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https://www.readbyqxmd.com/read/29244023/osteocalcin-expressing-cells-from-tendon-sheaths-in-mice-contribute-to-tendon-repair-by-activating-hedgehog-signaling
#1
Yi Wang, Xu Zhang, Huihui Huang, Yin Xia, YiFei Yao, Arthur Fuk-Tat Mak, Patrick Shu-Hang Yung, Kai-Ming Chan, Li Wang, Chenglin Zhang, Yu Huang, Kingston King-Lun Mak
Both extrinsic and intrinsic tissues contribute to tendon repair, but the origin and molecular functions of extrinsic tissues in tendon repair are not fully understood. Here we show that tendon sheath cells harbor stem/progenitor cell properties and contribute to tendon repair by activating Hedgehog signaling. We found that Osteocalcin (Bglap) can be used as an adult tendon-sheath-specific marker in mice. Lineage tracing experiments show that Bglap-expressing cells in adult sheath tissues possess clonogenic and multipotent properties comparable to those of stem/progenitor cells isolated from tendon fibers...
December 15, 2017: ELife
https://www.readbyqxmd.com/read/29244018/detection-of-novel-betapapillomaviruses-and-gammapapillomaviruses-in-eyebrow-hair-follicles-using-a-single-tube-hanging-droplet-pcr-assay-with-modified-pan-pv-codehop-primers
#2
Diego Chouhy, Boštjan J Kocjan, Jeannette P Staheli, Elisa M Bolatti, Lea Hošnjak, Martin Sagadin, Adriana A Giri, Timothy M Rose, Mario Poljak
A modified pan-PV consensus-degenerate hybrid oligonucleotide primer (CODEHOP) PCR was developed for generic and sensitive detection of a broad-spectrum of human papillomaviruses (HPVs) infecting the cutaneous epithelium. To test the analytical sensitivity of the assay we examined 149 eyebrow hair follicle specimens from immunocompetent male patients. HPV DNA was detected in 60 % (89/149) of analysed eyebrow samples with a total of 48 different HPV sequences, representing 21 previously described HPVs and 27 putative novel HPV types...
December 15, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29242275/igfbp7-regulates-the-osteogenic-differentiation-of-bone-marrow-derived-mesenchymal-stem-cells-via-wnt-%C3%AE-catenin-signaling-pathway
#3
Wei Zhang, Erman Chen, Mo Chen, Chenyi Ye, Yiying Qi, Qianhai Ding, Hang Li, Deting Xue, Xiang Gao, Zhijun Pan
Insulin-like growth factor-binding protein 7 (IGFBP7), a low-affinity IGF binder, may play an important role in bone metabolism. However, its function in osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs) remains unclear. Therefore, we investigated its effects on osteogenic differentiation. Overexpression of IGFBP7 enhanced the expression of osteo-specific genes and proteins, and IGFBP7 knockdown decreased osteogenesis-specific markers. More mineral deposits and higher alkaline phosphatase activity were observed after the up-regulation of IGFBP7 Moreover, β-catenin levels were up-regulated by the overexpression of IGFBP7 or the addition of extracellular IGFBP7 protein and were reduced by the depletion of IGFBP7 The increase in osteogenic differentiation due to the overexpression of IGFBP7 was partially decreased by specific Wnt/β-catenin signaling inhibitors...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29241923/maternal-serum-placental-growth-factor-combined-with-second-trimester-aneuploidy-screening-to-predict-small-for-gestation-neonates-without-preeclampsia
#4
Su Mi Kim, Hang Goo Yun, Ra Yon Kim, Yoo Hyun Chung, Ju Young Cheon, Jeong Ha Wie, Ji Young Kwon, Hyun Sun Ko, Yeon Hee Kim, Eun Hee Han, Joon Hong Park, Hyun Jung Kim, Myung Shin Kim, Jong Chul Shin, In Yang Park
OBJECTIVE: To investigate the role of maternal serum placenta growth factor (PlGF) and quadruple test parameters in predicting the risk of small for gestational age (SGA) infants of mothers without preeclampsia. MATERIALS AND METHODS: We prospectively enrolled 300 pregnant patients who underwent blood sampling at 15-18 weeks gestation and followed them until delivery. Cases with SGA neonate delivery (n = 100) were compared with matched AGA neonate controls (n = 200)...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241664/distinguishing-three-subtypes-of-hematopoietic-cells-based-on-gene-expression-profiles-using-a-support-vector-machine
#5
Yu-Hang Zhang, Yu Hu, Yuchao Zhang, Lan-Dian Hu, Xiangyin Kong
Hematopoiesis is a complicated process involving a series of biological sub-processes that lead to the formation of various blood components. A widely accepted model of early hematopoiesis proceeds from long-term hematopoietic stem cells (LT-HSCs) to multipotent progenitors (MPPs) and then to lineage-committed progenitors. However, the molecular mechanisms of early hematopoiesis have not been fully characterized. In this study, we applied a computational strategy to identify the gene expression signatures distinguishing three types of closely related hematopoietic cells collected in recent studies: (1) hematopoietic stem cell/multipotent progenitor cells; (2) LT-HSCs; and (3) hematopoietic progenitor cells...
