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https://www.readbyqxmd.com/read/29675508/are-trabecular-metal-cones-a-valid-option-to-treat-metaphyseal-bone-defects-in-complex-primary-and-revision-knee-arthroplasty
#1
REVIEW
Tommaso Bonanzinga, Thorsten Gehrke, Akos Zahar, Stefano Zaffagnini, Maurilio Marcacci, Carl Haasper
Purpose  Metaphyseal bone defects are a challenge in complex primary and revision total knee arthroplasty (TKA). Recently, several studies have been published with promising results about the use of Trabecular Metal (TM) cones to address bone defects. The aim of this study is to review the literature to assess the efficacy of TM cones to address metaphyseal bone loss. Methods  A comprehensive search was performed on PubMed, Medline, CINAHL, Cochrane, Embase, and Google Scholar databases using various combinations of the following keywords: "metaphyseal," "cones," "tantalum," "knee," and "revision...
March 2018: Joints
https://www.readbyqxmd.com/read/29672274/cutaneous-mucormycosis-as-a-presenting-feature-of-type-1-diabetes-in-a-boy-case-report-and-review-of-the-literature
#2
Ganesh Jevalikar, Siddhnath Sudhanshu, Sanjay Mahendru, Smita Sarma, Khalid J Farooqui, Ambrish Mithal
BACKGROUND: Mucormycosis is a potentially fatal complication of diabetes. The rhino-orbito-cerebral form is the most common presentation, however, rarely other types can also be seen. CASE PRESENTATION: We describe the case of a 4½ -year-old boy not previously known to be a diabetic who presented to the plastic surgery department for gangrene of the left middle finger with surrounding erythema and induration. After the diagnosis of diabetes and initial treatment, pus from the wound showed broad aseptate hyphae suggestive of mucormycosis which was further confirmed on culture...
April 19, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29672240/national-survey-of-operating-room-nurses-aseptic-techniques-and-interventions-for-patient-preparation-to-reduce-surgical-site-infections
#3
Camilla Wistrand, Karin Falk-Brynhildsen, Ulrica Nilsson
BACKGROUND: Surgical site infection (SSI), the third most common type of nosocomial infection in Sweden, is a patient injury that should be prevented. Methods of reducing SSIs include, for instance, disinfecting the skin, maintaining body temperature, and ensuring an aseptic environment. Guidelines for most of these interventions exist, but there is a lack of studies describing to what extent the preventive interventions have been implemented in clinical practice. We describe the daily clinical interventions Swedish operating room (OR) nurses performed to prevent SSIs following national guidelines...
April 19, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29671089/porous-metal-cones-gold-standard-for-massive-bone-loss-in-complex-revision-knee-arthroplasty-a-systematic-review-of-current-literature
#4
Stefano Divano, Luca Cavagnaro, Andrea Zanirato, Marco Basso, Lamberto Felli, Matteo Formica
INTRODUCTION: Revision knee arthroplasty is increasing, and in that case, bone loss management is still a challenging problem. In the last years, the body of literature and interest surrounding porous metal cones has grown, but few systematic evaluations of the existing evidence have been performed. The aim of our systematic review is to collect and critically analyze the available evidence about metal cones in revision knee arthroplasty especially focusing our attention on indications, results, complications, and infection rate of these promising orthopaedic devices...
