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JOURNAL ARTICLE
Mi-Kyoung Kang, Yooha Hong, Yoo Hwan Kim, Hong-Kyun Park, Soo-Kyoung Kim, Jong-Hee Sohn, Jiyoung Kim, Ki-Han Kwon, Soo-Jin Cho
BACKGROUND AND PURPOSE: Giant-cell arteritis (GCA) is the most common type of vasculitis in the elderly and is associated with high risks of visual loss and recurrence. Owing to its rarity in Asian populations, the current clinical interventions for these patients are not well known. Here we aimed to characterize the current management status of patients with GCA using Korean multicenter data. METHODS: This retrospective study analyzed medical records of patients with GCA at six Korean university hospitals from February 2009 to November 2022...
April 2, 2024: Journal of Clinical Neurology
#22
JOURNAL ARTICLE
NDUFV1-Related Mitochondrial Complex-1 Disorders: A Retrospective Case Series and Literature Review.
Aakash Mahesan, Puneet Kumar Choudhary, Gautam Kamila, Aradhana Rohil, Ankit Kumar Meena, Atin Kumar, Prashant Jauhari, Biswaroop Chakrabarty, Sheffali Gulati
BACKGROUND: Pathogenic variants in the NDUFV1 gene disrupt mitochondrial complex I, leading to neuroregression with leukoencephalopathy and basal ganglia involvement on neuroimaging. This study aims to provide a concise review on NDUFV1-related disorders while adding the largest cohort from a single center to the existing literature. METHODS: We retrospectively collected genetically proven cases of NDUFV1 pathogenic variants from our center over the last decade and explored reported instances in existing literature...
March 6, 2024: Pediatric Neurology
#23
JOURNAL ARTICLE
D Orsucci, A Tessa, E Caldarazzo Ienco, R Trovato, G Natale, G Bilancieri, M Giuntini, A Napolitano, S Salvetti, M Vista, F M Santorelli
OBJECTIVE: Essential Tremor (ET) is one of the most common neurological disorders. In most instances ET is inherited as an autosomal dominant trait with age-related penetrance (virtually complete in advanced age); however, ET genetics remains elusive. The current study aims to identify possibly pathogenic genetic variants in a group of well-characterized ET families. METHODS: 34 individuals from 14 families with dominant ET were clinically evaluated and studied by whole exome sequencing studies (after excluding trinucleotide expansion disorders)...
April 13, 2024: Journal of the Neurological Sciences
#24
JOURNAL ARTICLE
Shuliang Zhao, Huimin Jiang, Yiqun Miao, Wenwen Liu, Yanan Li, Yuanyuan Zhang, Aihua Wang, Xinghui Cui
BACKGROUND: Preterm infants have imperfect neurological development, uncoordinated sucking-swallowing-breathing, which makes it difficult to realize effective oral feeding after birth. How to help preterm infants achieve complete oral feeding as soon as possible has become an important issue in the management of preterm infants. Non-nutritive sucking (NNS), as a useful oral stimulation, can improve the effect of oral feeding in preterm infants. This review aimed to explore the effect of NNS on oral feeding progression through a meta-analysis...
2024: PloS One
#25
JOURNAL ARTICLE
Rashmi Savant, Raj Kumar Pradhan, Savita Bhagat, Rajeswara Babu Mythri, Anu Mary Varghese, Seena Vengalil, Atchayaram Nalini, Talakad N Sathyaprabha, Trichur R Raju, K Vijayalakshmi
Amyotrophic Lateral Sclerosis (ALS) is a multifactorial neurodegenerative disorder with a significant contribution of non-cell autonomous mechanisms to motor neuronal degeneration. Amongst a plethora of molecules, Fractalkine (C-X3-C motif chemokine ligand 1), and Heat Shock Protein 60 (HSP60), are key modulators of microglial activation. The contribution of these molecules in Sporadic ALS (SALS) remains unexplored. To investigate this, fractalkine levels were estimated in Cerebrospinal fluid (CSF) of SALS patients (ALS-CSF; n = 44) by Enzyme-linked Immunosorbent Assay (ELISA) and correlated with clinical parameters including disease severity and duration...
April 16, 2024: International Journal of Neuroscience
#26
JOURNAL ARTICLE
Fatma Özkan Tuncay
This study was conducted to determine the relationship between preparedness for caregiving and spiritual well-being in the carers of stroke patients. This descriptive and cross-sectional study was conducted with 130 primary carers of patients hospitalized with the diagnosis of stroke at the neurology clinic of a hospital. It was determined that the participants had moderate levels of preparedness for caregiving, they had high levels of spiritual well-being, and there was a positive significant relationship between these two variables...
April 16, 2024: Journal of Religion and Health
#27
Anushri R Patil, Snehal Samal, Nikita H Seth
Down syndrome (DS) is a genetic condition developing from a supplementary chromosome 21, referred to as trisomy 21. It ranks among the most prevalent developmental disabilities. People with DS often live inactive lifestyles, not meeting the weekly physical activity guidelines. With age, they face increased risks of cardiovascular disease and osteoporosis, as well as neurological and orthopedic concerns. Physiotherapy is especially important for improving balance, coordination, strength, and endurance in adults over the age of 50...
