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Microbiota depression

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https://www.readbyqxmd.com/read/29896124/-immune-gate-of-psychopathology-the-role-of-gut-derived-immune-activation-in-major-psychiatric-disorders
#1
REVIEW
Leszek Rudzki, Agata Szulc
Interaction between the gastrointestinal tract (GI) and brain functions has recently become a topic of growing interest in psychiatric research. These multidirectional interactions take place in the so-called gut-brain axis or more precisely, the microbiota-gut-brain axis. The GI tract is the largest immune organ in the human body and is also the largest surface of contact with the external environment. Its functions and permeability are highly influenced by psychological stress, which are often a precipitating factor in the first episode, reoccurrence and/or deterioration of symptoms of psychiatric disorders...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29872772/the-effects-of-repeated-antibiotic-administration-to-juvenile-balb-c-mice-on-the-microbiota-status-and-animal-behavior-at-the-adult-age
#2
Taha Ceylani, Ewa Jakubowska-Doğru, Rafig Gurbanov, Hikmet Taner Teker, Ayse Gul Gozen
Recent studies carried on germ -free (GF) animal models suggest that the gut microbiota (GM) may play a role in the regulation of anxiety, mood, and cognitive abilities such as memory and learning processes. Consistently, any treatment disturbing the gut microbiota, including the overuse of antibiotics, may influence the brain functions and impact behavior. In the present study, to address this issue, two wide-spectrum antibiotics (ampicillin and cefoperazone, 1 g/l) were repeatedly applied throughout a 6-week period to initially 21-day-old male BALB/c mice...
June 2018: Heliyon
https://www.readbyqxmd.com/read/29870270/impact-of-gut-microbiota-on-neurological-diseases-diet-composition-and-novel-treatments
#3
Ana Larroya-García, Diana Navas-Carrillo, Esteban Orenes-Piñero
Gut microbiota has significant effects on the structure and function of the enteric and central nervous system including human behaviour and brain regulation. Herein, we analyze the role of this intestinal ecosystem, the effects of dietary changes and the administration of nutritional supplements, such as probiotics, prebiotics, or fecal transplantation in neuropsychiatric disorders. Numerous factors have been highlighted to influence gut microbiota composition, including genetics, health status, mode of birth delivery and environment...
June 5, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29867313/mouse-strain-affects-behavioral-and-neuroendocrine-stress-responses-following-administration-of-probiotic-lactobacillus-rhamnosus-jb-1-or-traditional-antidepressant-fluoxetine
#4
Karen-Anne McVey Neufeld, Sebastian Kay, John Bienenstock
Currently, there is keen interest in the development of alternative therapies in the treatment of depression. Given the explosion of research focused on the microbiota-gut-brain axis, consideration has turned to the potential of certain probiotics to improve patient outcomes for those suffering from mood disorders. Here we examine the abilities of a known antidepressant, fluoxetine, and the probiotic Lactobacillus rhamnosus JB-1™, to attenuate responses to two established criteria for depressive-like behavior in animal models, the tail suspension test (TST) and the corticosterone response to an acute restraint stressor...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29843470/recognizing-depression-from-the-microbiota%C3%A2-gut%C3%A2-brain-axis
#5
REVIEW
Shan Liang, Xiaoli Wu, Xu Hu, Tao Wang, Feng Jin
Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain⁻gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota⁻gut⁻brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression...
May 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29807325/emerging-literature-in-the-microbiota-brain-axis-and-perinatal-mood-and-anxiety-disorders
#6
REVIEW
Hannah S Rackers, Stephanie Thomas, Kelsey Williamson, Rachael Posey, Mary C Kimmel
Perinatal Mood and Anxiety Disorders (PMAD) are common and can cause significant morbidity and mortality for mother and child. A healthy perinatal period requires significant adaptations; however, systems can become imbalanced resulting in depressive and anxiety symptoms. The interface between the microbiome, the immune system, and the stress system may be a model for understanding mechanisms underlying PMAD. Emerging literature from general populations regarding immune, hormone, and HPA axis changes in relation to the microbiome combined with literature on immune, gonadotropin, and stress systems in the perinatal period provides a background...
May 17, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29785336/targeting-the-microbiota-from-irritable-bowel-syndrome-to-mood-disorders-focus-on-probiotics-and-prebiotics
#7
M M Pusceddu, K Murray, M G Gareau
Purpose of review: The crosstalk between the gut and the brain has revealed a complex communication system responsible for maintaining a proper gastrointestinal homeostasis as well as affect emotional mood and cognitive functions. Recent research has revealed that beneficial manipulation of the microbiota by probiotics and prebiotics represent an emerging and novel strategy for the treatment of a large spectrum of diseases ranging from visceral pain to mood disorders. The review critically evaluates current knowledge of the effects exerted by both probiotics and prebiotics in irritable bowel syndrome (IBS) and mood disorders such as anxiety and depression...