April 18, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29663933/small-heterodimer-partner-negatively-regulates-tlr4-signaling-pathway-of-titanium-particles-induced-osteolysis-in-mice
#5
Chi Zhang, Changchuan Li, Shixun Li, Ling Qin, Manli Luo, Guangtao Fu, Junxiong Qiu, Peng Peng, Weibin Cai, Yue Ding
Arthroplasty has been widely performed worldwide. However, peri-prosthetic osteolysis and aseptic loosening induced by macrophages activated by wear particles still remain a predominant cause of long term prosthetic failure. Our study aimed to identify the role of small heterodimer partner (SHP) in secretion of proinflammatory cytokines by macrophages through Toll-like Recepters (TLR)s signaling pathway activated by wear particles both in vivo and in vitro. The effect of SHP on activation of TLR4 pathway and secretion of cytokines was observed in RAW264...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663650/content-of-distinct-metals-in-periprosthetic-tissues-and-pseudosynovial-joint-fluid-in-patients-with-total-joint-arthroplasty
#6
Martin Kuba, Jiří Gallo, Tomáš Pluháček, Martin Hobza, David Milde
This prospective study examined the content of metals released from total joint arthroplasty into joint fluid, whole blood and periprosthetic tissues. We determined the levels of Ti, V, Nb, Co, Cr, and Mo, using inductively coupled plasma mass spectrometry, in samples from patients who underwent reoperation of total hip or knee arthroplasty. All of the patients (n = 117) included in the study had either metal on polyethylene or ceramic on polyethylene-bearing pairs. First, our results conclusively showed that the majority of released metals were deposited in periprosthetic tissues...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29659450/aseptic-freeze-dried-vs-sterile-wet-packaged-human-cadaveric-acellular-dermal-matrix-adm-in-immediate-tissue-expander-breast-reconstruction-a-propensity-score-analysis-study
#7
Summer E Hanson, Jesse D Meaike, Jesse C Selber, Jun Liu, Liang Li, Victor J Hassid, Donald P Baumann, Charles E Butler, Patrick B Garvey
BACKGROUND: Although multiple acellular dermal matrix (ADM) sources exist, it is unclear how ADM processing impacts complication rates. We compared complications between two preparations of human cadaveric ADM (freeze dried [hADM-FD] and ready to use [hADM-RTU]) in immediate tissue expander (TE) breast reconstruction to analyze the effect of processing on complications. HADM-FD is aseptic while hADM-RTU is sterilized and wet-packaged. METHODS: We retrospectively reviewed all TE breast reconstructions with hADM-FD or hADM-RTU at a single center between 2006 and 2016...
January 20, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29657466/a-long-term-comparative-study-between-two-different-designs-of-cemented-stems-distal-cylindrical-versus-distal-taper
#8
Yuki Okutani, Koji Goto, Tomotoshi Kawata, Yaichiro Okuzu, Kazutaka So, Yutaka Kuroda, Shuichi Matsuda
Introduction: The aim of this study was to calculate the wear rate of highly cross-linked polyethylene (HXLPE) and investigate long-term clinical and radiographic outcomes related to two femoral stem designs, the distal-cylindrical (DC) and distal-taper (DT) stems. Materials and methods: Outcomes for the DC and DT stems were evaluated in 110 patients, who underwent total hip arthroplasty using an HXLPE socket, over a 5-year follow-up period. There were 56 hips (53 patients) in the DC group and 60 hips (57 patients) in the DT group...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29657457/effect-of-stem-alignment-on-long-term-outcomes-of-total-hip-arthroplasty-with-cementless-bi-metric-femoral-components
#9
Takaaki Shishido, Toshiyuki Tateiwa, Yasuhito Takahashi, Toshinori Masaoka, Tsunehito Ishida, Kengo Yamamoto
We investigated the effects of varus-valgus alignment on the long-term outcomes after cementless total hip arthroplasty (THA) using a porous coated version of Bi-Metric® femoral stems. The Kaplan-Meier survival analysis was performed in 71 hips. The survival rate with femoral revision for aseptic loosening as the end point was 100% at 17 years. Nevertheless, the initial stem alignment was more valgus in patients with the Engh grade III-IV stress shielding than patients with the Engh grade I-II. Our results suggest that valgus misalignment of cementless Bi-Metric stem might be a potential risk factor for the progression of stress shielding...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29657408/interspecies-comparison-of-probiotics-isolated-from-different-animals
#10
Amr M Abdou, Riham H Hedia, Shimaa T Omara, Mohamed Abd El-Fatah Mahmoud, Mai M Kandil, M A Bakry
