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https://www.readbyqxmd.com/read/29683984/effects-of-progressive-addition-lens-wear-on-digital-work-in-pre-presbyopes
#1
Chea-Su Kee, Tsz Wing Leung, Ka-Hung Kan, Christie Hang-I Lam
SIGNIFICANCE: Growing popularity of handheld digital devices imposes significant challenges to our visual system and clinical management. This study aimed to determine the effects of lens design on parameters that may influence the refractive management of pre-presbyopic adult computer users. PURPOSE: To determine the effects of wearing conventional single-vision lenses (SVL) versus progressive addition lenses (PAL) on the working distance and refractive status...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29683967/comparison-of-totally-3-dimensional-laparoscopic-pancreaticoduodenectomy-and-open-pancreaticoduodenectomy
#2
Hang Zhang, Xingjun Guo, Jia Xia, Feng Zhu, Ming Shen, Xin Wang, Min Wang, Renyi Qin
OBJECTIVE: The aim of this study was to evaluate the safety, feasibility, and oncologic outcomes of 3-dimensional total laparoscopic pancreaticoduodenectomy (3D-TLPD). METHODS: Data of all patients who underwent 3D-TLPD (n = 202) or open pancreaticoduodenectomy (OPD) (n = 213) at a single institution between October 2014 and December 2016 were reviewed. We evaluated the safety, feasibility, and oncologic outcomes of 3D-TLPD compared with OPD. RESULTS: The mean operative times in the 3D-TLPD and OPD groups were comparable (P = 0...
April 19, 2018: Pancreas
https://www.readbyqxmd.com/read/29682820/plga-spherical-nucleic-acids
#3
Shengshuang Zhu, Hang Xing, Pavlo Gordiichuk, Jungsoo Park, Chad A Mirkin
A new class of polymer spherical nucleic acid (SNA) conjugates comprised of poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) cores is reported. The nucleic acid shell that defines the PLGA-SNA exhibits a half-life of more than 2 h in fetal bovine serum. Importantly, the PLGA-SNAs can be utilized to encapsulate a hydrophobic model drug, coumarin 6, which can then be released in a polymer composition-dependent tunable manner, while the dissociation rate of the nucleic acid shell remains relatively constant, regardless of core composition...
April 23, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29679875/impurity-profiling-of-varenicline-tartrate-by-lc-qtof-mass-spectrometric-techniques-during-drug-development
#4
Yuting Lu, Xiyang Sun, Fan Song, Lei Wang, Min Song, Taijun Hang
An LC-QTOF-MS method was developed for the separation and characterization of related substances in varenicline tartrate. The separation was established on an InertSustain C18 column (4.6 mm × 150 mm, 5 μm) by liner gradient elution using 0.05% trifluoroacetic acid as mobile phase A and acetonitrile as mobile phase B. The degradation studies were conducted under the ICH prescribed stress conditions. Varenicline tartrate was found to be unstable to alkaline, oxidative, thermal and photolytic stresses, while relatively stable under acid stress condition...
April 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29679584/remember-the-vessels-craniofacial-fracture-predicts-risk-for-blunt-cerebrovascular-injury
#5
Elina Varjonen, Frank Bensch, Tuomo Pyhältö, Mika Koivikko, Johanna Snäll
PURPOSE: The risk factors for blunt cerebrovascular injuries (BCVIs) are currently under intensive research, yet it is still controversial who should be screened. This study aimed to determine whether craniofacial fractures are associated with BCVI. PATIENTS AND METHODS: This retrospective cohort study focused on patients with suspected polytrauma after whole-body computed tomographic angiography of the cervical arteries. Patients were reviewed for BCVI and craniofacial fractures...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679558/self-restrained-regulation-of-stem-cell-niche-activity-by-niche-components-in-the-drosophila-testis
#6
Ran Xu, Jing Li, Hang Zhao, Ruiyan Kong, Min Wei, Lin Shi, Guang Bai, Zhouhua Li
Most, if not all, stem cells reside in a defined microenvironment, called the niche. Short-ranged niche signal must be tightly controlled to be active only inside the niche to maintain the proper balance of stem cell self-renewal verse differentiation. However, how niche components restrict localized niche signal activation remains largely unknown. Here, we find that Thickveins (Tkv, a type I receptor of the Dpp signaling pathway) in cyst stem cells (CySCs) of the testis niche prevents Dpp signaling activation outside of the niche...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29679557/acetaminophen-induced-liver-injury-is-attenuated-in-transgenic-fat-1-mice-endogenously-synthesizing-long-chain-n-3-fatty-acids
#7
Ruibing Feng, Yang Wang, Conghui Liu, Chunyan Yan, Hang Zhang, Huanxing Su, Jing X Kang, Chang-Zhen Shang, Jian-Bo Wan
Acetaminophen (APAP) overdose-caused hepatotoxicity is the most commonly cause of drugs-induced liver failurecharacterized by oxidative stress, mitochondrial dysfunction, and cell damage. Therapeutic efficacy of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in several models of liver disease is well documented. However, the impacts of n-3 PUFA on APAP hepatotoxicity are not adequately addressed. In this study, the fat-1 transgenic mice that synthesize endogenous n-3 PUFA and wild type (WT) littermates were injected intraperitoneally with APAP at the dose of 400 mg/kg to induce liver injury, and euthanized at 0 h, 2 h, 4 h and 6 h post APAP injection for sampling...
