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https://www.readbyqxmd.com/read/27907189/structural-insights-into-streptococcal-competence-regulation-by-the-cell-to-cell-communication-system-comrs
#1
Antoine Talagas, Laetitia Fontaine, Laura Ledesma-Garca, Johann Mignolet, Inès Li de la Sierra-Gallay, Noureddine Lazar, Magali Aumont-Nicaise, Michael J Federle, Gerd Prehna, Pascal Hols, Sylvie Nessler
In Gram-positive bacteria, cell-to-cell communication mainly relies on extracellular signaling peptides, which elicit a response either indirectly, by triggering a two-component phosphorelay, or directly, by binding to cytoplasmic effectors. The latter comprise the RNPP family (Rgg and original regulators Rap, NprR, PrgX and PlcR), whose members regulate important bacterial processes such as sporulation, conjugation, and virulence. RNPP proteins are increasingly considered as interesting targets for the development of new antibacterial agents...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27754140/os-27-04-prediction-of-left-ventricular-dystolic-dysfunction-in-patient-with-arterial-hypertension
#2
Krasimira Hristova, Vera Bogdanova, Rumen Marinov
OBJECTIVE: Arterial hypertension (HTN) causes left ventricular (LV) dysfunction even if ejection function (EF) remains preserved. The objective of this study was to assess whether complex LAFI (left atrium functional index) had additional value in definition and grading of diastolic dysfunction and compare with indices of atrial deformation - longitudinal strain. DESIGN AND METHOD: Peak atrial longitudinal strain (PALS) was evaluated in 82 patients with systemic HTN and preserved EF (> = 55%) divided in 41 with diastolic dysfunction but no hypertrophy (HTNdd), and 41 with no diastolic dysfunction or hypertrophy (eHTN)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27741553/structural-basis-for-the-transcriptional-repressor-nicr2-in-nicotine-degradation-from-pseudomonas
#3
Kunzhi Zhang, Geng Wu, Hongzhi Tang, Chuanming Hu, Ting Shi, Ping Xu
Nicotine is an environmental toxicant in tobacco wastes, imposing severe hazards for the health of human and other mammalians. NicR2, a TetR-like repressor from Pseudomonas putida S16, plays a critical role in regulating nicotine degradation. Here, we determined the crystal structures of NicR2 and its complex with the inducer 6-hydroxy-3-succinoyl-pyridine (HSP). The N-terminal domain of NicR2 contains a conserved helix-turn-helix (HTH) DNA-binding motif, while the C-terminal domain contains a cleft for its selective recognition for HSP...
October 14, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27692964/the-preserved-hth-docking-cleft-of-hiv-1-integrase-is-functionally-critical
#4
Meytal Galilee, Elena Britan-Rosich, Sarah L Griner, Serdar Uysal, Viola Baumgärtel, Don C Lamb, Anthony A Kossiakoff, Moshe Kotler, Robert M Stroud, Ailie Marx, Akram Alian
HIV-1 integrase (IN) catalyzes viral DNA integration into the host genome and facilitates multifunctional steps including virus particle maturation. Competency of IN to form multimeric assemblies is functionally critical, presenting an approach for anti-HIV strategies. Multimerization of IN depends on interactions between the distinct subunit domains and among the flanking protomers. Here, we elucidate an overlooked docking cleft of IN core domain that anchors the N-terminal helix-turn-helix (HTH) motif in a highly preserved and functionally critical configuration...
November 1, 2016: Structure
https://www.readbyqxmd.com/read/27686023/structural-and-biophysical-properties-of-h-fanci-arm-repeat-protein
#5
Mohd Quadir Siddiqui, Rajan Kumar Choudhary, Pankaj Thapa, Neha Kulkarni, Yogendra S Rajpurohit, Hari S Misra, Nikhil Gadewal, Satish Kumar, Syed K Hasan, Ashok K Varma
Fanconi anemia complementation groups - I (FANCI) protein facilitates DNA ICL (Inter-Cross-link) repair and plays a crucial role in genomic integrity. FANCI is a 1328 amino acids protein which contains armadillo (ARM) repeats and EDGE motif at the C-terminus. ARM repeats are functionally diverse and evolutionarily conserved domain that plays a pivotal role in protein-protein and protein-DNA interactions. Considering the importance of ARM repeats, we have explored comprehensive in-silico and in-vitro approach to examine folding pattern...
