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https://www.readbyqxmd.com/read/28721126/the-thyroid-gland-in-postmenopausal-women-physiology-and-diseases
#1
REVIEW
Małgorzata Gietka-Czernel
The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Unrecognised thyroid dysfunction leads to increased: cardiovascular risk, bone fractures, cognitive impairment, depression, and mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28711080/menopause-and-chronic-kidney-disease
#2
Sofia B Ahmed
Premature menopause defined as secondary amenorrhea is common in women with kidney disease. Moreover, the aging population has resulted in increasing numbers of postmenopausal women with kidney disease. Though the pathophysiology is poorly understood, kidney transplantation and more frequent hemodialysis can restore menses and fertility, highlighting the challenges of diagnosing and managing the menopausal transition in the female population with kidney disease. Postmenopausal sex hormone levels affect renovascular physiology, but the clinical impact of menopause on kidney function is unclear...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28697037/the-association-of-surgical-versus-natural-menopause-with-future-left-ventricular-structure-and-function-the-coronary-artery-risk-development-in-young-adults-cardia-study
#3
Duke Appiah, Pamela J Schreiner, Chike C Nwabuo, Melissa F Wellons, Cora E Lewis, Joao A Lima
OBJECTIVE: To evaluate the association between surgical menopause (SM) versus natural menopause (NM) in relation to later left ventricular (LV) structure and function, while taking into account the LV parameters and other cardiovascular disease risk factor (CVDRF) levels that predate the menopausal transition. METHODS: We studied 825 premenopausal women from the Coronary Artery Risk Development in Young Adults study in 1990 to 1991 (baseline, mean age 32 years) who later reached menopause by 2010 to 2011 and had echocardiograms at these two time points...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28686517/clinical-update-osteoporosis-management
#4
Pelin Batur, Sheila Rice, Paola Barrios, Andrea Sikon
The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected recent publications relevant to osteoporosis management. We highlight articles on the safety of long-term use of denosumab and bisphosphonates, fracture risk after discontinuing menopausal hormone therapy, calcium intake and cardiovascular risk, as well as the value of repeat dual X-ray absorptiometry scanning to monitor those on osteoporosis treatment...
July 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28664754/safety-and-benefit-considerations-for-menopausal-hormone-therapy
#5
James H Pickar, David F Archer, Risa Kagan, JoAnn V Pinkerton, Hugh S Taylor
While benefits and risks of hormone therapy (HT) have been shown in rigorous randomized, controlled trials, clinical use and further study have discovered effects of age, time of HT initiation, and differential effects of various regimens and administration routes on its safety profile. Areas covered: The safety of HT with regard to cardiovascular disease, thrombosis, the endometrium, the breast, and cognition was reviewed. Differential safety effects of estradiol versus conjugated equine estrogens, and progesterone versus synthetic progestins are reported...
June 30, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28662351/the-emerging-role-of-curcumin-for-improving-vascular-dysfunction-a-review
#6
Marilyn S Campbell, Bradley S Fleenor
Curcumin, when administered in a bioavailable form, has potential to influence vascular health of various populations, leading to decreases in cardiovascular disease risk. Clinical intervention studies with curcumin have demonstrated significant improvements in endothelial function, arterial compliance, arterial stiffness, and other measures of vascular hemodynamics in young, middle-aged, old, post-menopausal, healthy, diabetic, and obese individuals. Mechanistically, curcumin is believed to improve vascular function through its effects on inflammation, oxidative stress, nitric oxide bioavailability, and structural proteins of the artery...
June 29, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28649100/-aging-and-homeostasis-sex-hormones-and-aging
#7
Keizo Ohnaka
The decline in sex hormones along with aging is suggested to be involved in age-associated diseases such as cardiovascular diseases, osteoporosis, and dementia. The decrease of estrogen level after menopause is related to osteoporosis in addition to climacteric disturbance in women, while that of testosterone to sarcopenia, osteoporosis and late-onset hypogonadism in men. New treatment strategy is expected for targeting age-associated diseases against the decreased level of sex hormones.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28646476/the-relationship-between-circulating-adiponectin-leptin-and-vaspin-with-bone-mineral-density-bmd-arterial-calcification-and-stiffness-a-cross-sectional-study-in-post-menopausal-women
#8
N Tanna, K Patel, A E Moore, D Dulnoan, S Edwards, G Hampson
OBJECTIVE: To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women. We hypothesised that adipokines produced by adipose tissue may be mediators of bone and cardiovascular disease (CVD) and explain, in part, the observed association between osteoporosis and CVD. DESIGN: We studied 386 ambulant community dwelling postmenopausal women aged (mean [SD] 61 [6...
