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Menopause cardiovascular disease

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https://www.readbyqxmd.com/read/29331535/estrogen-deprivation-aggravates-cardiometabolic-dysfunction-in-obese-insulin-resistant-rats-through-the-impairment-of-cardiac-mitochondrial-dynamics
#1
Wanitchaya Minta, Siripong Palee, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkum, Sasiwan Kerdpoo, Wasana Pratchayasakul, Sirinart Kumfu, Siriporn C Chattipakorn, Nipon Chattipakorn
The incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, suggesting estrogen has a vital role in their prevention. Mitochondrial dynamics are known to play an important role in the maintenance of cardiac physiological function. However, the effects of estrogen deprivation on cardiometabolic status and cardiac mitochondrial dynamics under conditions of obese-insulin resistance have never been investigated. We hypothesized that estrogen deprivation aggravates cardiac dysfunction through increased cardiac mitochondrial fission in obese-insulin resistant rats...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29288157/history-of-adverse-pregnancy-outcomes-blood-pressure-and-subclinical-vascular-measures-in-late-midlife-swan-study-of-women-s-health-across-the-nation
#2
Yamnia I Cortés, Janet M Catov, Maria Brooks, Siobán D Harlow, Carmen R Isasi, Elizabeth A Jackson, Karen A Matthews, Rebecca C Thurston, Emma Barinas-Mitchell
BACKGROUND: Adverse pregnancy outcomes, such as preterm birth (PTB), have been associated with elevated risk of maternal cardiovascular disease, but their effect on late midlife blood pressure (BP) and subclinical vascular measures remains understudied. METHODS AND RESULTS: We conducted a cross-sectional analysis with 1220 multiethnic parous women enrolled in SWAN (Study of Women's Health Across the Nation) to evaluate the impact of self-reported history of adverse pregnancy outcomes (PTB, small-for-gestational-age, stillbirth), on maternal BP, mean arterial pressure, and subclinical vascular measures (carotid intima-media thickness, plaque, and pulse wave velocity) in late midlife...
December 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29242848/effect-of-combined-endurance-resistance-training-and-soy-extract-supplementation-on-expression-of-enos-gene-in-ovariectomized-rats
#3
Morteza Jourkesh, Siroos Choobineh, Rahman Soori, Ali Asghar Ravasi
Introduction: Menopause is an independent risk factor for cardiovascular disease (CVD). Physical exercise and soybean diets have been suggested to reduce the risk of CVD in postmenopausal women. The purpose of this study was to investigate the effects of combined resistance and endurance (RE) training and soy extract (SOY) supplementation, both known to improve endothelial function, on expression of the eNOS gene in the heart of ovariectomized (OVX) rats. Material and methods: Fifty female Wistar rats were divided into five groups: 1) sham (SHAM); 2) ovariectomy (OVX); 3) ovariectomy with soy extract supplementation (OVX + SOY); 4) OVX with RE training (OVX + RE); 5) and ovariectomy plus RE training with soy extract supplementation (OVX + RE + SOY)...
2017: Archives of Medical Sciences. Atherosclerotic Diseases
https://www.readbyqxmd.com/read/29226551/premenstrual-symptoms-interference-and-equol-production-status-in-japanese-collegiate-athletes-a-cross-sectional-study
#4
Takashi Takeda, Tomomi Ueno, Shigeto Uchiyama, Masami Shiina
AIM: Consumption of soy isoflavones reduces the risk of estrogen-related diseases, such as menopausal symptoms, osteoporosis, and cardiovascular disease. Equol is metabolized from the isoflavone daidzein by intestinal bacteria and has higher bioavailability than other isoflavones. Equol producers are believed to benefit from soybean consumption to a greater extent than non-producers. Recently, we showed that equol non-producers were at significant risk of premenstrual syndrome (PMS). Previously, we reported that PMS is a common menstrual problem in female athletes, and almost half of the studied athletes felt a negative effect of premenstrual symptoms on their athletic performance...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29224098/role-of-estrogens-in-the-regulation-of-liver-lipid-metabolism
#5
Brian T Palmisano, Lin Zhu, John M Stafford
Before menopause, women are protected from atherosclerotic heart disease associated with obesity relative to men. Sex hormones have been proposed as a mechanism that differentiates this risk. In this review, we discuss the literature around how the endogenous sex hormones and hormone treatment approaches after menopause regulate fatty acid, triglyceride, and cholesterol metabolism to influence cardiovascular risk.The important regulatory functions of estrogen signaling pathways with regard to lipid metabolism have been in part obscured by clinical trials with hormone treatment of women after menopause, due to different formulations, routes of delivery, and pairings with progestins...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29222337/menopausal-hormone-therapy-and-cardiovascular-disease-unraveling-the-role-of-age-and-time-since-menopause-onset
#6
Shilpa N Bhupathiraju, Meir J Stampfer
No abstract text is available yet for this article.
