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https://www.readbyqxmd.com/read/28087725/neurodevelopmental-outcomes-of-extremely-low-birthweight-infants-randomised-to-different-pco2-targets-the-phelbi-follow-up-study
#1
Ulrich H Thome, Orsolya Genzel-Boroviczeny, Bettina Bohnhorst, Manuel Schmid, Hans Fuchs, Oliver Rohde, Stefan Avenarius, Hans-Georg Topf, Andrea Zimmermann, Dirk Faas, Katharina Timme, Barbara Kleinlein, Horst Buxmann, Wilfried Schenk, Hugo Segerer, Norbert Teig, Annett Bläser, Roland Hentschel, Matthias Heckmann, Rolf Schlösser, Jochen Peters, Rainer Rossi, Wolfgang Rascher, Ralf Böttger, Jürgen Seidenberg, Gesine Hansen, Maria Zernickel, Harald Bode, Jens Dreyhaupt, Rainer Muche, Helmut D Hummler
BACKGROUND: Tolerating higher partial pressures of carbon dioxide (PCO2) in mechanically ventilated extremely low birthweight infants to reduce ventilator-induced lung injury may have long-term neurodevelopmental side effects. This study analyses the results of neurodevelopmental follow-up of infants enrolled in a randomised multicentre trial. METHODS: Infants (n=359) between 400 and 1000 g birth weight and 23 0/7-28 6/7 weeks gestational age who required endotracheal intubation and mechanical ventilation within 24 hours of birth were randomly assigned to high PCO2 or to a control group with mildly elevated PCO2 targets...
January 13, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28086969/multicenter-neonatal-databases-trends-in-research-uses
#2
Liza M Creel, Sean Gregory, Catherine J McNeal, Madhava R Beeram, David R Krauss
BACKGROUND: In the US, approximately 12.7% of all live births are preterm, 8.2% of live births were low birth weight (LBW), and 1.5% are very low birth weight (VLBW). Although technological advances have improved mortality rates among preterm and LBW infants, improving overall rates of prematurity and LBW remains a national priority. Monitoring short- and long-term outcomes is critical for advancing medical treatment and minimizing morbidities associated with prematurity or LBW; however, studying these infants can be challenging...
January 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28086763/the-prevalence-and-factors-associated-with-malnutrition-among-infants-with-cleft-palate-and-or-lip-at-a-hospital-in-uganda-a-cross-sectional-study
#3
Martin Tungotyo, Daniel Atwine, Deborah Nanjebe, Andrew Hodges, Martin Situma
BACKGROUND: To determine the prevalence and factors associated with malnutrition among infants with Cleft palate and/or cleft lip (CP+/-L) at Comprehensive Rehabilitation for Uganda Hospital (CoRSU) in Uganda. METHODS: This was a cross-sectional study done on infants with CP+/-L and their caretakers admitted between November 2013 and October 2014 at CoRSU hospital which was the study setting. A questionnaire was answered by the infants' caretakers. The main outcome measure, malnutrition was defined and classified based on Z-scores obtained using the W...
January 13, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28081574/gstp1-and-cyp2b6-genetic-polymorphisms-and-the-risk-of-bronchopulmonary-dysplasia-in-preterm-neonates
#4
Sophia Zachaki, Aggeliki Daraki, Elena Polycarpou, Chrysa Stavropoulou, Kalliopi N Manola, Stavroula Gavrili
Objectives Antioxidant response plays a key role in bronchopulmonary dysplasia (BPD) pathogenesis. The glutathione-S-tranferases pi 1 (GSTP1) and cytochrome P450 (CYP) detoxification enzymes protect cells from oxidative damage. The aim of the study was to investigate whether the A(313)G GSTP1 and G(516)T CYP2B6 inactivating polymorphisms could be associated with BPD susceptibility. Study Design To test this hypothesis, we conducted a case-control study enrolled 138 premature neonates ≤32 weeks of gestational age; of the 138, 46 developed BPD and 92 did not develop BPD...