March 2018: Current Pathobiology Reports
https://www.readbyqxmd.com/read/29758946/gut-microbiome-is-altered-in-patients-with-alzheimer-s-disease
#8
Zhen-Qian Zhuang, Lin-Lin Shen, Wei-Wei Li, Xue Fu, Fan Zeng, Li Gui, Yang Lü, Min Cai, Chi Zhu, Yin-Ling Tan, Peng Zheng, Hui-Yun Li, Jie Zhu, Hua-Dong Zhou, Xian-Le Bu, Yan-Jiang Wang
Previous studies suggest that gut microbiota is associated with neuropsychiatric disorders, such as Parkinson's disease, amyotrophic lateral sclerosis, and depression. However, whether the composition and diversity of gut microbiota is altered in patients with Alzheimer's disease (AD) remain largely unknown. In the present study, we collected fecal samples from 43 AD patients and 43 age- and gender-matched cognitively normal controls. 16S ribosomal RNA sequencing technique was used to analyze the microbiota composition in feces...
May 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29757063/gut-microbiota-composition-in-mid-pregnancy-is-associated-with-gestational-weight-gain-but-not-prepregnancy-body-mass-index
#9
Anna-Katariina Aatsinki, Henna-Maria Uusitupa, Eveliina Munukka, Henri Pesonen, Anniina Rintala, Sami Pietilä, Leo Lahti, Erkki Eerola, Linnea Karlsson, Hasse Karlsson
BACKGROUND: Pregnancy is a time of numerous hormonal, metabolic, and immunological changes for both the mother and the fetus. Furthermore, maternal gut microbiota composition (GMC) is altered during pregnancy. One major factor affecting GMC in pregnant and nonpregnant populations is obesity. The aim was to analyze associations between maternal overweight/obesity, as well as gestational weight gain (GWG) and GMC. Moreover, the modifying effect of depression and anxiety symptom scores on weight and GMC were investigated...
May 14, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29752710/inflammation-in-psychiatric-disorders-what-comes-first
#10
REVIEW
Moisés E Bauer, Antonio L Teixeira
Neuropsychiatric disorders (i.e., mood disorders and schizophrenia) and inflammation are closely intertwined, and possibly powering each other in a bidirectional loop. Depression facilitates inflammatory reactions and inflammation promotes depression and other neuropsychiatric disorders. Patients with neuropsychiatric disorders exhibit all cardinal features of inflammation, including increased circulating levels of inflammatory inducers, activated sensors, and inflammatory mediators targeting all tissues. Inflammation may contribute to the pathophysiology and clinical progression of these disorders...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29731182/effect-of-probiotic-and-prebiotic-vs-placebo-on-psychological-outcomes-in-patients-with-major-depressive-disorder-a-randomized-clinical-trial
#11
Asma Kazemi, Ahmad Ali Noorbala, Kamal Azam, Mohammad Hadi Eskandari, Kurosh Djafarian
BACKGROUND: Disturbance in the equilibrium of the gut microbiota has been involved in the pathophysiology of depression. Probiotics have the potential to healthfully modulate the gut microbiome. Prebiotics could also be effective by stimulation of growth of some bacterial species in the gut microbiota. OBJECTIVE: The aim of this double blind clinical trial, was to compare the effect of supplementation with the probiotic and prebiotic on the Beck Depression Inventory (BDI) score as a primary outcome as well as the kynurenine/tryptophan ratio and tryptophan/branch chain amino acids (BCAAs) ratio as secondary outcomes in patients with major depressive disorder (MDD)...
April 24, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29705711/alcohol-microbiome-and-their-effect-on-psychiatric-disorders
#12
REVIEW
Thomas Hillemacher, Oliver Bachmann, Kai G Kahl, Helge Frieling
There is accumulating evidence that alcohol consumption and especially alcohol withdrawal increase brain levels of known innate immune signaling molecules and cause neuroinflammation. It has been shown that microbiota play a pivotal role in this process and affect central neurochemistry and behavior. Disruption of or alterations in the intimate cross-talk between microbiome and brain may be a significant factor in many psychiatric disorders. Alterations in the composition of the microbiome, so called dysbiosis, may result in detrimental distortion of microbe-host homeostasis modulating the hypothalamic-pituitary-adrenal axis...
April 26, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29702390/development-and-application-of-bio-sample-quantification-to-evaluate-stability-and-pharmacokinetics-of-inulin-type-fructo-oligosaccharides-from-morinda-officinalis
#13
Liandi Chi, Lingxiao Chen, Jiwen Zhang, Jing Zhao, Shaoping Li, Ying Zheng
Inulin-type fructooligosaccharides (FOS) purified from Morinda Officinalis, with degrees of polymerization (DP) from 3 to 9, have been approved in China as an oral prescribed drug for mild and moderate depression episode, while the stability and oral absorption of this FOS mixtures are largely unknown. As the main active component and quality control marker for above FOS, DP5 was selected as the representative FOS in this study. Desalting method by ion exchange resin was developed to treat bio-sample, followed by separation and quantification by high performance liquid chromatography-charged aerosol detector...