April 18, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29679350/alleviation-mechanisms-of-selenium-on-cadmium-spiked-in-chicken-ovarian-tissue-perspectives-from-autophagy-and-energy-metabolism
#8
Shuang Wang, Zhe Xu, Hang Yin, Yahong Min, Shu Li
Cadmium (Cd) is a kind of toxic heavy metal and it can cause damage to organs and tissues. Selenium (Se) can antagonize some metal element toxicity including Cd. The present study was designed to investigate Cd-induced damage to chicken ovary by autophagy and the protective mechanism of Se on Cd-induced damage. Administration of Cd for 12 weeks led to energy metabolism disorder of the chicken ovarian tissues, which resulted in autophagy. In addition, the mRNA expression of glucose-related genes including hexokinase II (HK2), pyruvate kinase (PK), pyruvate dehydrogenase complex (PDHX), and succinate dehydrogenase (SDH) and the activities of ATPase, including Na+ -K+ -ATPase, Ca2+ -ATPase, Mg2+ -ATPase, were all downregulated remarkably compared with the control...
April 21, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29679074/tunable-transmission-and-deterministic-interface-states-in-double-zero-index-acoustic-metamaterials
#9
Wei Zhao, Yuting Yang, Zhi Tao, Zhi Hong Hang
Following the seminal work by Dubois et al. (Nat. Commun. 8, 14871 (2017)), we study a double-zero-index acoustic metamaterial with triangular lattice. By varying the height and diameter of air scatterers inside a parallel-plate acoustic waveguide, acoustic dispersion of the first-order waveguide mode can be manipulated and various interesting properties are explored. With accidental degeneracy of monopolar and dipolar modes, we numerically prove the double-zero-index properties of this novel acoustic metamaterial...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678905/phosphorylation-of-xiap-at-threonine-180-controls-its-activity-in-wnt-signaling
#10
Victoria H Ng, Brian I Hang, Leah M Sawyer, Leif R Neitzel, Emily E Crispi, Kristie L Rose, Tessa M Popay, Alison Zhong, Laura A Lee, William P Tansey, Stacey Huppert, Ethan Lee
X-linked Inhibitor of Apoptosis (XIAP) plays an important role in preventing apoptotic cell death. XIAP has been shown to participate in signaling pathways, including Wnt signaling. XIAP regulates Wnt signaling by promoting the monoubiquitination of the co-repressor Groucho/TLE, decreasing its affinity for TCF/Lef and allowing assembly of transcriptionally active β-catenin-TCF/Lef complexes. We now demonstrate that XIAP is phosphorylated by GSK3 at threonine 180 and that an alanine mutant (XIAPT180A ) exhibits decreased Wnt activity compared to wild-type XIAP in cultured human cells and in Xenopus embryos...
April 20, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29678897/lack-of-associations-between-aurka-gene-polymorphisms-and-neuroblastoma-susceptibility-in-chinese-children
#11
Jue Tang, Yuanmin Qian, Jinhong Zhu, Jiao Zhang, Feng-Hua Wang, Jia-Hang Zeng, Jiang-Hua Liang, Hui Wang, Huimin Xia, Jing He, Wei Liu
Previous studies have demonstrated that polymorphisms in the AURKA gene are associated with various types of cancer. In neuroblastoma, AURKA protein product regulates N-myc protein levels and plays a critical role in tumorigenesis. To investigate the association between three AURKA polymorphisms (rs1047972 C>T, rs2273535 T>A and rs8173 G>C) and neuroblastoma susceptibility in Chinese populations, we performed this two-center case-control study including 393 neuroblastoma cases and 812 controls. Two study populations were recruited from two different regions in China...