Aim: The aim of the current study was to isolate and identify naturally occurring probiotic Lactobacillus species in different animals with the different environmental background including fish, and farm animals to investigate interspecies differences in probiotics on the species level. Materials and Methods: A total of 44 fecal and milk samples were collected under aseptic conditions from cattle, buffalo, camel, sheep, goats, and fish. The samples were cultured, and the isolated strains were confirmed biochemically and molecularly using 16S rRNA multiplex polymerase chain reaction (PCR) analysis following DNA extraction from the bacterial isolates...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29657391/bacteriological-cure-rate-and-changes-in-milk-composition-in-mastitis-vaccinated-ewes-affected-with-subclinical-mastitis
#11
Myassar O Alekish, Z Bani Ismail, H M Hammouri, M H Daradka, S Al Taha, I Olymat
Aim: The aim of this study was to investigate the effects of using a commercially-available polyvalent mastitis vaccine on the bacteriological cure rate of existing subclinical mastitis in Awassi sheep. Materials and Methods: A total of 164 lactating ewes were divided into two main groups according to udder health and milk somatic cell count (SCC): Group 1=normal (N; n=80) and Group 2=subclinical mastitis (SC; n=84). Each group was then subdivided randomly into two treatment groups: N vaccinated (Nvax ; n=38), N non-vaccinated (Nnvax ; n=42), SC vaccinated (SCvax ; n=42), and SC non-vaccinated (SCnvax ; n=42)...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29656978/high-rate-of-early-revision-after-iuni-custom-made-unicondylar-knee-arthroplasty
#12
Carl T Talmo, Marie C Anderson, Eliot S Jia, Claire E Robbins, Jason D Rand, Brian P McKeon
BACKGROUND: There has been a recent interest in custom-made partial knee arthroplasties to provide patient-specific instrumentation and better fit of the prosthesis. While unicondylar knee arthroplasties (UKAs) have demonstrated good outcomes and durable results in many studies, there is little evidence on outcomes of these custom-made implants. METHODS: We performed a retrospective review of all custom-made UKAs performed at our institution by one surgeon from 2008 to 2015...
March 15, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29656971/long-term-outcomes-after-metal-on-metal-total-hip-arthroplasty-with-a-28-mm-head-a-17-to-23-year-follow-up-study-of-a-previous-report
#13
Jun-Ki Moon, Yeesuk Kim, Kyu-Tae Hwang, Jae-Hyuk Yang, Young-Ha Oh, Young-Ho Kim
BACKGROUND: Second-generation, metal-on-metal total hip arthroplasty (MoM THA) using a 28-mm head has shown favorable results compared with large head MoM THA. The purpose of this study is to evaluate the long-term outcomes of cementless primary MoM THA with a 28-mm head and the incidence of osteolysis using computed tomography. METHODS: A total of 92 patients (53 men and 39 women) who underwent primary cementless MoM THA (114 hips) with a 28-mm head were enrolled in this study...
March 12, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29656965/total-hip-arthroplasty-for-periacetabular-metastatic-disease-an-original-technique-of-reconstruction-according-to-the-harrington-classification
#14
Julien Wegrzyn, Matthieu Malatray, Turki Al-Qahtani, Vincent Pibarot, Cyrille Confavreux, Gilles Freyer
BACKGROUND: Periacetabular metastatic disease requires complex acetabular reconstruction. The complication rate for these frail patients is high. Various cement-rebar reinforced techniques allowing cemented total hip arthroplasty (THA) have been described. The optimal procedure has not yet been identified. METHODS: A continuous series of 131 THAs performed in 126 patients with periacetabular metastatic disease was prospectively included in this study. After bone metastasis curettage and cementation, an original technique of acetabular reconstruction was performed using a dual mobility cup cemented into an acetabular reinforcement device (ie, Kerboull cross-plate or Burch-Schneider antiprotrusio cage) according to the Harrington classification...
March 17, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29656802/impact-on-the-brain-of-the-inflammatory-response-to-surgery
#15
Sarah Saxena, Mervyn Maze
The brain is both the orchestrator as well as the target of the innate immune system's response to the aseptic trauma of surgery. When trauma-induced inflammation is not appropriately regulated persistent neuro-inflammation interferes with the synaptic plasticity that underlies the learning and memory aspects of cognition. The complications that ensue, include postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) at two poles of a constellation that is now termed perioperative neurocognitive disorders...
