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Lars Breimer, Håkan Geijer, Lars Berggren
Central venous catheter bloodstream infections are an important cause of hospital-acquired infection with increased morbidity, mortality and cost. The incidence varies between countries and even hospitals. Needleless connector hubs are used on virtually all intravascular devices and colonization of these is considered the cause of much of the postinsertion catheter-related infections through breaks in aseptic technique and failure to disinfect properly. This systematic review evaluated 165 search hits on hub disinfection practices with particular emphasis on the time of scrubbing the connector for 15 sec but also the impact of measures of education and compliance...
June 15, 2018: Läkartidningen
Maria Koshy, John Mathew, Reginald Alex, John Antony Jude, Ravikar Ralph, Thambu David Sudarsanam, Sowmya Sathyendra, J Visalakshi, John Victor Peter
Background & objectives: The pathological hallmark of scrub typhus infection is focal or disseminated vasculitis. As with other infections, antinuclear antibodies (ANA) have been previously described in scrub typhus. However, the underlying mechanisms and implications of this immunological phenomenon is not well understood. In the present work it was assessed whether ANA is associated with illness severity and outcomes. Methods: In this prospective study spanning one year, patients fulfilling the diagnostic criteria for scrub typhus were recruited...
January 2018: Journal of Vector Borne Diseases
Christopher Dowding, Johanna S Dobransky, Paul R Kim, Paul E Beaulé
BACKGROUND: Metal on metal hip resurfacing (MoM-HR) is an alternative to total hip arthroplasty in young and active patients. The purpose was to determine the survivorship of MoM-HR procedures performed in patients aged 45 years and younger assessing patient-reported outcome measures (PROMs) at minimum 5-year follow-up. METHODS: All 217 patients equal to or younger than 45 years of age at the time of surgical intervention presenting to our center with MoM-HR between May 2002 and May 2011 were prospectively followed...
June 1, 2018: Journal of Arthroplasty
Giuliana Banche, Alessandro Bistolfi, Valeria Allizond, Claudia Galletta, Maria Rita Iannantuoni, Elisa Simona Marra, Chiara Merlino, Alessandro Massè, Anna Maria Cuffini
Prosthetic joint infection diagnosis is often difficult since biofilm-embedded microorganisms attach well to the prosthetic surfaces and resist their detection by conventional methods. DL-dithiothreitol has been described as a valid method for biofilm detachment on orthopedic devices. We report the case of an occasional detection of Listeria monocytogenes in a non immuno-compromised patient with a preoperative diagnosis of aseptic loosening. The infection diagnosis due to such rare bacteria was made postoperatively, thanks to a DL-dithiothreitol-based device...
June 18, 2018: Future Microbiology
Elizabeth A King, Philippe Favre, Amin Eldemerdash, Jeffrey E Bischoff, Mark Palmer, Jeffrey N Lawton
PURPOSE: Wear of polyethylene bearings represents a limiting factor in the long-term success of total elbow prostheses. Bearing stress is 1 factor contributing to accelerated wear. Physiological loading of total elbow prostheses and implant design influence upon bearing stresses have not been well described. This study evaluates bearing stresses in 3 commercially available implant designs under loads associated with daily living. METHODS: Motion tracking from a healthy volunteer helped establish a musculoskeletal model to simulate flexor and extensor muscle activation at 0°, 45°, and 90° of shoulder abduction with a 2...
June 13, 2018: Journal of Hand Surgery
C Sartori, V Perreten, I Ivanovic, M C Härdi-Landerer, H U Graber
In Switzerland, sanitation programs of dairy herds infected with the contagious mastitis pathogen Staphylococcus aureus genotype B (GTB) have been established for several years. In recent years, Streptococcus uberis and non-aureus staphylococci have emerged as the bacteria most frequently isolated from bovine milk samples. The latter cause subclinical mastitis, and some species are more persistent or pathogenic than others. The present study aimed to investigate the developments in the intramammary colonization spectrum of 5 dairy herds undergoing a sanitation program for Staph...