June 23, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28622476/the-effect-of-transdermal-estrogen-patch-use-on-cardiovascular-outcomes-a-systematic-review
#9
Prema Bezwada, Atif Shaikh, Deepika Misra
BACKGROUND: Vasomotor symptoms are the most commonly reported menopausal symptoms. Hormone therapy has been widely used to relieve postmenopausal symptoms. With studies suggesting an increased risk of cardiovascular events and breast cancer with oral hormone therapy use, there has been reluctance to use it. The transdermal estrogen patch provides relief from menopausal symptoms. However, there are limited data on mortality and cardiovascular outcomes, while on the transdermal estrogen patch...
June 16, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28620545/cardiovascular-risk-factors-among-women-with-self-reported-infertility
#10
Shruthi Mahalingaiah, Fangui Sun, J Jojo Cheng, Erika T Chow, Kathryn L Lunetta, Joanne M Murabito
BACKGROUND: Amongst women with certain types of ovulatory disorder infertility, the studies are conflicting whether there is an increased risk of long-term cardiovascular disease risk. This paper evaluates the associations of several CVD risk factors among Framingham women with self-reported infertility. METHODS: Women who completed the Framingham Heart Study Third Generation and Omni Cohort 2 Exam 2 (2008-2011), and reported on past history of infertility and current cardiovascular disease status were included in this cross-sectional study...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28584559/schisandrae-fructus-reduces-symptoms-of-4-vinylcyclohexene-diepoxide-induced-ovarian-failure-in-mice
#11
Dasom Shin, Jinhee Ha, Seong Bin Hong, Geun-Hyung Kang, Deok-Sang Hwang, Hyunsu Bae
Menopause is associated with a decrease in the level of sex hormones such as ovarian estradiol and progesterone and can cause various symptoms such as depression, hot flash, fatigue, heart palpitations, and headache. Furthermore, there is a risk of developing complications such as osteoporosis, cardiovascular diseases, Alzheimer's disease, and ovarian cancer. Schisandrae Fructus (SF) is widely used in Korean medicine as a cure for such complications. This study was conducted to evaluate the therapeutic effects of SF against menopause symptoms associated with follicle depletion caused by the industrial chemical 4-vinylcyclohexene diepoxide (VCD) in mice...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28552254/a-study-of-chronic-fatigue-in-norwegian-cervical-cancer-survivors
#12
REVIEW
Rita Steen, Alv A Dahl, Siri Lothe Hess, Cecilie E Kiserud
OBJECTIVE: Chronic fatigue after treatment is a common adverse event in cancer patients, but there are few studies in long-term survivors of cervical cancer. The aim of this investigation was to explore the prevalence of chronic fatigue and its association with various clinical and treatment-related factors in a population-based cohort of Norwegian cervical cancer survivors treated by any modality. METHODS: All patients, treated for cervical cancer from 2000 through 2007 in the Health Region of South-Eastern Norway, cancer-free, alive and aged ≤75years by the end 2013 (n=822) received a questionnaire covering chronic fatigue and other clinical variables...
May 25, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28551920/-women-s-cardiac-health-from-theory-to-activism
#13
REVIEW
Avital Porter
Cardiovascular disease (CVD) is the leading cause of death in the western world, in both genders. Although awareness of the importance of prevention, diagnosis and optimal treatment of CVD has risen in general, most women are not fully aware of their CVD risk. Moreover, women are not alert to the burden of risk in their reproductive years (e.g. complicated pregnancy and/or peri-menopausal period) and their impact on future CVD. Unique Female issues such as: fertile age, menopause, oral contraceptives, hormonal and metabolic disorders during pregnancy, labor, as well as psychological matters, and healthy life-style are major contributors to primary and secondary prevention of CVD...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28540087/elevated-cardiovascular-risks-among-postmenopausal-women-a-community-based-case-control-study-from-nepal
#14
Bashu Dev Pardhe, Sumitra Ghimire, Jyotsna Shakya, Sabala Pathak, Shreena Shakya, Anjeela Bhetwal, Puspa Raj Khanal, Narayan Prasad Parajuli
Cardiovascular disease (CVD) is one of the leading causes of death worldwide which is more prevalent in women after menopause. Hormonal changes associated with menopause are accountable for dyslipidemic pattern that causes CVD and associated complications. Therefore, the present study was commenced to compare the lipid profile in pre- and postmenopausal women. A descriptive cross-sectional study was conducted at Manmohan Memorial Institute of Health Sciences (MMIHS) from February 2016 to July 2016. A total of 260 fasting samples were collected from healthy women, 130 from premenopausal and 130 from postmenopausal women, and analyzed for Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoprotein Cholesterol (HDL-C), and Low Density Lipoprotein Cholesterol (LDL-C) as per the guideline provided by the reagent manufacturer (Human, Germany)...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28533839/-epidemiology-of-the-relationship-between-atrial-fibrillation-and-heart-failure