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29206775/menopause-improves-the-predictive-value-of-common-cardiovascular-risk-scores-in-women-with-premature-coronary-artery-disease
#7
Karolina Ewa Kryczka, Mariusz Kruk, Walerian Piotrowski, Ewa Księżycka, Radosław Pracoń, Adam Witkowski, Marcin Demkow, Barbara Lubiszewska
OBJECTIVE: Menopause, particularly its early stage (≤3 years from onset), may be an important risk factor for premature coronary artery disease. The objective of the study was to assess whether the addition of the presence of menopause in women with premature coronary artery disease could improve the predictive value of the Atherosclerotic Cardiovascular Disease risk estimator and the Systematic COronary Risk Evaluation model. METHODS: The case-control study included 307 women with coronary artery disease aged 55 or less, and 347 age-matched controls without coronary artery disease...
December 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29193539/comprehensive-evaluation-of-the-role-of-soy-and-isoflavone-supplementation-in-humans-and-animals-over-the-past-two-decades
#8
REVIEW
Yunqi Xiao, Shan Zhang, Haibing Tong, Shourong Shi
Soy and soy-based foods are considered healthy, particularly in many Asia-Pacific countries, where soy products have long been consumed. Soy and soy-related products have been found to help prevent the occurrence of cardiovascular diseases and certain types of cancer, such as breast and prostate cancer. These products can also have antioxidative effects that alleviate hot flashes during menopause and bone loss. These biological and therapeutic functions are primarily due to the isoflavones derived from soy, whose structure is similar to the structure of 17-β-oestradiol...
November 29, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29186452/gender-and-cardiovascular-disease-are-sex-biased-mirna-networks-a-driving-force-behind-heart-failure-with-preserved-ejection-fraction-in-women
#9
Barend W Florijn, Roel Bijkerk, Eric van der Veer, Anton Jan van Zonneveld
CVD is the primary cause of death among men and women worldwide. Nevertheless, our comprehension of how CVD progresses in women and elicits clinical outcomes is lacking, leading CVD to be under-diagnosed and under-treated in women. A clear example of this differential presentation of CVD pathophysiologies in females is the strikingly higher prevalence of heart failure with preserved ejection fraction (HFpEF). Women with a history of preeclampsia, or those that present co-morbidities such as obesity, hypertension and diabetes mellitus are at increased risk to develop HFpEF...
November 24, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29170360/sex-specific-cardiovascular-susceptibility-to-ischaemic-myocardial-injury-following-exposure-to-prenatal-hypoxia
#10
Michal Zeman, Monika Okuliarova
Cardiovascular diseases (CVDs) are the leading cause of mortality and hypertension contributes substantially to the incidence of stroke, coronary artery disease, heart failure, atrial fibrillation and peripheral vascular disease. The origin of hypertension is clearly multifactorial, and a complex and multifaceted approach is necessary to decrease its incidence. The most recognizable factors involved in reducing the incidence of hypertension are prevention, early diagnosis and treatment; however, the importance of the foetal environment and early postnatal development has recently been considered...