April 20, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29678744/long-noncoding-rna-lncarsr-promotes-hepatic-cholesterol-biosynthesis-via-modulating-akt-srebp-2-hmgcr-pathway
#12
Jiabin Hang, Shangjun Chen, Dongliang Cai, Deqiang Bian, Fengling Wang
AIMS: Disruption of cholesterol homeostasis has been identified as a major factor in the pathogenesis of atherosclerosis, myocardial infarction, and strokes. Long noncoding RNAs (lncRNAs) have emerged as critical players in cellular cholesterol metabolism, but their functions are still largely unknown. MATERIALS AND METHODS: C57BL6/j mice were fed with high cholesterol diet (containing 4% cholesterol) or chow diet. Adenoviruses-lncARSR and lncARSR shRNA were used to overexpress or knockdown lncARSR expression...
April 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29677083/east-multicenter-trial-on-targeted-temperature-management-for-hanging-induced-cardiac-arrest
#13
Cindy H Hsu, Bryce E Haac, Mack Drake, Andrew C Bernard, Alberto Aiolfi, Kenji Inaba, Holly E Hinson, Chinar Agarwal, Joseph Galante, Emily M Tibbits, Nicholas J Johnson, David Carlbom, Mina F Mirhoseini, Mayur B Patel, Karen R OʼBosky, Christian Chan, Pascal O Udekwu, Megan Farrell, Jeffrey L Wild, Katelyn A Young, Daniel C Cullinane, Deborah J Gojmerac, Alexandra Weissman, Clifton Callaway, Sarah M Perman, Mariana Guerrero, Imoigele P Aisiku, Raghu R Seethala, Ivan N Co, Debbie Y Madhok, Bryan Darger, Dennis Y Kim, Lara Spence, Thomas M Scalea, Deborah M Stein
BACKGROUND: We sought to determine the outcome of suicidal hanging and the impact of targeted temperature management (TTM) on hanging-induced cardiac arrest (CA) through an Eastern Association for the Surgery of Trauma (EAST) multicenter retrospective study. METHODS: We analyzed hanging patient data and TTM variables from January 1992 to December 2015. Cerebral performance category (CPC) score of 1 or 2 was considered good neurologic outcome, while CPC of 3 or 4 was considered poor outcome...
April 19, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29676183/synthesis-%C3%AE-glucosidase-inhibitory-glucose-consumption-promoting-activities-of-flavonoid-coumarin-hybrids
#14
Hua Sun, Xiaotong Song, Yunchang Tao, Ming Li, Ke Yang, Hang Zheng, Zongxin Jin, Robert H Dodd, Guojun Pan, Kui Lu, Peng Yu
AIM: The research of novel and potent antidiabetic agents is urgently needed for the control of the exploding diabetic population. We previously reported the synthesis and antidiabetic activity of natural 8-(6"-umbelliferyl)-apigenin (1), but its antidiabetic targets are not known. Therefore, four series of derivatives were synthesized and evaluated for their antidiabetic activities. Results & methodology: Compounds (5a) and (14a) were identified as new α-glucosidase and α-amylase dual inhibitors...