#15
Yassine Ragbaoui, Chafia Chehbouni, Ayoub El Hammiri, Rachida Habbal
Atrial fibrillation and heart failure are diseases which often coexist aggravating prognosis and constituting a major public health problem. The aim of this study was to assess the prevalence of atrial fibrillation in patients with chronic heart failure and to determine the clinical profile of this group of patients. We conducted a retrospective descriptive study based on the registry of heart failure of the Department of Cardiology at the University Hospital Centre from June 2006 to March 2015. All patients over 18 years of age with chronic heart failure associated with atrial fibrillation were included in the study...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28525295/duration-of-reproductive-years-and-the-risk-of-cardiovascular-and-cerebrovascular-events-in-older-women-insights-from-the-national-health-and-nutrition-examination-survey
#16
Hend Mansoor, Islam Y Elgendy, Richard Segal, Abraham Hartzema
BACKGROUND: Studies have shown conflicting information regarding the association between the age at menarche and/or menopause and cardiovascular and cerebrovascular diseases in older women. This study aimed to determine whether a longer duration of reproductive years in older women in the U.S. population was associated with a lower risk of cardiovascular and cerebrovascular diseases. MATERIALS AND METHODS: Women ≥60 years who participated in the National Health and Nutrition Examination Survey from 2007 to 2012 were included...
May 19, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28523945/prevention-of-postmenopausal-osteoporosis-in-chinese-women-a-5-year-double-blind-randomized-parallel-placebo-controlled-study
#17
S Y Ran, Q Yu, Y Chen, S Q Lin
OBJECTIVES: To observe the effectiveness and safety of menopause-related hormone therapy (MHT) to prevent bone loss in Chinese women during the menopausal transition and early menopause, as well as to evaluate the effects of 5-year MHT on overall health to add Level I evidence for the prevention of osteoporosis using MHT. DESIGN: This clinical study was a prospective, double-blind, randomized, parallel placebo-controlled study. Chinese women in the menopausal transition and early menopause were randomly allocated to the MHT group or the placebo group...
May 19, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28507296/sleep-disorder-an-independent-risk-associated-with-arterial-stiffness-in-menopause
#18
Yang Zhou, Ruwei Yang, Changbin Li, Minfang Tao
As women age and go through menopause, they suffer a higher incidence of sleep disorder, cardiovascular morbidity and mortality. In addition, evidences suggested that sleep disorder was an important pathological indicator for coronary heart disease. However, the relationship between different menopausal status, sleep disorder and cardiovascular diseases was unclear. Thus, we aim to assess the association between sleep disorder with arterial stiffness in females of 40-60 years free of cardiovascular diseases through self-administered Pittsburgh Sleep Quality Index (PSQI) and brachial-ankle pulse wave velocity (baPWV)...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28502486/jcl-roundtable-cardiovascular-disease-risk-reduction-in-menopausal-women
#19
REVIEW
William Virgil Brown, Martha Gulati, Gina P Lundberg
Ovarian failure occurs in most women during the late fifth decade or early sixth decade of life. This causes a number of changes in physiology as estrogen and progestin concentrations decline. These involve lipoprotein metabolism and the vasculature. The risk factors for large vessel disease increase, and dysfunction of the small resistance vessels responds with changes in blood flow to the skin causing unpleasant symptoms. These and other changes result in visits to the physician. A reassessment of risk factors and symptoms is needed to develop a new plan for effective management, both short term and long term...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28490509/vitamin-d-and-calcium-intake-and-risk-of-early-menopause
#20
Alexandra C Purdue-Smithe, Brian W Whitcomb, Kathleen L Szegda, Maegan E Boutot, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Lisa M Troy, Karin B Michels, Elizabeth R Bertone-Johnson
Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects ∼10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk factors for early menopause have been identified, but emerging data suggest that high vitamin D intake may reduce risk.Objective: We evaluated how intakes of vitamin D and calcium are associated with the incidence of early menopause in the prospective Nurses' Health Study II (NHS2)...
June 2017: American Journal of Clinical Nutrition
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