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https://www.readbyqxmd.com/read/28106291/ocular-effects-of-sulfur-mustard-and-therapeutic-approaches-a-review
#1
Yunes Panahi, Seyyed Mahdi Rajaee, Amirhossein Sahebkar
Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28101786/evaluation-of-t-regulatory-lymphocytes-transcription-factors-in-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-ham-tsp-patients
#2
Sanaz Ahmadi Ghezeldasht, Hamed Sadeghian, Mahmoud Reza Azarpazhooh, Seyyed Ali Akbar Shamsian, Houshang Rafatpanah, Mahmood Mahmoodi, Seyyed Abdolrahim Rezaee
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an aggressive neurological disease. The CD4(+)CD25(+) T cell population plays pivotal roles in the maintenance of immunological tolerance and prevention of such autoimmune diseases. In the current study, proviral load (PVL), factor forkhead box p3 (Foxp3), and glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) gene expression and regulatory T cells (Tregs) counts of 21 HAM/TSP patients and 16 HTLV-1 healthy carriers (ACs) were measured using real-time PCR, TaqMan method, and flow cytometry...
January 18, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28101475/anticonvulsive-effects-of-licofelone-on-status-epilepticus-induced-by-lithium-pilocarpine-in-wistar-rats-a-role-for-inducible-nitric-oxide-synthase
#3
Seyyed Majid Eslami, Mohammad Mobin Moradi, Mehdi Ghasemi, Ahmad Reza Dehpour
BACKGROUND AND PURPOSE: Status epilepticus (SE) is a neurological disorder with high prevalence and mortality rates, requiring immediate intervention. Licofelone is a cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor, which its effectiveness to treat osteoarthritis has been approved. Increasing evidence suggests an involvement of COX and LOX enzymes in epileptic disorders. Thus, in the present study we investigate possible effects of licofelone on prevention and termination of SE...
December 2016: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/28098460/sulfate-mediated-end-to-end-assembly-of-gold-nanorods
#4
Seyyed Mohammad Hossein Abtahi, Nathan D Burrows, Fred A Idesis, Catherine J Murphy, Navid B Saleh, Peter J Vikesland
There is interest in the controlled aggregation of gold nanorods (GNRs) for the production of extended nanoassemblies. Prior studies have relied upon chemical modification of the GNR surface to achieve a desired final aggregate structure. Herein, we illustrate that control of electrolyte composition can facilitate end-to-end assembly of cetyltrimethylammonium bromide (CTAB) coated GNRs. By adjusting either the sulfate anion concentration or the exposure time it is possible to connect GNRs in chain-like assemblies...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28081325/plasma-levels-of-serotonin-gastrointestinal-symptoms-and-sleep-problems-in-children-with-autism
#5
Sorayya Kheirouri, Parinaz Kalejahi, Seyyed Gholamreza Noorazar
BACKGROUND/AIM: Autism is a neurodevelopmental disorder identified with higher frequency of serotonin abnormalities and gastrointestinal (GI) and sleep problems. This study aimed to evaluate the plasma levels of serotonin, GI symptoms, and sleep problems, and their relationship with autism severity in children with autism. MATERIALS AND METHODS: Thirty-five children with autism and 31 healthy subjects were studied. GI problems, sleep disorders, and severity of disorder were assessed...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28059488/resveratrol-ameliorates-palmitate-induced-inflammation-in-skeletal-muscle-cells-by-attenuating-oxidative-stress-and-jnk-nf-kb-pathway-in-a-sirt1-independent-mechanism
#6
Asie Sadeghi, Shadi Sadat Seyyed Ebrahimi, Abolfazl Golestani, Reza Meshkani
Resveratrol has been shown to exert anti-inflammatory and anti-oxidant effects in a variety of cell types, however, its role in prevention of inflammatory responses mediated by palmitate in skeletal muscle cells remains unexplored. In the present study we investigated the effects of resveratrol on palmitate-induced inflammation and elucidated the underlying mechanisms in skeletal muscle cells. The results showed that palmitate significantly enhanced TNF-α and IL-6 mRNA expression and protein secretion from C2C12 cells at 12, 24 and 36h treatments...
