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Cheng Peng, Chensi Shen, Siyuan Zheng, Weiling Yang, Hang Hu, Jianshe Liu, Jiyan Shi
Many studies have shown the effect of solution chemistry on the environmental behavior of metal-based nanoparticles (NPs), except CuO NPs. Here, we investigated the agglomeration, sedimentation, dissolution, and speciation of CuO NPs by varying pH, ionic strength, ionic valence, and natural organic matter (NOM). The results showed that as the pH moved away from 6, the size of CuO agglomerates decreased, along with the enhanced NP suspension stabilization, due to the increase of electrostatic repulsive force...
October 14, 2017: Nanomaterials
Ji Ye Yan, Wen Sheng Zhao, Zhen Chen, Qi Kai Xing, Wei Zhang, K W Thilini Chethana, Min Feng Xue, Jian Ping Xu, Alan J L Phillips, Yong Wang, Jian Hua Liu, Mei Liu, Ying Zhou, Ruvishika S Jayawardena, Ishara S Manawasinghe, Jin Bao Huang, Guang Hang Qiao, Chun Yuan Fu, Fei Fei Guo, Asha J Dissanayake, You Liang Peng, Kevin D Hyde, Xing Hong Li
Botryosphaeriaceae are an important fungal family that cause woody plant diseases worldwide. Recent studies have established a correlation between environmental factors and disease expression; however, less is known about factors that trigger these diseases. The current study reports on the 43.3 Mb de novo genome of Lasiodiplodia theobromae and five other genomes of Botryosphaeriaceae pathogens. Botryosphaeriaceous genomes showed an expansion of gene families associated with cell wall degradation, nutrient uptake, secondary metabolism and membrane transport, which contribute to adaptations for wood degradation...
October 3, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
Abdulla Al Mamun Bhuyan, A K M Ashiqul Haque, Itishri Sahu, Hang Cao, Michael S D Kormann, Florian Lang
BACKGROUND/AIMS: The Polo-like kinase 1 (Plk1) inhibitor volasertib is used in the treatment of malignancy. Volasertib is partially effective by triggering suicidal death or apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal cell death or eryptosis, which is characterized by cell membrane scrambling with phosphatidylserine translocation to the cell surface and by cell shrinkage. Stimulators of eryptosis include energy depletion, hyperosmotic shock, oxidative stress and excessive increase of cytosolic Ca2+ activity ([Ca2+]i)...
October 16, 2017: Cellular Physiology and Biochemistry
Yousef Veisani, Ali Delpisheh, Kourosh Sayehmiri, Ghobad Moradi, Jafar Hassanzadeh
Little attention has been paid to seasonality in suicide in Iran. Time pattern in suicide deaths and suicide attempts for some related factors such as gender, mental disorders has been found. In present study, we focus on suicide methods and the association with seasonality and other putative covariates such as gender. Through a cross-sectional study, overall identified suicide attempts and suicide deaths in the province of Ilam from 1 January 2010 and 31 December 2014 were enrolled. We used Edwards' test for test of seasonality in suicide methods...
August 2017: Acta Medica Iranica
Ye Zhang, Longchang Huang, Haoze Shi, Hang Chen, Jianxin Tao, Renhui Shen, Tong Wang
It has been reported that ursolic acid has the anti-tumor activity and it enhanced the therapeutic effect of oxaliplatin in colorectal cancer (CRC). However, the underlying mechanisms remain unknown. In this study, the mechanism of therapeutic effects enhancement by ursolic acid was investigated. We treated CRC cell lines HCT8 and SW480 with ursolic acid and oxaliplatin and monitored the effects on cell proliferation, apoptosis, reactive oxygen species (ROS) production and drug resistant gene production. We discovered that treatment of ursolic acid and oxaliplatin combination resulted in significant inhibition of cell proliferation, significantly increased apoptosis and ROS production and significant inhibition of drug resistance genes expression...
October 16, 2017: Cancer Science
Amy L Stamates, Ashley N Linden-Carmichael, Brynn E Sheehan, Peter D Preonas, Cathy Lau-Barraco
OBJECTIVE: The current study examined event-level characteristics (e.g., contextual factors, risk behaviors) during the most recent episode of Molly use among a sample of college students who reported previously using Molly. PARTICIPANTS: Participants (N = 151; 66.7% female) were drinkers aged 18 to 25. Data were collected from October to November 2014, February to April 2015, and September to November 2015. METHOD: Participants completed measures regarding typical Molly use and items related to context and behaviors during their most recent episode of Molly use...