September 30, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27643067/os-27-04-prediction-of-left-ventricular-dystolic-dysfunction-in-patient-with-arterial-hypertension
#6
Krasimira Hristova, Vera Bogdanova, Rumen Marinov
OBJECTIVE: Arterial hypertension (HTN) causes left ventricular (LV) dysfunction even if ejection function (EF) remains preserved. The objective of this study was to assess whether complex LAFI (left atrium functional index) had additional value in definition and grading of diastolic dysfunction and compare with indices of atrial deformation - longitudinal strain. DESIGN AND METHOD: Peak atrial longitudinal strain (PALS) was evaluated in 82 patients with systemic HTN and preserved EF (> = 55%) divided in 41 with diastolic dysfunction but no hypertrophy (HTNdd), and 41 with no diastolic dysfunction or hypertrophy (eHTN)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27630031/continuous-quality-improvement-efforts-increase-survival-with-favorable-neurologic-outcome-after-out-of-hospital-cardiac-arrest
#7
Karl Sporer, Michael Jacobs, Leo Derevin, Sue Duval, James Pointer
OBJECTIVE: To assess system-wide implementation of specific therapies focused on perfusion during cardiopulmonary resuscitation (CPR) and cerebral recovery after Return of Spontaneous Circulation (ROSC). METHODS: Before and after retrospective analysis of an out-of-hospital cardiac arrest database. Implementation trial in the urban/suburban community of Alameda County, California, USA, population 1.6 million, from November 2009-December 2012. Adult patients with non-traumatic out-of-hospital cardiac arrest (OHCA) who received CPR and/or defibrillation...
September 14, 2016: Prehospital Emergency Care
https://www.readbyqxmd.com/read/27626238/a-model-of-the-spatio-temporal-dynamics-of-drosophila-eye-disc-development
#8
Patrick Fried, Máximo Sánchez-Aragón, Daniel Aguilar-Hidalgo, Birgitta Lehtinen, Fernando Casares, Dagmar Iber
Patterning and growth are linked during early development and have to be tightly controlled to result in a functional tissue or organ. During the development of the Drosophila eye, this linkage is particularly clear: the growth of the eye primordium mainly results from proliferating cells ahead of the morphogenetic furrow (MF), a moving signaling wave that sweeps across the tissue from the posterior to the anterior side, that induces proliferating cells anterior to it to differentiate and become cell cycle quiescent in its wake...
September 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27622187/parb-partition-proteins-complex-formation-and-spreading-at-bacterial-and-plasmid-centromeres
#9
REVIEW
Barbara E Funnell
In bacteria, active partition systems contribute to the faithful segregation of both chromosomes and low-copy-number plasmids. Each system depends on a site-specific DNA binding protein to recognize and assemble a partition complex at a centromere-like site, commonly called parS. Many plasmid, and all chromosomal centromere-binding proteins are dimeric helix-turn-helix DNA binding proteins, which are commonly named ParB. Although the overall sequence conservation among ParBs is not high, the proteins share similar domain and functional organization, and they assemble into similar higher-order complexes...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27502436/increased-avidity-for-dpp-bmp2-maintains-the-proliferation-of-progenitors-like-cells-in-the-drosophila-eye
#10
Marta Neto, Daniel Aguilar-Hidalgo, Fernando Casares
During organ development, the progenitor state is transient, and depends on specific combinations of transcription factors and extracellular signals. Not surprisingly, abnormal maintenance of progenitor transcription factors may lead to tissue overgrowth, and the concurrence of signals from the local environment is often critical to trigger this overgrowth. Therefore, identifying specific combinations of transcription factors/signals promoting -or opposing- proliferation in progenitors is essential to understand normal development and disease...