June 13, 2018: Journal of Dairy Science
Chun-Hung Chang, Shang-Wen Tsai, Cheng-Fong Chen, Po-Kuei Wu, Wing-Wai Wong, Ming-Chau Chang, Wei-Ming Chen
INTRODUCTION: Evidence about the optimal timing for total hip replacement (THR) in HIV-positive patients is scant. HYPOTHESIS: Preoperative criteria: cluster of differentiation 4 (CD4) counts>200 cells/mm3 and an undetectable HIV virus load before THR, improve infection rates, aseptic loosenings, and functional outcomes. MATERIALS AND METHODS: We recruited 16 HIV-positive patients who had undergone 25 THRs between 2003 and 2015. None had hemophilia, and none were intravenous drug users (IVDUs)...
June 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Kimaya Reddy, Myo Htut, Amrita Krishnan, Sanjeet S Dadwal
No abstract text is available yet for this article.
May 28, 2018: Clinical Lymphoma, Myeloma & Leukemia
I Aguado-Maestro, E Cebrián Rodríguez, E Paredes Herrero, F Brunie Vegas, M Oñate Miranda, N Fernández García, M García Alonso
OBJECTIVES: We present the results of the prospective follow up of a sample of large head metal-metal total hip arthroplasty obtained after the safety alert regarding a higher incidence of revision of these implants. MATERIAL AND METHODS: All patients implanted with the Recap-M2a-Magnum cup between 2008 and 2011 were included. They were prospectively reviewed recording Harris Hip Score, clinical symptoms of chromium or cobalt intoxication. Serum levels of these ions were requested as well as X-Rays and ultrasonography...
June 11, 2018: Revista Española de Cirugía Ortopédica y Traumatología
Tianxiang Geng, Xi Chen, Mengxue Zheng, Haochen Yu, Shuai Zhang, Shouxuan Sun, Haohui Guo, Qunhua Jin
Aseptic loosening and menopause‑induced osteoporosis are caused by an imbalance between bone formation and osteolysis. With an aging population, the probability of simultaneous occurrence of such conditions in an elderly individual is increasing. Strontium ranelate (SR) is an anti‑osteoporosis drug that promotes bone formation and inhibits osteolysis. The present study compared the effects of SR with those of the traditional anti‑osteoporosis drug alendronate (ALN) using an ovariectomized mouse model of osteolysis...
June 5, 2018: Molecular Medicine Reports
Justin T Deen, Terry B Clay, Dane A Iams, MaryBeth Horodyski, Hari K Parvataneni
Background: In an effort to minimize backside polyethylene wear and osteolysis associated with titanium tibial baseplates, many manufacturers have transitioned to cobalt chromium alloys. Recent literature has implicated thicker cobalt chromium designs as a potential source of increased stress shielding and resorption. We report the incidence of proximal tibial bone resorption in a large consecutive series of patients undergoing total knee arthroplasty, with a modern total knee design...
June 2018: Arthroplasty Today
William J Long, Samir Nayyar, Kevin K Chen, David Novikov, Roy I Davidovitch, Jonathan M Vigdorchik
Ultraporous acetabular components were developed to improve osseointegration and fit for increased longevity and better outcomes after total hip arthroplasty. There is a paucity of literature detailing this acetabular component's clinical performance, with even less detailing those with screw fixation. We identify 5 patients at our institution who underwent revision total hip arthroplasty for early aseptic acetabular cup loosening of an ultraporous acetabular component known as the Tritanium primary cup with secondary screw fixation...
June 2018: Arthroplasty Today
Ryan Stancil, Nathan Summers, Douglas Van Citters, Adam Sassoon
Femoral component fracture is a rare complication in unicompartmental knee arthroplasty, especially in cemented prostheses. We present a 75-year-old man who presented with a fractured single-peg Vanguard component 9 years postoperatively. He was revised to a total knee arthroplasty with an excellent functional outcome at 1 year. The components were additionally examined at an outside biomechanical engineering laboratory. Theories as to the cause of the component fracture include aseptic loosening due to a thin anterior cement mantle and the single-peg Oxford design...
