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https://www.readbyqxmd.com/read/28432283/efficacy-and-safety-of-single-balloon-versus-double-balloon-enteroscopy-a-single-center-retrospective-analysis
#1
Zhanjun Lu, Yu Qi, Jianjun Weng, Lei Ma, Xinjian Wan, Rong Wan, Lungen Lu, Hang Zhao
BACKGROUND Single-balloon endoscopy (SBE) has been introduced as a simplified endoscopy technique after the promotion of double-balloon endoscopy (DBE). The difference in clinical performance between DBE and SBE is still not very clear. In this study, we aimed to compare the efficacy and safety between these 2 endoscopic procedures. MATERIAL AND METHODS A total of 173 patients with suspected small bowel disease were enrolled into this study from January 2007 to December 2011. All cases were divided into DBE or SBE groups according to the endoscopic procedures they underwent...
April 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28431451/-experience-with-the-hind-foot-relaxation-boot
#2
Hans Zwipp, Michael Borrmann, Eberhard Walter
The goal of this paper is to report our experience with hindfoot fractures using our specially developed boot, with a follow-up of 557 cases. This boot works like the well-known Allgöwer-Röck ortheses (ARO), but is a hybrid between a boot and an orthesis. It allows full weightbearing without using crutches and completely protects an acutely operated hind foot fracture, hind foot arthrodesis or a hind foot fracture which is suitable for conservative treatment. In its first generation, this boot was custom made and used in 408 cases, from March 1999 to February 2011...
April 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28431400/local-delivery-of-hmgb1-in-gelatin-sponge-scaffolds-combined-with-mesenchymal-stem-cell-sheets-to-accelerate-fracture-healing
#3
Deting Xue, Wei Zhang, Erman Chen, Xiang Gao, Ling Liu, Chenyi Ye, Yanbin Tan, Zhijun Pan, Hang Li
Fracture nonunion and delayed union continue to pose challenges for orthopedic surgeons. In the present study, we combined HMGB1 gelatin sponges with MSC sheets to promote bone healing after surgical treatment of rat tibial fractures. The HMGB1 gelatin sponge scaffolds supported the expansion of mesenchymal stem cells (MSCs) and promoted the osteogenic differentiation of MSCs and MSC sheets. Lentiviral vectors were then used to overexpress HMGB1 in MSCs. The results indicated that HMGB1 promotes the osteogenic differentiation of MSCs through the STAT3 pathway...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430659/lncrna-afap1-as1-promotes-growth-and-metastasis-of-cholangiocarcinoma-cells
#4
Xiuhui Shi, Hang Zhang, Min Wang, Xiaodong Xu, Yan Zhao, Ruizhi He, Min Zhang, Min Zhou, Xu Li, Feng Peng, Chengjian Shi, Ming Shen, Xin Wang, Xingjun Guo, Renyi Qin
We investigated the role of actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) lncRNA in promoting cholangiocarcinoma (CCA). qRT-PCR analysis of patient samples showed that AFAP1-AS1 expression was higher in CCA tumors than matched adjacent non-tumor tissue. AFAP1-AS1 levels were also higher in CCA cell lines (HuCCT1 and TFK-1) than a normal biliary epithelium cell line (HIBEpic). AFAP1-AS1 knockdown in CCA cell lines using shAFAP1-AS1 reduced cell proliferation and colony formation in CCK-8 and colony formation assays, respectively...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430621/lymphovascular-invasion-is-a-high-risk-factor-for-stage-i-ii-colorectal-cancer-a-systematic-review-and-meta-analysis
#5
Hang Yuan, Quanjin Dong, Bo'an Zheng, Xinye Hu, Jian-Bo Xu, Shiliang Tu
The prognostic value of lymphovascular invasion (LVI) in stage I/II colorectal cancer (CRC) does not reach a consensus. To systematically assess prognostic significance of LVI, databases of PubMed, Web of Science, and Embase were searched from inception up to 10 Dec 2016. The pooled hazard ratio (HR) and 95% confidence intervals (CI) were used to determine the prognostic effects. Nineteen relevant studies including 9881 total patients were enrolled. Our results showed that LVI is significantly associated with poor prognosis in overall survival (OS) (HR=2...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430593/genetic-variants-within-the-cancer-susceptibility-region-8q24-and-ovarian-cancer-risk-in-han-chinese-women