December 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29169589/vitamin-d-deficiency-is-associated-with-metabolic-syndrome-in-postmenopausal-women
#11
Eneida Boteon Schmitt, Jorge Nahas-Neto, Flavia Bueloni-Dias, Priscila Ferreira Poloni, Claudio Lera Orsatti, Eliana Aguiar Petri Nahas
OBJECTIVE: To evaluate the association between vitamin D (VD) deficiency and risk factors for metabolic syndrome (MetS) in postmenopausal women. STUDY DESIGN: Observational, cross-sectional cohort study. MAIN OUTCOME MEASURES: In this study, 463 women, aged 45-75 years, with amenorrhea >12months, without VD supplementation or established cardiovascular disease were included. Clinical and anthropometric data were collected. Biochemical parameters, including total cholesterol (TC), HDL, LDL, triglycerides, glucose, insulin and 25-hydroxyvitamin-D [25(OH)D] were measured...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29169577/excess-fat-in-the-abdomen-but-not-general-obesity-is-associated-with-poorer-metabolic-and-cardiovascular-health-in-premenopausal-and-postmenopausal-asian-women
#12
Victor Hng Hang Goh, William George Hart
OBJECTIVES: To examine the associations of various metabolites and hormones and hormone replacement therapy (HRT) with obesity. METHODS: This is a cross-sectional study of 1326 Singaporean women. A DXA-derived percent body fat (PBF) of ≥35% and percent abdominal fat (PAbdF) of >21.8% were used, respectively, to define women with general (GOb) and abdominal (AbdOb) obesity. RESULTS: Higher levels of insulin and glucose, lower levels of HDL, higher levels of TC/HDL and HOMA values, and different levels of some hormones were noted only in the women with abdominal, and not general obesity...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29159396/association-of-nonalcoholic-fatty-liver-disease-with-lower-brain-volume-in-healthy-middle-aged-adults-in-the-framingham-study
#13
Galit Weinstein, Shira Zelber-Sagi, Sarah R Preis, Alexa S Beiser, Charles DeCarli, Elizabeth K Speliotes, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri
Importance: Nonalcoholic fatty liver disease (NAFLD) is a common condition that is most often asymptomatic. It is associated with metabolic syndrome, incident diabetes, carotid atherosclerosis, and endothelial dysfunction, conditions that in turn are strongly linked with brain damage and cognitive impairment. However, it is not known whether NAFLD is associated with structural brain measures in humans. Objective: To assess the association between prevalent NAFLD and brain magnetic resonance imaging (MRI) measures...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29149179/postmenopausal-hormone-therapy-and-risk-of-stroke-a-pooled-analysis-of-data-from-population-based-cohort-studies
#14
Germán D Carrasquilla, Paolo Frumento, Anita Berglund, Christer Borgfeldt, Matteo Bottai, Chiara Chiavenna, Mats Eliasson, Gunnar Engström, Göran Hallmans, Jan-Håkan Jansson, Patrik K Magnusson, Peter M Nilsson, Nancy L Pedersen, Alicja Wolk, Karin Leander
BACKGROUND: Recent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT in relation to haemorrhagic stroke risk. The importance of the route of administration, type, active ingredient, and duration of HT for stroke risk is also unclear...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29138210/what-happens-after-menopause-wham-protocol-for-a-prospective-multicentre-age-matched-cohort-trial-of-risk-reducing-bilateral-salpingo-oophorectomy-in-high-risk-premenopausal-women
#15
Martha Hickey, Alison Trainer, Sabine Braat, Mary-Ann Davey, Efrosinia Krejany, John Wark
INTRODUCTION: Women at high inherited risk of ovarian cancer are advised to undergo risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 40-45 years or when their families are complete. Most women are premenopausal at this age, so RRBSO will induce surgical menopause. Despite the clear benefits of RRBSO for cancer risk reduction, much less is known about the impact on non-cancer outcomes that contribute to health and well-being and inform surveillance and management strategies...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29133274/gender-differences-in-the-impact-of-anemia-on-subclinical-myocardial-damage-and-cardiovascular-mortality-in-the-general-population-the-yamagata-takahata-study
#16
Yuki Honda, Tetsu Watanabe, Yoichiro Otaki, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Yoko Shibata, Tsuneo Konta, Ryo Kawasaki, Makoto Daimon, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota
BACKGROUND: Anemia has been shown to worsen cardiovascular diseases. However, it is unclear whether there is a gender difference in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population. METHODS: A prospective cohort study was conducted in a community based on annual health checks. Serum heart-type fatty acid binding protein (H-FABP) levels, which is a marker for myocardial damage, and blood counts were measured at baseline in subjects without previous cardiovascular diseases (n=3111)...
