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https://www.readbyqxmd.com/read/28806027/a-rare-case-of-lymphadenopathy-kikuchi-fujimoto-disease
#1
Josh Rezkalla, Douglas W Lynch
A relatively unknown cause of cervical lymphadenopathy is Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis. This is a rare and benign condition that presents with painful cervical lymphadenopathy, fevers, night sweats, and weight loss. This disease is most prevalent in Asian women between the age of 20-35 years. The diagnosis of Kikuchi Disease is made histologically and is characterized by paracortical areas of necrosis and a notable complete absence of neutrophils. The painful lymphadenopathy can be simply treated with antipyretics, but due to its presenting symptoms of Kikuchi disease, it is often mistaken for malignant lymphoma...
July 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28776316/a-case-of-sigmoid-colon-adenocarcinoma-diagnosed-as-facial-cutaneous-metastasis-for-survival-after-operation-for-37%C3%A2-months
#2
Junji Ueda, Hiroshi Yoshida, Hiroshi Makino, Hiroshi Maruyama, Tadashi Yokoyama, Atsushi Hirakata, Hideyuki Takata, Natsuki Seki, Yuta Kikuchi, Eiji Uchida
Cutaneous metastasis of an internal malignancy is uncommon and is estimated to occur in 0.7-9% of patients with internal cancer including autopsy cases. We would like to report a case of long survival of sigmoid colon adenocarcinoma diagnosed as an instance of facial cutaneous metastasis. A 68-year-old male was admitted to our hospital for a tumor mass on the left side of his cheek. In his past history, acute myocardial infarction had occurred 2 years earlier. He also had chronic renal failure and chronic obstructive pulmonary disease...
August 3, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28764185/kikuchi-fujimoto-disease-masquerading-as-acute-appendicitis
#3
Vinita Pandey, Yasmeen Khatib, Rahul Pandey, Archana L Khade, Manisha Khare
Kikuchi-Fujimoto Disease (KFD) is a self-limiting necrotizing lymphadenitis that usually presents with fever and cervical lymphadenopathy. Recognition of this condition is crucial, because it can be mistaken for tuberculosis, lymphoma and connective tissue disorders. When present at an unusual location the diagnosis can be challenging. We present an unusual case of Kikuchi-Fujimoto disease involving mesenteric lymph node masquerading as acute appendicitis along with its differential diagnosis. A 30-year-old female presented with complaints of acute abdominal pain, vomiting and fever...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28754237/treatment-of-larva-migrans-syndrome-with-long-term-administration-of-albendazole
#4
Amy Hombu, Ayako Yoshida, Taisei Kikuchi, Eiji Nagayasu, Mika Kuroki, Haruhiko Maruyama
BACKGROUND: Larva migrans syndrome is a food-borne parasitic disease in humans, caused by accidental ingestion of eggs or larvae of ascarid nematodes, namely, Toxocara canis, Toxocara cati, or Ascaris suum, the roundworms commonly found in the intestines of dogs, cats and pigs respectively. When a patient is diagnosed as having larva migrans syndrome, oral-administration of albendazole is recommended, however, the regimen remains controversial worldwide. In Japan, the duration of albendazole administration is longer than those of European and North American countries...
July 14, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28742156/ct-pattern-analysis-of-necrotizing-and-nonnecrotizing-lymph-nodes-in-kikuchi-disease
#5
Eun Jung Shim, Kyung Mi Lee, Eui Jong Kim, Hyug-Gi Kim, Ji Hye Jang
OBJECTIVE: The purpose of this study was to determine whether a CT interpretation with imaging pattern analysis differentiates Kikuchi disease (KD) from the two more frequently encountered differential lymph nodes diagnoses of tuberculous lymphadenopathy (TL) and reactive hyperplasia (RH). MATERIALS AND METHODS: Between January 2012 and July 2015, 20 patients with KD (6 men, 14 women; mean age, 27.80 years), 36 patients with RH (10 men, 26 women; mean age, 33.08 years) and 34 patients with TL (17 men, 17 women; mean age, 39...
