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https://www.readbyqxmd.com/read/28531915/bone-marrow-stem-cells-anti-liver-fibrosis-potency-inhibition-of-hepatic-stellate-cells-activity-and-extracellular-matrix-deposition
#1
Ervina Julien Sitanggang, Radiana Dhewayani Antarianto, Sri Widia A Jusman, Jeanne Adiwinata Pawitan, Ahmad Aulia Jusuf
Transplantation of bone marrow derived stem cells (BMSCs) has been reported inhibits liver fibrosis. Several in vitro studies by co-culturing BMSCs and hepatic stellate cells (HSCs) indirectly or directly in 2D models showed inhibition of HSC as the key player in liver fibrosis. In this study, we investigated direct effect of BMSCs on HSCs by co-culturing BMSCs and HSCs in 3D model as it represents the liver microenvironment with intricate cell-cell and cell-matrix interactions. Primary isolated rat HSCs and BMSCs were directly co-cultured at 1:1 ratio with hanging drop method...
May 30, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28531311/the-genotypes-of-orientia-tsutsugamushi-identified-in-scrub-typhus-patients-in-northern-vietnam
#2
Hang L K Nguyen, Hang T T Pham, Tinh V Nguyen, Phuong Vm Hoang, Mai T Q Le, Taichiro Takemura, Futoshi Hasebe, Daisuke Hayasaka, Akio Yamada, Kozue Hotta
Background: There are an estimated one million patients with scrub typhus in the Asia-Pacific region. There are few reports describing the incidence of scrub typhus in Vietnam. Methods: Blood samples collected from 63 patients clinically diagnosed as having scrub typhus from July 2015 to September 2016 were subjected to genotyping of Orientia tsutsugamushi. Results and Conclusions: Of these patients, 42 (67%) tested positive for O. tsutsugamushi, and the most common genotype was identified to be Karp (55%)...
May 22, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28531166/-epiafzelechin-protects-against-ovariectomy-induced-bone-loss-in-adult-mice-and-modulate-osteoblastic-and-osteoclastic-functions-in-vitro
#3
Ka-Chun Wong, Sisi Cao, Xiaoli Dong, Man-Chun Law, Tak-Hang Chan, Man-Sau Wong
The present study was designed to characterize the bone protective effects of (-)-epiafzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to four months old) were either ovariectomised (OVX) or sham-operated and subjected to treatment (vehicle, 17β-oestradiol (E2, 200 μg/kg/day) or EAF (500 μg/kg/day) orally for six weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin (OCN), and urinary deoxy-pyridinoline (DPD); increased bone mineral density (BMD); and improved micro-architectural properties in OVX mice...
May 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28530657/normal-and-cancerous-mammary-stem-cells-evade-interferon-induced-constraint-through-the-mir-199a-lcor-axis
#4
Toni Celià-Terrassa, Daniel D Liu, Abrar Choudhury, Xiang Hang, Yong Wei, Jose Zamalloa, Raymundo Alfaro-Aco, Rumela Chakrabarti, Yi-Zhou Jiang, Bong Ihn Koh, Heath A Smith, Christina DeCoste, Jun-Jing Li, Zhi-Ming Shao, Yibin Kang
Tumour-initiating cells, or cancer stem cells (CSCs), possess stem-cell-like properties observed in normal adult tissue stem cells. Normal and cancerous stem cells may therefore share regulatory mechanisms for maintaining self-renewing capacity and resisting differentiation elicited by cell-intrinsic or microenvironmental cues. Here, we show that miR-199a promotes stem cell properties in mammary stem cells and breast CSCs by directly repressing nuclear receptor corepressor LCOR, which primes interferon (IFN) responses...
May 22, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28529817/coordinated-and-iterative-enzyme-catalysis-in-fungal-polyketide-biosynthesis
#5
Leibniz Hang, Nicholas Liu, Yi Tang
Fungal polyketides are natural products with great chemical diversity that exhibit a wide range of biological activity. This chemical diversity stems from specialized enzymes encoded in the biosynthetic gene cluster responsible for the natural product biosynthesis. Fungal polyketide synthases (PKS) are the megasynthases that produce the carbon scaffolds for the molecules. Subsequent downstream tailoring enzymes such as oxygenases will then further modify the organic framework. In fungi, many of these enzymes have been found to work iteratively-catalyzing multiple reactions on different sites of the substrate...
