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Magnesium deficiency

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https://www.readbyqxmd.com/read/28915968/magnesium-to-counteract-elastin-degradation-and-vascular-calcification-in-chronic-obstructive-pulmonary-disease
#1
Rob Janssen
Accelerated elastin degradation is an important pathogenic mechanism in chronic obstructive pulmonary disease (COPD) leading to irreversible lung function loss and cardiovascular comorbidities. The rate of elastin breakdown is a predictor of mortality in patients with COPD. Decelerating elastinolysis might be an attractive therapeutic target in this debilitating condition. Vascular calcification starts in the elastin network of the arterial wall and is enhanced in patients with COPD. Elastin calcification is accompanied by an upregulation of matrix metalloproteinase gene expression and consequently a shift in the elastase/anti-elastase balance towards degradation...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28877896/intake-of-potassium-and-magnesium-enriched-salt-improves-functional-outcome-after-stroke-a-randomized-multicenter-double-blind-controlled-trial
#2
Wen-Harn Pan, Ying-Ho Lai, Wen-Ting Yeh, Jiunn-Rong Chen, Jiann-Shing Jeng, Chyi-Huey Bai, Ruey-Tay Lin, Tsong-Hai Lee, Ku-Chou Chang, Huey-Juan Lin, Chin-Fu Hsiao, Chang-Ming Chern, Li-Ming Lien, Chung-Hsiang Liu, Wei-Hung Chen, Anna Chang
Background: Stroke is one of the leading causes of mortality and neurologic deficits. Management measures to improve neurologic outcomes are in great need. Our previous intervention trial in elderly subjects successfully used salt as a carrier for potassium, demonstrating a 41% reduction in cardiovascular mortality by switching to potassium-enriched salt. Dietary magnesium has been associated with lowered diabetes and/or stroke risk in humans and with neuroprotection in animals.Objective: Because a large proportion of Taiwanese individuals are in marginal deficiency states for potassium and for magnesium and salt is a good carrier for minerals, it is justifiable to study whether further enriching salt with magnesium at an amount near the Dietary Reference Intake (DRI) amount may provide additional benefit for stroke recovery...
September 6, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28871398/effect-of-pulsed-electric-fields-pef-on-accumulation-of-magnesium-in-lactobacillus-rhamnosus-b-442-cells
#3
Małgorzata Góral, Urszula Pankiewicz
The aim of this study was to determine the effect of pulsed electric fields (PEF) on accumulation of magnesium ions in Lactobacillus rhamnosus B 442 cells. Under optimized conditions, this is, on 15 min exposure of the 20 h grown culture to PEF of the 2.0 kV/cm and 20 µs pulse width at concentration 400 μg Mg(2+)/mL medium, accumulation of magnesium in the biomass reached maximum 4.28 mg/g d.m. Optimization of PEF parameters caused an increase of magnesium concentration in the cells by 220% in comparison to the control not treated with PEF...
September 4, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28871377/the-maize-cora-mrs2-mgt-type-mg-transporter-zmmgt10-responses-to-magnesium-deficiency-and-confers-low-magnesium-tolerance-in-transgenic-arabidopsis
#4
Hongyou Li, Ning Wang, Jianzhou Ding, Chan Liu, Hanmei Du, Kaifeng Huang, Moju Cao, Yanli Lu, Shibin Gao, Suzhi Zhang
ZmMGT10 was specifically expressed in maize roots and induced by a deficiency of magnesium. Overexpression of ZmMGT10 restored growth deficiency of the Salmonella typhimurium MM281 strain and enhanced the tolerance in Arabidopsis to stress induced by low magnesium levels by increasing uptake of Mg(2+) via roots. CorA/MRS2/MGT-type Mg(2+) transporters play a significant role in maintaining magnesium (Mg) homeostasis in plants. Although the maize CorA/MRS2/MGT family comprises of 12 members, currently no member has been functionally characterized...