April 12, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29656074/protein-phosphatase-2a-as-a-new-target-for-downregulating-osteoclastogenesis-and-alleviating-titanium-particle-induced-bone-resorption
#16
Liangliang Wang, Xiaobin Guo, Wei Zhou, Yayun Ding, Jiawei Shi, Xiexing Wu, Yu Liu, Yaozeng Xu, Huilin Yang, Dechun Geng
Receptor activator of nuclear factor-кB ligand (RANKL)-induced osteoclastogenesis is believed to play a critical role in osteolytic diseases including peri-prosthetic osteolysis (PPO), the primary reason for implant failure and revision surgery. In this study, we observed that protein phosphatase 2A (PP2A), a major serine-threonine phosphatase, was highly expressed in human periprosthetic interface membranes with aseptic loosening and in a murine osteolysis model induced by titanium particle irritation. PP2A inhibition effectively alleviated titanium particle-induced bone destruction at osteolytic sites...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29655409/orthodontic-tooth-movement-the-biology-and-clinical-implications
#17
REVIEW
Yina Li, Laura A Jacox, Shannyn H Little, Ching-Chang Ko
Orthodontic tooth movement relies on coordinated tissue resorption and formation in the surrounding bone and periodontal ligament. Tooth loading causes local hypoxia and fluid flow, initiating an aseptic inflammatory cascade culminating in osteoclast resorption in areas of compression and osteoblast deposition in areas of tension. Compression and tension are associated with particular signaling factors, establishing local gradients to regulate remodeling of the bone and periodontal ligament for tooth displacement...
April 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29652642/powassan-virus-disease-in-the-united-states-2006-2016
#18
Elisabeth R Krow-Lucal, Nicole P Lindsey, Marc Fischer, Susan L Hills
BACKGROUND: Powassan virus (POWV) is a tick-borne flavivirus that causes rare, but often severe, disease in humans. POWV neuroinvasive disease was added to the U.S. nationally notifiable disease list in 2001 and nonneuroinvasive disease was added in 2004. The only previous review of the epidemiology of POWV disease in the United States based on cases reported to the Centers for Disease Control and Prevention (CDC) covered the period from 1999 through 2005. METHODS: We describe the epidemiology and clinical features of laboratory-confirmed POWV disease cases reported to CDC from 2006 through 2016...
March 13, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29651439/micrometer-sized-titanium-particles-induce-aseptic-loosening-in-rabbit-knee
#19
Hao Xu, Cui-Cui Guo, Zheng-Yu Gao, Chang-Yao Wang, Hai-Ning Zhang, Cheng-Yu Lv, Zi-Yan Yin, Ying-Zhen Wang
Wear debris induced aseptic loosening is the leading cause of total knee arthroplasty (TKA) failure. The complex mechanism of aseptic loosening has been a major issue for introducing effective prevention and treatment methods, so a simplified yet efficient rabbit model was established to address this concern with the use of micrometer-sized titanium particles. 20 New Zealand white rabbits were selected and divided into two groups (control = 10, study = 10). A TKA surgery was then performed for each of them, with implantation of a titanium rod prosthesis which was coated evenly with micrometer-sized titanium in the study group and nothing in the control group, into right femoral medullary cavity...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29648630/identification-of-prosthetic-joint-infection-pathogens-using-a-shotgun-metagenomics-approach
#20
Matthew Thoendel, Patricio Jeraldo, Kerryl E Greenwood-Quaintance, Janet Yao, Nicholas Chia, Arlen D Hanssen, Matthew P Abdel, Robin Patel
Background: Metagenomic shotgun sequencing has the potential to change how many infections, particularly those caused by difficult to culture organisms, are diagnosed. Metagenomics was used to investigate prosthetic joint infections (PJIs), where pathogen detection can be challenging. Methods: 408 sonicate fluid samples generated from resected hip and knee arthroplasties were tested, including 213 from subjects with infections and 195 from subjects without infection...
April 10, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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