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Yuqiang Liu, Cui Chen, Yunlong Liu, Wei Li, Zhihong Wang, Qifeng Sun, Hang Zhou, Xiangjun Chen, Yongchun Yu, Yun Wang, Nashat Abumaria
The TRPM7 chanzyme contributes to several biological and pathological processes in different tissues. However, its role in the CNS under physiological conditions remains unclear. Here, we show that TRPM7 knockdown in hippocampal neurons reduces structural synapse density. The synapse density is rescued by the α-kinase domain in the C terminus but not by the ion channel region of TRPM7 or by increasing extracellular concentrations of Mg2+ or Zn2+ . Early postnatal conditional knockout of TRPM7 in mice impairs learning and memory and reduces synapse density and plasticity...
June 19, 2018: Cell Reports
Zhi-Cheng Lai, Jin-Yu Liang, Li-Da Chen, Zhu Wang, Si-Min Ruan, Xiao-Yan Xie, Ming-De Lu, Hang-Tong Hu, Wei Wang
AIMS: To determine if tumors located in the subcapsular space or in proximity to vessels would be a risk factor of local tumor progression (LTP2 ) in hepatocellular carcinomas (HCC) after radiofrequency ablation. MATERIALS AND METHODS: A search of the MEDLINE, EMBASE and Cochrane Library databases from 1998 to 2017 was performed to identify studies examining the risk factors of LTP after radiofrequency ablation (RFA3 ) in HCC. No language or other restrictions were imposed...
June 17, 2018: Life Sciences
Ivan Kosik, William L Ince, Lauren E Gentles, Andrew J Oler, Martina Kosikova, Matthew Angel, Javier G Magadán, Hang Xie, Christopher B Brooke, Jonathan W Yewdell
[This corrects the article DOI: 10.1371/journal.ppat.1006796.].
June 2018: PLoS Pathogens
Dantong Geng, Min Zhang, Xinxin Hang, Wenjie Xie, Yucai Qin, Qiang Li, Yanfeng Bi, Zhiping Zheng
A 2D layered structure {[Co4(TC4A)Cl](L)2][(CH3CH2)4N]}n (+solvent)(1) has been solvothermally synthesized by assembly of Co4-TC4A (H4TC4A = p-tert-butylthiacalix[4]arene) subunits and L (H2L = 4-(1H-tetrazol-5-yl)benzoic acid) ligands. The layers arranged in an edge-to-edge (AAAA) manner, which represented the only example of 2D porous coordination polymers (PCPs) with 1D uniform channels of metal-thiacalix[4]arene. The activated PCP 1 exhibited high selectivity for C3H8/C2H6, C3H6/C2H4, and C3H8/C2H4, which makes it a competitive porous material for C3/C2 alkane and/or olefin separations...
June 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Hang Jin Jo, Vincenzo Di Lazzaro, Monica A Perez
KEY POINTS: Although corticospinal function changes following spinal cord injury (SCI), the extent to which we can activate the corticospinal tract after the injury remains poorly understood. To address this question, we used transcranial magnetic stimulation (TMS) over the hand motor cortex to elicit motor evoked potentials (MEPs) using posterior-anterior (PA) and anterior-posterior (AP) induced currents in the brain and compared them with responses evoked using latero-medial (LM) currents in participants with and without cervical incomplete SCI during small levels of index finger abduction...
June 19, 2018: Journal of Physiology
Brian H H Lang, Yu-Cho Woo, Keith Wan-Hang Chiu
OBJECTIVES: Assessing the efficacy of single high-intensity focused ultrasound (HIFU) ablation in benign thyroid nodules beyond 12 months. METHODS: One hundred and eight patients underwent single HIFU treatment. Extent of nodule shrinkage [by volume reduction ratio (VRR)] and obstructive symptom score [by 0-10 visual analogue scale (VAS)] were evaluated for 24 months after treatment. VRR (%) was calculated based on the formula: [baseline volume - volume at visit] / [baseline volume] × 100...
June 19, 2018: European Radiology
Yan Chen, Xiaoyang Shi, Mingjia Li, Yilun Liu, Hang Xiao, Xi Chen
The phase transition of monolayer black phosphorene (MBP, α-P) to β-P and γ-P is explored by density functional theory (DFT) calculations and molecular dynamics (MD) simulations using reactive force fields. It is found that MBP can convert to a mixed phase of β-P and γ-P under biaxial strain, while the Stone-Wales defect (SW-2) in MBP can serve as an excellent 'phase transition catalyzer', significantly decreasing the critical strain for phase transition and increasing the homogeneity of the phase transition...