#6
Jing Han, Jing Zhou, Hua Yuan, Longbiao Zhu, Hongxia Ma, Dong Hang, Dake Li
Accumulating evidence suggests that genetic variants at chromosome 8q24 confer susceptibility to various types of cancer. This case-control study was designed to explore the relationship between genetic variants at 8q24 and ovarian cancer risk in Han Chinese women. Two variants (rs13281615 A > G and rs6983267 T > G) were genotyped in 377 ovarian cancer cases and 1034 cancer-free controls using TaqMan allelic discrimination assay. Logistic regression analysis revealed that the G allele of rs6983267 was significantly associated with increased risk of ovarian cancer (additive model: adjusted OR = 1...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429931/heterobimetallic-nitrido-complexes-of-group-8-metalloporphyrins
#7
Wai-Man Cheung, Wai-Hang Chiu, Matthew de Vere-Tucker, Herman H-Y Sung, Ian D Williams, Wa-Hung Leung
Heterobimetallic nitrido porphyrin complexes with the [(L)(por)M-N-M'(LOEt)Cl2] formula {por(2-) = 5,10,15,20-tetraphenylporphyrin (TPP(2-)) or 5,10,15,20-tetra(p-tolyl)porphyrin (TTP(2-)) dianion; LOEt(-) = [Co(η(5)-C5H5){P(O)(OEt)2}3](-); M = Fe, Ru, or Os; M' = Ru or Os; L = H2O or pyridine} have been synthesized, and their electrochemistry has been studied. Treatment of trans-[Fe(TPP)(py)2] (py = pyridine) with Ru(VI) nitride [Ru(LOEt)(N)Cl2] (1) afforded Fe/Ru μ-nitrido complex [(py)(TPP)Fe(μ-N)Ru(LOEt)Cl2] (2)...
April 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28429595/ultrasensitive-detection-of-micrornas-with-morpholino-functionalized-nanochannel-biosensor
#8
Tangbin Liao, Xiaorui Li, Qian Tong, Kai Zou, Hang Zhang, Lina Tang, Zhongyue Sun, Guo-Jun Zhang
Here we demonstrate a phosphorodiamidate morpholino oligos (PMO)-functionlized nanochannel biosensor for label-free detection of microRNAs (miRNAs) with ultrasensitivity and high sequence-specificity. PMO, as a capture probe, was covalently anchored on the nanochannel surface. Because of the neutral character and high sequence-specific affinity of PMO, hybridization efficiency between PMO and miRNAs was enhanced, thus decreasing background signals largely and improving the detection specificity and sensitivity highly...
April 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28429587/thermal-conductivity-enhancement-of-coaxial-carbon-boron-nitride-nanotube-arrays
#9
Lin Jing, Majid Kabiri Samani, Bo Liu, Hongling Li, Roland Yingjie Tay, Siu Hon Tsang, Olivier Cometto, Andreas Nylander, Johan Liu, Edwin Hang Tong Teo, Alfred Iing Yoong Tok
We demonstrate the thermal conductivity enhancement of the vertically aligned carbon nanotube (CNT) arrays (from ~15.5 to 29.5 W/mK, ~90% increase) by encapsulating outer boron nitride nanotube (BNNT, 0.97 nm-thick with ~3-4 walls). The heat transfer enhancement mechanism of the coaxial C@BNNT was further revealed by molecular dynamics simulations. Owing to their highly coherent lattice structures, the outer BNNT serves as additional heat conducting path without impairing the thermal conductance of inner CNT...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28429475/common-carotid-artery-sonography-versus-transthoracic-echocardiography-for-cardiac-output-measurements-in-intensive-care-unit-patients
#10
Qian-Yi Peng, Li-Na Zhang, Mei-Lin Ai, Li Li, Cheng-Huan Hu, Yan-Xin Zhang, Wei Liu, Qing Feng, Yu Zou, Yu-Hang Ai
OBJECTIVES: This study was designed to test the effectiveness of common carotid artery sonography in comparison with transthoracic echocardiography (TTE) for cardiac output measurements to provide an easier alternative for cardiac output monitoring in the intensive care unit. METHODS: This study included 148 patients who had common carotid artery Doppler examinations and TTE performed within 8 hours of each other, and the cardiac output measurement results were compared with each other...
