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JOURNAL ARTICLE
Aisling Rafferty, Alida Fe Talento, Richard Drew, Patrick Fitzpatrick, Kara Tedford, Michael Barrett, Husnain Mahomed, Sabrina O'Regan, Louise Delany, Síle O'Connor, Agne Buseckyte, Andrei Brovchin, Elhaytham Hassan, Anna Marzec, Donna Martin, Clare Greene, John Marriott, Robert Cunney
OBJECTIVES: To determine the percentage of patients across Ireland who are discharged from the Emergency Department (ED) with an antimicrobial prescription, the indication, classification of infections, and guideline compliance. To identify potential areas for antimicrobial stewardship (AMS) interventions in the ED. PATIENTS AND METHODS: A multicentre, prospective cohort analysis study in EDs across eight hospitals in Ireland. At each site, patients aged 1 month and older who presented to the ED and were discharged directly from the ED were included...
April 2024: JAC-antimicrobial resistance
#22
JOURNAL ARTICLE
Savannah Racketa, Kelvin Gandhi, Matthew Lambie
PURPOSE: To date, there are three published guidelines discussing management of infected pancreatic necrosis (IPN) with conflicting recommendations. Specifically, The World Society of Emergency Surgery lists piperacillin-tazobactam as a treatment option in addition to meropenem and ciprofloxacin plus metronidazole. Piperacillin-tazobactam may serve as an effective carbapenem-sparing alternative. Although previous studies shed light on antimicrobial penetration data, there is a lack of clinical data comparing piperacillin-tazobactam to meropenem...
February 10, 2024: Diagnostic Microbiology and Infectious Disease
#23
JOURNAL ARTICLE
Jérémie F Cohen, Robert R Tanz, Stanford T Shulman
The most common cause of bacterial pharyngitis is Group A Streptococcus (GAS). Accurate diagnosis of GAS pharyngitis is crucial to identify children who would benefit from antibiotic treatment. Rapid diagnosis has the potential to reduce antibiotic overuse. Current national guidelines differ in their recommendations for GAS testing. While rapid antigen detection tests are widely used, their sensitivity is considered too low for stand-alone testing by several expert bodies. Newer molecular tests using nucleic acid amplification show higher accuracy and fast results, but their cost, complexity, and very high sensitivity may limit widespread adoption...
March 8, 2024: Journal of the Pediatric Infectious Diseases Society
#24
JOURNAL ARTICLE
Stephanie Spivack, Jeremy A W Gold, Shawn R Lockhart, Priyanka Anand, Laura A S Quilter, Dallas J Smith, Briana Bowen, Jane M Gould, Ahmed Eltokhy, Ahmed Gamal, Mauricio Retuerto, Thomas S McCormick, Mahmoud A Ghannoum
We describe a case of tinea genitalis in an immunocompetent woman in Pennsylvania, USA. Infection was caused by Trichophyton indotineae potentially acquired through sexual contact. The fungus was resistant to terbinafine (first-line antifungal) but improved with itraconazole. Clinicians should be aware of T. indotineae as a potential cause of antifungal-resistant genital lesions.
April 2024: Emerging Infectious Diseases
#25
REVIEW
Reagan K Barfield, Matthew L Brown, Benjamin Albrecht, Katie E Barber, Jeannette Bouchard, Amy L Carr, Elias B Chahine, David Cluck, Elizabeth W Covington, Connor R Deri, Spencer H Durham, Carmen Faulkner-Fennell, Lauren K Freeman, Timothy P Gauthier, Geneen M Gibson, Sarah B Green, Athena L V Hobbs, Bruce M Jones, Caroline C Jozefczyk, Ashley H Marx, Edoabasi U McGee, Lacie J McKamey, Rachel Musgrove, Emily Perez, Douglas Slain, Kayla R Stover, Michelle S Turner, Cyle White, P Brandon Bookstaver, Christopher M Bland
Keeping abreast of the antimicrobial stewardship-related articles published each year is challenging. The Southeastern Research Group Endeavor identified antimicrobial stewardship-related, peer-reviewed literature that detailed an actionable intervention during 2022. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight actionable interventions used by antimicrobial stewardship programs to capture potentially effective strategies for local implementation...