September 2, 2016: ACS Catalysis
https://www.readbyqxmd.com/read/28529590/cepharanthine-exerts-antitumor-activity-on-choroidal-melanoma-by-reactive-oxygen-species-production-and-c-jun-n-terminal-kinase-activation
#6
Qi Zhu, Baofeng Guo, Linlin Chen, Qiuye Ji, Hang Liang, Naiyan Wen, Ling Zhang
Choroidal melanoma is the most common primary intraocular tumor in adults. Cepharanthine (CEP), a natural alkaloid extracted from the roots of Stephania cepharantha Hayata, has been demonstrated to inhibit the proliferation of various cancer cells. However, its potential anticancer effect in choroidal melanoma has not been clarified yet. In the present study, it was identified that CEP may potently inhibit the proliferation of human choroidal melanoma cells, induce cell death and cell cycle arrest, and activate cellular apoptotic proteins, including Bcl-2-associated X protein, caspase and poly(ADP-ribose) polymerase...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28529431/sharp-inequalities-for-tangent-function-with-applications
#7
Hui-Lin Lv, Zhen-Hang Yang, Tian-Qi Luo, Shen-Zhou Zheng
In the article, we present new bounds for the function [Formula: see text] on the interval [Formula: see text] and find sharp estimations for the Sine integral and the Catalan constant based on a new monotonicity criterion for the quotient of power series, which refine the Redheffer and Becker-Stark type inequalities for tangent function.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/28526083/improving-local-health-workers-knowledge-of-malaria-in-the-elimination-phase-determinants-and-strategies-a-cross-sectional-study-in-rural-china
#8
Ruoxi Wang, Shangfeng Tang, Jun Yang, Tian Shao, Piaopiao Shao, Chunyan Liu, Da Feng, Hang Fu, Xiaoyu Chen, Tao Hu, Zhanchun Feng
BACKGROUND: The current stage of malaria elimination in China requires experienced local health workers with sufficient knowledge of malaria who help to keep the public health system vigilant about a possible resurgence. However, the influencing factors of local health workers' knowledge level are not fully comprehended. This study aims to explore the factors with heavy impact on local health worker's knowledge of malaria and propose corresponding suggestions. METHODS: Underpinned by stratified sampling method, a cross-sectional survey was carried out between November 2014 and April 2016...
May 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28525908/mri-based-radiotherapy-planning-method-using-rigid-image-registration-technique-combined-with-outer-body-correction-scheme-a%C3%A2-feasibility-study
#9
Ki Mun Kang, Hoon Sik Choi, Bae Kwon Jeong, Jin Ho Song, In-Bong Ha, Yun Hee Lee, Chul Hang Kim, Hojin Jeong
An alternative pseudo CT generation method for magnetic resonance image (MRI)-based radiotherapy planning was investigated in the work. A pseudo CT was initially generated using the rigid image registration between the planning MRI and previously acquired diagnostic CT scan. The pseudo CT generated was then refined to have the same morphology with that of the referenced planning image scan by applying the outer body correction scheme. This method was applied to some sample of brain image data and the feasibility of the method was assessed by comparing dosimetry results with those from the current gold standard CT-based calculations...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28525861/an-experimental-and-theoretical-study-of-solvent-hydrogen-bond-donating-capacity-effects-on-ultrafast-intramolecular-charge-transfer-of-ld-490
#10
Hui Li, Hang Yin, Xiaochun Liu, Ying Shi, Mingxing Jin, Dajun Ding
The excited-state intramolecular charge transfer (ICT) of LD 490 were investigated in different hydrogen-bond-donating solvents (α scale) on the basis of the Kamlet-Taft solvatochromic parameters (π*, α, β). The femtosecond transient absorption spectra and the kinetics decay rate reveal that with an increase of solvent's α capacity, the long-lived picosecond process, which is attributed to the ICT, becomes much faster. Combining with time-dependent density functional theory (TDDFT) calculations, we demonstrate that the enhancement of α acidity substantially increases the electronegativity of the carbonyl oxygen in LD 490, which strengthen excited-state intermolecular hydrogen bonding interactions and consequently facilitate the ICT process...