April 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28429032/obstructive-sleep-apnoea-and-type-2-diabetes-mellitus-are-they-connected
#11
Yingjuan Mok, Chee Wei Tan, Hang Siang Wong, Choon How How, Kah Leong Alvin Tan, Pon Poh Hsu
Obstructive sleep apnoea (OSA), a sleep-related breathing condition, is diagnosed based on a patient's apnoea-hypopnea index from a sleep study, and the presence or absence of symptoms. Diabetes mellitus (DM) and OSA share a significant common risk factor, obesity, with all three conditions contributing to the risk of developing cardiovascular diseases. The pathophysiological links between OSA and DM are still unclear, but intermittent hypoxia may be an important mechanism. More awareness of the possible link between OSA and DM is needed, given their increasing prevalence locally and worldwide...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28428557/the-prognostic-significance-of-cdc6-and-cdt1-in-breast-cancer
#12
Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Yuchen Bai, Cian M McCrudden, Hiu Fung Yuen, Qing Wen, Shu Dong Zhang, Hang Fai Kwok
DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers are largely unknown. In the present study, we have shown that the expression levels of Cdc6 and Cdt1 were both significantly correlated with an increasing number of MCM2-7 genes overexpression. Both Cdc6 and Cdt1, when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort (n = 1441)...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428253/twitchin-kinase-inhibits-muscle-activity
#13
Yohei Matsunaga, Hyundoo Hwang, Barbara Franke, Rhys Williams, McKenna Penley, Hiroshi Qadota, Hong Yi, Levi T Morran, Hang Lu, Olga Mayans, Guy M Benian
Muscle sarcomeres contain giant polypeptides composed of multiple immunoglobulin and fibronectin domains and one or two protein kinase domains. Although binding partners for a number of this family's kinase domains have been identified, the catalytic necessity of these kinase domains remains unknown. In addition, various members of this kinase family are suspected pseudokinases with no, or little, activity. Here, we address catalytic necessity for the first time using the prototypic invertebrate representative twitchin (UNC-22) from C...
April 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28428015/plasma-neurofilament-light-chain-levels-in-alzheimer-s-disease
#14
Wenjun Zhou, Jie Zhang, Fanlong Ye, Guangzheng Xu, Hang Su, Yindan Su, Xiangyang Zhang
Plasma neurofilament light (NFL) levels may be a marker of neuronal injury. We examined whether plasma NFL might be a potential biomarker for the prodromal and dementia stages of AD. Participants included 193 cognitively normal (CN), 198 amnestic mild cognitive impairment (aMCI) and 187 Alzheimer's disease (AD) individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Plasma NFL levels were examined by the Single Molecule array (Simoa) technique. Our results showed significantly increased plasma NFL levels in both AD (50...
April 17, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28427611/experimental-study-on-the-influence-of-low-frequency-and-low-intensity-ultrasound-on-the-permeability-of-the-mycobacterium-smegmatis-cytoderm-and-potentiation-with-levofloxacin
#15
Yu Dong, Hang Su, Hexun Jiang, Huimin Zheng, Yonghong Du, Junru Wu, Dairong Li
Tuberculosis is an infectious disease caused by the bacterium M. tuberculosis. The aim of this study was to investigate the bactericidal effect and underlying mechanisms of low-frequency and low-intensity ultrasound combined with levofloxacin treatment against M. smegmatis (a surrogate of M. tuberculosis). As part of this study, M. smegmatis was continuously irradiated with low frequency ultrasound (42kHz) using several different doses whereby both intensity (0.138, 0.190 and 0.329W/cm(2)) and exposure time (5, 15 and 20min) were varied...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427220/multiparametric-imaging-using-18f-fdg-pet-ct-heterogeneity-parameters-and-functional-mri-techniques-prognostic-significance-in-patients-with-primary-advanced-oropharyngeal-or-hypopharyngeal-squamous-cell-carcinoma-treated-with-chemoradiotherapy
#16
Sheng-Chieh Chan, Nai-Ming Cheng, Chia-Hsun Hsieh, Shu-Hang Ng, Chien-Yu Lin, Tzu-Chen Yen, Cheng-Lung Hsu, Hung-Ming Wan, Chun-Ta Liao, Kai-Ping Chang, Jiun-Jie Wang
BACKGROUND: In this study, PET heterogeneity was combined with functional MRI techniques to refine the prediction of prognosis in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). METHODS: A total of 124 patients with primary advanced OHSCC who underwent pretreatment 18F-FDG PET/CT, dynamic contrast-enhanced MR imaging (DCE-MRI), and diffusion-weighted MR imaging (DWI) were enrolled. Conventional and heterogeneity parameters from 18F-FDG PET as well as perfusion parameters from DCE-MRI and diffusion parameter from DWI of primary tumors were analyzed in relation to recurrence-free survival (RFS) and overall survival (OS)...
