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https://www.readbyqxmd.com/read/29231996/molecular-mechanisms-of-tributyltin-induced-alterations-in-cholesterol-homeostasis-and-steroidogenesis-in-hamster-testis-in-vivo-and-in-vitro-studies
#1
V Kanimozhi, K Palanivel, M A Akbarsha, B Kadalmani
Tributyltins (TBT) are ubiquitous and persistent environmental contaminants that disturb normal endocrine function including gonadal function in humans and marine organisms. TBT was administered through oral route to male Syrian hamsters at daily doses of 50, 100 and 150 ppm/kg for 65 days. Changes in testis morphology, immunohistochemistry of iNOS, 3β-HSD and 17β-HSD, cholesterol transport receptor, nuclear receptors, and transcription factors were analyzed. TBT treatment affected each of these parameters to significant levels in a dose-dependent manner compared to vehicle treated control...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231065/serum-interleukin-6-levels-as-an-indicator-of-aseptic-meningitis-among-children-with-enterovirus-71-induced-hand-foot-and-mouth-disease
#2
Joo Young Lee, Minji Son, Jin Han Kang, Ui Yoon Choi
OBJECTIVES: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. It is often performed based on physicians' clinical suspicion. A diagnostic method that can aid in deciding whether this procedure should be performed is necessary. Cytokines are speculated to be associated with neurologic complications...
December 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29227271/-immune-system-internship-with-symbiotic-microorganisms-in-gnotobiotic-animal-s-intestinum-ileum
#3
B Kochlamasashvili, L Gogiashvili, K Jandieri
Structures, responsible for acceptive (comensaling relation) and protective (pathogenic defense) immunity, were studied and compared in small intestine - to ileum mucosa. Data shown, that main application of the both domains of immune system is to support the correlation between body and foreign microbes, but they response is different. Most significant differences are as follows: in acceptive reactions presented only in aseptic animals - gnotobionts, inflammatory changes absent, so immune reaction complex develops into physiological condition...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29225753/study-of-bacterial-flora-associated-with-mobile-phones-of-healthcare-workers-and-non-healthcare-workers
#4
Raghavendra Rao Morubagal, Sowmya Govindanahalli Shivappa, Rashmi Padmanabha Mahale, Sumana Mhadevaiah Neelambike
Background and Objectives: Despite improvements in modern diagnosis and therapies, hospital acquired infections remain a leading problem of global health systems. Healthcare workers mobile phones is a reservoir for potential pathogens. Despite the high possibility of being contaminated, mobile phones are rarely clean and are often touched during or after examination of patients and handling of specimens without proper hand washing. The main objective of the present study was to isolate, identify different types of bacteria and their antibiotic sensitivity from mobile phones of healthcare workers and non-health-care workers...
June 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29223609/-recurrent-postpartum-pyoderma-gangrenosum-and-fatal-cardiomyopathy
#5
I Naciri, M Meziane, L Benzekri, M Ghaouti, K Senouci, B Hassam
BACKGROUND: We report a case of recurrent post-partum pyoderma gangrenosum (PG) complicated by post-partum cardiomyopathy (PPCM). PATIENTS AND METHODS: A 23-year-old woman presented with a previous medical history of aseptic abscess of the left breast in her fourth pregnancy, which developed after surgical drainage of an inflammatory ulceration treated by atraumatic topical care. During her fifth pregnancy, the patient presented a large and painful ulceration in relation to the scar of the Caesarean section, despite the introduction of broad-spectrum antibiotic therapy...
December 6, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29221839/cementless-one-stage-revision-in-chronic-periprosthetic-hip-joint-infection-ninety-one-percent-infection-free-survival-in-56-patients-at-minimum-2-year-follow-up
#6
Jeppe Lange, Anders Troelsen, Søren Solgaard, Kristian S Otte, Niels K Jensen, Kjeld Søballe
BACKGROUND: Cementless 1-stage revision in chronic periprosthetic hip joint infections is limited evaluated. The purpose of this study was to evaluate a specific treatment protocol in this patient group. METHODS: The study was performed as a multicenter, proof-of-concept, observational study with prospective data collection. Patients were treated with a cementless 1-stage revision according to the CORIHA protocol between 2009 and 2014. Fifty-six patients, McPherson type III-A/B-1/2, were enrolled with a mean follow-up time from the CORIHA procedure of 4 years (minimum of 2 years)...