December 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29241208/exosomes-from-mir-126-overexpressing-adscs-are-therapeutic-in-relieving-acute-myocardial-ischaemic-injury
#6
Qiancheng Luo, Dongfeng Guo, Guorong Liu, Guo Chen, Min Hang, Mingming Jin
BACKGROUND/AIMS: Recent studies have indicated that exosomes play an important role in adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy. However, the treatment effect is not obvious. The aim of this study is to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-126 have a more protective effect on acute myocardial infarction (AMI). METHODS: Exosomes were characterized by transmission electron microscopy, and the exosome particles were further examined using nanoparticle tracking analyses...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29240174/all-fiber-second-order-optical-vortex-generation-based-on-strong-modulated-long-period-grating-in-a-four-mode-fiber
#7
Hang Wu, Shecheng Gao, Bingsen Huang, Yuanhua Feng, Xincheng Huang, Weiping Liu, Zhaohui Li
We propose an effective all-fiber method to generate a high-order optical vortex (OV) via twisting a strong modulated long-period fiber grating (LPFG) written in a four-mode fiber (4MF). With a special design and optimization of the procedures of CO2-laser irradiation, an LPFG with strong period deformation is achieved in the 4MF. Based on this LPFG, we can directly convert the linear polarization (LP) fiber fundamental mode (LP01) to the high-order LP core mode (LP21) with efficiency of 99.7% and then transform the LP21 mode into a high-order OV mode (±2 order)...
December 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29239295/kdm6a-overexpression-improves-the-development-of-cloned-mouse-embryos
#8
Guang-Yu Bai, Si-Hang Song, Yu-Wei Zhang, Xiang Huang, Xing-Wei Huang, Rui-Zhen Sun, Lei Lei
Somatic cell nuclear transfer (SCNT) is an important technique for life science research. However, most SCNT embryos fail to develop to term due to undefined reprogramming defects. Here, we show that abnormal Xi occurs in somatic cell NT blastocysts, whereas in female blastocysts derived from cumulus cell nuclear transfer, both X chromosomes were inactive. H3K27me3 removal by Kdm6a mRNA overexpression could significantly improve preimplantation development of NT embryos, and even reached a 70.2% blastocyst rate of cleaved embryos compared with the 38...
December 14, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/29239134/recent-advances-in-managing-atherosclerosis-via-nanomedicine
#9
REVIEW
Cecilia Ka Wing Chan, Lei Zhang, Chak Kwong Cheng, Hongrong Yang, Yu Huang, Xiao Yu Tian, Chung Hang Jonathan Choi
Atherosclerosis, driven by chronic inflammation of the arteries and lipid accumulation on the blood vessel wall, underpins many cardiovascular diseases with high mortality rates globally, such as stroke and ischemic heart disease. Engineered bio-nanomaterials are now under active investigation as carriers of therapeutic and/or imaging agents to atherosclerotic plaques. This Review summarizes the latest bio-nanomaterial-based strategies for managing atherosclerosis published over the past five years, a period marked by a rapid surge in preclinical applications of bio-nanomaterials for imaging and/or treating atherosclerosis...
