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https://www.readbyqxmd.com/read/29218545/a2b-adenosine-receptor-agonist-induces-cell-cycle-arrest-and-apoptosis-in-breast-cancer-stem-cells-via-erk1-2-phosphorylation
#1
Seyyed Mehdi Jafari, Hamid Reza Joshaghani, Mojtaba Panjehpour, Mahmoud Aghaei
PURPOSE: It has been reported that cancer stem cells (CSCs) may play a crucial role in the development, recurrence and metastasis of breast cancer. Targeting signaling pathways in CSCs is considered to be a promising strategy for the treatment of cancer. Here, we investigated the role of the A2B adenosine receptor (A2BAR) and its associated signaling pathways in governing the proliferation and viability of breast cancer cell line derived CSCs. METHODS: CSCs were isolated from the breast cancer cell lines MCF-7 and MDA-MB-231 using a mammosphere assay...
December 7, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29218399/lung-image-doege-potter-syndrome
#2
Sami Karapolat, Kubra Nur Seyis, Alaaddin Buran, Atila Turkyilmaz, Safak Ersoz, Celal Tekinbas
No abstract text is available yet for this article.
December 7, 2017: Lung
https://www.readbyqxmd.com/read/29207772/comparison-of-pain-relief-from-different-intravenous-doses-of-ketorolac-after-reduction-of-mandibular-fractures
#3
Saeed Nezafati, Reza Khorshidi Khiavi, Seyyed Sina Mirinejhad, Dawood Aghamoh Ammadi, Milad Ghanizadeh
Introduction: Pain is an unpleasant feeling due to tissue destruction, which disturbs an individual's daily routines even at its lowest levels. The majority of surgeons and anaesthesiologists are increasingly trying to administer non-opioid analgesics because excessive use of opioids after surgery results in patient dissatisfaction. Aim: To evaluate the analgesic effect of intravenous injection of different doses of ketorolac at different intervals in patients undergoing surgery for unilateral fractures of the mandible...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207742/use-of-multi-response-format-test-in-the-assessment-of-medical-students-critical-thinking-ability
#4
Mahboobeh Khabaz Mafinejad, Seyyed Kamran Soltani Arabshahi, Alireza Monajemi, Mohammad Jalili, Akbar Soltani, Javad Rasouli
Introduction: To evaluate students critical thinking skills effectively, change in assessment practices is must. The assessment of a student's ability to think critically is a constant challenge, and yet there is considerable debate on the best assessment method. There is evidence that the intrinsic nature of open and closed-ended response questions is to measure separate cognitive abilities. Aim: To assess critical thinking ability of medical students by using multi-response format of assessment...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205403/increased-th17-functions-are-accompanied-by-tregs-activities-in-lupoid-leishmaniasis
#5
Nafiseh Sadat Nabavi, Fakhrozzaman Pezeshkpoor, Narges Valizadeh, Sanaz Ahmadi Ghezeldasht, Seyyed Abdolrahim Rezaee
The immunopathogenesis of lupoid leishmaniasis is challenging. Although, an appropriate immune response is critical for controlling these parasites, inappropriate inflammatory reactions can also promote increased pathology. The role of immune-modulatory effect of the main transcription factors and cytokines of Tregulatory and Th-17 cells in pathogenesis of leishmaniasis chronicity was investigated in the present study. The gene expression of interleukin-10 (IL-10), transforming growth factor-β (TGF-β1), forkhead box P3 (Foxp3), interleukin-17(IL-17A), and retinoic acid-related orphan receptor gamma t (ROrC) was assessed in PBMCs of eighty blood samples from cutaneous leishmaniasis (CL) patients with usual lesions (n = 31), lupoid lesions (n = 29), and healthy volunteers (n = 20)...