November 22, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29220341/auditing-safety-of-compounding-and-reconstituting-of-intravenous-medicines-on-hospital-wards-in-finland
#7
Eeva Suvikas-Peltonen, Joni Palmgren, Verner Häggman, Ercan Celikkayalar, Raija Manninen, Marja Airaksinen
On the hospital wards in Finland, nurses generally reconstitute intravenous medicines, such as antibiotics, analgesics, and antiemetics prescribed by doctors. Medicine reconstitution is prone to many errors. Therefore, it is important to identify incorrect practices in the reconstitution of medicine to improve patient safety in hospitals. The aim of this study was to audit the compounding and reconstituting of intravenous medicines on hospital wards in a secondary-care hospital in Finland by using an assessment tool and microbiological testing for identifying issues posing patient safety risks...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29219196/evaluation-of-efficacy-of-repeated-decontamination-and-sterilization-of-single-incision-laparoscopic-surgery-ports-intended-for-1-time-use
#8
Brian Petrovsky, Eric Monnet
OBJECTIVE: To determine the efficacy of repeated decontamination and sterilization of a disposable port intended for 1-time use during single-incision laparoscopy. STUDY DESIGN: Experimental; prospective, controlled design. METHODS: Six single-access ports used 4 times and 6 single-access ports used 8 times to perform various clean, minimally invasive surgeries were evaluated. Ports were decontaminated in an enzymatic cleaner (dilution, 3:100) and cleaned with a scrub brush for 5 minutes...
December 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29217393/acetabular-revision-using-trabecular-metal-augments-for-paprosky-type-3-defects
#9
Cathleen J O'Neill, Stephen B Creedon, Stephen A Brennan, Fiona J O'Mahony, Rosanne S Lynham, Shane Guerin, Rehan Gul, James A Harty
BACKGROUND: Trabecular Metal (TM) augments are one option when reconstructing bone loss during acetabular side revision surgery. METHODS: We studied 38 consecutive patients with Paprosky type 3 defects that were revised using a TM shell and one or more augments over a 6-year period. There were 29 Paprosky type 3A defects and 9 Paprosky type 3B defects. The mean age of the patients at the time of surgery was 68.2 years (range 48-84). The mean length of follow-up was 36 months (range 18-74)...
December 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29217229/idiopathic-facial-aseptic-granuloma-clinical-and-ultrasound-findings-in-3-cases
#10
A I Rodríguez-Bandera, M Feito-Rodríguez, R Maseda-Pedrero, R de Lucas-Laguna
Idiopathic facial aseptic granuloma is a typical childhood disease characterized by the presence of one or more asymptomatic nodules on the cheek. Although pathogenesis remains unclear, the disease is thought to be a type of childhood rosacea. It resolves spontaneously, yet it could be confused with other lesions that require treatment. We present clinical and ultrasound findings and outcome from 3 new cases. In 2 cases, the lesion presented as childhood rosacea. Ultrasound revealed a characteristic pattern, with variations depending on the stage of development...
December 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29212694/minimising-aseptic-loosening-in-extreme-bone-resections-custom-made-tumour-endoprostheses-with-short-medullary-stems-and-extra-cortical-plates
#11
J D Stevenson, C Wigley, H Burton, S Ghezelayagh, G Morris, S Evans, M Parry, L Jeys
AIMS: Following the resection of an extensive amount of bone in the treatment of a tumour, the residual segment may be insufficient to accept a standard length intramedullary cemented stem. Short-stemmed endoprostheses conceivably have an increased risk of aseptic loosening. Extra-cortical plates have been added to minimise this risk by supplementing fixation. The aim of this study was to investigate the survivorship of short-stemmed endoprostheses and extra-cortical plates. PATIENTS AND METHODS: The study involved 37 patients who underwent limb salvage surgery for a primary neoplasm of bone between 1998 and 2013...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212102/-conservative-treatment-of-an-aseptic-abscess-syndrome-with-splenic-abscesses-in-crohn-s-disease
#12
Thomas Göbel, Jutta Rauen-Vossloh, Hubert Georg Hotz, Andree Boldt, Andreas Erhardt
A 24-year old woman with a history of Crohn's disease developed bloody diarrhea and multiple abdominal abscesses, daily fever, leukocytosis, and elevated CRP several months after her immunosuppressive therapy with azathioprine was stopped. Recurrent abscess punctures did not detect any pathogenic germs and neither clinical nor serological response was achieved by administration of different antimicrobial therapies. Additionally, new splenic abscesses arose despite ongoing therapy. Under the suspicion of the rare aseptic abscess syndrome, representing an auto-inflammatory, extra-intestinal manifestation of Crohn's disease, the antimicrobial therapy was stopped and an intravenous therapy with prednisolone was initiated...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29207792/clinical-evaluation-of-efficacy-and-performance-of-all-poly-tibial-freedom%C3%A2-total-knee-system-for-treating-osteoarthritis-patients-three-year-follow-up-study
#13
Avatar Singh, Kanwar Kulwinder Singh
Introduction: Advancement in technology in terms of design and building materials has made Total Knee Replacement (TKR) a highly effective, safe, and predictable orthopedic procedure. Aim: To review the clinical outcomes for efficacy and performance of Freedom Total Knee System for the management of Osteoarthritis (OA), at a minimum of three years follow up. Materials and Methods: For this retrospective, post-marketing study, clinical data of patients treated with Freedom Total Knee System was retrieved from the clinical records after approval from the Institutional Ethics Committee ...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207046/nano-sized-titanium-alloy-particles-inhibit-the-proliferation-and-promote-the-apoptosis-of-bone-marrow-mesenchymal-stem-cells-in%C3%A2-vitro