December 14, 2017: Small
https://www.readbyqxmd.com/read/29238369/reversal-of-wolff-parkinson-white-syndrome-induced-dilated-cardiomyopathy-via-resynchronization-and-subsequent-accessory-pathway-ablation
#10
Long-Bin Liu, Chang-Zuan Zhou, Hui Lin, Li-Ping Meng, Chang Bian, Yu Zhang, Hang-Yuan Guo
No abstract text is available yet for this article.
October 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29237940/a-huge-congenital-left-atrial-appendage-aneurysm
#11
He-Qing Wang, Zhe Zhang, Hang Yang, Song Wu, Yuan-Hao Fu, Zhi-Ming Song, Feng Wan
No abstract text is available yet for this article.
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29237926/endoscopic-approach-to-remove-intra-extracranial-tumors-in-various-skull-base-regions-10-year-experience-of-a-single-center
#12
Qiu-Hang Zhang, Zhen-Lin Wang, Hong-Chuan Guo, Feng Kong, Bo Yan, Ming-Chu Li, Ge Chen, Jian-Tao Liang, Yu-Hai Bao, Feng Ling
BACKGROUND: Some problems have been found in the usually adopted combined approach for the removal of intra-extracranial tumors in skull base. Herein, we described a pure endoscopic transnasal or transoral approach (ETA) for the removal of intra-extracranial tumors in various skull base regions. METHODS: Retrospectively, clinical data, major surgical complications, pre- and postoperative images, and follow-up information of a series of 85 patients with intra-extracranial tumors in various skull base regions who were treated by surgery via ETA in our skull base center during the past 10 years were reviewed and analyzed...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29235580/corrigendum-interleukin-7-induces-osteoclast-formation-via-stat5-independent-of-receptor-activator-of-nf-kappab-ligand
#13
Jin-Hee Kim, Ji Hyun Sim, Sunkyung Lee, Min A Seol, Sang-Kyu Ye, Hyun Mu Shin, Eun Bong Lee, Yun Jong Lee, Yun Jung Choi, Wan-Hee Yoo, Jin Hyun Kim, Wan-Uk Kim, Dong-Sup Lee, Jin-Hong Kim, Insoo Kang, Seong Wook Kang, Hang-Rae Kim
[This corrects the article on p. 1376 in vol. 8, PMID: 29104576.].
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29235476/breast-cancer-metastasis-suppressor-otud1-deubiquitinates-smad7
#14
Zhengkui Zhang, Yao Fan, Feng Xie, Hang Zhou, Ke Jin, Li Shao, Wenhao Shi, Pengfei Fang, Bing Yang, Hans van Dam, Peter Ten Dijke, Xiaofeng Zheng, Xiaohua Yan, Junling Jia, Min Zheng, Jin Jin, Chen Ding, Sheng Ye, Fangfang Zhou, Long Zhang
Metastasis is the main cause of death in cancer patients. TGF-β is pro-metastatic for malignant cancer cells. Here we report a loss-of-function screen in mice with metastasis as readout and identify OTUD1 as a metastasis-repressing factor. OTUD1-silenced cancer cells show mesenchymal and stem-cell-like characteristics. Further investigation reveals that OTUD1 directly deubiquitinates the TGF-β pathway inhibitor SMAD7 and prevents its degradation. Moreover, OTUD1 cleaves Lysine 33-linked poly-ubiquitin chains of SMAD7 Lysine 220, which exposes the SMAD7 PY motif, enabling SMURF2 binding and subsequent TβRI turnover at the cell surface...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29235213/models-meet-data-challenges-and-opportunities-in-implementing-land-management-in-earth-system-models
#15
REVIEW
Julia Pongratz, Han Dolman, Axel Don, Karl-Heinz Erb, Richard Fuchs, Martin Herold, Chris Jones, Tobias Kuemmerle, Sebastiaan Luyssaert, Patrick Meyfroidt, Kim Naudts
As the applications of Earth system models (ESMs) move from general climate projections toward questions of mitigation and adaptation, the inclusion of land management practices in these models becomes crucial. We carried out a survey among modeling groups to show an evolution from models able only to deal with land-cover change to more sophisticated approaches that allow also for the partial integration of land management changes. For the longer term a comprehensive land management representation can be anticipated for all major models...