December 4, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29201636/laryngotracheoesophageal-cleft-type-3-and-severe-laryngotracheomalacia-delayed-surgical-repair-a-treatment-challenge-with-an-excellent-outcome
#6
Ahmad Khaleghnejad, Saeed Sadr, Seyyed Ahmad Tabatabaei, Nazanin Farahbakhsh, Payman Dabirmoghaddam, Saeed Saadat Mansori
Laryngotracheoesophageal clefts (LTEC) are rare malformations which involve the upper respiratory and digestive tract. Surgical repair should be undertaken promptly to maintain a secure airway and prevent serious pulmonary aspiration. This paper reports the first case of LTEC type 3 with severe laryngotracheomalacia that was brought to Mofid children's hospital in late infancy with a poor health status. Delayed defect correction was our team strategy for the patient when she had achieved good weight gain. At the age of 22 months in collaboration with the pediatric surgical and otolaryngologist team, the repair of the laryngeal cleft was done with lateral open approach method...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29201099/synthesis-and-biological-evaluation-of-thiosemicarbazide-derivatives-endowed-with-high-activity-toward-mycobacterium-bovis
#7
Soroush Sardari, Samaneh Feizi, Ali Hossein Rezayan, Parisa Azerang, Seyyed Mohammad Shahcheragh, Ghazaleh Ghavami, Azizollah Habibi
Thiosemicarbazides are potent intermediates for the synthesis of pharmaceutical and bioactive materials and thus, they are used extensively in the field of medicinal chemistry. The imine bond (-N=CH-) in this compounds are useful in organic synthesis, in particular for the preparation of heterocycles and non-natural β-aminoacids. In this paper the synthesis of some new thiosemicarbazide derivatives by condensation reaction of various aldehydes or ketones with 4-phenylthiosemicarbazide or thiosemicarbazide is reported...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29192377/how-does-transient-signaling-input-affect-the-spike-timing-of-postsynaptic-neuron-near-the-threshold-regime-an-analytical-study
#8
Safura Rashid Shomali, Majid Nili Ahmadabadi, Hideaki Shimazaki, Seyyed Nader Rasuli
The noisy threshold regime, where even a small set of presynaptic neurons can significantly affect postsynaptic spike-timing, is suggested as a key requisite for computation in neurons with high variability. It also has been proposed that signals under the noisy conditions are successfully transferred by a few strong synapses and/or by an assembly of nearly synchronous synaptic activities. We analytically investigate the impact of a transient signaling input on a leaky integrate-and-fire postsynaptic neuron that receives background noise near the threshold regime...
December 1, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29182875/synthesis-characterization-and-application-of-partially-blocked-amine-functionalized-magnetic-nanoparticles
#9
Abdu Rahman Hosseini Far, S A Seyyed Ebrahimi, Mojtaba Shariaty-Niassar, Mahdi Moshref-Javadi
In this study, a novel technique was introduced for selective surface modification of amine-functionalized magnetic nanoparticles. The method was based on alignment of magnetic nanoparticles in an external magnetic field which resulted in formation of chain-like assemblies in diluted suspensions. The aligned chains were then modified on the surface via reaction of isocyanate species with the particles functionalities. Finally, after removing from the reactor medium, particles with segmented distribution of surface functionalities were achieved...
November 28, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29177177/does-intradisciplinary-conflict-influence-to-outcomes-of-emergency-medicine-residency-program-a-mixed-methods-study
#10
Mohammadreza Maleki, Seyyed Meysam Mousavi, Mina Anjomshoa, Nasrin Shaarbafchizadeh, Zeinab Naimi Taleghani
Objective: To explore impact of emergency medicine residency program on patient waiting times in emergency department (ED) and determine the associated factors. Methods: A two-phased sequential exploratory mixed-methods approach was used. The first phase was comprised of retrospective before-after design of ED encounters for a 3-month period, six months before and six months after the introduction of an emergency medicine residency program in an Iranian teaching hospital...
October 2017: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29167581/publisher-correction-time-dependent-decomposition-of-ammonia-borane-for-the-controlled-production-of-2d-hexagonal-boron-nitride
#11
Vitaliy Babenko, George Lane, Antal A Koos, Adrian T Murdock, Karwei So, Jude Britton, Seyyed Shayan Meysami, Jonathan Moffat, Nicole Grobert
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29159211/the-relationship-between-knowledge-of-leadership-and-knowledge-management-practices-in-the-food-industry-in-kurdistan-province-iran
#12
Seyyed Mohammad Moosavi Jad, Sahar Geravandi, Mohammad Javad Mohammadi, Rashin Alizadeh, Mohammad Sarvarian, Babak Rastegarimehr, Abolhasan Afkar, Ahmad Reza Yari, Mahboobeh Momtazan, Aliasghar Valipour, Mohammad Mahboubi, Azimeh Karimyan, Alireza Mazraehkar, Ali Soleimani Nejad, Hafez Mohammadi
The aim of this study was to identify the relationship between the knowledge of leadership and knowledge management practices. This research strategy, in terms of quantity, procedure and obtain information, is descriptive and correlational. Statistical population, consist of all employees of a food industry in Kurdistan province of Iran, who were engaged in 2016 and their total number is about 1800 people. 316 employees in the Kurdistan food industry (Kurdistan FI) were selected, using Cochran formula. Non-random method and valid questions (standard) for measurement of the data are used...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29155558/correlated-absorption-and-scattering-spectroscopy-of-individual-pt-decorated-au-nanorods-reveals-strong-excitation-enhancement-in-the-non-plasmonic-metal
#13
Anneli Joplin, Seyyed Ali Hosseini Jebeli, Eric Sung, Nathan Diemler, Patrick J Straney, Mustafa Yorulmaz, Wei-Shun Chang, Jill E Millstone, Stephan Link
Bimetallic nanocatalysts have the potential to surmount current limitations in industrial catalysis if their electronic and optical properties can be effectively controlled. However, improving the performance of bimetallic photocatalysts requires a functional understanding of how the intricacies of their morphology and composition dictate every element of their optical response. In this work, we examine Au and Pt-decorated Au nanorods on a single particle level to ascertain how Pt influences the plasmon resonance of the bimetallic nanostructure...