June 20, 2018: Physical Chemistry Chemical Physics: PCCP
Fan Tang, Hui Feng, Hang Zhao, Hongxia Dan, Yuqi Du, Yandi Xiao, Qianming Chen
Recently, supramolecular hydrogels have attracted increasing interest owing to their tunable stability and inherent biocompatibility. However, only few studies have been reported in the literature on self-healing supramolecular nucleoside hydrogels, compared to self-healing polymer hydrogels. In this work, we successfully developed a self-healing supramolecular nucleoside hydrogel obtained by simply mixing equimolar amounts of guanosine (G) and isoguanosine (isoG) in the presence of K+. The gelation properties have been studied systematically by comparing different alkali metal ions as well as mixtures with different ratios of G and isoG...
June 19, 2018: Chemistry, An Asian Journal
Fumi Mizuhashi, Kaoru Koide
BACKGROUND/AIM: Mouthguard sheet materials such as ethylene vinyl acetate and polyolefin have been used commonly; however, the change of the sheet temperature during heating of the polyolefin has not been determined. The aim of this study was to examine the change of the sheet temperature during heating and to examine the vacuum-formed mouthguard characteristics for the sheet materials. MATERIALS AND METHODS: The mouthguard materials used were 4.0 mm sheets of ethylene vinyl acetate and polyolefin...
June 19, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Bo Hang, Jian-Hua Mao, Antoine M Snijders
THS, the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents an underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Vulnerable populations are believed to include infants and children living in a smoking household exposed to THS and/or SHS and exposure has been identified as a risk factor for lung cancer later in life. These and future studies will provide novel and important evidence of how early-life exposure to THS affects cancer development and other diseases, which should be useful for framing and enforcing new policies against passive smoking in the the world...
June 16, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Thuy Thu Bui, Meng Ling Moi, Takeshi Nabeshima, Taichiro Takemura, Trang Thu Nguyen, Linh Ngoc Nguyen, Hang Thi Thu Pham, Thi Thu Thuy Nguyen, Dao Huy Manh, Shyam Prakash Dumre, Shusaku Mizukami, Kenji Hirayama, Shigeru Tajima, Mai Thi Quynh Le, Kiyoshi Aoyagi, Futoshi Hasebe, Kouichi Morita
Dengue virus (DENV) replication between mosquito and human hosts is hypothesized to be associated with viral determinants that interact in a differential manner between hosts. However, the understanding of inter-host viral determinants that drive DENV replication and growth between hosts is limited. Through the use of clinical isolates, we identified an amino acid variation of Ala, Met and Val at position 116 of DENV-1 NS4B. While the proportion of virus with the NS4B-116V variant remained constantly high in serial passages in a mosquito cell line, populations of the NS4B-116M and NS4B-116A variants became dominant after serial passages in mammalian cell lines...
June 19, 2018: Journal of General Virology
Hang Shi, Alastair N Herron, Ying Shao, Qian Shao, Jin-Quan Yu
Enantioselective carbon-hydrogen (C-H) activation reactions by asymmetric metallation could provide new routes for the construction of chiral molecules1,2 . However, current methods are typically limited to the formation of five- or six-membered metallacycles, thereby preventing the asymmetric functionalization of C-H bonds at positions remote to existing functional groups. Here we report enantioselective remote C-H activation using a catalytic amount of a chiral norbornene as a transient mediator, which relays initial ortho-C-H activation to the meta position...
June 18, 2018: Nature
Hualiang Lin, Jun Tao, Zhengmin Min Qian, Zengliang Ruan, Yanjun Xu, Jian Hang, Xiaojun Xu, Tao Liu, Yuming Guo, Weilin Zeng, Jianpeng Xiao, Lingchuan Guo, Xing Li, Wenjun Ma
Substantial evidence has linked short-term exposure to ambient fine particulate matter (PM2.5 ) with increased cardiovascular mortality, however, the specific chemical constituent and emission source responsible for this effect remained largely unclear. A time series Poisson model was employed to quantify the association of cardiovascular mortality with two sets of shipping pollution emission: nickel (Ni), vanadium (V) (the indices of shipping emission) and estimated shipping emission using a source apportionment approach in Guangzhou, China in 2014...