October 1, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27491035/streptococcus-pneumoniae-genome-wide-identification-and-characterization-of-box-element-binding-domains
#11
Qiao Zhang, Changzheng Wang, Min Wan, Yin Wu, Qianli Ma
The BOX elements are short repetitive DNA sequences that distribute randomly in intergenic regions of the Streptococcus pneumoniae genome. The function and origin of such elements are still unknown, but they were found to modulate expression of neighboring genes. Evidences suggested that the modulation's mechanism can be fulfilled by sequence-specific interaction of BOX elements with transcription factor family proteins. However, the type and function of these BOX-binding proteins still remain largely unexplored to date...
November 2015: Molecular Informatics
https://www.readbyqxmd.com/read/27485943/multiprotein-bridging-factor-1-regulates-vegetative-growth-osmotic-stress-and-virulence-in-magnaporthe-oryzae
#12
Gaili Fan, Kai Zhang, Hao Huang, Heng Zhang, Ao Zhao, Libin Chen, Ruiqi Chen, Guangpu Li, Zonghua Wang, Guo-Dong Lu
Multiprotein bridging factor 1 (MBF1) is a transcriptional co-activator that mediates transcriptional activation by bridging sequence-specific activator like proteins and the TATA-box binding protein (TBP). MBF1 has been well-studied in Arabidopsis thaliana, Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens, but it is not well understood in filamentous fungi. In this study, we report the identification and characterization of a MBF1 ortholog (MoMBF1) in the rice blast fungus Magnaporthe oryzae), which causes the devastating rice blast disease and is an ideal model for studying the growth, development and pathogenic mechanisms of filamentous fungi...
August 2, 2016: Current Genetics
https://www.readbyqxmd.com/read/27468278/region-4-of-rhizobium-etli-primary-sigma-factor-siga-confers-transcriptional-laxity-in-escherichia-coli
#13
Orlando Santillán, Miguel A Ramírez-Romero, Luis Lozano, Alberto Checa, Sergio M Encarnación, Guillermo Dávila
Sigma factors are RNA polymerase subunits engaged in promoter recognition and DNA strand separation during transcription initiation in bacteria. Primary sigma factors are responsible for the expression of housekeeping genes and are essential for survival. RpoD, the primary sigma factor of Escherichia coli, a γ-proteobacteria, recognizes consensus promoter sequences highly similar to those of some α-proteobacteria species. Despite this resemblance, RpoD is unable to sustain transcription from most of the α-proteobacterial promoters tested so far...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27381228/retinal-determination-genes-coordinate-neuroepithelial-specification-and-neurogenesis-modes-in-the-drosophila-optic-lobe
#14
Holger Apitz, Iris Salecker
Differences in neuroepithelial patterning and neurogenesis modes contribute to area-specific diversifications of neural circuits. In the Drosophila visual system, two neuroepithelia, the outer (OPC) and inner (IPC) proliferation centers, generate neuron subtypes for four ganglia in several ways. Whereas neuroepithelial cells in the medial OPC directly convert into neuroblasts, in an IPC subdomain they generate migratory progenitors by epithelial-mesenchymal transition that mature into neuroblasts in a second proliferative zone...
July 1, 2016: Development
https://www.readbyqxmd.com/read/27365174/%C3%AE-2a-adrenergic-receptors-highly-expressed-in-mesoprefrontal-dopamine-neurons
#15
M Paola Castelli, Saturnino Spiga, Andrea Perra, Camilla Madeddu, Giovanna Mulas, M Grazia Ennas, Gian Luigi Gessa
α2 adrenoreceptors (α2-ARs) play a key role in the control of noradrenaline and dopamine release in the medial prefrontal cortex (mPFC). Here, using UV-laser microdissection-based quantitative mRNA expression in individual neurons we show that in hTH-GFP rats, a transgenic line exhibiting intense and specific fluorescence in dopaminergic (DA) neurons, α2A adrenoreceptor (α2A-AR) mRNA is expressed at high and low levels in DA cells in the ventral tegmental area (VTA) and substantia nigra compacta (SNc), respectively...