March 2024: Open Forum Infectious Diseases
#26
JOURNAL ARTICLE
Gregory A Ballash, Elizabeth M Parker, Dixie F Mollenkopf, Thomas E Wittum
Once considered to be a simple cause-and-effect relationship with localized impact, the concept of how antimicrobial use drives antimicrobial resistance is now recognized as a complex, transdisciplinary problem on a global scale. While the issue of antimicrobial resistance is often studied and addressed at the antimicrobial-human or antimicrobial-animal treatment interface, the role of the environment in the One Health dynamics of antimicrobial resistance is not as well understood. Antimicrobial-resistant bacteria, including those resistant to carbapenem drugs, are emerging in veterinary clinical environments, on farms, and in natural habitats...
March 1, 2024: Journal of the American Veterinary Medical Association
#27
JOURNAL ARTICLE
Santosh Pantha, Hiramani Parajuli, Charu Arjyal, Shovana Thapa Karki, Dhiraj Shrestha
BACKGROUND: The production of extended-spectrum beta-lactamases (ESBLs) among uropathogens, particularly E. coli and Klebsiella spp., poses a severe public health concern. This study explored the epidemiology of ESBL-producing E. coli and Klebsiella spp. isolated from urine samples obtained at a tertiary care children's hospital in Nepal. METHODS: A cross-sectional study was conducted from August 2016 to February 2017. A total of 745 clean catch urine samples were obtained from pediatric patients under the age of 13 and subjected to semiquantitative culture...
March 1, 2024: Tropical Medicine and Health
#28
JOURNAL ARTICLE
Sebastiaan J van Hal, Slade O Jensen, Stephen Y C Tong, Stephen Bentley, Matthew T Holden
OBJECTIVES: This study aims to elucidate the genomic dynamics driving the emergence of antimicrobial resistance (AMR), with a specific focus on the interplay between AMR and antimicrobial usage. METHODS: We conducted a comprehensive analysis using a ST239 methicillin-resistant Staphylococcus aureus (MRSA) dataset over a continuous 12-year period from a single hospital. Genomic analyses were performed tracking the changes in MRSA populations, particularly the emergence of reduced vancomycin susceptibility, and assessing the impact of glycopeptide use on these emergence events...
February 27, 2024: Journal of Antimicrobial Chemotherapy
#29
JOURNAL ARTICLE
Lukas Arenz, Annika Porger, Michaela De Michel, Alexandra Weber, Jette Jung, Heidi Horns, Sandra Gscheidle, Tobias Weiglein, Joachim Pircher, Johanna Becker-Lienau, Sophia Horster, Matthias Klein, Rika Draenert
OBJECTIVES: To explore effectiveness and sustainability of guideline adherence and antibiotic consumption after establishing treatment guidelines and initiating antimicrobial stewardship (AMS) ward rounds in a university hospital emergency department (ED). METHODS: Data were gathered retrospectively from 2017 to 2021 in the LMU University Hospital in Munich, Germany. Four time periods were compared: P1 (pre-intervention period); P2 (distribution of guideline pocket cards); P3 (reassessment after 3 years); and P4 (refresher of guideline pocket cards and additional daily AMS ward rounds for different medical disciplines)...
February 2024: JAC-antimicrobial resistance
#30
JOURNAL ARTICLE
Mahuya Bhattacharyya, Ananya Saha, Subhash Todi
Background: The efficacy of combination empiric antibiotic therapy for all intensive care unit (ICU) patients with community-acquired sepsis is a subject of ongoing debate in the era of increasing antibiotic resistance. This study was conducted to evaluate the patterns of antibiotic usage and microbial resistance in sepsis patients admitted to the ICU with both hemodynamically stable (HS) and unstable states and to analyze their clinical outcomes. Methods: In this observational study, patients aged 18 years and above who received antibiotics upon admission and had a culture report were included...