January 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28044147/self-templated-synthesis-of-uniform-nanoporous-cuco2o4-double-shelled-hollow-microspheres-for-high-performance-asymmetric-supercapacitors
#7
Saeid Kamari Kaverlavani, Seyyed Ebrahim Moosavifard, Ali Bakouei
Multilevel interior nanoporous CuCo2O4 microspheres have been for the first time developed using a facile self-templated method. Electrochemical results in three- and two-electrode systems show that the double-shelled hollow microsphere electrode is a promising candidate for high-performance supercapacitors.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28043591/evaluation-of-specific-antibodies-against-mycobacterium-tuberculosis-recombinant-antigens-for-detection-of-recent-infection
#8
Majid Tebianian, Nader Mosavari, Morteza Taghizadeh, Seyyed Mahmoud Ebrahimi
INTRODUCTION: Since an accurate test for detection of Mycobacterium tuberculosis early infection is urgently needed, this study was designed for development of an efficient screening test in diagnosis of tuberculosis infection. MATERIALS AND METHODS: In the present study, two recombinant proteins CFP-10, ESAT-6 were tested as antigens for the diagnosis of recent tuberculosis. The proteins were produced in Escherichia coli, purified and tested in indirect ELISAs with sera from 63 subjects with positive clinical results...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28042538/rora-and-autism-in-the-isfahan-population-is-there-an-epigenetic-relationship
#9
Mansoor Salehi, Elahe Kamali, Mojgan Karahmadi, Seyyed Mohammad Mousavi
OBJECTIVE: Autism is a neurodevelopmental disorder characterized by difficulty in verbal and non-verbal communication, impaired social interaction, and restricted and repetitive behavior. It has been recently introduced as a multigenic disorder with significant epigenetic effects on its pathology. Recently, epigenetic silencing of retinoic acid receptor- related orphan receptor alpha (RORα) gene (which has an essential role in neural tissue development) was shown to have occurred in autistic children due to methylation of its promoter region...
2017: Cell Journal
https://www.readbyqxmd.com/read/28041913/a-three-dimensional-in-vitro-model-to-demonstrate-the-haptotactic-effect-of-monocyte-chemoattractant-protein-1-on-atherosclerosis-associated-monocyte-migration
#10
Neda Ghousifam, Hamid Mortazavian, Rudra Bhowmick, Yolanda Vasquez, Frank D Blum, Heather Gappa-Fahlenkamp
Monocyte transendothelial migration is a multi-step process critical for the initiation and development of atherosclerosis. The chemokine monocyte chemoattractant protein-1 (MCP-1) is overexpressed during atheroma and its concentration gradients in the extracellular matrix (ECM) is critical for the transendothelial recruitment of monocytes. Based on prior observations, we hypothesize that both free and bound gradients of MCP-1 within the ECM are involved in directing monocyte migration. The interaction between a three-dimensional (3D), cell-free, collagen matrix and MCP-1; and its effect on monocyte migration was measured in this study...
December 29, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28034773/randomized-clinical-trial-of-ligasure%C3%A2-versus-conventional-splenectomy-for-injured-spleen-in-blunt-abdominal-trauma
#11
Vejdan Seyyed Amirkazem, Khosravi Malihe
BACKGROUND: Spleen is the most common organ damaged in cases of blunt abdominal trauma and splenectomy and splenorrhaphy are the main surgical procedures that are used in surgical treatment of such cases. In routine open splenectomy cases, after laparotomy, application of sutures in splenic vasculature is the most widely used procedure to cease the bleeding. This clinical trial evaluates the role and benefits of the Ligasure™ system in traumatic splenectomy without using any suture materials and compares the result with conventional method of splenectomy...
December 26, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/28033744/influence-of-sio2-and-graphene-oxide-nanoparticles-on-efficiency-of-biological-removal-process
#12
Seyyed Hamid Esmaeili-Faraj, Mohsen Nasr Esfahany
The effects of the presence of synthesized silica (SS) and exfoliated graphene oxide (EGO) on the removal of sulfide ion with activated sludge (AS) are experimentally investigated. The maximum removal efficiency of sulfide ion for AS without nanoparticles, and the samples with SS and EGO nanoparticles were 81%, 88% and 79%, respectively. Moreover, the maximum elimination capacity (ECmax) for the bioreactor with SS-nanoparticles is 7542 mg/L s, while the ECmax of AS and EGO samples were 7075 and 6625 mg/L s, respectively...
January 19, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28030337/occurrence-of-naegleria-species-in-therapeutic-geothermal-water-sources-northern-iran
#13
Ali Reza Latifi, Maryam Niyyati, Jacob Lorenzo-Morales, Ali Haghighi, Seyyed Javad Seyyed Tabaei, Zohreh Lasjerdi, Eznolah Azargashb
Potentially pathogenic Free-Living Amoebae include members belonging to Naegleria genus. The species N. fowleri is known worldwide as the causative agent of the lethal Primary Amoebic Meningoencephalitis (PAM). Only one clinical case of N. fowleri has been reported in Iran. Several species of Naegleria have been reported to be natural carriers of other potentially pathogenic microbial agents. The thermotolerance properties of this genus facilitates their presence in geothermal water sources including hot springs and spas...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28028508/effects-of-aspirin-as-an-anti-inflammatory-drug-on-azole-resistant-candida-glabrata-in-vitro
#14
Sanaz Goodarzi, Seyyed Amin Ayatollahi Mousavi, Somayeh Sharifynia, Azar Berahmeh, Sassan Rezaie
No abstract text is available yet for this article.
November 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28028501/aptamer-conjugated-magnetic-nanoparticles-as-targeted-magnetic-resonance-imaging-contrast-agent-for-breast-cancer
#15
Mohammad Keshtkar, Daryoush Shahbazi-Gahrouei, Seyyed Mehdi Khoshfetrat, Masoud A Mehrgardi, Mahmoud Aghaei
Early detection of breast cancer is the most effective way to improve the survival rate in women. Magnetic resonance imaging (MRI) offers high spatial resolution and good anatomic details, and its lower sensitivity can be improved by using targeted molecular imaging. In this study, AS1411 aptamer was conjugated to Fe3O4@Au nanoparticles for specific targeting of mouse mammary carcinoma (4T1) cells that overexpress nucleolin. In vitro cytotoxicity of aptamer-conjugated nanoparticles was assessed on 4T1 and HFFF-PI6 (control) cells...
