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kikuchi disease

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https://www.readbyqxmd.com/read/29325675/mycophenolate-mofetil-as-a-therapeutic-agent-for-interstitial-lung-diseases-in-systemic-sclerosis
#1
REVIEW
Takahiro Ueda, Takuro Sakagami, Toshiaki Kikuchi, Toshinori Takada
Systemic sclerosis (SSc) is an intractable disease that causes fibrosis in all organs. Approximately 40% of patients with SSc have some degree of interstitial lung disease (ILD). One third of patients with SSc and ILD, approximately 15% of all patients, have pulmonary lesions, which slowly progress to respiratory failure resistant to corticosteroid and other treatments. A randomized controlled trial conducted in the United States indicated that one year of treatment with oral cyclophosphamide in patients with SSc-ILD had a significant but modest beneficial effect on lung function, dyspnea, thickening of the skin, and health-related quality of life...
January 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29310344/polymyositis-with-elevated-serum-igg4-levels-and-abundant-igg4-plasma-cell-infiltration-a-case-report-and-literature-review
#2
Ryusuke Anan, Mitsuhiro Akiyama, Yuko Kaneko, Jun Kikuchi, Kazuko Suzuki, Shiro Matsubara, Tsutomu Takeuchi
INTRODUCTION: Polymyositis (PM) is a type of autoimmune, inflammatory myopathy. IgG4-related disease (IgG4-RD) is a recently recognized disease entity characterized by elevated serum IgG4 levels and IgG4 plasma-cell infiltration of various organs. However, several reports have described cases of other diseases that present with those features, suggesting the importance of careful differential diagnosis. Herein, we report the first case of PM with elevated serum IgG4 levels and IgG4 plasma cells in the muscles, mimicking IgG4-RD...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29290321/-kikuchi-disease-evolution-during-outbreaks-and-its-response-to-antimalarial-treatment
#3
David Castro Corredor, Isabel María de Lara Simón, David Bellido Pastrana
Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a syndrome characterized by the presence of usually painful cervical lymphadenopathy with fever and night sweats. It is a rare clinical entity that mainly affects young Asian women, although it found worldwide. It is a benign and self-limiting condition; however, its importance lies in its differential diagnosis with other clinical entities such as lymphoma or histiocytoma. We present a case of Kikuchi-Fujimoto disease, with special emphasis on its clinicopathological significance and its evolution during outbreaks...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29289620/balance-between-angiogenic-and-anti-angiogenic-isoforms-of-vegf-a-is-associated-with-the-complexity-and-severity-of-coronary-artery-disease
#4
Yohei Shibata, Ryosuke Kikuchi, Hideki Ishii, Susumu Suzuki, Kazuhiro Harada, Kenshi Hirayama, Atsuo Suzuki, Yosuke Tatami, Kazuhisa Kondo, Toyoaki Murohara
INTRODUCTION: Assessing the complexity of coronary artery disease (CAD) is clinically important. Vascular endothelial growth factor A (VEGF-A) is a powerful and the most important regulator of angiogenesis. It has been reported that the anti-angiogenic isoform of VEGF-A (VEGF-A165b) inhibits angiogenesis. The purpose of this study was to evaluate the relationship between the complexities of CAD using the Syntax score (SS) and the levels of circulating total VEGF-A or VEGF-A165b. METHODS: A total of 268 patients who underwent percutaneous coronary intervention (PCI) were enrolled...
December 28, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29283682/domiciliary-high-flow-nasal-cannula-oxygen-therapy-for-stable-hypercapnic-copd-patients-a-multicenter-randomized-crossover-trial
#5
Kazuma Nagata, Takashi Kikuchi, Takeo Horie, Akira Shiraki, Takamasa Kitajima, Toru Kadowaki, Fumiaki Tokioka, Naohiko Chohnabayashi, Akira Watanabe, Susumu Sato, Keisuke Tomii
RATIONALE: A growing evidence base suggests a benefit of using high-flow nasal cannula oxygen therapy (HFNC) in the acute setting. However, the clinical benefit of domiciliary use of HFNC in patients with chronic hypercapnic respiratory failure due to chronic obstructive pulmonary disease (COPD) remains unclear. OBJECTIVES: To evaluate the efficacy and safety of HFNC use in stable COPD patients. METHODS: This was a multicenter, randomized crossover trial comparing HFNC plus long-term oxygen therapy (HFNC/LTOT) with LTOT-only in 32 adults with stable hypercapnic COPD...