September 4, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28870199/effects-of-dietary-gelatin-hydrolysates-on-bone-mineral-density-in-magnesium-deficient-rats
#5
Teruyuki Noma, Satoshi Takasugi, Miho Shioyama, Taketo Yamaji, Hiroyuki Itou, Yoshio Suzuki, Keishoku Sakuraba, Keisuke Sawaki
BACKGROUND: The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal models. In contrast, there is limited study showing the effects of dietary gelatin hydrolysates from fish on BMD. The quantity and structure of peptides in the plasma after oral administration of gelatin hydrolysates depend on the gelatin source, which suggests that the biological activity of gelatin hydrolysates depend on the gelatin source...
September 5, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28866256/evaluation-of-ecdysteroid-antisera-for-a-competitive-enzyme-immunoassay-and-extraction-procedures-for-the-measurement-of-mosquito-ecdysteroids
#6
David A McKinney, Michael R Strand, Mark R Brown
Ecdysteroid hormones regulate several aspects of insect development and reproduction. The predominant ecdysteroids produced by insects including mosquitoes are ecdysone (E) and 20-hydroxyecdysone (20E). The ability to measure E and 20E titers is essential for many studies, but few sensitive, low cost options are currently available for doing so. To address this deficiency, we developed a new enzyme-linked immunoassay (EIA). In the first part of the study, we compared the affinity of two new antisera named EAB25 and EAB27 to other available ecdysteroid antisera...
September 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28836935/microrna-mediated-responses-to-long-term-magnesium-deficiency-in-citrus-sinensis-roots-revealed-by-illumina-sequencing
#7
Wei-Wei Liang, Jing-Hao Huang, Chun-Ping Li, Lin-Tong Yang, Xin Ye, Dan Lin, Li-Song Chen
BACKGROUND: Magnesium (Mg)-deficiency occurs most frequently in strongly acidic, sandy soils. Citrus are grown mainly on acidic and strong acidic soils. Mg-deficiency causes poor fruit quality and low fruit yield in some Citrus orchards. For the first time, we investigated Mg-deficiency-responsive miRNAs in 'Xuegan' (Citrus sinensis) roots using Illumina sequencing in order to obtain some miRNAs presumably responsible for Citrus Mg-deficiency tolerance. RESULTS: We obtained 101 (69) miRNAs with increased (decreased) expression from Mg-starved roots...
August 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28828979/chronic-latent-magnesium-deficiency-in-obesity-decreases-positive-effects-of-vitamin-d-on-cardiometabolic-risk-indicators
#8
Edita Stokic, Andrea Romani, Branislava Ilincic, Aleksandar Kupusinac, Zoran Stosic, Esma R Isenovic
BACKGROUND: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and cardiovascular disease (CVD). OBJECTIVE: We examined the frequency of concomitant deficit of magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. METHOD: Non-diabetic middle aged adults (n = 80; mean age 36 ± 4 years, 52% women) were recruited based on weight/adiposity parameters [i...
August 21, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28828060/prevalence-of-vitamin-d-insufficiency-in-children-with-forearm-fractures
#9
Y Saglam, H Kizildag, G Toprak, N B Alp, E Y Yalcinkaya
PURPOSE: This study aimed to determine whether children with distal radius impaction fractures have increased prevalence of 25-hydroxyvitamin D (25(OH) D) insufficiency compared with healthy controls. PATIENTS AND METHODS: This is a prospective controlled study. The 30 children who were diagnosed with forearm fracture at the orthopaedic emergency clinic were included in the study and 30 healthy children from the routine paediatric outpatient unit were included as the control group...
