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Microbiota depression

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https://www.readbyqxmd.com/read/28483500/probiotic-bifidobacterium-longum-ncc3001-reduces-depression-scores-and-alters-brain-activity-a-pilot-study-in-patients-with-irritable-bowel-syndrome
#1
Maria Ines Pinto-Sanchez, Geoffrey B Hall, Kathy Ghajar, Andrea Nardelli, Carolina Bolino, Jennifer T Lau, Francois-Pierre Martin, Ornella Cominetti, Christopher Welsh, Amber Rieder, Jenna Traynor, Caitlin Gregory, Giada De Palma, Marc Pigrau, Alexander C Ford, Joseph Macri, Bernard Berner, Gabriela Bergonzelli, Michael G Surette, Stephen M Collins, Paul Moayyedi, Premysl Bercik
BACKGROUND & AIMS: Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to evaluate the effects of Bifidobacterium longum NCC3001 (BL) on anxiety and depression in patients with IBS. METHODS: We performed a randomized, double-blind, placebo-controlled study of 44 adults with IBS and diarrhea or a mixed-stool pattern (based on Rome III criteria) and mild to moderate anxiety and/or depression (based on the Hospital Anxiety and Depression scale) at McMaster University in Canada, from March 2011 to May 2014...
May 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28482009/the-microbiota-the-gut-and-the-brain-in-eating-and-alcohol-use-disorders-a-m%C3%A3-nage-%C3%A3-trois
#2
Jamie E Temko, Sofia Bouhlal, Mehdi Farokhnia, Mary R Lee, John F Cryan, Lorenzo Leggio
Aims: Accumulating evidence for the influence of the gut microbiota on the bidirectional communication along the gut-brain axis suggests a role of the gut microbiota in eating disorders (EDs) and alcohol and substance use disorders. The potential influence of altered gut microbiota (dysbiosis) on behaviors associated with such disorders may have implications for developing therapeutic interventions. Methods: A systematic review of preclinical and clinical studies evaluating the gut microbiota, EDs and alcohol and substance use disorders was conducted using MEDLINE, Embase and Web of Science databases with the objective being to examine the role of the gut microbiota in behavioral correlates of these disorders...
May 8, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28466983/review-of-mechanisms-of-deoxynivalenol-induced-anorexia-the-role-of-gut-microbiota
#3
REVIEW
Zhao Peng, Liangkai Chen, Jie Xiao, Xiaoqi Zhou, Andreas K Nüssler, Liegang Liu, Jinping Liu, Wei Yang
Deoxynivalenol (DON) is one of the most important mycotoxins in cereal-based foods or other food productions, produced by Fusarium species. Because of the high occurrence of DON in food combined with vast consumption of cereals and grain worldwide, the DON-contaminated food is a very harmful factor for human and animal health. DON has been reported to induce anorexia at lower or chronic doses in animal models. However, further researches for DON-induced anorexia are limited. Previous publications demonstrated a close link between Bacteroidetes and Firmicutes, two kinds of gut microbiota, with weight loss and the effect of low administration of DON on neurotransmitters in the frontal cortex, cerebellum, hypothalamus, hippocampus and pons/medulla...
May 3, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28450222/probiotic-treatment-protects-against-the-pro-depressant-like-effect-of-high-fat-diet-in-flinders-sensitive-line-rats
#4
Anders Abildgaard, Betina Elfving, Marianne Hokland, Sten Lund, Gregers Wegener
Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that a high-fat diet (HFD) exacerbated depressive-like behaviour uniquely in Flinders Sensitive Line (FSL) rats that inherently present with an increased level of depressive-like behaviour compared with Flinders Resistant Line (FRL) rats. We therefore investigated whether multispecies probiotics possessed anti-depressant-like effect in FSL rats or protected against the pro-depressant-like effect of HFD...