April 20, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29675417/developing-a-reliable-mouse-model-for-cancer-therapy-induced-cardiovascular-toxicity-in-cancer-patients-and-survivors
#15
Kyung Ae Ko, Yin Wang, Sivareddy Kotla, Yuka Fujii, Hang Thi Vu, Bhanu P Venkatesulu, Tamlyn N Thomas, Jan L Medina, Young Jin Gi, Megumi Hada, Jane Grande-Allen, Zarana S Patel, Sarah A Milgrom, Sunil Krishnan, Keigi Fujiwara, Jun-Ichi Abe
Background: The high incidence of cardiovascular events in cancer survivors has long been noted, but the mechanistic insights of cardiovascular toxicity of cancer treatments, especially for vessel diseases, remain unclear. It is well known that atherosclerotic plaque formation begins in the area exposed to disturbed blood flow, but the relationship between cancer therapy and disturbed flow in regulating plaque formation has not been well studied. Therefore, we had two goals for this study; (1) Generate an affordable, reliable, and reproducible mouse model to recapitulate the cancer therapy-induced cardiovascular events in cancer survivors, and (2) Establish a mouse model to investigate the interplay between disturbed flow and various cancer therapies in the process of atherosclerotic plaque formation...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29675156/cell-imaging-of-dopamine-receptor-using-agonist-labeling-iridium-iii-complex
#16
Kasipandi Vellaisamy, Guodong Li, Chung-Nga Ko, Hai-Jing Zhong, Sarwat Fatima, Hiu-Yee Kwan, Chun-Yuen Wong, Wai-Jing Kwong, Weihong Tan, Chung-Hang Leung, Dik-Lung Ma
Dopamine receptor expression is correlated with certain types of cancers, including lung, breast and colon cancers. In this study, we report luminescent iridium(iii) complexes ( 11-14 ) as intracellular dopamine receptor (D1R/D2R) cell imaging agents. Complexes 11 and 13 , which are conjugated with a dopamine receptor agonist, showed superior cell imaging characteristics, high stability and low cytotoxicity (>100 μM) in A549 lung cancer cells. siRNA knockdown and dopamine competitive assays indicated that complexes 11 and 13 could selectively bind to dopamine receptors (D1R/D2R) in A549 cells...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29674940/dispatch-from-the-field-ii-the-mystery-of-the-red-and-blue-opadometa-male-araneae-tetragnathidae-opadometa-sarawakensis
#17
Jeremy A Miller, Christian Freund, Liselotte Rambonnet, Lianne Koets, Nadine Barth, Corné van der Linden, József Geml, Menno Schilthuizen, Richard Burger, Benoit Goossens
Background: Males of Opadometa are difficult to associate with conspecific females, and sex-matching errors may persist in the taxonomic literature. Recommended best practices for definitive sex matching in this genus suggest finding a male in the web of a female, or better yet, mating pairs. New information: A male Opadometa was observed hanging on a frame line of the web of a female Opadometa sarawakensis , a species for which the male was previously undescribed...
2018: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29674719/gene-refashioning-through-innovative-shifting-of-reading-frames-in-mosses
#18
Yanlong Guan, Li Liu, Qia Wang, Jinjie Zhao, Ping Li, Jinyong Hu, Zefeng Yang, Mark P Running, Hang Sun, Jinling Huang
Early-diverging land plants such as mosses are known for their outstanding abilities to grow in various terrestrial habitats, incorporating tremendous structural and physiological innovations, as well as many lineage-specific genes. How these genes and functional innovations evolved remains unclear. In this study, we show that a dual-coding gene YAN/AltYAN in the moss Physcomitrella patens evolved from a pre-existing hemerythrin gene. Experimental evidence indicates that YAN/AltYAN is involved in fatty acid and lipid metabolism, as well as oil body and wax formation...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29674167/neuraminidase-as-an-influenza-vaccine-antigen-a-low-hanging-fruit-ready-for-picking-to-improve-vaccine-effectiveness
#19
REVIEW
Maryna C Eichelberger, David M Morens, Jeffery K Taubenberger
Neuraminidase (NA) plays an essential role in influenza virus replication, facilitating multicycle infection predominantly by releasing virions from infected cells. NA-inhibiting antibodies provide resistance to disease and NA-specific antibodies contribute to vaccine efficacy. The primary reason NA vaccine content and immunogenicity was not routinely measured in the past, was the lack of suitable assays to quantify NA and NA-specific antibodies. These are now available and with recent appreciation of its contribution to immunity, NA content of seasonal and pandemic vaccines is being considered...
April 16, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29672713/imprinting-of-repeated-influenza-a-h3-exposures-on-antibody-quantity-and-antibody-quality-implications-on-seasonal-vaccine-strain-selection-and-vaccine-performance
#20
Martina Kosikova, Lei Li, Peter Radvak, Zhiping Ye, Xiu-Feng Wan, Hang Xie
Background: Reduced seasonal influenza vaccine effectiveness (VE) was observed in individuals who received repeated annual vaccinations. Pre-existing influenza antibody levels were also found inversely correlated with post-vaccination titers. These reports suggest that pre-existing immunity may affect contemporary seasonal vaccine performance. Methods: Influenza A/H3 specific cross-reactivity of post-vaccination sera from humans with or without pre-existing immunity was assessed by hemagglutination inhibition (HAI) assay...
April 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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