April 21, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29684865/the-effect-of-fecal-microbiota-transplantation-on-psychiatric-symptoms-among-patients-with-irritable-bowel-syndrome-functional-diarrhea-and-functional-constipation-an-open-label-observational-study
#14
Shunya Kurokawa, Taishiro Kishimoto, Shinta Mizuno, Tatsuhiro Masaoka, Makoto Naganuma, Kuo-Ching Liang, Momoko Kitazawa, Moeko Nakashima, Chie Shindo, Wataru Suda, Masahira Hattori, Takanori Kanai, Masaru Mimura
BACKGROUNDS: The intestinal microbiota is considered as a potential common underpinning pathophysiology of Functional Gastrointestinal Disorders (FGIDs) and psychiatric disorders such as depression and anxiety. Fecal Microbiota Transplantation (FMT) has been reported to have therapeutic effects on diseases related to dysbiosis, but few studies have evaluated its effect on psychiatric symptoms. METHODS: We followed 17 patients with either Irritable Bowel Syndrome (IBS), Functional Diarrhea (FDr) or Functional Constipation (FC) who underwent FMT for the treatment of gastrointestinal symptoms and observation of psychiatric symptoms...
August 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29671359/current-evidence-linking-diet-to-gut-microbiota-and-brain-development-and-function
#15
Florencia Ceppa, Andrea Mancini, Kieran Tuohy
The gut:brain axis is emerging as an important information highway linking the foods we eat with neurophysiological development and functions. Some gut microorganisms have shown to alleviate anxiety and depression, improve cognitive performance and play a role in brain development in early life. However, most studies were conducted in laboratory animals and these findings await confirmation in carefully designed human interventions. Similarly, little attention has been given to how diet:microbe interactions within the gut can impact on neurotransmitter production or their subsequent biological effects within the nervous system...
April 19, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29660942/the-role-of-the-gut-microbiota-in-the-metabolism-of-polyphenols-as-characterized-by-gnotobiotic-mice
#16
Giulio Maria Pasinetti, Risham Singh, Susan Westfall, Francis Herman, Jeremiah Faith, Lap Ho
A growing body of experimental data suggests that microbes in the gut influence behavior and can alter brain physiology and neurochemistry. Although promising, researchers are only starting to understand the potential of the gut microbiota for use in neurological disease. Recent evidence demonstrated that gastrointestinal activities are linked to mood disorders such as anxiety, depression, and most recently, cognitive functions in age-related neurodegenerative disorders. Studies from our group and others are uncovering new evidence suggesting that the gut microbiota plays a crucial role in the metabolism and bioavailability of certain dietary compounds and synthetic drugs...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29627254/technical-note-a-simple-rumen-collection-device-for-calves-an-adaptation-of-a-manual-rumen-drenching-system
#17
R N Klopp, M J Oconitrillo, A Sackett, T M Hill, R L Schlotterbeck, G J Lascano
A limited amount of research is available related to the rumen microbiota of calves, yet there has been a recent spike of interest in determining the diversity and development of calf rumen microbial populations. To study the microbial populations of a calf's rumen, a sample of the rumen fluid is needed. One way to take a rumen fluid sample from a calf is by fistulating the animal. This method requires surgery and can be very stressful on a young animal that is trying to adapt to a new environment and has a depressed immune system...
April 4, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29615850/interplay-between-the-gut-brain-axis-obesity-and-cognitive-function
#18
REVIEW
Ana Agustí, Maria P García-Pardo, Inmaculada López-Almela, Isabel Campillo, Michael Maes, Marina Romaní-Pérez, Yolanda Sanz
Obesity continues to be one of the major public health problems due to its high prevalence and co-morbidities. Common co-morbidities not only include cardiometabolic disorders but also mood and cognitive disorders. Obese subjects often show deficits in memory, learning and executive functions compared to normal weight subjects. Epidemiological studies also indicate that obesity is associated with a higher risk of developing depression and anxiety, and vice versa . These associations between pathologies that presumably have different etiologies suggest shared pathological mechanisms...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29614774/the-brain-intestinal-mucosa-appendix-microbiome-brain-loop
#19
Luis Vitetta, Gemma Vitetta, Sean Hall
The brain and the gut are connected from early fetal life. The mother's exposure to microbial molecules is thought to exert in utero developmental effects on the fetus. These effects could importantly underpin the groundwork for subsequent pathophysiological mechanisms for achieving immunological tolerance and metabolic equilibrium post birth, events that continue through to 3-4 years of age. Furthermore, it is understood that the microbiome promotes cues that instruct the neonate's mucosal tissues and skin in the language of molecular and cellular biology...
April 1, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29610580/infectious-bursal-disease-virus-inoculation-infection-modifies-campylobacter-jejuni-host-interaction-in-broilers
#20
Li Li, Colin Pielsticker, Zifeng Han, Tereza Kubasová, Ivan Rychlik, Bernd Kaspers, Silke Rautenschlein
Background: Campylobacter jejuni is considered as a chicken commensal. The gut microbiota and the immune status of the host may affect its colonization. Infectious bursal disease virus (IBDV) is an immunosuppressive virus of chickens, which allows secondary pathogens to invade or exacerbates their pathogenesis. To investigate the effect of IBDV-induced immunosuppression on the pathogenesis of C. jejuni , broiler chickens were inoculated with a very virulent (vv) strain of IBDV at 14 days post hatch followed by C...
2018: Gut Pathogens
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