May 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28524849/structural-basis-for-conductance-through-tric-cation-channels
#11
Min Su, Feng Gao, Qi Yuan, Yang Mao, De-Lin Li, Youzhong Guo, Cheng Yang, Xiao-Hui Wang, Renato Bruni, Brian Kloss, Hong Zhao, Yang Zeng, Fa-Ben Zhang, Andrew R Marks, Wayne A Hendrickson, Yu-Hang Chen
Mammalian TRICs function as K(+)-permeable cation channels that provide counter ions for Ca(2+) handling in intracellular stores. Here we describe the structures of two prokaryotic homologues, archaeal SaTRIC and bacterial CpTRIC, showing that TRIC channels are symmetrical trimers with transmembrane pores through each protomer. Each pore holds a string of water molecules centred at kinked helices in two inverted-repeat triple-helix bundles (THBs). The pores are locked in a closed state by a hydrogen bond network at the C terminus of the THBs, which is lost when the pores assume an open conformation...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28524200/isolation-of-a-novel-bioactive-protein-from-an-edible-mushroom-pleurotus-eryngii-and-its-anti-inflammatory-potential
#12
Biao Yuan, Liyan Zhao, Kanyasiri Rakariyatham, Yanhui Han, Zili Gao, Benard Muinde Kimatu, Qiuhui Hu, Hang Xiao
Edible mushrooms are rich sources of bioactive components. In this study, a bioactive protein, PEP, was isolated from an edible mushroom, Pleurotus eryngii, through (NH4)2SO4 precipitation and ion-exchange chromatography. Proteomic analysis by matrix assisted laser desorption ionization-time of flight mass spectrometry showed that PEP was a novel protein with a molecular weight of 40 kDa. PEP exhibited anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by inhibiting the overproduction of pro-inflammatory mediators including nitric oxide (NO), cytokine IL-1β and IL-6...
May 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28523453/optimizing-the-lee-carter-approach-in-the-presence-of-structural-changes-in-time-and-age-patterns-of-mortality-improvements
#13
Hong Li, Johnny Siu-Hang Li
Researchers using the Lee-Carter approach have often assumed that the time-varying index evolves linearly and that the parameters describing the age pattern of mortality decline are time-invariant. However, as several empirical studies suggest, the two assumptions do not seem to hold when the calibration window begins too early. This problem gives rise to the question of identifying the longest calibration window for which the two assumptions hold true. To address this question, we contribute a likelihood ratio-based sequential test to jointly test whether the two assumptions are satisfied...
May 18, 2017: Demography
https://www.readbyqxmd.com/read/28522706/genome-sequence-of-a-novel-canine-picornavirus-isolated-from-an-american-foxhound
#14
Erica E Norby, Richard G Jarman, Paul B Keiser, Leonard N Binn, Jun Hang
A candidate new canine picornavirus was isolated from a respiratory swab collected from an American foxhound (Canis lupus familiaris) in 1968. The assembled genome sequence of strain A128thr is 7,618 bases in length, comprising a complete protein-coding sequence of the 2,213-amino-acid polyprotein and partial terminal untranslated sequences.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28521903/motorcycle-related-hospitalizations-of-the-elderly
#15
Ching-Hua Hsieh, Hang-Tsung Liu, Shiun-Yuan Hsu, Hsiao-Yun Hsieh, Yi-Chun Chen
BACKGROUND: To investigate the injury pattern, mechanisms, severity, and mortality of the elderly hospitalized for treatment of trauma following motorcycle accidents. METHODS: Motorcycle-related hospitalization of 994 elderly and 5078 adult patients from the 16,548 hospitalized patients registered in the Trauma Registry System between January 1, 2009 and December 31, 2013. RESULTS: The motorcycle-related elderly trauma patients had higher injury severity, less favorable outcomes, higher proportion of patients admitted to the intensive care unit (ICU), prolonged hospital and ICU stays and higher mortality than those adult motorcycle riders...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28521888/clinical-significance-of-lipid-rich-plaque%C3%A2-detected-by-optical-coherence%C3%A2-tomography-a%C3%A2-4-year-follow-up-study
#16
Lei Xing, Takumi Higuma, Zhao Wang, Aaron D Aguirre, Kyoichi Mizuno, Masamichi Takano, Harold L Dauerman, Seung-Jung Park, Yangsoo Jang, Chong-Jin Kim, Soo-Joong Kim, So-Yeon Choi, Tomonori Itoh, Shiro Uemura, Harry Lowe, Darren L Walters, Peter Barlis, Stephen Lee, Amir Lerman, Catalin Toma, Jack Wei Chieh Tan, Erika Yamamoto, Krzysztof Bryniarski, Jiannan Dai, Thomas Zanchin, Shaosong Zhang, Bo Yu, Hang Lee, James Fujimoto, Valentin Fuster, Ik-Kyung Jang
BACKGROUND: Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. OBJECTIVES: This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). METHODS: The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel...