December 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29234413/salidroside-protects-against-mpp-induced-neuronal-injury-through-dj-1-nrf2-antioxidant-pathway
#16
Leitao Wu, Hang Xu, Liang Cao, Tao Li, Ruru Li, Yang Feng, Jianzong Chen, Jing Ma
Parkinson's disease (PD) is the second most common neurodegenerative disorder. We have found that salidroside (Sal) exhibited neuroprotective effects against MPP+ toxicity. However, the molecular mechanism is not fully understood. In this study, we found that Sal significantly prevented MPP+-induced decrease of mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in SH-SY5Y cells. Moreover, silencing of Nrf2 significantly inhibited Sal-induced increase in mRNA and protein expression of GCLc, SOD1, and SOD2...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234053/liquid-crystal-based-electrically-tuned-electromagnetically-induced-transparency-metasurface-switch
#17
Hang Su, Hao Wang, Hua Zhao, Tingyu Xue, Jingwen Zhang
In this study, a structure to realize a switchover between two different responses of electromagnetically induced transparency (EIT) was designed and implemented by simulation. Taking advantage of the anisotropy in the structure and the coupling between the radiative and dark elements, a metasurface switch with modulation depth of over 85% between orthogonal polarization incident light illuminations was demonstrated. The key mode switchover between the "on" and "off" states was achieved by electrically changing the dressing light polarization with a liquid crystals layer pre-aligned with a mature technology, without changing the incident light and an expected and reversible transition from an EIT-like spectrum to a strong spectral dip was observed...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233974/author-correction-nanoscale-control-of-competing-interactions-and-geometrical-frustration-in-a-dipolar-trident-lattice
#18
Alan Farhan, Charlotte F Petersen, Scott Dhuey, Luca Anghinolfi, Qi Hang Qin, Michael Saccone, Sven Velten, Clemens Wuth, Sebastian Gliga, Paula Mellado, Mikko J Alava, Andreas Scholl, Sebastiaan van Dijken
The original version of this article contained an error in the legend to Figure 4. The yellow scale bar should have been defined as '~600 nm', not '~600 µm'. This has now been corrected in both the PDF and HTML versions of the article.
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29232599/bioinspired-self-standing-macroporous-au-zno-sponges-for-enhanced-photocatalysis
#19
Ping She, Kongliang Xu, Shengyan Yin, Yinxing Shang, Qinrong He, Shan Zeng, Hang Sun, Zhenning Liu
A self-standing macroporous noble metal-zinc oxide (ZnO) sponge of robust 3D network has been fabricated through in-situ growth method. The key to the construction of the bioinspired sponge lies in the choice of commercial polyurethane sponge (CPS) with interconnected and junction-free macroporous structure as the skeleton to support Au/ZnO nanorods (Au/ZnONRs). The resultant Au/ZnO/CPS not only exhibits hierarchical structures representing physical features of CPS, but also demonstrates durable superior photocatalytic activity and hydrogen generation capability...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29232579/structure-based-identification-of-a-nedd8-activating-enzyme-inhibitor-via-drug-repurposing
#20
Ke-Jia Wu, Hai-Jing Zhong, Guodong Li, Chenfu Liu, Hui-Min David Wang, Dik-Lung Ma, Chung-Hang Leung
NEDD8-activating enzyme (NAE) is an essential player of the NEDD8 conjugation pathway that regulates protein degradation. Meanwhile, drug repurposing is a cost-efficient strategy to identify new therapeutic uses for existing scaffolds. In this report, mitoxantrone (1) was repurposed as an inhibitor of NAE by virtual screening of an FDA-approved drug database. Compound 1 inhibited NAE activity in cell-free and cell-based systems with high selectivity and was competitive with ATP. Furthermore, compound 1 induced apoptosis of colorectal adenocarcinoma cancer cells through inhibiting the degradation of the neddylation substrate p53...
December 6, 2017: European Journal of Medicinal Chemistry
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