January 12, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28081150/the-association-of-birth-weight-and-infant-growth-with-energy-balance-related-behavior-a-systematic-review-and-best-evidence-synthesis-of-human-studies
#5
Arend W van Deutekom, Mai J M Chinapaw, Elise P Jansma, Tanja G M Vrijkotte, Reinoud J B J Gemke
BACKGROUND: Suboptimal prenatal and early postnatal growths are associated with obesity in later life, but the underlying mechanisms are unknown. The aim of this study was to systematically review the literature that reports on the longitudinal association of (i) birth size or (ii) infant growth with later (i) energy intake, (ii) eating behaviors, (iii) physical activity or (iv) sedentary behavior in humans. METHODS: A comprehensive search of MEDLINE, EMBASE, PsycINFO and The Cochrane Library was conducted to identify relevant publications...
2017: PloS One
https://www.readbyqxmd.com/read/28081048/a-prospective-cohort-study-of-common-childhood-infections-in-south-african-hiv-exposed-uninfected-and-hiv-unexposed-infants
#6
Amy L Slogrove, Monika M Esser, Mark F Cotton, David P Speert, Tobias R Kollmann, Joel Singer, Julie A Bettinger
BACKGROUND: Much evidence of HIV-exposed uninfected (HEU) infant infectious morbidity predates availability of maternal combination antiretroviral therapy and does not control for universal risk factors (preterm birth, low birth weight, suboptimal breastfeeding and poverty). METHODS: This prospective cohort study identified HIV-infected and HIV-uninfected mothers and their newborns from South African community midwife unit. The primary outcome, infectious cause hospitalization or death before 6 months of age, was compared between HEU and HIV-unexposed (HU) infants and classified for type and severity using validated study-specific case definitions...
February 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28077516/early-onset-invasive-candidiasis-in-extremely-low-birth-weight-infants-perinatal-acquisition-predicts-poor-outcome
#7
Michelle Barton, Alex Shen, Karel O'Brien, Joan L Robinson, H Dele Davies, Kim Simpson, Elizabeth Asztalos, Joanne Langley, Nicole Le Saux, Reginald Sauve, Anne Synnes, Ben Tan, Louis de Repentigny, Earl Rubin, Chuck Hui, Lajos Kovacs, Yvonne Cw Yau, Susan E Richardson
BACKGROUND: Neonatal invasive candidiasis (IC)presenting in the first week of life is less common and less well described than later onset IC. Risk factors, clinical features and disease outcomeshave not been studied in early onset disease (EOD, ≤7d) or compared to late onset disease (LOD, >7d). METHODS: All extremely low birth weight (ELBW, <1000g) cases with IC and controls froma multicentre study of neonatal candidiasisenrolledfrom 2001 to 2003were included in this study...
January 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28074825/goldenhar-syndrome-cardiac-anesthesiologist-s-perspective
#8
REVIEW
Minati Choudhury, Poonam Malhotra Kapoor
Goldenhar syndrome or oculo-auriculo-vertebral dysplasia was defined by Goldenhar in 1952 and redefined by Grolin et al. later. As the name denotes, children with this syndrome present with craniofacial and vertebral anomalies which increase the risk of airway compromise. Neonates and infants with this syndrome often have premature internal organs, low birth weight, and airway disorders. For this reason, safe anesthesia in such infants requires a complete knowledge regarding metabolism and side effects of the drugs...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28070654/anesthesia-management-of-cesarean-section-in-parturient-with-anti-n-methyl-d-aspartate-receptor-encephalitis-a-case-report
#9
Zhimin Liao, Xiaoqin Jiang, Juan Ni
A 24-year-old woman at 29 weeks' gestation, and with psychiatric symptoms, was admitted to hospital and diagnosed as having anti-N-methyl-D-aspartate receptor encephalitis. After 4 weeks of immunotherapy with little effect, an emergency cesarean section was performed at 33(+4) weeks gestation under general anesthesia. The parturient was intubated after rapid sequence induction with etomidate, remifentanil and succinylcholine. Anesthesia was maintained with sevoflurane and remifentanil. Except for low weight, the infant was normal at birth...