March 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426816/ex-vivo-cultures-combined-with-vivo-morpholino-induced-gene-knockdown-provide-a-system-to-assess-the-role-of-wt1-and-gata4-during-gonad-differentiation
#17
Lucas J Rudigier, Christof Dame, Holger Scholz, Karin M Kirschner
Gonad morphogenesis relies on the correct spatiotemporal expression of a number of genes that together fulfill the differentiation of the bipotential gonad into testes or ovaries. As such, the transcription factors WT1 and GATA4 are pivotal for proper gonadal development. Here we address the contributions of GATA4 and WT1 to the sex differentiation phase in testes and ovaries. We applied an ex vivo technique for cultivating gonads in hanging droplets of media that were supplemented with vivo-morpholinos to knockdown WT1 and GATA4 either alone or in combination at the same developmental stage...
2017: PloS One
https://www.readbyqxmd.com/read/28426514/comparison-of-the-hang-high-pull-and-loaded-jump-squat-for-the-development-of-vertical-jump-and-isometric-force-time-characteristics
#18
Dustin J Oranchuk, Tracey L Robinson, Zachary J Switaj, Eric J Drinkwater
Weightlifting movements have high skill demands and require expert coaching. Loaded jumps have a comparably lower skill demand, but may be similarly effective for improving explosive performance. The purpose of this study was to compare vertical jump performance, isometric force, and rate of force development (RFD) following a ten-week intervention employing the hang high-pull (hang-pull) or trap-bar jump squat (jump-squat). Eighteen NCAA Division II swimmers (8 males, 10 females) with at least one year of resistance training experience volunteered to participate...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28425263/combination-therapy-with-dendritic-cell-based-vaccine-and-anti-cd69-antibody-enhances-antitumor-efficacy-in-renal-cell-carcinoma-bearing-mice
#19
Si-Ming Wei, Hang-Li Pan, Li Wang, Guo-Li Yin, Kai Zhong, Ya Zhou, Shu-Jiao Yang, Zhao-Liang Xin
BACKGROUND/AIM: Dendritic cell-based vaccine therapy for renal cell carcinoma is effective but requires improvement. Here we explored whether combination therapy with dendritic cell-based vaccine and anti-CD69 antibody can enhance antitumor efficacy in renal cell carcinoma-bearing mice. MATERIALS AND METHODS: Balb/c mice were challenged subcutaneously with murine renal cell carcinoma (Renca) cells. On day 3 after tumor cell inoculation, tumor-bearing mice either were left untreated or were treated with Renca tumor lysate-pulsed dendritic cells (i...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425141/efficacy-of-helicobacter-pylori-eradication-therapies-in-korea-a-systematic-review-and-network-meta-analysis
#20
REVIEW
Yoon Suk Jung, Chan Hyuk Park, Jung Ho Park, Eunwoo Nam, Hang Lak Lee
BACKGROUND: The efficacy of Helicobacter pylori eradication regimens may depend on the country where the studies were performed because of the difference in antibiotic resistance. We aimed to analyze the efficacy of H. pylori eradication regimens in Korea where clarithromycin resistance rate is high. METHODS: We searched for all relevant randomized controlled trials published until November 2016 that investigated the efficacy of H. pylori eradication therapies in Korea...
April 19, 2017: Helicobacter
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