February 25, 2024: Journal of Intensive Care Medicine
#31
JOURNAL ARTICLE
Francesco Ferrara, Roberta Pasquinucci, Maurizio Capuozzo, Giacomo Polito, Gabriele Bagaglini, Marcello Vaccaro, Adriana Coluccia, Roberto Langella, Ugo Trama, Eduardo Nava, Andrea Zovi
Introduction : The emergence and spread of drug-resistant pathogens due to the improper use of antibiotics have become increasingly apparent in recent years. Objective : This retrospective comparative analysis aimed to assess and compare antibiotic prescription trends in Italy across two different regions based on geographic area and healthcare structure. One region represents a large hospital institution, while the other represents a populous local Italian health agency. The study also examined the impact of documented antibiotic stewardship programs and efforts to promote responsible antibiotic use at all levels, in alignment with international goals...
January 30, 2024: Pharmaceuticals
#32
JOURNAL ARTICLE
Sylvia M Maveke, Gabriel O Aboge, Laetitia W Kanja, Alfred O Mainga, Naftaly Gachau, Beatrice W Muchira, Gervason A Moriasi
BACKGROUND: The emergence of antimicrobial resistance (AMR) and multidrug resistance (MDR) among Escherichia coli and Klebsiella pneumoniae , especially through the production of extended spectrum β -lactamases (ESBLs), limits therapeutic options and poses a significant public health threat. OBJECTIVE: The aim of this study was to assess the phenotypic and genetic determinants of antimicrobial resistance of ESBL-producing Escherichia coli and Klebsiella pneumoniae isolates from patient samples in two Kenyan Hospitals...
2024: International Journal of Microbiology
#33
JOURNAL ARTICLE
Hersh Attal, Zhilian Huang, Win Sen Kuan, Yanyi Weng, Hann Yee Tan, Eillyne Seow, Li Lee Peng, Hoon Chin Lim, Angela Chow
BACKGROUND: Antimicrobial stewardship programs attempting to optimize antibiotic therapy and clinical outcomes mainly focus on inpatient and outpatient settings. The lack of antimicrobial stewardship program studies in the emergency department (ED) represents a gap in tackling the problem of antimicrobial resistance as EDs treat a substantial number of upper respiratory tract infection cases throughout the year. OBJECTIVE: We intend to implement two evidence-based interventions: (1) patient education and (2) providing physician feedback on their prescribing rates...
February 21, 2024: JMIR Research Protocols
#34
JOURNAL ARTICLE
Md Atiqul Haque, Huilong Hu, Jiaqi Liu, Md Aminul Islam, Foysal Hossen, Md Arifur Rahman, Firoz Ahmed, Cheng He
BACKGROUND: Antimicrobial resistance poses a huge risk to human health worldwide, while Bangladesh is confronting the most severe challenge between the food supply and the huge consumption of antibiotics annually. More importantly, probiotics containing Bacillus spp. are claimed to be an alternative to antimicrobial stewardship programs. However, their antibiotic resistance remains elusive. Thus, we employed the antimicrobial susceptibility test and PCR to assess the prevalence of resistance, including multidrug resistance (MDR) and resito-genotyping of isolated Bacillus spp...
February 19, 2024: BMC Microbiology
#35
JOURNAL ARTICLE
J Ruiz Ramos, A Suárez-Lledó Grande, M R Santolaya Perrín, C Caballero Requejo, M Hijazi Vega, M López Vinardell, A García Martín, Y Campos Baeta, A J Marcos González, M Alonso Díez, S Conde Giner, S Herrera Carranza, A Such Diáz, M Prats Riera, L Menendez Liendo, C Toro Blanch, A Revuelta Amallo, C Calzón Blanco
OBJECTIVE: Antimicrobial stewardship programs (ASP) have become a key tool in the adaptation of these drugs to the health system. The information available on the application and indicators used in these programs in emergency departments is scarce. The objective of this study is to know the extent of ASP implementation in the emergency departments, as well as the use of antimicrobials in these units. METHODS: Multicenter retrospective study. An invitation was sent to all participants of the REDFASTER-SEFH emergency pharmacist working group...