2017: Journal of Drug Issues
Ran Zhao, Yuehou Zhang, Fanggang Ning, Yongqian Cao, Chengyu Zang, Siyuan Yin, Ru Song, Hang Jiang, Yibing Wang
OBJECTIVE: To explore the prevalence of pediatric (0-72 months old) scalds, and to clarify its relationship with household vacuum flasks. METHODS: A cross sectional online survey based on the largest social media in China. Online questionnaire was pushed twice a day to our target respondents for successive seven days. We were authorized to gain, analyze and publish the information related to this research by the Sina & Weibo data center. RESULTS: Prevalence of pediatric scalds was 5...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
Bich Hang Do, Minh Tan Nguyen, Jung-A Song, Sangsu Park, Jiwon Yoo, Jaepyeong Jang, Sunju Lee, Seoungjun So, Yejin Yoon, Inki Kim, Kyungjin Lee, Yeon Jin Jang, Han Choe
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered as an anti-tumor agent due to its ability to induce apoptosis of cancer cells without imparting toxicity toward most normal cells. TRAIL is produced in poor yield due to its insoluble expression in the cytoplasm of E. coli. In this study, we achieved soluble expression of TRAIL by fusing maltose-binding protein (MBP), b'a' domain of protein disulfide isomerase (PDIb'a'), or protein disulfide isomerase (PDI) at the N-terminus of TRAIL...
October 14, 2017: Journal of Microbiology and Biotechnology
Anna Mallone, Chantal Stenger, Arnold Von Eckardstein, Simon P Hoerstrup, Benedikt Weber
Atherosclerotic plaques are cholesterol-induced inflammatory niches accumulating in the vascular sub-endothelial space. Cellular and extracellular composition of human plaques is maneuvered by local inflammation that leads to alterations in the original vascular microenvironment and to the recruitment of an invading fibrous layer (fibroatharoma). In the present study we introduce a bioengineered three-dimensional model of human fibroatheroma (ps-plaque) assembled with a tailored hanging-drop protocol. Using vi-SNE based multidimensional flow cytometry data analysis we compared the myeloid cell-populations in ps-plaques to those in plaques isolated from human carotid arteries...
September 28, 2017: Biomaterials
Qian-Yi Peng, Yi-Min Wang, Cai-Xia Chen, Yu Zou, Li-Na Zhang, Song-Yun Deng, Yu-Hang Ai
BACKGROUND: The CD38/cADPR pathway has been found to play roles in various inflammatory conditions. However, whether CD38 plays a protective or detrimental effect in the central nervous system (CNS) is controversial. The aim of this study was to determine the effect of CD38/cADPR pathway in sepsis associated brain injury. MATERIALS AND METHODS: Male Sprague-Dawley rats were undergone cecal ligation and puncture (CLP) or sham laparotomies. NAD(+), cADPR and CD38 were measured in the hippocampus of septic rats at 0, 6, 12, 24, and 48 h after CLP surgery...
October 10, 2017: Brain Research
Glen M DeLoid, Yanli Wang, Klara Kapronezai, Laura Rubio Lorente, Roujie Zhang, Georgios Pyrgiotakis, Nagarjun V Konduru, Maria Ericsson, Jason C White, Roberto De La Torre-Roche, Hang Xiao, David Julian McClements, Philip Demokritou
BACKGROUND: Engineered nanomaterials (ENMs) are increasingly added to foods to improve their quality, sensory appeal, safety and shelf-life. Human exposure to these ingested ENMs (iENMS) is inevitable, yet little is known of their hazards. To assess potential hazards, efficient in vitro methodologies are needed to evaluate particle biokinetics and toxicity. These methodologies must account for interactions and transformations of iENMs in foods (food matrix effect) and in the gastrointestinal tract (GIT) that are likely to determine nano-biointeractions...
October 13, 2017: Particle and Fibre Toxicology
Hang Tuo, Yufeng Wang, Liang Wang, Bowen Yao, Qing Li, Cong Wang, Zhikui Liu, Shaoshan Han, Guozhi Yin, Kangsheng Tu, Qingguang Liu
Recently, it has been reported that miR-324-3p participates in regulation of the carcinogenesis and tumor progression in various cancers. However, the expression and function of miR-324-3p in hepatocellular carcinoma (HCC) remain unclear. In the current study, miR-324-3p expression was significantly up-regulated in HCC tissues and cell lines. HCC patients with high miR-324-3p level showed poor prognostic features and shorter overall survival and disease-free survival. And in vitro and in vivo experiments revealed that miR-324-3p promoted cell viability, colony formation, proliferation and cell cycle progression of HCC cells...
September 12, 2017: Oncotarget
Kai- Chen, Xin-Xin Wang, Fang-Fang Shen, Zi-Yi Hua, Sheng-Chao Qiu, Yun-Qian Zhang, Hang Cong, Qing-Yun Liu, Zhu Tao, Xiao Xin
A new inverted cucurbituril, namely inverted hexamethylcucurbit[3,3]uril (iMe6Q[3,3]), has been isolated and characterized. It incorporates a single inverted un-substituted glycoluril unit oriented towards the interior of the cavity, shows good solubility in water and organic solvents (DMSO), and exhibits different selecties for guests to those of iQ[6] and other known Q[6]s.