2017: PloS One
https://www.readbyqxmd.com/read/28741050/risk-factors-for-progression-of-chronic-kidney-disease-in-the-eppic-trials-and-the-effect-of-ast-120
#6
Gerald Schulman, Tomas Berl, Gerald J Beck, Giuseppe Remuzzi, Eberhard Ritz, Miho Shimizu, Mami Kikuchi, Yuko Shobu
BACKGROUND: Two randomized, double-blind, placebo-controlled trials (EPPIC-1 and EPPIC-2) investigated the efficacy and safety of AST-120, an oral spherical carbon adsorbent, in adults with chronic kidney disease (CKD). While the benefit of adding AST-120 to standard therapy was not supported by these trials, we performed a post hoc analysis to focus on CKD progression and to determine the risk factors for the primary endpoint in the EPPIC trial population. METHODS: In the EPPIC trials, patients were randomly assigned 1:1 to treatment with AST-120 or placebo...
July 24, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28739049/polyporus-and-bupleuri-radix-effectively-alter-peripheral-circadian-clock-phase-acutely-in-male-mice
#7
Hiroaki Motohashi, Haruna Sukigara, Yu Tahara, Keisuke Saito, Mayu Yamazaki, Takuya Shiraishi, Yosuke Kikuchi, Atsushi Haraguchi, Shigenobu Shibata
In mammals, daily physiological events are precisely regulated by an internal circadian clock system. An important function of this system is to readjust the phase of the clock daily. In Japan, traditional herb medicines, so-called crude drugs (Shoyaku), are widely used for many diseases, and some are reported to affect circadian clock impairment, suggesting that some of them might have an ability to modify clock gene expression rhythms. Therefore, from selected 40 crude drugs, finding candidates that control the circadian clock phases was the first purpose of this study...
July 2017: Nutrition Research
https://www.readbyqxmd.com/read/28725300/epstein-barr-virus-ebv-associated-epithelial-and-non-epithelial-lesions-of-the-oral-cavity
#8
REVIEW
Kentaro Kikuchi, Harumi Inoue, Yuji Miyazaki, Fumio Ide, Masaru Kojima, Kaoru Kusama
Epstein-Barr virus (EBV) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (LPDs) in immunocompromised patients. EBV, a B-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. Furthermore, EBV is associated with epithelial malignancies such as nasopharyngeal carcinoma (NPC), salivary gland tumor, gastric carcinoma and breast carcinoma. In terms of oral disease, there have been several reports of EBV-related oral squamous cell carcinoma (OSCC) worldwide...
August 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28721279/age-related-circadian-disorganization-caused-by-sympathetic-dysfunction-in-peripheral-clock-regulation
#9
Yu Tahara, Yuta Takatsu, Takuya Shiraishi, Yosuke Kikuchi, Mayu Yamazaki, Hiroaki Motohashi, Aya Muto, Hiroyuki Sasaki, Atsushi Haraguchi, Daisuke Kuriki, Takahiro J Nakamura, Shigenobu Shibata
The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. To date, little is known about age-related changes in the entrainment of peripheral clocks to external cues. We therefore evaluated the ability of the peripheral clocks of the kidney, liver, and submandibular gland to be entrained by external stimuli including light, food, stress, and exercise in young versus aged mice using in vivo bioluminescence monitoring...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28720684/fsgs-as-an-adaptive-response-to-growth-induced-podocyte-stress
#10
Ryuzoh Nishizono, Masao Kikuchi, Su Q Wang, Mahboob Chowdhury, Viji Nair, John Hartman, Akihiro Fukuda, Larysa Wickman, Jeffrey B Hodgin, Markus Bitzer, Abhijit Naik, Jocelyn Wiggins, Matthias Kretzler, Roger C Wiggins
Glomerular sclerotic lesions develop when the glomerular filtration surface area exceeds the availability of podocyte foot process coverage, but the mechanisms involved are incompletely characterized. We evaluated potential mechanisms using a transgenic (podocin promoter-AA-4E-BP1) rat in which podocyte capacity for hypertrophy in response to growth factor/nutrient signaling is impaired. FSGS lesions resembling human FSGS developed spontaneously by 7 months of age, and could be induced earlier by accelerating kidney hypertrophy by nephrectomy...
July 18, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28695380/macular-capillary-recovery-in-systemic-lupus-erythematosus-complicated-by-kikuchi-fujimoto-disease
#11
Reiko Kinouchi, Motoshi Kinouchi, Akihiro Ishibazawa, Akitoshi Yoshida
PURPOSE: Few case reports have described vaso-occlusive retinopathy in systemic lupus erythematosus (SLE) using optical coherence tomography (OCT) angiography. Here we report the clinical features of a patient with SLE, complicated by Kikuchi-Fujimoto disease, who developed vaso-occlusive retinopathy. We then describe the subsequent recovery of the macular capillaries as assessed by OCT angiography. CASE: A 16-year-old male was referred to us with fever, a 1-month history of violaceous red papules and erythematous plaques on his face and a painful nodule in his right neck...