June 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28822768/functional-dissection-and-transport-mechanism-of-magnesium-in-plants
#10
REVIEW
Zhi Chang Chen, Wen Ting Peng, Jian Li, Hong Liao
Magnesium (Mg) is the second most abundant cation in plants, and, as such, is involved in numerous physiological and biochemical processes, including photosynthesis, enzyme activation, and synthesis of nucleic acids and proteins. Due to its relatively small ionic radius and large hydrated radius, Mg binds weakly to soil and root surfaces, and thereby is easily leached from soil. Mg deficiency not only affects crop productivity and quality, but also contributes to numerous chronic human diseases. Therefore, Mg nutrition in plants is an important issue in nutrition and food security...
August 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28806179/interpreting-magnesium-status-to-enhance-clinical-care-key-indicators
#11
Rebecca B Costello, Forrest Nielsen
PURPOSE OF REVIEW: To update advances in identifying factors affecting magnesium (Mg) status that assist in providing improved evidence-based clinical decision-making for assessing Mg status. RECENT FINDINGS: Findings from recent cohort studies, small randomized control trials, and multiple meta-analyses reinforce earlier work that serum Mg concentrations, urinary Mg excretion, and Mg dietary intakes are inversely associated with cardiovascular disease, chronic kidney disease, and diabetes...
August 12, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28806048/electrolytes-calcium-disorders
#12
Craig Barstow
A normal serum calcium level is 8 to 10 mg/dL. The diagnosis of hypercalcemia (ie, levels 10.5 mg/dL or greater) should be confirmed with an albumin-adjusted or ionized calcium level. The two most common causes of hypercalcemia are hyperparathyroidism and malignancy. Drugs, notably lithium and thiazide diuretics, also can cause hypercalcemia. Patients with severe or symptomatic hypercalcemia should be treated initially with hydration to decrease calcium levels. The evaluation should include a parathyroid hormone (PTH) level...
August 2017: FP Essentials
https://www.readbyqxmd.com/read/28792457/impact-of-frequency-of-multi-vitamin-multi-mineral-supplement-intake-on-nutritional-adequacy-and-nutrient-deficiencies-in-u-s-adults
#13
Jeffrey B Blumberg, Balz B Frei, Victor L Fulgoni, Connie M Weaver, Steven H Zeisel
Although >50% of U.S. adults use dietary supplements, little information is available on the impact of supplement use frequency on nutrient intakes and deficiencies. Based on nationally representative data in 10,698 adults from the National Health and Nutrition Examination Surveys (NHANES) 2009 to 2012, assessments were made of intakes from food alone versus food plus multi-vitamin/multi-mineral supplements (MVMS) of 17 nutrients with an Estimated Average Requirement (EAR) and a Tolerable Upper Intake Level (UL), and of the status of five nutrients with recognized biomarkers of deficiency...
August 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28771408/promoting-early-child-development-with-interventions-in-health-and-nutrition-a-systematic-review
#14
REVIEW
Tyler Vaivada, Michelle F Gaffey, Zulfiqar A Bhutta
CONTEXT: Although effective health and nutrition interventions for reducing child mortality and morbidity exist, direct evidence of effects on cognitive, motor, and psychosocial development is lacking. OBJECTIVE: To review existing evidence for health and nutrition interventions affecting direct measures of (and pathways to) early child development. DATA SOURCES: Reviews and recent overviews of interventions across the continuum of care and component studies...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28768651/combined-bioavailable-isoflavones-and-probiotics-improve-bone-status-and-estrogen-metabolism-in-postmenopausal-osteopenic-women-a-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Max Norman Tandrup Lambert, Catrine Bundgaard Thybo, Simon Lykkeboe, Lars Melholt Rasmussen, Xavier Frette, Lars Porskjær Christensen, Per Bendix Jeppesen
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therapy is demonstrated to increase cancer risk. Bioavailable isoflavones with selective estrogen receptor affinity show potential to prevent and treat osteoporosis while minimizing or eliminating carcinogenic side effects.Objective: In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28764146/role-of-anaemia-and-magnesium-levels-at-the-initiation-of-tuberculosis-therapy-with-sputum-conversion-among-pulmonary-tuberculosis-patients