October 12, 2017: Chemistry: a European Journal
Georges Danhoundo, Mary E Wiktorowicz, Shahirose Sadrudin Premji, Khalidha Nasiri
BACKGROUND: Malaria is a major global health challenge. This study aims to clarify the manner in which contextual factors determine the use and maintenance of bed nets and the extent to which malaria prevention policy is responsive to them in Southern Benin. METHODS: Semi-structured interviews and direct observations were undertaken with 30 pregnant women in the municipality of So-Ava from June to August 2015. Key informants in the Ministry of Health and local community health workers were also interviewed regarding malaria prevention policy formation, and the monitoring and evaluation of bed net interventions, respectively...
October 13, 2017: International Journal of Health Planning and Management
Sophie George, Louise Pankhurst, Alasdair Hubbard, Antonia Votintseva, Nicole Stoesser, Anna E Sheppard, Amy Mathers, Rachel Norris, Indre Navickaite, Chloe Eaton, Zamin Iqbal, Derrick W Crook, Hang T T Phan
This study aimed to assess the feasibility of using the Oxford Nanopore Technologies (ONT) MinION long-read sequencer in reconstructing fully closed plasmid sequences from eight Enterobacteriaceae isolates of six different species with plasmid populations of varying complexity. Species represented were Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae, Serratia marcescens and Klebsiella oxytoca, with plasmid populations ranging from 1-11 plasmids with sizes of 2-330 kb. Isolates were sequenced using Illumina (short-read) and ONT's MinION (long-read) platforms, and compared with fully resolved PacBio (long-read) sequence assemblies for the same isolates...
August 2017: Microbial Genomics
Xiangyu Zhang, Jianfang Li, Xin Wang, Yueyue Wang, Ruiqiang Hang, Xiaobo Huang, Bin Tang, Paul K Chu
Copper (Cu) has garnered increasing interest due to its excellent antimicrobial activity and important roles in human metabolism. Although the biological effects of Cu have been studied, the effects of Cu nanoparticles (NPs) on cell behavior are not well understood. In this study, porous TiO2 coatings doped with different amounts of Cu NPs (designated as 0 Cu, 0.3 Cu, and 3.0 Cu) are deposited on titanium by micro-arc oxidation (MAO). The Cu NPs coated samples exhibit excellent antibacterial activity against Staphylococcus aureus (S...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Fazle Rabbi Chowdhury, Gourab Dewan, Vasundhara R Verma, Duleeka W Knipe, Ishrat Tahsin Isha, M Abul Faiz, David J Gunnell, Michael Eddleston
Background: Pesticide self-poisoning is a major problem in Bangladesh. Over the past 20-years, the Bangladesh government has introduced pesticide legislation and banned highly hazardous pesticides (HHPs) from agricultural use. We aimed to assess the impacts of pesticide bans on suicide and on agricultural production. Methods: We obtained data on unnatural deaths from the Statistics Division of Bangladesh Police, and used negative binomial regression to quantify changes in pesticide suicides and unnatural deaths following removal of WHO Class I toxicity HHPs from agriculture in 2000...
August 18, 2017: International Journal of Epidemiology
Jianzhang Wang, Gene Chi Wai Man, Tak Hang Chan, Joseph Kwong, Chi Chiu Wang
Anti-angiogenesis effect of a prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) in malignant tumors is not well studied. Here, we investigated how the treatment with Pro-EGCG inhibited tumor angiogenesis in endometrial cancer. Tumor xenografts of human endometrial cancer were established and subjected to microarray analysis after Pro-EGCG treatment. First, we showed Pro-EGCG inhibited tumor angiogenesis in xenograft models through down-regulation of vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF1α) in tumor cells and chemokine (C-X-C motif) ligand 12 (CXCL12) in host stroma by immunohistochemical staining...
October 9, 2017: Cancer Letters
Liyan Tang, Bo Zhao, Hui Zhang, Qiao Du, Jiang Zhu, Zhijiang Zhao, Ce Chen, Cheng Luo, Qiyuan Kang, Wenbing Yuan, Shaohua Bian, Hang Bi, Huimin Sun, Yingyi Li
Nonylphenol (NP) is an environmental chemical that affects apoptosis and male infertility. In our study, we found that a high concentration of NP could down-regulate the expression of microRNA-361-3p (miR-361-3p) in the murine GC-1 spermatogonia cell line and in vivo in murine spermatogonia. Additionally, one direct target of this miR, the 3' untranslated region of Killin (Klln) mRNA, was identified. Klln encodes a transcription factor that directly regulates the expression of Tp73 (transcriptionally active p73), whose encoded protein can up-regulate the expression of Puma (P53 upregulated modulator of apoptosis)...
October 12, 2017: Molecular Reproduction and Development
Ashleigh Scott, Nicholas Weber, Campbell Tiley, Kerry Taylor, John Taper, Simon Harrison, Kah-Lok Chan, Richard Stark, Cindy Lee, Kirk Morris, P Joy Ho, Anthony Dodds, Sundra Ramanathan, Raj Ramakrishna, Anne-Marie Watson, Bradley Auguston, Fiona Kwok, Hang Quach, Pauline Warburton, Philip Rowlings, Peter Mollee
No abstract text is available yet for this article.
October 12, 2017: Leukemia & Lymphoma
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