November 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29118949/cardiovascular-disease-events-and-its-predictors-in-women-isfahan-cohort-study-ics
#17
Masoumeh Sadeghi, Azam Soleimani, Hamidreza Roohafza, Safoura Yazdekhasti, Shahram Oveisgharan, Mohammad Talaei, Nizal Sarrafzadegan
Introduction: As a lack of validated data about cardiovascular (CV) events and its risk factors (RFs) in women of Eastern Mediterranean region, we aimed to evaluate common predictors of CV events among Iranian women. Methods: Isfahan cohort study (ICS) is a prospective cohort that followed 6323 residents (51.3% women, aged 35-75 years) from three counties and their rural districts in central Iran. Common cardiovascular disease (CVD) RFs namely hypertension (HTN), diabetes mellitus, dyslipidemia, abdominal obesity, smoking, low apolipoproteins A ( apo-A) and high apolipoprotein B (apo-B) were evaluated...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29117982/menopause-characteristics-total-reproductive-years-and-risk-of-cardiovascular-disease-among-chinese-women
#18
Ling Yang, Liling Lin, Christiana Kartsonaki, Yu Guo, Yiping Chen, Zheng Bian, Kaixu Xie, Donghui Jin, Liming Li, Jun Lv, Zhengming Chen
BACKGROUND: Previous studies, mostly of Western women, have reported inconsistent findings on the association of menopause characteristics (status, age, and time since menopause) and total reproductive years with risk of cardiovascular disease (CVD). METHODS AND RESULTS: The China Kadoorie Biobank recruited 302 632 women in 2004 to 2008 from 10 regions across China. During 9-year follow-up, 19 393 incident cases of stroke, 18 611 of ischemic heart disease, and 4978 CVD deaths occurred...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29112599/genetic-variants-associated-with-earlier-age-at-menopause-increase-the-risk-of-cardiovascular-events-in-women
#19
Chloé Sarnowski, Maryam Kavousi, Steve Isaacs, Ellen W Demerath, Linda Broer, Taulant Muka, Oscar H Franco, Mohammad Arfan Ikram, André Uitterlinden, Nora Franceschini, Kathryn L Lunetta, Joanne M Murabito
OBJECTIVE: To better understand the relationship between cardiovascular disease risk and age-at-natural menopause using genetic data. METHODS: Early menopause is associated with cardiovascular disease risk. We constructed a genetic risk score comprising 56 age-at-natural menopause decreasing alleles in men and women from the Framingham Heart Study, the Atherosclerosis Risk in Communities Study, and the Rotterdam Study. If the genetic predisposition to earlier age-at-natural menopause is associated with increased cardiovascular disease risk, it is reasonable to ask whether the risk is shared by men carrying the alleles, despite not experiencing menopause...
November 6, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29111858/women-s-health-endocrine-update
#20
Ekta Kapoor, Stephanie Faubion, Stephanie Hines, Cynthia A Stuenkel
The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected four recent high-impact publications related to endocrine issues in women. We have chosen to highlight research on subclinical hypothyroidism during pregnancy and adverse pregnancy outcomes, including cognitive outcomes in offspring; the progression of metabolic syndrome severity during the menopausal transition; and the association of diabetes and metformin use with cancer risk and mortality...
November 7, 2017: Journal of Women's Health
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