July 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28693162/kikuchi-fujimoto-disease-in-the-regional-lymph-nodes-with-node-metastasis-in-a-patient-with-tongue-cancer-a-case-report-and-literature-review
#12
Tessho Maruyama, Kazuhide Nishihara, Masanao Saio, Toshiyuki Nakasone, Fumikazu Nimura, Akira Matayoshi, Takahiro Goto, Naoki Yoshimi, Akira Arasaki
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare self-limiting disorder typically affecting the cervical lymph nodes (LNs), which is often misdiagnosed as other LN-associated diseases. KFD frequently presents with necrotic lesions and recurrences, which are also features of metastatic LNs. Clinicians may thus suspect LN metastasis when they encounter ipsilateral cervical lymphadenopathy in a patient with head and neck cancer. The present study reports the case of a 48-year-old man with tongue cancer and KFD affecting the right edge of his tongue and ipsilateral cervical LNs...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28685308/pseudo-autologous-stem-cell-transplantation-for-donor-derived-mantle-cell-lymphoma-12%C3%A2-years-after-allogeneic-transplantation
#13
Masaharu Tamaki, Hidenori Wada, Ayumi Gomyo, Jin Hayakawa, Yu Akahoshi, Naonori Harada, Machiko Kusuda, Yuko Ishihara, Koji Kawamura, Aki Tanihara, Miki Sato, Kiriko Terasako-Saito, Kazuaki Kameda, Misato Kikuchi, Shun-Ichi Kimura, Hideki Nakasone, Shinichi Kako, Yoshinobu Kanda
Donor-derived malignancy is a rare morbidity after allogeneic hematopoietic stem cell transplantation (HSCT), in which most previous cases have presented as acute leukemia or myelodysplastic syndrome. There have, however, been very few reports of donor-derived lymphoma. Here, we present a case of donor-derived mantle cell lymphoma 12 years after allogeneic HSCT, which was successfully treated with chemotherapy followed by pseudo-autologous HSCT (pASCT), i.e., an autologous HSC transplant following allogeneic HSCT in which the infused stem cell is considered to be derived from the donor cells...
July 6, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28681912/occludin-as-a-functional-marker-of-vascular-endothelial-cells-on-tube-forming-activity
#14
Toshie Kanayasu-Toyoda, Akiko Ishii-Watabe, Yutaka Kikuchi, Hiroko Kitagawa, Hiroko Suzuki, Hiroomi Tamura, Minoru Tada, Takuo Suzuki, Hiroyuki Mizuguchi, Teruhide Yamaguchi
Cell therapy using endothelial progenitor cells (EPCs) is a promising strategy for the treatment of ischemic diseases. Two types of EPCs have been identified: early EPCs and late EPCs. Late EPCs are able to form tube structure by themselves, and have a high proliferative ability. The functional marker(s) of late EPCs, which relate to their therapeutic potential, have not been fully elucidated. Here we compared the gene expression profiles of several human cord blood derived late EPC lines which exhibit different tube formation activity, and we observed that the expression of occludin (OCLN) in these lines correlated with the tube formation ability, suggesting that OCLN is a candidate functional marker of late EPCs...
July 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28680009/contrast-enhanced-harmonic-endoscopic-ultrasonography-in-gallbladder-cancer-and-pancreatic-cancer
#15
Mitsuru Sugimoto, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuichi Waragai, Mika Takasumi, Yuki Sato, Takuto Hikichi, Hiromasa Ohira
Endoscopic ultrasonography (EUS) plays a major role in diagnosing gallbladder (GB) cancer and pancreatic cancer (PC). In cases of GB cancer, EUS allows for precise observations of morphology and wall layers. However, proficiency is required for the morphologic diagnosis of GB tumors. Therefore, contrast-enhanced harmonic EUS (CH-EUS) began to be performed to diagnose GB lesions. CH-EUS enables real-time observation of the hemodynamics of GB tumors. The enhanced patterns generated by CH-EUS improve precision in the diagnosis of such tumors...