March 2024: Curēus
#28
Nilesh Barwar, Param Jit Singh, Tarun Goyal, Pankaj Kumar Sharma, Sanjay Jain, Lakshman Das
Child abuse is a matter of serious concern that can often result in devastating injuries. Incidence of spinal injuries from child abuse has been reported in <1-3 % of spinal injury cases. In the present study, a case of thoracolumbar translational injury (AO type C) is presented following an incidence of child abuse in a 2-year-old female. After successful management with operative fixation, the child showed a remarkable recovery in her neurological function with ambulatory power.
June 2024: Trauma Case Reports
#29
JOURNAL ARTICLE
Y Li, X Z Hu, C Y Liu, X P Tao, R Wang, R Lu, Y Li, Y Pu, C R Mu, J H Xu, H M Fu
Objective: To investigate the clinical characteristics of 130 children with severe SARS-CoV-2 infection in Yunnan province after the relaxation of non-pharmaceutical interventions, and analyze the risk factors for mortality. Methods: This study is a retrospective case summary that analyzed the demographic data, underlying diseases, clinical diagnoses, disease outcomes, and laboratory results of 130 children with severe COVID-19 infections admitted to nine top-tier hospitals in Yunnan Province from December 2022 to March 2023...
April 16, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
#30
JOURNAL ARTICLE
Shukun Hu, Liqian Xie, Yi Zhang
Microrecurrent glioma is a common neurological tumor, and the key to its surgical treatment is to accurately evaluate the size, location and degree of recurrence of the lesion. The purpose of this study was to explore the surgical treatment of microrecurrent glioma based on MR Imaging, and to provide accurate and reliable basis for clinical decision-making. Before surgery, detailed MR Imaging tests were performed for each patient to accurately locate and evaluate the characteristics of the lesions. Multimodal imaging examination were arranged to accurate the pre-operation diagnosis...
April 2024: Medical Engineering & Physics
#31
JOURNAL ARTICLE
Gianluca Scalia, Massimiliano Porzio, Roberta Costanzo, Eliana Giurato, Fabio Gibilisco, Domenico Gerardo Iacopino, Rosario Maugeri, Giovanni Federico Nicoletti, Giuseppe Emmanuele Umana, Raffaele Alessandrello
BACKGROUND: Skull metastases from follicular thyroid carcinoma (FTC) are infrequent but clinically significant, often presenting with localized pain, neurologic deficits, and cranial nerve dysfunction. Early detection and accurate diagnosis pose challenges due to their asymptomatic nature in some cases. METHODS: A systematic literature review, conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, identified and analyzed 15 relevant studies focusing on large skull metastases in FTC...
April 15, 2024: Journal of Neurological Surgery. Part A, Central European Neurosurgery
#32
JOURNAL ARTICLE
Hanuman Prasad Prajapati, Deepak Kumar Singh
BACKGROUND: Although, cranioplasty is a commonly performed neurosurgical procedure worldwide, the cost of available cranioplasty implants is a major issue in a low-income country like India. The aims of this study were to introduce a novel and low-cost technique using a single standard three-dimensional (3D) skull model to guide the polymethyl methacrylate (PMMA) cranioplasty flap production and to evaluate the functional and cosmetic outcomes. METHODS: We retrospectively evaluated 47 cases of PMMA cranioplasty in the period from February 2019 to June 2022...
April 15, 2024: Journal of Neurological Surgery. Part A, Central European Neurosurgery
#33
JOURNAL ARTICLE
Manel Krouma, Kaissar Farah, Anis Choucha, Romain Appay, Florence Duffaud, Stephane Fuentes, Henry Dufour
Intradural Extraosseous Ewing sarcoma (IEES) is an infrequent occurrence. We report a case of a 66-year-old male who presented with a 2-month history of low back pain and bilateral S1 sciatica, with acute sphincter dysfunction. Imaging studies revealed an intradural extramedullary lesion in the cauda equina spanning from level L4 to S1. The patient underwent partial removal of the intradural lesion. Histopathological examination showed the presence of small round cells, which were consistent with Ewing Sarcoma...
April 13, 2024: Neuro-Chirurgie
#34
JOURNAL ARTICLE
Caio Brenno Abreu, Bárbara Flores Culau Merlo, Vinícius da Silva Varandas, Juliana de Sá Freire Medrado Dias
INTRODUCTION: Genetic mutations or inflammatory, degenerative, or neoplastic conditions can trigger amyloidosis. Hereditary gelsolin amyloidosis is a genetic disorder primarily marked by amyloid fibrils composed of misfolded gelsolin fragments. CASE REPORT: We present three sisters with AGel amyloidosis, illustrating its clinical diversity. Patient 1, a 51-year-old, had bilateral ptosis, ocular discomfort, and dry eye syndrome due to cranial nerve involvement. Patient 2, a 53-year-old, experienced progressive bilateral visual impairment...