April 24, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28438331/-the-intestinal-microbiota-a-new-player-in-depression
#5
M Meyrel, L Varin, B Detaint, F Mouaffak
Depression is the leading cause of disability in the world according to the World Health Organization. The effectiveness of the available antidepressant therapies is limited. Data from the literature suggest that some subtypes of depression may be associated with chronic low grade inflammation. The uncovering of the role of intestinal microbiota in the development of the immune system and its bidirectional communication with the brain have led to growing interest on reciprocal interactions between inflammation, microbiota and depression...
April 21, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28399458/the-role-of-maternal-anxiety-and-depressive-disorders-prior-to-and-during-pregnancy-and-perinatal-psychopathological-symptoms-for-early-infant-diseases-and-drug-administration
#6
Linda Krause, Franziska Einsle, Johanna Petzoldt, Hans-Ulrich Wittchen, Julia Martini
BACKGROUND: Maternal mental health prior to and during pregnancy has been shown to be associated with inflammatory diseases and gastrointestinal complaints in the offspring. Unfortunately, many studies merely focused on perinatal distress without consideration of lifetime anxiety and depressive disorders. AIMS: To prospectively investigate associations of anxiety and depressive disorders prior to and during pregnancy as well as perinatal distress with infants' inflammatory diseases, gastrointestinal complaints and corresponding drug administration...
April 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/28368029/bifidobacterium-in-the-gut-microbiota-confer-resilience-to-chronic-social-defeat-stress-in-mice
#7
Chun Yang, Yuko Fujita, Qian Ren, Min Ma, Chao Dong, Kenji Hashimoto
Accumulating evidence suggests that abnormalities in the composition of the gut microbiota may play a role in the pathogenesis of depression. Although approximately 30% mice are resilient to chronic social defeat stress (CSDS), the role of gut microbiota in this stress resilience is unknown. In this study, male C57BL/6 mice were exposed to a different CD1 aggressor mouse for 10 min on 10 consecutive days. A social interaction test was applied to distinguish between resilient and susceptible mice. Using 16S rRNA analysis, we examined the composition of gut microbiota in feces from control, resilient, and susceptible mice...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28360846/stress-and-the-emerging-roles-of-chromatin-remodeling-in-signal-integration-and-stable-transmission-of-reversible-phenotypes
#8
REVIEW
Ian C G Weaver, Austin C Korgan, Kristen Lee, Ryan V Wheeler, Amos S Hundert, Donna Goguen
The influence of early life experience and degree of parental-infant attachment on emotional development in children and adolescents has been comprehensively studied. Structural and mechanistic insight into the biological foundation and maintenance of mammalian defensive systems (metabolic, immune, nervous and behavioral) is slowly advancing through the emerging field of developmental molecular (epi)genetics. Initial evidence revealed that differential nurture early in life generates stable differences in offspring hypothalamic-pituitary-adrenal (HPA) regulation, in part, through chromatin remodeling and changes in DNA methylation of specific genes expressed in the brain, revealing physical, biochemical and molecular paths for the epidemiological concept of gene-environment interactions...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28346923/gut-brain-axis-and-behavior
#9
Clair R Martin, Emeran A Mayer
In the last 5 years, interest in the interactions among the gut microbiome, brain, and behavior has exploded. Preclinical evidence supports a role of the gut microbiome in behavioral responses associated with pain, emotion, social interactions, and food intake. Limited, but growing, clinical evidence comes primarily from associations of gut microbial composition and function to behavioral and clinical features and brain structure and function. Converging evidence suggests that the brain and the gut microbiota are in bidirectional communication...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346507/olive-oil-bioactives-protect-pigs-against-experimentally-induced-chronic-inflammation-independently-of-alterations-in-gut-microbiota
#10
Martin Liehr, Alessandro Mereu, Jose Javier Pastor, Jose Carlos Quintela, Stefanie Staats, Gerald Rimbach, Ignacio Rodolfo Ipharraguerre
Subclinical chronic inflammation (SCI) is associated with impaired animal growth. Previous work has demonstrated that olive-derived plant bioactives exhibit anti-inflammatory properties that could possibly counteract the growth-depressing effects of SCI. To test this hypothesis and define the underlying mechanism, we conducted a 30-day study in which piglets fed an olive-oil bioactive extract (OBE) and their control counterparts (C+) were injected repeatedly during the last 10 days of the study with increasing doses of Escherichia coli lipopolysaccharides (LPS) to induce SCI...