January 9, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28068438/variation-in-performance-of-neonatal-intensive-care-units-in-the-united-states
#10
Jeffrey D Horbar, Erika M Edwards, Lucy T Greenberg, Kate A Morrow, Roger F Soll, Madge E Buus-Frank, Jeffrey S Buzas
Importance: Hospitals use rates from the best quartile or decile as benchmarks for quality improvement aims, but to what extent these aims are achievable is uncertain. Objective: To determine the proportion of neonatal intensive care units (NICUs) in 2014 that achieved rates for death and major morbidities as low as the shrunken adjusted rates from the best quartile and decile in 2005 and the time it took to achieve those rates. Design, Setting, and Participants: A total of 408 164 infants with a birth weight of 501 to 1500 g born from January 1, 2005, to December 31, 2014, and cared for at 756 Vermont Oxford Network member NICUs in the United States were evaluated...
January 9, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28063717/half-life-of-plasma-phytosterols-in-very-low-birth-weight-preterm-infants-on-routine-parenteral-nutrition-with-vegetable-oil-based-lipid-emulsions
#11
Daniele Pupillo, Alessio Correani, Chiara Biagetti, Rita D'Ascenzo, Manuela Simonato, Giovanna Verlato, Paola Cogo, Marco B L Rocchi, Virgilio P Carnielli
BACKGROUND: Phytosterols in vegetable oil (VO)-based lipid emulsions (LE) likely contribute to parenteral nutrition-associated cholestasis (PNAC) in preterm infants. No characterization of plasma phytosterol half-lives has been done in very low birth weight (VLBW) preterm infants receiving parenteral nutrition (PN) with LE. METHODS: In a prospective cohort study, 45 VLBW preterm infants who received PN underwent serial blood sample measurements of sitosterol (SITO), campesterol (CAMP), and stigmasterol (STIGM)...
December 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28063217/maternal-acculturation-and-the-growth-of-impoverished-mexican-american-infants
#12
Linda J Luecken, Shannon L Jewell, David P MacKinnon
OBJECTIVE: Identification of early life risk factors that predispose low-income Hispanic children to obesity is critical. For low-income Mexican American mothers, the cultural context may influence maternal experience and behaviors relevant to infant weight and growth. METHODS: In a longitudinal study of 322 low-income Mexican American mother-infant dyads, linear growth modeling examined the relation of maternal acculturation to infant weight gain across the first year and evaluated birth outcomes, breastfeeding, and maternal BMI as mediators...
January 7, 2017: Obesity
https://www.readbyqxmd.com/read/28061833/combining-adverse-pregnancy-and-perinatal-outcomes-for-women-exposed-to-antiepileptic-drugs-during-pregnancy-using-a-latent-trait-model
#13
Xuerong Wen, Abraham Hartzema, Joseph A Delaney, Babette Brumback, Xuefeng Liu, Robert Egerman, Jeffrey Roth, Rich Segal, Kimford J Meador
BACKGROUND: Application of latent variable models in medical research are becoming increasingly popular. A latent trait model is developed to combine rare birth defect outcomes in an index of infant morbidity. METHODS: This study employed four statewide, retrospective 10-year data sources (1999 to 2009). The study cohort consisted of all female Florida Medicaid enrollees who delivered a live singleton infant during study period. Drug exposure was defined as any exposure to Antiepileptic drugs (AEDs) during pregnancy...
January 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28057383/reference-values-for-nucleated-red-blood-cells-and-serum-lactate-in-very-and-extremely-low-birth-weight-infants-in-the-first-week-of-life
#14
Martin Poryo, Antonia Wissing, Aylin Aygün, Jürgen Geisel, Stefan Wagenpfeil, Michael Zemlin, Sascha Meyer
STUDY PURPOSE: To provide reference values for nucleated red blood cells and serum lactate concentrations in very and extremely low birth weight (VLBW/ELBW) infants in the first week of life. PATIENTS AND METHODS: Retrospective data analysis of serial, daily measurements of NRBC counts and serum lactate during the first 6days of life in VLBW and ELBW infants. RESULTS: In total, 250 infants<1500g were included in this study. Intrauterine growth retardation (IUGR) was seen in 87 (34...