July 5, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28677058/structural-changes-in-parkinson-s-disease-voxel-based-morphometry-and-diffusion-tensor-imaging-analyses-based-on-123-i-mibg-uptake
#16
Kazufumi Kikuchi, Akio Hiwatashi, Osamu Togao, Koji Yamashita, Ryo Somehara, Ryotaro Kamei, Shingo Baba, Hiroo Yamaguchi, Jun-Ichi Kira, Hiroshi Honda
OBJECTIVE: Patients with Parkinson's disease (PD) may exhibit symptoms of sympathetic dysfunction that can be measured using (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. We investigated the relationship between microstructural brain changes and (123)I-MIBG uptake in patients with PD using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) analyses. METHODS: This retrospective study included 24 patients with PD who underwent 3 T magnetic resonance imaging and (123)I-MIBG scintigraphy...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28638624/kikuchi-fujimoto-disease-a-case-report-of-a-multi-drug-resistant-grueling-disease
#17
Alexey Youssef, Rahaf Ali, Kinan Ali, Zuheir AlShehabi
Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto disease (KFD) is characterized by its rare occurrence. Mostly prevalent among Asian women, KFD manifests with lymphadenopathy-affecting mostly cervical and rarely generalized or retroperitoneal regions-in addition to fever. It is a self-limited disease that resolves within 1-4 months, responding remarkably to glucocorticosteroids or hydroxychloroquine. However, some rare cases prove to be unresponsive to the previously mentioned therapies. Here is a description of a case of KFD affecting a 67-year-old Syrian woman with a history of hypothyroidism due to iodine-deficiency...
June 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28617827/nog-hil-4-tg-a-new-humanized-mouse-model-for-producing-tumor-antigen-specific-igg-antibody-by-peptide-vaccination
#18
Yoshie Kametani, Ikumi Katano, Asuka Miyamoto, Yusuke Kikuchi, Ryoji Ito, Yukari Muguruma, Banri Tsuda, Sonoko Habu, Yutaka Tokuda, Kiyoshi Ando, Mamoru Ito
Immunodeficient mice transplanted with human peripheral blood mononuclear cells (PBMCs) are promising tools to evaluate human immune responses to vaccines. However, these mice usually develop severe graft-versus-host disease (GVHD), which makes estimation of antigen-specific IgG production after antigen immunization difficult. To evaluate antigen-specific IgG responses in PBMC-transplanted immunodeficient mice, we developed a novel NOD/Shi-scid-IL2rγnull (NOG) mouse strain that systemically expresses the human IL-4 gene (NOG-hIL-4-Tg)...
2017: PloS One
https://www.readbyqxmd.com/read/28613919/hypercapnia-accelerates-adipogenesis-a-novel-role-of-high-co2-in-exacerbating-obesity
#19
Ryota Kikuchi, Takao Tsuji, Osamu Watanabe, Kazuhiro Yamaguchi, Kinya Furukawa, Hiroyuki Nakamura, Kazutetsu Aoshiba
Obesity is a major risk factor for the development of obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS), which manifest as intermittent hypercapnia and sustained plus intermittent hypercapnia, respectively. In this study, we investigated whether CO2 affects adipocyte differentiation (adipogenesis) and maturation (hypertrophy). Human visceral or subcutaneous preadipocytes were grown to confluence and then induced to differentiate to adipocytes under hypocapnia, normocapnia, and hypercapnia with or without hypoxia...
June 14, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28594066/novel-biallelic-mutations-in-the-pnpt1-gene-encoding-a-mitochondrial-rna-import-protein-pnpase-cause-delayed-myelination
#20
Ryo Sato, Natsuko Arai-Ichinoi, Atsuo Kikuchi, Tetsuro Matsuhashi, Yurika Numata-Uematsu, Mitsugu Uematsu, Yuji Fujii, Kei Murayama, Akira Ohtake, Takaaki Abe, Shigeo Kure
Recent studies suggest that impaired transcription or mitochondrial translation of small RNAs can cause abnormal myelination. A polynucleotide phosphorylase (PNPase) encoded by PNPT1 facilitates the import of small RNAs into mitochondria. PNPT1 mutations have been reported in patients with neurodevelopmental diseases with mitochondrial dysfunction. We report here two siblings with PNPT1 mutations who presented delayed myelination as well as mitochondrial dysfunction. We identified compound heterozygous mutations (c...
June 8, 2017: Clinical Genetics
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