December 28, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29277819/hepatic-resection-followed-by-hepatic-arterial-infusion-chemotherapy-for-hepatocellular-carcinoma-with-intrahepatic-dissemination
#6
Kunitaka Kuramoto, Toru Beppu, Hidetoshi Nitta, Katsunori Imai, Toshiro Masuda, Tatsunori Miyata, Yuki Koga, Yuki Kitano, Takayoshi Kaida, Shigeki Nakagawa, Hirohisa Okabe, Hiromitsu Hayashi, Daisuke Hashimoto, Yo-Ichi Yamashita, Akira Chikamoto, Ken Kikuchi, Hideo Baba
BACKGROUND/AIM: To investigate the utility of adjuvant hepatic arterial infusion chemotherapy (HAIC) following hepatectomy for patients with hepatocellular carcinoma (HCC) with intrahepatic dissemination (IHD) after local ablation therapy. PATIENTS AND METHODS: Twelve patients with HCC with IHD were divided into two groups: HAIC group (n=6) underwent hepatectomy followed by HAIC; and the non-HAIC group (n=6) underwent hepatectomy alone. HAIC with cisplatin and 5-fluorouracil was started within a month and was continued for a month: Results: At the first local ablation, tumors close to the major portal vein and insufficient ablation were recognized in eight (67...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29277280/lymphadenopathies-in-human-immunodeficiency-virus-infection
#7
REVIEW
Carlos Barrionuevo-Cornejo, Daniela Dueñas-Hancco
This article describes the various non-neoplastic lymphadenopathies that occur in patients infected with the human immunodeficiency virus (HIV), before or during the stage of acquired immunodeficiency syndrome (AIDS). The stages that develop during the HIV infection include: primary infection (acute infection, spread of the virus, development of host immune response, and acute retroviral syndrome), chronic infection or clinical latency, and finally, the AIDS stage. Non-neoplastic lymphadenopathies can occur at any of these phases of the infection and are due to multiple causes that can be divided into infectious causes (bacterial, fungal, parasitic, viral), and reactive causes (persistent generalized lymphadenopathy and a variety of situations that they also occur in immunocompetent people such as Castleman's disease and Kikuchi-Fujimoto's disease, among others)...
December 6, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29247656/mrna-expression-of-platelet-activating-factor-receptor-pafr-in-peripheral-blood-mononuclear-cells-is-associated-with-albuminuria-and-vascular-dysfunction-in-patients-with-type-2-diabetes
#8
Mihoko Kurano, Sahar Ghavidel Darestani, Atsushi Shinnakasu, Kiyoaki Yamamoto, Yukari Dochi, Kayo Uemura, Yuko Ikeda, Akira Kikuchi, Hiroshi Hashiguchi, Takahisa Deguchi, Yoshihiko Nishio
AIMS: Renal dysfunction in addition to diabetes is a serious risk factor for cardiovascular events. We hypothesized that some of the changes in gene expression in blood cells cause renal dysfunction and macrovascular disease through impaired endothelial function. This study aimed to define which changes in gene expression in peripheral blood mononuclear cells (PBMCs) are related to renal function parameters and endothelial function of large arteries in patients with type 2 diabetes mellitus (T2DM)...
December 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29247561/protein-altering-variants-of-ptpn2-in-childhood-onset-type-1a-diabetes
#9
M Okuno, T Ayabe, I Yokota, I Musha, K Shiga, T Kikuchi, N Kikuchi, A Ohtake, A Nakamura, K Nakabayashi, K Okamura, Y Momozawa, M Kubo, J Suzuki, T Urakami, T Kawamura, S Amemiya, T Ogata, S Sugihara, M Fukami
AIM: To conduct PTPN2 mutation analysis in Japanese people with childhood-onset Type 1A diabetes in order to examine whether PTPN2 variants contribute to the risk of this condition. METHODS: PTPN2 mutation analysis was carried out for 169 unrelated Japanese people with childhood-onset Type 1A diabetes. We searched for coding variants that were absent or extremely rare in the general population and were scored as damaging by multiple in silico programs. We performed mRNA analysis and three-dimensional structural prediction of the detected variants, when possible...