2017: PloS One
https://www.readbyqxmd.com/read/28301775/the-microbiome-and-host-behavior
#11
Helen E Vuong, Jessica M Yano, Thomas C Fung, Elaine Y Hsiao
The microbiota is increasingly recognized for its ability to influence the development and function of the nervous system and several complex host behaviors. In this review, we discuss emerging roles for the gut microbiota in modulating host social and communicative behavior, stressor-induced behavior, and performance in learning and memory tasks. We summarize effects of the microbiota on host neurophysiology, including brain microstructure, gene expression, and neurochemical metabolism across regions of the amygdala, hippocampus, frontal cortex, and hypothalamus...
March 8, 2017: Annual Review of Neuroscience
https://www.readbyqxmd.com/read/28291971/can-gut-microbes-play-a-role-in-mental-disorders-and-their-treatment
#12
Klara Latalova, Miroslav Hajda, Jan Prasko
The gut microbes, collectively called microbiota, are linked to the brain through a bidirectional system that involves the vagus nerve, the immune system, and various neurotransmitters. Stress response, memory functions, social behavior, and mood are modulated by microbiota. Furthermore, microbiota play a role in the development of the central nervous system. These features, established largely in rodent studies, have informed hypotheses about the role of microbiota in human psychiatric disorders. Microbiota affect phenomena that are known to be parts of the depression phenotype, such as exaggerated response to stress and inflammatory features...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28270247/gut-brain-actions-underlying-comorbid-anxiety-and-depression-associated-with-inflammatory-bowel-disease
#13
Áine Abautret-Daly, Elaine Dempsey, Adolfo Parra-Blanco, Carlos Medina, Andrew Harkin
Introduction Inflammatory bowel disease (IBD) is a chronic relapsing and remitting disorder characterised by inflammation of the gastrointestinal tract. There is a growing consensus that IBD is associated with anxiety- and depression-related symptoms. Psychological symptoms appear to be more prevalent during active disease states with no difference in prevalence between Crohn's disease and ulcerative colitis. Behavioural disturbances including anxiety- and depression-like symptoms have also been observed in animal models of IBD...
March 8, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28266612/microbiota-alteration-is-associated-with-the-development-of-stress-induced-despair-behavior
#14
Ioana A Marin, Jennifer E Goertz, Tiantian Ren, Stephen S Rich, Suna Onengut-Gumuscu, Emily Farber, Martin Wu, Christopher C Overall, Jonathan Kipnis, Alban Gaultier
Depressive disorders often run in families, which, in addition to the genetic component, may point to the microbiome as a causative agent. Here, we employed a combination of behavioral, molecular and computational techniques to test the role of the microbiota in mediating despair behavior. In chronically stressed mice displaying despair behavior, we found that the microbiota composition and the metabolic signature dramatically change. Specifically, we observed reduced Lactobacillus and increased circulating kynurenine levels as the most prominent changes in stressed mice...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259042/probiotic-treatment-reduces-depressive-like-behaviour-in-rats-independently-of-diet
#15
Anders Abildgaard, Betina Elfving, Marianne Hokland, Gregers Wegener, Sten Lund
The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive disorder (MDD). However, some conceptual and mechanistical aspects need further elucidation. We therefore aimed at investigating whether the habitual diet may interact with the effect of probiotics on depression-related behaviour and further examined some potentially involved mechanisms underlying the microbe-mediated behavioural effects...