June 2018: Arthroplasty Today
Marc R Angerame, Jason M Jennings, Douglas A Dennis
Failures unique to posterior cruciate-substituting total knee prostheses rarely include polyethylene post fractures but have been described. We report a case involving a fracture of the distal insert cone of a rotating-platform (RP) polyethylene liner in a primary total knee arthroplasty. This case highlights a 67-year-old male presenting with new-onset knee pain and recurrent effusions with osteolysis 11 years following placement of a posterior-stabilized, RP total knee arthroplasty. At the time of revision surgery, the polyethylene insert cone was found to be fractured just below the junction between cone and the body of the insert...
June 2018: Arthroplasty Today
Mohamad J Halawi, David Brigati, William Messner, Peter J Brooks
Background: Total hip arthroplasty (THA) is increasingly performed in younger patients. The purpose of this study is to report on the midterm outcomes of primary cementless THA in patients 55 years and younger; and specifically to examine the risk factors for aseptic failure, all-cause revision, and mortality in this patient population. Methods: Four hundred and twenty-six consecutive patients with minimum 5-year follow-up were retrospectively reviewed. Multivariate analyses were conducted to control for potential confounding factors identified by univariate analyses...
April 2018: Journal of Clinical Orthopaedics and Trauma
Qingpan Zhai, Fengxuan Han, Zhiwei He, Chen Shi, Pinghui Zhou, Caihong Zhu, Qianping Guo, Xuesong Zhu, Huilin Yang, Bin Li
Poly (methyl methacrylate) (PMMA)-based bone cements are the most commonly used injectable orthopedic materials due to their excellent injectability and mechanical properties. However, their poor biocompatibility and excessive stiffness may cause complications such as aseptic implant loosening and stress shielding. In this study, we aimed to develop a new type of partially biodegradable composite bone cement by incorporating magnesium (Mg) microspheres, known as "Mg sacrifices" (MgSs), in the PMMA matrix...
June 12, 2018: International Journal of Molecular Sciences
S Maham, F Fallah, Z Gholinejad, A Seifi, S M Hoseini-Alfatemi
BACKGROUND: Due to the diverse nature of bloodstream infections etiology and to the antibiotic resistance patterns in periodic intervals, rational and accurate use of antibiotics requires an understanding of common causative agents of septicemia and their susceptibility patterns. The present study aimed to determine the bacterial etiology of the neonate and pediatric septicemia, and their antibiotic resistance pattern in Tehran, North of Iran. MATERIAL AND METHODS: This retrospective cross-sectional study was conducted along two years, from October 2014 to November 2016 among children with suspected bloodstream infection...
July 2018: Annali di Igiene: Medicina Preventiva e di Comunità
Elizabeth Sutton, Rachel Groff, Leigh M Sutton
No abstract text is available yet for this article.
May 2018: Cutis; Cutaneous Medicine for the Practitioner
Ines Sellami, Veronika Mall, Peter Schieberle
Application of the aroma extract dilution analysis (AEDA) on the volatiles isolated by extraction/SAFE distillation from NFC (not from concentrate) juice from Hamlin or-anges revealed 51 odor-active constituents in the flavor dilution (FD) factor range of 8 to 8192 among which vanillin, wine lactone and (R)-linalool appeared with the highest FD factors. The AEDA applied on the volatile fraction of the same batch of juice stored at 0 °C for ten months under aseptic conditions showed clear changes in the aroma profile as well as in the FD factors of key odorants...
June 11, 2018: Journal of Agricultural and Food Chemistry
Philippe Nicolas, Olivier Guerrier, Amandine Benoit, Francoise Durand-Dubief, Gerald Raverot, Sebastien Debarbieux, Clemence Delteil, Alexandre Vasiljevic, Emmanuel Jouanneau, Francois Cotton, Romain Marignier, Sandra Vukusic
No abstract text is available yet for this article.
July 2018: Neurology® Neuroimmunology & Neuroinflammation
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