December 16, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29247200/association-of-plasma-free-amino-acids-with-hyperuricemia-in-relation-to-diabetes-mellitus-dyslipidemia-hypertension-and-metabolic-syndrome
#10
M H Mahbub, Natsu Yamaguchi, Hidekazu Takahashi, Ryosuke Hase, Yasutaka Ishimaru, Hiroshi Sunagawa, Hiroki Amano, Mikiko Kobayashi-Miura, Hideyuki Kanda, Yasuyuki Fujita, Hiroshi Yamamoto, Mai Yamamoto, Shinya Kikuchi, Atsuko Ikeda, Naoko Kageyama, Mina Nakamura, Tsuyoshi Tanabe
Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects without LSRDs (no-LSRD, n = 2805), and with diabetes mellitus (DM, n = 415), dyslipidemia (n = 3207), hypertension (n = 2736) and metabolic syndrome (MetS, n = 717). The concentrations of most amino acids differed significantly between the subjects with and without hyperuricemia (HU) and also between the no-LSRD and LSRD groups (p < 0...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29246252/fever-with-lymphadenopathy-kikuchi-fujimoto-disease-a-great-masquerader-a-case-report
#11
Chamara Dalugama, Indika Bandara Gawarammana
BACKGROUND: Kikuchi Fujimoto disease is an uncommon benign condition of necrotizing histiocytic lymphadenitis commonly seen in East Asian and Japanese populations. It commonly presents with fever, cervical lymphadenopathy, and elevated inflammatory markers. Diagnosis of Kikuchi Fujimoto disease is based on histopathological studies of the involved lymph nodes. The presentation of Kikuchi Fujimoto disease can mimic many sinister conditions including lymphoma. Treatment is mainly supportive provided that accurate diagnosis is made and sinister conditions like lymphoma ruled out...
December 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29241936/teriparatide-and-denosumab-treatment-for-pregnancy-and-lactation-associated-osteoporosis-with-multiple-vertebral-fractures-a-case-study
#12
Akifumi Ijuin, Hiromi Yoshikata, Ryoko Asano, Taku Tsuburai, Ritsuko Kikuchi, Hideya Sakakibara
OBJECTIVE: Pregnancy and lactation-associated osteoporosis (PLO) is a rare disease, which can lead to vertebral fractures in women of reproductive age. No treatment strategy for PLO has been established. Here we report a case of PLO treated with teriparatide followed by denosumab, in which remarkable improvement in bone mineral density (BMD) was achieved. CASE REPORT: A 27-year-old woman experienced severe back pain two weeks after her first delivery. PLO was diagnosed from her low BMD and multiple vertebral compression fractures...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29238000/elevation-of-serum-acid-sphingomyelinase-activity-in-children-with-acute-respiratory-syncytial-virus-bronchiolitis
#13
Shuichiro Yoshida, Atsuko Noguchi, Wataru Kikuchi, Hiroshi Fukaya, Kiyoshi Igarashi, Tsutomu Takahashi
Acid sphingomyelinase (ASM) is a lysosomal enzyme that hydrolyzes sphingomyelin into ceramide, a bioactive lipid to regulate cellular physiological functions. Thus, ASM activation has been reported as a key event in pathophysiological reactions including inflammation, cytokine release, oxidative stress, and endothelial damage in human diseases. Since ASM activation is associated with extracellular ASM secretion through unknown mechanisms, it can be detected by recognizing the elevation of secretory ASM (S-ASM) activity...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29230240/utility-of-endoscopic-examination-in-the-diagnosis-of-acute-graft-versus-host-disease-in-the-lower-gastrointestinal-tract
#14
Kosuke Nomura, Toshiro Iizuka, Daisuke Kaji, Hisashi Yamamoto, Yasutaka Kuribayashi, Masami Tanaka, Tsukasa Furuhata, Satoshi Yamashita, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Yasunori Ota, Shuichi Taniguchi, Shu Hoteya
Background and Aims: We retrospectively investigated the incidence of acute graft-versus-host disease (GVHD) in the lower gastrointestinal (GI) tract and the diagnostic accuracy of endoscopy. Methods: Of 1231 patients who underwent allogeneic hematopoietic stem cell transplantation between January 2005 and December 2014, 186 of whom underwent colonoscopy and biopsy and had no cytomegalovirus infection. The endoscopic findings and histologic diagnosis from these 186 patients were retrospectively analyzed...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29220607/case-of-cone-dystrophy-with-normal-fundus-appearance-associated-with-biallelic-poc1b-variants
#15
Azusa Kominami, Shinji Ueno, Taro Kominami, Ayami Nakanishi, Yasuki Ito, Kaoru Fujinami, Kazushige Tsunoda, Takaaki Hayashi, Sachiko Kikuchi, Shuhei Kameya, Takeshi Iwata, Hiroko Terasaki
BACKGROUND: Biallelic variants of POC1B were recently reported to cause autosomal recessive non-syndromic cone dystrophy. However, the number of studies supporting this is limited, and the clinical phenotypes of cone dystrophy have not been definitively determined. The purpose of this study was to report the phenotype of a case of POC1B-associated cone dystrophy. MATERIALS AND METHODS: The medical chart of one case diagnosed with cone dystrophy was reviewed. RESULTS: The patient was a 20-year-old Japanese man whose chief complaint was a progressive decrease in his central vision...
