft-wire is commonly used for a tension band wiring method for patellar or olecranon fractures. TECHNIQUE: Two representative cases are presented: one is a 43-year-old male with enchondroma in the middle phalanx of the left index finger, and the other is a 28-year-old female with enchondroma in the distal phalanx of the right thumb...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29051751/evaluation-of-different-pcr-based-assays-and-lamp-method-for-rapid-detection-of-phytophthora-infestans-by-targeting-the-ypt1-gene
#18
Mehran Khan, Benjin Li, Yue Jiang, Qiyong Weng, Qinghe Chen
Late blight, caused by the oomycete Phytophthora infestans, is one of the most devastating diseases affecting potato and tomato worldwide. Early diagnosis of the P. infestans pathogen causing late blight should be the top priority for addressing disease epidemics and management. In this study, we performed a loop-mediated isothermal amplification (LAMP) assay, conventional polymerase chain reaction (PCR), nested PCR, and real-time PCR to verify and compare the sensitivity and specificity of the reaction based on the Ypt1 (Ras-related protein) gene of P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29051723/autopilot-mind-wandering-and-the-out-of-the-loop-performance-problem
#19
REVIEW
Jonas Gouraud, Arnaud Delorme, Bruno Berberian
To satisfy the increasing demand for safer critical systems, engineers have integrated higher levels of automation, such as glass cockpits in aircraft, power plants, and driverless cars. These guiding principles relegate the operator to a monitoring role, increasing risks for humans to lack system understanding. The out of the loop performance problem arises when operators suffer from complacency and vigilance decrement; consequently, when automation does not behave as expected, understanding the system or taking back manual control may be difficult...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29051573/nucleation-and-annihilation-of-skyrmions-in-mn2coal-observed-through-the-topological-hall-effect
#20
B M Ludbrook, G Dubuis, A-H Puichaud, B J Ruck, S Granville
Magnetic skyrmions are topologically protected spin textures with great technological potential. These topologically non-trivial non-coplanar spin textures give rise to a topological Hall effect, enabling the purely electronic detection of magnetic skyrmions. We report a clear topological Hall effect in thin films of the the Heusler alloy Mn2CoAl, a ferromagnetic spin-gapless semiconductor, capped by a thin layer of Pd. We exploit the strong thickness- and temperature-dependence of the anomalous Hall effect in this system, tuning it to zero to enable the unambiguous measurement of the topological Hall effect, which is observed for temperatures between 3 K and 280 K...
October 19, 2017: Scientific Reports
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