January 2, 2017: Early Human Development
https://www.readbyqxmd.com/read/28056907/lung-function-in-very-low-birth-weight-infants-after-pharmacological-and-surgical-treatment-of-patent-ductus-arteriosus-a-retrospective-analysis
#15
Payman Barikbin, Hannes Sallmon, Silke Wilitzki, Joachim Photiadis, Christoph Bührer, Petra Koehne, Gerd Schmalisch
BACKGROUND: The indications and strategies for treatment of patent ductus arteriosus (PDA) are controversial, and the safety and long-term benefits of surgical PDA closure remain uncertain. The aim of this study was to compare the lung function of very low birth weight (VLBW) infants after successful PDA treatment with a cyclooxygenase inhibitor or secondary surgical ligation. METHODS: A total of 114 VLBW infants (birth weight < 1500 g), including 94 infants (82%) with a birth weight < 1000 g, who received treatment for hemodynamically significant PDA (hsPDA), were examined at a median postmenstrual age of 48 weeks...
January 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28056272/-status-of-and-factors-associated-with-complementary-feeding-among-infants-and-young-children-aged-6-23-months-in-poor-rural-areas-of-hunan-province-china
#16
X Zhou, J Q Fang, J Y Luo, H Wang, Q Y Du, G W Huang, B B Feng
Objective: To describe the status of, and to identify the factors associated with, complementary feeding among infants and young children aged 6- 23 months in poor rural areas of Hunan Province, China. Methods: A total of 8 735 infants and young children aged 6- 23 months from 30 poor rural counties in the Wuling and Luoxiao Mountains in Hunan Province were selected by township-level probability-proportional-to-size sampling in August 2015. Questionnaires were used to collect information on the feeding status of the infants in the previous 24 hours, along with personal/family information...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28056115/a-tiered-approach-to-retinopathy-of-prematurity-screening-tarp-using-a-weight-gain-predictive-model-and-a-telemedicine-system
#17
Jaclyn Gurwin, Lauren A Tomlinson, Graham E Quinn, Gui-Shuang Ying, Agnieshka Baumritter, Gil Binenbaum
Importance: The Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) Study telemedicine system of remote fundus image grading and The Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP-ROP) postnatal weight gain predictive model are 2 approaches for improving ROP screening efficiency. Current screening has low specificity for severe ROP. Objective: To describe a tiered approach to ROP screening (TARP) for identifying children who develop severe ROP using telemedicine and a predictive model synergistically...
January 5, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28052714/efficacy-and-safety-of-rectal-ibuprofen-for-patent-ductus-arteriosus-closure-in-very-low-birth-weight-preterm-infants
#18
Nihat Demir, Erdal Peker, İbrahim Ece, Ragıp Balahoroğlu, Oğuz Tuncer
BACKGROUND: To compare rectal ibuprofen with oral ibuprofen for closure of hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) preterm infants. STUDY DESIGN AND SUBJECTS: In a prospective, randomized study, 72 VLBW infants who had hsPDA received either rectal or oral ibuprofen. The plasma concentration of ibuprofen and renal functions were determined in both groups by high performance liquid chromatography (HPLC) method and cystatin-C (cys-C), respectively...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28052185/early-administration-of-inhaled-corticosteroids-for-preventing-chronic-lung-disease-in-very-low-birth-weight-preterm-neonates
#19
REVIEW
Vibhuti S Shah, Arne Ohlsson, Henry L Halliday, Michael Dunn
BACKGROUND: Chronic lung disease (CLD) remains a common complication among preterm infants. There is increasing evidence that inflammation plays an important role in the pathogenesis of CLD. Due to their strong anti-inflammatory properties, corticosteroids are an attractive intervention strategy. However, there are growing concerns regarding short- and long-term effects of systemic corticosteroids. Theoretically, administration of inhaled corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable systemic side effects...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28050019/survey-and-evidence-based-review-of-probiotics-used-in-very-low-birth-weight-preterm-infants-within-the-united-states
#20
S Viswanathan, C Lau, H Akbari, C Hoyen, M C Walsh
No abstract text is available yet for this article.
January 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
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