October 2016: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/28028462/network-based-analysis-of-differentially-expressed-genes-in-cerebrospinal-fluid-csf-and-blood-reveals-new-candidate-genes-for-multiple-sclerosis
#16
Nahid Safari-Alighiarloo, Mostafa Rezaei-Tavirani, Mohammad Taghizadeh, Seyyed Mohammad Tabatabaei, Saeed Namaki
BACKGROUND: The involvement of multiple genes and missing heritability, which are dominant in complex diseases such as multiple sclerosis (MS), entail using network biology to better elucidate their molecular basis and genetic factors. We therefore aimed to integrate interactome (protein-protein interaction (PPI)) and transcriptomes data to construct and analyze PPI networks for MS disease. METHODS: Gene expression profiles in paired cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMCs) samples from MS patients, sampled in relapse or remission and controls, were analyzed...
2016: PeerJ
https://www.readbyqxmd.com/read/28024882/dha-enriched-fish-oil-upregulates-cyclin-dependent-kinase-inhibitor-2a-p16-ink-expression-and-downregulates-telomerase-activity-without-modulating-effects-of-ppar%C3%AE-pro12ala-polymorphism-in-type-2-diabetic-patients-a-randomized-double-blind-placebo-controlled
#17
Omid Toupchian, Gity Sotoudeh, Anahita Mansoori, Shima Abdollahi, Seyyed Ali Keshavarz, Mahmoud Djalali, Ensieh Nasli-Esfahani, Ehsan Alvandi, Reza Chahardoli, Fariba Koohdani
OBJECTIVE: The present study investigated the effects of docosahexaenoic acid (DHA)-enriched fish oil supplement on telomerase activity, mRNA expression of P16(INK), IL-6, and TNF-α considering Pro12Ala polymorphism in the PPARγ gene. METHODS/DESIGN: In this double-blind randomized controlled trial, 72 PPARγ Pro12Ala polymorphism genotyped type 2 diabetic patients aged 30-70 years were randomly assigned to receive 2.4 gr of DHA-enriched fish oil or a placebo for 8 weeks...
December 19, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27998138/differential-protein-adsorption-and-cellular-uptake-of-silica-nanoparticles-based-on-size-and-porosity
#18
Jiban Saikia, Mostafa Yazdimamaghani, Seyyed Pouya Hadipour Moghaddam, Hamidreza Ghandehari
Slight alterations in nanoparticles' surface properties can significantly influence the corona composition which may alter their interaction with the biological milieu. Size and porosity of silica nanoparticles (SNPs) are known to be predominant factors influencing their dose-dependent toxicity. Little is known however about the extent and type of protein adsorption on SNPs as a function of physicochemical properties and the role this might play on mechanisms of cellular uptake and toxicity. In this work we investigated the influence of size and porosity of SNPs on protein adsorption, cellular uptake, and toxicity in RAW 264...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27994822/the-effect-of-nutrition-consultation-on-dietary-diversity-score-of-cardiac-patients-referred-to-cardiac-rehabilitation-research-center-isfahan-cardiovascular-research-institute-during-2008-2013
#19
Sepideh Mehrabani, Noushin Mohammadifard, Sanaz Mehrabani, Masoumeh Sadeghi, Firouzeh Sajjadi, Maryam Maghroun, Mohammad Reza Maracy, Seyyed Morteza Safavi
BACKGROUND: Dietary diversity score (DDS) measurement was used to assessment of diet quality in different disease like cardiovascular disease. One way to improve the cardiovascular patient's ability is cardiac rehabilitation program that include exercise training, nutrition consultation and psychological treatment. No study was designed to compare the DDS before and after dietary consultation among cardiac rehabilitation patients, so this study was designed to examine this purpose. METHODS: Subjects were participated in the 2-month cardiac rehabilitation program...
2016: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27992855/amplified-detection-of-leukemia-cancer-cells-using-an-aptamer-conjugated-gold-coated-magnetic-nanoparticles-on-a-nitrogen-doped-graphene-modified-electrode
#20
Seyyed Mehdi Khoshfetrat, Masoud A Mehrgardi
The increasing demands for early, accurate and ultrasensitive diagnosis of cancers demonstrate the importance of the development of new amplification strategies or diagnostic technologies. In the present study, an aptamer-based electrochemical biosensor for ultrasensitive and selective detection of leukemia cancer cells has been introduced. The thiolated sgc8c aptamer was immobilized on gold nanoparticles-coated magnetic Fe3O4 nanoparticles (Apt-GMNPs). Ethidium bromide (EB), intercalated into the stem of the aptamer hairpin, provides the read-out signal for the quantification of the leukemia cancer cells...
December 12, 2016: Bioelectrochemistry
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