#14
Xiao-Bo He, Tao Ma, Wei Zheng, Qing-He Geng, Kai-Jin Guo
Aseptic loosening of artificial joints is the leading cause of failure for patients who receive total joint arthroplasty. Prior reports indicate that bone marrow mesenchymal stem cells (BSMC) are critical in the stabilization of implanted artificial joints, and that deregulated interaction between BMSCs and artificial joint derived particles is a risk factor for aseptic loosening with an unknown mechanism. In the present study, the pathomechanisms whereby titanium and its alloy derived particles facilitate aseptic loosing were investigated in vitro...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29204494/a-classification-based-approach-to-the-patella-in-revision-total-knee-arthroplasty
#15
Matthew W Tetreault, Christopher E Gross, Paul H Yi, Daniel D Bohl, Scott M Sporer, Craig J Della Valle
Background: There is a paucity of data to guide management of the patella in revision total knee arthroplasty (RTKA). The purpose of this study was to review our experience with patellar management in RTKA. Methods: We retrospectively reviewed 422 consecutive RTKAs at a minimum of 2 years (mean, 42 months). Patellar management was guided by a classification that considered stability, size, and position of the implanted patellar component, thickness/quality of remaining bone stock, and extensor mechanism competence...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29204021/cranioplasty-using-autoclaved-autologous-skull-bone-flaps-preserved-at-ambient-temperature
#16
Dominic Anto, Raju Paul Manjooran, Rajeev Aravindakshan, Kumar Lakshman, Raymond Morris
Context: Decompressive craniectomy followed by cranioplasty (CP) uses autologous craniectomy flaps or synthetic materials like titanium. Sterilization and preservation methods for the autologous bone flaps continue to be the surgeon's choice. Aim: This study aimed to assess the short-term as well as long-term clinical outcomes of CP using autoclaved autologous bone grafts. Settings and Design: This retrospective observational study was performed on patients admitted in a tertiary care teaching neurosurgery department...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29203432/propionibacterium-acnes-prosthetic-joint-infection-diagnosis-and-treatment
#17
REVIEW
P Boisrenoult
Propionibacterium acnes is a commensal skin bacterium, regularly implicated in prosthetic joint infection, particularly of the shoulder. Diagnosis has been improved by progress in bacteriological techniques: longer culture time, liquid medium culture, MALDI-TOF mass spectrography, and universal 16S rRNA PCR, associated by some authors to sonication of ablated implants. P. acnes pathogenicity involves many virulence factors, notably including biofilm formation. P. acnes may lead to infection that is clinically evident or, frequently, relatively asymptomatic...
December 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29203104/evaluating-the-effect-of-myrtus-communis-on-programmed-cell-death-in-hydatid-cyst-protoscolices
#18
Mojtaba Shahnazi, Abbas Azadmehr, Moazzam Dosti Jondabeh, Reza Hajiaghaee, Reza Norian, Hamidreza Aghaei, Mehrzad Saraei, Mahmood Alipour
OBJECTIVE: To evaluate the possible involvement of programmed cell death strategy in hydatid cyst protoscolices following treatment with Myrtus communis (M. communis) as an herbal medicine. METHODS: Protoscolices were aseptically collected from sheep liver hydatid cysts. Evaluating the effect of M. communis extract on programmed cell death and increased activity of caspases 3, 8, and 9 in hydatid cyst protoscolices was conducted by treating the protoscolices with different concentration (5, 50, and 100 mg/mL) of M...
November 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29201007/erythropoietin-attenuates-postoperative-cognitive-dysfunction-by-shifting-macrophage-activation-toward-the-m2-phenotype
#19
Jae Hoon Lee, Eun Hee Kam, So Yeon Kim, So Yeong Cheon, Eun Jung Kim, Seungsoo Chung, Ji-Hyun Jeong, Bon-Nyeo Koo
Postoperative cognitive dysfunction (POCD) may be driven by transference of the innate immune response to the brain after aseptic surgical damage. Macrophages are key mediators of innate immunity that can display a pro-inflammatory M1 phenotype or an anti-inflammatory M2 phenotype. Erythropoietin (EPO) is a hematopoietic hormone that exerts anti-inflammatory effects by influencing macrophage function. We hypothesized that EPO would prevent POCD by promoting macrophage phenotype switching to the M2 phenotype post-surgery...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29200709/total-knee-arthroplasty-in-young-patients-factors-predictive-of-aseptic-failure-in-the-2nd-4th-decade
#20
Tristan Camus, William J Long
Objective: In a recently published article we reviewed our long term outcomes of TKA in young patients (<55) with end stage OA. The purpose of this study was to identify what additional factors may predict aseptic failure in these young patients. Methods: A retrospective review of all patients in our young TKA database was performed, and included failure only for mechanical wear and loosening. Results: The IB-II prosthesis, a thin polyethylene (<9 mm), and higher Knee Society functional class at midterm follow-up was associated with higher failure rate...
March 2018: Journal of Orthopaedics
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