December 8, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29211010/meta-analysis-of-fecal-microbiota-and-metabolites-in-experimental-colitic-mice-during-the-inflammatory-and-healing-phases
#16
Toshifumi Osaka, Eri Moriyama, Shunichi Arai, Yasuhiro Date, Junji Yagi, Jun Kikuchi, Satoshi Tsuneda
The imbalance of gut microbiota is known to be associated with inflammatory bowel disease, but it remains unknown whether dysbiosis is a cause or consequence of chronic gut inflammation. In order to investigate the effects of gut inflammation on microbiota and metabolome, the sequential changes in gut microbiota and metabolites from the onset of colitis to the recovery in dextran sulfate sodium-induced colitic mice were characterized by using meta 16S rRNA sequencing and proton nuclear magnetic resonance (¹H-NMR) analysis...
December 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29202390/abnormal-functional-connectivity-of-high-frequency-rhythms-in-drug-na%C3%A3-ve-schizophrenia
#17
Tetsuya Takahashi, Takashi Goto, Sou Nobukawa, Yuji Tanaka, Mitsuru Kikuchi, Masato Higashima, Yuji Wada
OBJECTIVE: The "dysconnection hypothesis" has been proposed as a core neural basis for schizophrenia. Although growing neuroimaging-based evidence suggests atypical functional connectivity in patients with schizophrenia, the results are inconsistent and the effects of antipsychotic treatment remain elusive. METHODS: We performed resting-state electroencephalography (EEG) in 21 drug-naïve patients with schizophrenia (14 patients were re-evaluated after administration of antipsychotic treatment) and 31 age-matched healthy control subjects...
November 21, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29197466/kikuchi-fujimoto-disease-with-scalp-involvement
#18
A Combalia, X Fustà-Novell, A García-Herrera, J Ferrando
No abstract text is available yet for this article.
November 29, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29196910/radiopharmaceutical-tracers-for-cardiac-imaging
#19
Osamu Manabe, Tatsuya Kikuchi, Arthur J H A Scholte, Mohammed El Mahdiui, Ryuichi Nishii, Ming-Rong Zhang, Eriko Suzuki, Keiichiro Yoshinaga
Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Nuclear myocardial perfusion imaging with either single-photon emission computed tomography or positron emission tomography has been used extensively to perform diagnosis, monitor therapies, and predict cardiovascular events. Several radiopharmaceutical tracers have recently been developed to evaluate CVD by targeting myocardial perfusion, metabolism, innervation, and inflammation. This article reviews old and newer used in nuclear cardiac imaging...
December 1, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29190634/focal-segmental-glomerulosclerosis-associated-with-chronic-progressive-external-ophthalmoplegia-and-mitochondrial-dna-a3243g-mutation
#20
Kaori Narumi, Eikan Mishima, Yukako Akiyama, Tetsuro Matsuhashi, Takashi Nakamichi, Kiyomi Kisu, Shuhei Nishiyama, Hajime Ikenouchi, Akio Kikuchi, Rumiko Izumi, Mariko Miyazaki, Takaaki Abe, Hiroshi Sato, Sadayoshi Ito
Focal segmental glomerulosclerosis (FSGS) is caused by various etiologies, with mitochondrial dysfunction being one of the causes. FSGS is known to be associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), which is a subclass of mitochondrial disease. However, it has rarely been reported in other mitochondrial disease subclasses. Here, we reported a 20-year-old man diagnosed with FSGS associated with chronic progressive external ophthalmoplegia (CPEO) due to mitochondrial DNA (mtDNA) 3243A>G mutation...
November 30, 2017: Nephron
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