September 22, 2016: Neuroscience
https://www.readbyqxmd.com/read/27307238/wnt-signaling-specifies-anteroposterior-progenitor-zone-identity-in-the-drosophila-visual-center
#16
Takumi Suzuki, Olena Trush, Tetsuo Yasugi, Rie Takayama, Makoto Sato
UNLABELLED: During brain development, various types of neuronal populations are produced from different progenitor pools to produce neuronal diversity that is sufficient to establish functional neuronal circuits. However, the molecular mechanisms that specify the identity of each progenitor pool remain obscure. Here, we show that Wnt signaling is essential for the specification of the identity of posterior progenitor pools in the Drosophila visual center. In the medulla, the largest component of the visual center, different types of neurons are produced from two progenitor pools: the outer proliferation center (OPC) and glial precursor cells (GPCs; also known as tips of the OPC)...
June 15, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27244552/shelf-life-of-chlorine-solutions-recommended-in-ebola-virus-disease-response
#17
Qais Iqbal, Maya Lubeck-Schricker, Emma Wells, Marlene K Wolfe, Daniele Lantagne
In Ebola Virus Disease (EVD) outbreaks, it is widely recommended to wash living things (handwashing) with 0.05% (500 mg/L) chlorine solution and non-living things (surfaces, personal protective equipment, dead bodies) with 0.5% (5,000 mg/L) chlorine solution. Chlorine solutions used in EVD response are primarily made from powdered calcium hypochlorite (HTH), granular sodium dichloroisocyanurate (NaDCC), and liquid sodium hypochlorite (NaOCl), and have a pH range of 5-11. Chlorine solutions degrade following a reaction highly dependent on, and unusually sensitive to, pH, temperature, and concentration...
2016: PloS One
https://www.readbyqxmd.com/read/27243817/accuracy-precision-ease-of-use-and-cost-of-methods-to-test-ebola-relevant-chlorine-solutions
#18
Emma Wells, Marlene K Wolfe, Anna Murray, Daniele Lantagne
To prevent transmission in Ebola Virus Disease (EVD) outbreaks, it is recommended to disinfect living things (hands and people) with 0.05% chlorine solution and non-living things (surfaces, personal protective equipment, dead bodies) with 0.5% chlorine solution. In the current West African EVD outbreak, these solutions (manufactured from calcium hypochlorite (HTH), sodium dichloroisocyanurate (NaDCC), and sodium hypochlorite (NaOCl)) have been widely used in both Ebola Treatment Unit and community settings...
2016: PloS One
https://www.readbyqxmd.com/read/27188254/genesis-of-the-vertebrate-foxp-subfamily-member-genes-occurred-during-two-ancestral-whole-genome-duplication-events
#19
Xiaowei Song, Yezhong Tang, Yajun Wang
The vertebrate FoxP subfamily genes play important roles in the construction of essential functional modules involved in physiological and developmental processes. To explore the adaptive evolution of functional modules associated with the FoxP subfamily member genes, it is necessary to study the gene duplication process. We detected four member genes of the FoxP subfamily in sea lampreys (a representative species of jawless vertebrates) through genome screenings and phylogenetic analyses. Reliable paralogons (i...
August 22, 2016: Gene
https://www.readbyqxmd.com/read/27148744/neuronal-cell-fate-specification-by-the-convergence-of-different-spatiotemporal-cues-on-a-common-terminal-selector-cascade
#20
Hugo Gabilondo, Johannes Stratmann, Irene Rubio-Ferrera, Irene Millán-Crespo, Patricia Contero-García, Shahrzad Bahrampour, Stefan Thor, Jonathan Benito-Sipos
Specification of the myriad of unique neuronal subtypes found in the nervous system depends upon spatiotemporal cues and terminal selector gene cascades, often acting in sequential combinatorial codes to determine final cell fate. However, a specific neuronal cell subtype can often be generated in different parts of the nervous system and at different stages, indicating that different spatiotemporal cues can converge on the same terminal selectors to thereby generate a similar cell fate. However, the regulatory mechanisms underlying such convergence are poorly understood...
May 2016: PLoS Biology
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