February 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28242013/targeting-the-microbiota-gut-brain-axis-prebiotics-have-anxiolytic-and-antidepressant-like-effects-and-reverse-the-impact-of-chronic-stress-in-mice
#16
Aurelijus Burokas, Silvia Arboleya, Rachel D Moloney, Veronica L Peterson, Kiera Murphy, Gerard Clarke, Catherine Stanton, Timothy G Dinan, John F Cryan
BACKGROUND: The realization that the microbiota-gut-brain axis plays a critical role in health and disease, including neuropsychiatric disorders, is rapidly advancing. Nurturing a beneficial gut microbiome with prebiotics, such as fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS), is an appealing but underinvestigated microbiota manipulation. Here we tested whether chronic prebiotic treatment modifies behavior across domains relevant to anxiety, depression, cognition, stress response, and social behavior...
February 24, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28219800/variations-in-gut-microbiota-and-fecal-metabolic-phenotype-associated-with-depression-by-16s-rrna-gene-sequencing-and-lc-ms-based-metabolomics
#17
Meng Yu, Hongmei Jia, Chao Zhou, Yong Yang, Yang Zhao, Maohua Yang, Zhongmei Zou
As a prevalent, life-threatening and highly recurrent psychiatric illness, depression is characterized by a wide range of pathological changes; however, its etiology remains incompletely understood. Accumulating evidence supports that gut microbiota affects not only gastrointestinal physiology but also central nervous system (CNS) function and behavior through the microbiota-gut-brain axis. To assess the impact of gut microbiota on fecal metabolic phenotype in depressive conditions, an integrated approach of 16S rRNA gene sequencing combined with ultra high-performance liquid chromatography-mass spectrometry (UHPLC-MS) based metabolomics was performed in chronic variable stress (CVS)-induced depression rat model...
February 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28215162/gut-brain-axis-role-of-lipids-in-the-regulation-of-inflammation-pain-and-cns-diseases
#18
Roberto Russo, Claudia Cristiano, Carmen Avagliano, Carmen De Caro, Giovanna La Rana, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli, Antonio Calignano
The human gut is a composite anaerobic environment with a large, diverse and dynamic enteric microbiota, represented by more than 100 trillion microorganisms, including at least 1000 distinct species. The discovery that a different microbial composition can influence behavior and cognition, and in turn the nervous system can indirectly influence enteric microbiota composition, has significantly contributed to establish the well-accepted concept of gut-brain axis. This hypothesis is supported by several evidence showing mutual mechanisms, which involve the vague nerve, the immune system, the hypothalamic-pituitary-adrenal (HPA) axis modulation and the bacteria-derived metabolites...
February 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28164854/the-microbiome-gut-brain-axis-in-health-and-disease
#19
REVIEW
Timothy G Dinan, John F Cryan
Gut microbes are capable of producing most neurotransmitters found in the human brain. Evidence is accumulating to support the view that gut microbes influence central neurochemistry and behavior. Irritable bowel syndrome is regarded as the prototypic disorder of the brain-gut-microbiota axis that can be responsive to probiotic therapy. Translational studies indicate that certain bacteria may have an impact on stress responses and cognitive functioning. Manipulating the gut microbiota with psychobiotics, prebiotics, or even antibiotics offers a novel approach to altering brain function and treating gut-brain axis disorders, such as depression and autism...
March 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28161446/drunk-bugs-chronic-vapour-alcohol-exposure-induces-marked-changes-in-the-gut-microbiome-in-mice
#20
Veronica L Peterson, Nicholas J Jury, Raúl Cabrera-Rubio, Lorraine A Draper, Fiona Crispie, Paul D Cotter, Timothy G Dinan, Andrew Holmes, John F Cryan
The gut microbiota includes a community of bacteria that play an integral part in host health and biological processes. Pronounced and repeated findings have linked gut microbiome to stress, anxiety, and depression. Currently, however, there remains only a limited set of studies focusing on microbiota change in substance abuse, including alcohol use disorder. To date, no studies have investigated the impact of vapour alcohol administration on the gut microbiome. For research on gut microbiota and addiction to proceed, an understanding of how route of drug administration affects gut microbiota must first be established...
April 14, 2017: Behavioural Brain Research
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