February 19, 2024: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
#36
JOURNAL ARTICLE
Matteo Boattini, Gabriele Bianco, Laura Iglesias Llorente, Laura Alonso Acero, Daniel Nunes, Miguel Seruca, Vasco Santos Mendes, André Almeida, Paulo Bastos, Ángel Rodríguez-Villodres, Adelina Gimeno Gascón, Ana Verónica Halperin, Rafael Cantón, Maria Nieves Larrosa Escartín, Juan José González-López, Pauline Floch, Clémence Massip, Delphine Chainier, Olivier Barraud, Laurent Dortet, Gaëlle Cuzon, Clément Zancanaro, Assaf Mizrahi, Rogier Schade, Asger Nellemann Rasmussen, Kristian Schønning, Axel Hamprecht, Lukas Schaffarczyk, Stefan Glöckner, Jürgen Rödel, Katalin Kristóf, Ágnes Balonyi, Stefano Mancini, Chantal Quiblier, Teresa Fasciana, Anna Giammanco, Bianca Paglietti, Salvatore Rubino, Ana Budimir, Branka Bedenić, Zana Rubic, Jelena Marinović, Konstantina Gartzonika, Eirini Christaki, Viktoria Eirini Mavromanolaki, Sofia Maraki, Tuğba Yanık Yalçın, Özlem Kurt Azap, Monica Licker, Corina Musuroi, Daniela Talapan, Vrancianu Corneliu Ovidiu, Sara Comini, Patrycja Zalas-Więcek, Anna Michalska, Rossana Cavallo, José Melo Cristino, Cristina Costa
INTRODUCTION: The ESCPM group (Enterobacter species including Klebsiella aerogenes - formerly Enterobacter aerogenes, Serratia species, Citrobacter freundii complex, Providencia species and Morganella morganii) has not yet been incorporated into systematic surveillance programs. METHODS: We conducted a multicentre retrospective observational study analysing all ESCPM strains isolated from blood cultures in 27 European hospitals over a three-year period (2020-2022)...
February 15, 2024: International Journal of Antimicrobial Agents
#37
JOURNAL ARTICLE
Chih-Hao Chang, Chiung-Hsin Chang, Shih-Hao Huang, Chung-Shu Lee, Po-Chuan Ko, Chun-Yu Lin, Meng-Heng Hsieh, Yu-Tung Huang, Horng-Chyuan Lin, Li-Fu Li, Fu-Tsai Chung, Chun-Hua Wang, Hung-Yu Huang
PURPOSE: Multidrug-resistant (MDR) bacteria impose a considerable health-care burden and are associated with bronchiectasis exacerbation. This study investigated the clinical outcomes of adult patients with bronchiectasis following MDR bacterial infection. METHODS: From the Chang Gung Research Database, we identified patients with bronchiectasis and MDR bacterial infection from 2008 to 2017. The control group comprised patients with bronchiectasis who did not have MDR bacterial infection and were propensity-score matched at a 1:2 ratio...
February 13, 2024: Annals of Clinical Microbiology and Antimicrobials
#38
JOURNAL ARTICLE
Andie Lloyd, Jonathan Grey, Christopher Fronczek, Heather Durkin, Kerry Marr
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Cefdinir and cephalexin are cephalosporin antibiotics commonly used in the treatment of urinary tract infections (UTIs)...
February 13, 2024: American Journal of Health-system Pharmacy: AJHP
#39
REVIEW
Karyne Rangel, Salvatore Giovanni De-Simone
Acinetobacter pneumonia is a significant healthcare-associated infection that poses a considerable challenge to clinicians due to its multidrug-resistant nature. Recent world events, such as the COVID-19 pandemic, have highlighted the need for effective treatment and management strategies for Acinetobacter pneumonia. In this review, we discuss lessons learned from recent world events, particularly the COVID-19 pandemic, in the context of the treatment and management of Acinetobacter pneumonia. We performed an extensive literature review to uncover studies and information pertinent to the topic...
2024: Infection and Drug Resistance
#40
JOURNAL ARTICLE
Gregory Stone, Mark Wise, Eric Utt
Oxacillinases (OXA)-48-like β-lactamases are one of the most common resistance determinants among carbapenem-resistant Enterobacterales reported globally. Moreover, there is no standard treatment available against organisms producing OXA-48-like enzymes, and they are sometimes difficult to detect, making treatment challenging. The objective of this study was to evaluate the distribution and antimicrobial susceptibility of bla OXA-48-like Enterobacterales isolates against ceftazidime-avibactam (CAZ-AVI) and a panel of comparators collected worldwide from 2016 to 2020 as a part of the Antimicrobial Testing Leadership and Surveillance program...
February 8, 2024: Microbiology Spectrum
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