May 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28521793/height-inequalities-and-their-change-trends-in-china-during-1985-2010-results-from-6-cross-sectional-surveys-on-children-and-adolescents-aged-7-18%C3%A2-years
#17
Yong Xu, Lei Hang
BACKGROUND: Great health inequalities have been reported in China over the past few years. Height has been used as an important parameter of health and it may also be distributed unequally in different regions. By studying height data of Chinese children and adolescents aged 7 to 18 years, we analyze height inequalities and their change trends during 1985-2010. METHODS: On the base of data from 6 successive cross-sectional surveys of the Chinese National Survey on Student's Constitution and Health(CNSSCH) conducted in 1985,1991,1995,2000,2005 and 2010, we calculated difference of height for children and adolescents aged 7-18 years in different regions...
May 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28521410/effect-of-momordica-charantia-protein-on-proliferation-apoptosis-and-the-akt-signal-transduction-pathway-in-the-human-endometrial-carcinoma-ishikawa-h-cell-line-in-vitro
#18
Hang-Zhi Gu, Rong-Rong Lin, Han-Chu Wang, Xue-Jie Zhu, Yan Hu, Fei-Yun Zheng
Endometrial carcinoma (EC) is one of the most common female malignancies, and there is an urgent requirement to explore new therapeutic strategies. In the present study, Ishikawa H cells were treated with Momordica charantia protein (MCP30). The cell morphology, growth inhibition rate, cell cycle distribution, and expression of phosphate and tensin homolog, P-AKT and AKT were measured. DNA fragmentation analysis and Annexin V-fluorescein isothiocyanate/propidium iodide double staining assay were used to analyze cell apoptosis...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28521272/impact-of-prematurity-on-exercise-capacity-and-agility-of-children-and-youth-aged-8-to-18
#19
Tatjana Robič Pikel, Gregor Starc, Janko Strel, Marjeta Kovač, Janez Babnik, Petra Golja
BACKGROUND: Preterm (PT) birth and low birth mass (LBW) can impair growth and development of children and may therefore affect their physical performance up to adulthood. AIMS: Our aim was to evaluate long-term consequences of prematurity, especially (an)aerobic exercise capacity and agility up to adulthood, by comparing premature and full-term (FT) individuals. STUDY DESIGN, SUBJECTS: From 474 subjects born in 1987, who were enrolled into a longitudinal study, 396 (178 PT and 218 FT (with 127 of them LBW)) were followed-up into their early adulthood...
May 15, 2017: Early Human Development
https://www.readbyqxmd.com/read/28520527/open-label-multicenter-phase-ii-study-of-ceritinib-in-patients-with-non-small-cell-lung-cancer-harboring-ros1-rearrangement
#20
Sun Min Lim, Hye Ryun Kim, Jong-Seok Lee, Ki Hyeong Lee, Yun-Gyoo Lee, Young Joo Min, Eun Kyung Cho, Sung Sook Lee, Bong-Seog Kim, Moon Young Choi, Hyo Sup Shim, Jin-Haeng Chung, Yoon La Choi, Min Jeong Lee, Maria Kim, Joo-Hang Kim, Siraj M Ali, Myung-Ju Ahn, Byoung Chul Cho
Purpose ROS1 rearrangement is a distinct molecular subset of non-small-cell lung cancer (NSCLC). We investigated the efficacy and safety of ceritinib in patients with ROS1-rearranged NSCLC. Patients and Methods We enrolled 32 patients with advanced NSCLC who tested positive for ROS1 rearrangement by fluorescent in situ hybridization. Ceritinib 750 mg was administered once daily. The primary end point was objective response rate. The secondary end points were disease control rate; duration of response; progression-free survival; overall survival; toxicity; and concordance among fluorescent in situ hybridization, immunohistochemistry, and next-generation sequencing...
May 18, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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