April 15, 2024: European Journal of Ophthalmology
#35
JOURNAL ARTICLE
Naomi Kouri, Isabelle Frankenhauser, Zhongwei Peng, Sydney A Labuzan, Baayla D C Boon, Christina M Moloney, Cyril Pottier, Daniel P Wickland, Kelsey Caetano-Anolles, Nick Corriveau-Lecavalier, Jessica F Tranovich, Ashley C Wood, Kelly M Hinkle, Sarah J Lincoln, A J Spychalla, Matthew L Senjem, Scott A Przybelski, Erica Engelberg-Cook, Christopher G Schwarz, Rain S Kwan, Elizabeth R Lesser, Julia E Crook, Rickey E Carter, Owen A Ross, Christian Lachner, Nilüfer Ertekin-Taner, Tanis J Ferman, Julie A Fields, Mary M Machulda, Vijay K Ramanan, Aivi T Nguyen, R Ross Reichard, David T Jones, Jonathan Graff-Radford, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Dennis W Dickson, Val J Lowe, Prashanthi Vemuri, Melissa E Murray
IMPORTANCE: Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement. OBJECTIVES: To examine clinicopathologic and neuroimaging characteristics of disease heterogeneity in AD along a quantitative continuum using the corticolimbic index (CLix) to account for individuality of spatially distributed tangles found at autopsy...
April 15, 2024: JAMA Neurology
#36
JOURNAL ARTICLE
Suna Aşkın Turan, Şenay Aydın
UNLABELLED: OBJECTıVE: Cluster headache (CH) is a coronavirus 2019 (COVID-19) vaccination-related adverse event. There are a few case reports of relapses or de novo cluster episodes following the vaccine. The disease's pathophysiology is still not clear. The most widely accepted mechanism is activation of the trigeminocervical complex (TCC). However, the correlation between vaccination and CH is unexplainable. Its goal is to compare the CH bouts of patients before and after the vaccine...
April 15, 2024: Acta Neurologica Belgica
#37
JOURNAL ARTICLE
Nurşah Eker, Gülnur Tokuç, Alican Sarısaltık, Adnan Dağçınar, Dilek Gül, Beste Melek Atasoy, Barış Yılmaz, Burcu Tufan Taş
PURPOSE: Children under 3 years old represent a notable portion, about 25 to 30%, of all central nervous system tumor (CNS) cases. Their clinical course, prognosis, and treatment significantly differ from older children. This single-center retrospective study aims to comprehensively analyze survival factors in children under three diagnosed with CNS tumors. METHODS: Between April 2012 and December 2023, cases under 3 years of age with CNS tumors diagnosed at our center were retrospectively evaluated...
April 15, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#38
JOURNAL ARTICLE
Ghani Haider, Vaibhavi Shah, Ivan Lopez, Katherine E Wagner, Martin N Stienen, Anand Veeravagu
BACKGROUND: Robotic assistance in spine surgery is emerging as an accurate, effective and enabling technology utilized in the treatment of patients with surgical spinal pathology. The safety and reproducibility of robotic assistance in the placement of pedicle screw instrumentation is still being investigated. The objective of this study was to present our experience of instrumented spinal fusion utilizing an intraoperative robotic guidance system. METHODS: We retrospectively reviewed all cases of spinal instrumentation of the thoracic and lumbo-sacral spine using the Mazor X robotic system (Medtronic Inc, Minneapolis, MN, USA), performed at our institution by one surgeon between July 2017 and June 2020...
April 12, 2024: Journal of Neurosurgical Sciences
#39
JOURNAL ARTICLE
Erik Öhlén, Victor Gabriel El-Hajj, Alexander Fletcher-Sandersjöö, Erik Edström, Adrian Elmi Terander
INTRODUCTION: Peripheral nerve sheath tumors are the most common tumor of the peripheral nerves. In general, surgery has a favorable outcome and is the treatment of choice. However, postoperative neurologic deficits are not uncommon, and predictors of outcome are poorly defined. OBJECTIVE: To evaluate clinical outcomes after surgical treatment of benign peripheral nerve sheath tumors and identify outcome predictors that may affect preoperative decision making and improve surgical outcomes...
April 15, 2024: International Journal of Neuroscience
#40
D López, F Espinel, E Andrade, A S Aguirre
In pediatric patients, an acute altered mental status refers to a sudden and significant change in a child's brain function and level of consciousness. It may manifest as confusion, disorientation, agitation, lethargy or even a loss of consciousness. This condition is a medical emergency, and requires immediate evaluation and attention. There are several causes of acute altered mental status in children, including infections of the central nervous system such as meningitis or encephalitis, traumatic brain injury, metabolic disorders, seizures and poisoning, among others...
April 16, 2024: Revista de Neurologia
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