June 12, 2018: Environmental Pollution
Zhuhong Wang, Jun-Qing Ge, Hang Chen, Xiaoyan Cheng, Yiqun Yang, Jun Li, R Jeff Whitworth, Ming-Shun Chen
Like pathogens, galling insects deliver effectors into plant tissues that induce gall formation. The gall midge Mayetiola destructor, also called Hessian fly, can convert a whole wheat seedling into a gall by inducing the formation of nutritive cells at the feeding site, inhibiting wheat growth, and reprogramming metabolic pathways of the attacked plants. Here we demonstrated the identification of a secreted Hessian fly protein, the nucleoside diphosphate kinase (NDK), in infested wheat plants through liquid chromatography-tandem mass spectrometry (LC-MS/MS) and western blots...
June 15, 2018: Insect Biochemistry and Molecular Biology
Long Bai, Yanlian Liu, Zhibin Du, Zeming Weng, Wei Yao, Xiangyu Zhang, Xiaobo Huang, Xiaohong Yao, Ross Crawford, Ruiqiang Hang, Di Huang, Bin Tang, Yin Xiao
Coating materials applied for intraosseous implants must be optimized to stimulate osseointegration. Osseointegration is a temporal and spatial physiological process that not only requires interactions between osteogenesis and angiogenesis but also necessitates a favorable immune microenvironment. It is now well-documented that hierarchical nano-micro surface structures promote the long-term stability of implants, the interactions between nano-micro structure and the immune response are largely unknown. Here, we report the effects of microporous titanium (Ti) surfaces coated with nano-hydroxyapatite (HA) produced by micro-arc oxidation and steam-hydrothermal treatment (SHT) on multiple cell behavior and osseointegration...
June 14, 2018: Acta Biomaterialia
Charles L Raison, Jennifer M Knight, Carmine Pariante
No abstract text is available yet for this article.
June 14, 2018: Brain, Behavior, and Immunity
Ping Tan, Hang Xu, Liangren Liu, Jianzhong Ai, Huan Xu, Yong Jiang, Xiaoyu Zhang, Lu Yang, Qiang Wei
BACKGROUND: We evaluated the prognostic impact of the preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy treatment. METHODS: A total of 717 patients were identified between 2003 and 2016. The cutoff value of NLR was set as 2.5. Kaplan-Meier method and Cox's proportional hazards regression models were utilized to analyze the association between NLR and oncological outcomes. RESULTS: The median follow-up was 42 months...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Zeng-Hui Diao, Jian-Jun Du, Dan Jiang, Ling-Jun Kong, Wen-Yi Huo, Cui-Mei Liu, Qi-Hang Wu, Xiang-Rong Xu
Cr6+ and Pb2+ are both highly toxic pollutants and commonly co-exist in some industrial effluents and contaminated waters. In this study, simultaneous removal of Cr6+ and Pb2+ by a novel sewage sludge-derived biochar immobilized nanoscale zero-valent iron (SSB-nZVI) was systematically investigated. It was well demonstrated that a porous structure was successfully formed on the SSB-nZVI when the starch was used as an additive. A synergistic effect on the adsorption and reduction over the SSB-nZVI was achieved, resulting in nearly 90 and 82% of Cr6+ and Pb2+ removal within 30 min, respectively...
June 13, 2018: Science of the Total Environment
Leifang Zhang, Chenming Xu, Xiaoming Chen, Qiwen Shi, Weike Su, Hang Zhao
Smoke inhalation leads to acute lung injury (ALI), a devastating clinical problem associated with high mortality rates. Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of proinflammatory cytokine signaling. We have found that adenoviral gene transfer of SOCS-1 ameliorates smoke inhalation-induced lung injury in C57BL/6 mice. We also found that the release of adenosine triphosphate (ATP) was increased post smoke exposure, while oxidized ATP, an inhibitor of purinergic P2X7 receptor, suppressed smoke-induced NALP3 inflammasome assembly, caspase-1 activation, and K+ efflux...
June 16, 2018: Inflammation
Hanjun Zhao, Kelvin K W To, Hin Chu, Qiulu Ding, Xiaoyu Zhao, Cun Li, Huiping Shuai, Shuofeng Yuan, Jie Zhou, Kin-Hang Kok, Shibo Jiang, Kwok-Yung Yuen
Limited efficacy of current antivirals and antiviral-resistant mutations impairs anti-influenza treatment. Here, we evaluate the in vitro and in vivo antiviral effect of three defective interfering genes (DIG-3) of influenza virus. Viral replication is significantly reduced in cell lines transfected with DIG-3. Mice treated with DIG-3 encoded by jetPEI-vector, as prophylaxis and therapeutics against A(H7N7) virus, respectively, have significantly better survivals (80% and 50%) than control mice (0%). We further develop a dual-functional peptide TAT-P1, which delivers DIG-3 with high efficiency and concomitantly exerts antiviral activity by preventing endosomal acidification...
June 15, 2018: Nature Communications
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