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Linda J Reha-Krantz, Chithra Hariharan, Usharani Subuddhi, Shuangluo Xia, Chao Zhao, Jeff Beckman, Thomas Christian, William Konigsberg
The adenine base analogue 2-aminopurine (2AP) is a potent base substitution mutagen in prokaryotes because of its enhanceed ability to form a mutagenic base pair with an incoming dCTP. Despite more than 50 years of research, the structure of the 2AP-C base pair remains unclear. We report the structure of the 2AP-dCTP base pair formed within the polymerase active site of the RB69 Y567A-DNA polymerase. A modified wobble 2AP-C base pair was detected with one H-bond between N1 of 2AP and a proton from the C4 amino group of cytosine and an apparent bifurcated H-bond between a proton on the 2-amino group of 2-aminopurine and the ring N3 and O2 atoms of cytosine...
November 22, 2011: Biochemistry
B P Drayer, D Gur, S K Wolfson, E E Cook
Xenon-enhanceed cranial computed tomography (CT) was used to derive the partition coefficient (lambda) and flow rate constant (kappa) and thus provide a functional neuroanatomic map of local cerebral blood flow in eight nonhuman primates. Sequential CT imaging defined the temporal changes of xenon concentration in arterial blood and brain tissue both during and after xenon inhalation. Several methodologies including clearance, buildup, and in vivo "autoradiography" were used to estimate flow in various brain locales...
January 1980: AJR. American Journal of Roentgenology
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