November 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29147494/renoprotective-effect-of-crocin-following-liver-ischemia-reperfusion-injury-in-wistar-rats
#14
Seyyed Ali Mard, Ghaidafeh Akbari, Esrafil Mansouri, Mahdi Parsanahad
Objectives: The objectives of the current study were to evaluate the effects of hepatic ischemia/reperfusion (IR) injury on the activity of antioxidant enzymes, biochemical factors, and histopathological changes in rat kidney, and to investigate the effect of crocin on IR-related changes. Materials and Methods: Thirty-two male Wistar rats were randomly allocated into four groups (n=8). They were sham-operated, IR, crocin pre-treatment, and crocin pretreatment+IR groups...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29124622/medicinal-plants-with-antithrombotic-property-in-persian-medicine-a-mechanistic-review
#15
REVIEW
Zahra Memariani, Reihaneh Moeini, Shokooh Sadat Hamedi, Narjes Gorji, Seyyed Ali Mozaffarpur
Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties...
November 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29124050/association-between-healthy-eating-index-2010-and-fetuin-a-levels-in-patients-with-type-2-diabetes-a-case-control-study
#16
Farzad Roshanzamir, Maryam Miraghajani, Marjan Mansourian, Reza Ghiasvand, Seyyed Morteza Safavi
The Healthy Eating Index-2010 (HEI-2010) assesses compliance with the 2010 Dietary Guidelines for Americans. Studies suggest that adherence to the HEI-2010 is related to lower the risk of type 2 diabetes (T2D). Fetuin-A, a novel biomarker for T2D, may play a linking role in the inverse association between HEI-2010 and T2D. Thus, a case-control analysis involving 107 patients with T2D and107 healthy subjects was conducted to determine the association between HEI-2010 and serum fetuin-A levels. The results of simple regression analysis showed that fetuin-A levels were positively associated with full name of body mass index (BMI) (p < 0...
October 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29117819/role-of-ultrasound-in-confirmation-of-endotracheal-tube-in-neonates-a-review
#17
Deepak Sharma, Seyyed Ahmad Tabatabaii, Nazanin Farahbakhsh
Tracheal intubation is a commonly done procedure in neonatal intensive care unit and delivery room during resuscitation. The confirmation of endotracheal tube (ETT) position should be done quickly as tube malposition is associated with various serious adverse outcomes like hypoxemia, right upper lobe collapse, atelectasis, air leak syndromes and esophageal intubation. ETT position can be confirmed by various methods like clinical sign, chest radiography, capnography, external digital tracheal palpation, ultrasonography (USG), respiratory function monitor, video-laryngoscope and fiberoptic devices...
November 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29114553/compare-the-effect-of-flaxseed-evening-primrose-oil-and-vitamin-e-on-duration-of-periodic-breast-pain
#18
Farzaneh Jaafarnejad, Elham Adibmoghaddam, Seyyed Ahmad Emami, Azadeh Saki
BACKGROUND: Breast periodic pain is the most common disorder of the breast which leads to consultation with knowledgeable people like a midwife. The aim of this study was to compare the therapeutic effect of flaxseed, evening primrose oil, and Vitamin E on the duration of the period of breast pain. MATERIALS AND METHODS: This study is a quasi-randomized clinical trial conducted in 2015 on ninety patients complaining of breast periodic pain referring to Gynecologic Clinics of Ghaem Hospital or residents living in dormitories of Mashhad University of Medical Sciences...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29114549/evaluation-of-body-image-in-cancer-patients-and-its-association-with-clinical-variables
#19
Masoud Bahrami, Marjan Mohamadirizi, Shahla Mohamadirizi, Seyyed Abbas Hosseini
BACKGROUND: Cancer and its treatments have been shown to have a negative psychological effect on many cancer patients. One of these effects is often described as body image disturbance. Due to the limited number of studies in this area, this study was performed to assess body image in cancer patients and its association with clinical variables. MATERIALS AND METHODS: This was a descriptive and correlational research that was designed in Sayyed-Al-Shohda Hospital affiliated to Isfahan University of Medical Sciences, Iran in 2013...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29114376/dihydroartemisinin-induces-apoptosis-in-human-bladder-cancer-cell-lines-through-reactive-oxygen-species-mitochondrial-membrane-potential-and-cytochrome-c-pathway
#20
Farhad Poupel, Mahmoud Aghaei, Ahmad Movahedian, Seyyed Mehdi Jafari, Mohammad Keyvanloo Shahrestanaki
Background: Dihydroartemisinin (DHA) is a semisynthetic derivative of artemisinin and has antiproliferative effect. However, such effects of DHA have not yet been revealed for bladder cancer cells. Methods: We used as bladder cancer cell lines to examine the effect of DHA on the cell viability, cell apoptosis, and monitoring of mitochondrial membrane potential (ΔΨm) changes. Furthermore, the effect of DHA on the reactive oxygen species (ROS) production and cytochrome c release were also detected...
2017: International Journal of Preventive Medicine
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