#16
Yuthika Agrawal, Vipin Goyal, Abhishek Singh, Sandhya Lal
INTRODUCTION: Both pulmonary Tuberculosis (TB) and anaemia are prevalent in India. Magnesium levels also influence TB. There is limited and inconsistent literature on the association among anaemia, serum magnesium levels and sputum conversion during tuberculosis treatment. AIM: To study the effect of anaemia and serum magnesium levels on sputum conversion in pulmonary TB patients. MATERIALS AND METHODS: One hundred each of newly diagnosed sputum smear positive Pulmonary Tuberculosis (PTB), sputum smear negative PTB patients initiated on Directly Observed Treatment Short Course chemotherapy (DOTS) and healthy age and sex matched controls were recruited in the study...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28746059/nutrition-micronutrients-in-child-growth-and-development-a-systematic-review-on-current-evidence-recommendations-and-opportunities-for-further-research
#17
Mohammad Yawar Yakoob, Clifford W Lo
OBJECTIVE: An important aspect of malnutrition is deficiency of different micronutrients during pregnancy or early childhood. We systematically reviewed the role of nutrition in child growth (weight or height gain) and development. METHODS: A comprehensive literature search was done on PubMed/Cochrane Library browsing through 38,795 abstracts until December 31, 2016 to select systematic reviews/meta-analyses and individual randomized controlled trials (RCTs) of micronutrient supplementation...
July 25, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28742311/an-analysis-of-selected-risk-factors-of-osteoporosis-%C3%A2-dietary-patterns-and-physical-activity-%C3%A2-in-pubescent-girls-from-the-lubelskie-province
#18
Anna Czeczuk, Elżbieta Huk-Wieliczuk, Agnieszka Dmitruk, Helena Popławska
INTRODUCTION: Peak bone mass is modulated by intrinsic (genetic) and extrinsic factors, such as diet, physical activity, stimulants and medications. Approximately 80-85% of peak bone mass is achieved during puberty. OBJECTIVE: The aim of the study was to analyze selected risk factors for osteoporosis, specifically diet and physical activity, in 10- to 15-year-old girls. MATERIAL AND METHODS: The study included 461 girls from Eastern Poland (Lublin Province)...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28710691/monitoring-of-inland-waters-for-culturing-shrimp-litopenaeus-vannamei-application-of-a-method-based-on-survival-and-chemical-composition
#19
G Valencia-Castañeda, M I Millán-Almaraz, J F Fierro-Sañudo, M G Fregoso-López, F Páez-Osuna
This study evaluated the suitability of 21 inland waters (16 well waters and 5 surface waters) from Northwest Mexico via short- (48 h) and medium-term (28 days) tests using postlarvae (PL18) of Litopenaeus vannamei. In the short test, survival was assessed at 48 h after shrimp were placed in groups of 10 postlarvae into 2-L containers of inland water, to which they had been previously acclimated. The second, medium-term test consisted of four replicates with 10 postlarvae, and each group was placed in 15-L containers with the treatment water...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28690617/transcriptomic-analysis-of-soil-grown-t-aestivum-cv-root-to-reveal-the-changes-in-expression-of-genes-in-response-to-multiple-nutrients-deficiency
#20
Saurabh Gupta, Brijesh S Yadav, Utkarsh Raj, Shiri Freilich, Pritish K Varadwaj
Deficiency of necessary macronutrients, i.e., Potassium (K), Magnesium (Mg), Nitrogen (N), Phosphorus (P), and Sulfate (S) in the soil leads to a reduction in plant growth and yield, which is a result of changes in expression level of various genes. This study was performed to identify the differentially expressed genes and its associated metabolic pathways occurred in soil grown wheat root samples excavated from the control and treated fields. To identify the difference in gene expression levels due to deficiency of the said nutrients, a transcriptomic, meta-analysis was performed on array expression profile data...
2017: Frontiers in Plant Science
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