Zitong Li, Wenpeng Huang, Ming Zhang, Yan Huo, Feifei Li, Lele Song, Sitong Wu, Qi Yang, Xiaoming Li, Jianjun Zhang, Liu Yang, Jianchen Hao, Lei Kang
BACKGROUND: Corneal neovascularization (CoNV) threatens vision by disrupting corneal avascularity, however, current treatments, including pharmacotherapy and surgery, are hindered by limitations in efficacy and adverse effects. Minocycline, known for its anti-inflammatory properties, could suppress CoNV but faces challenges in effective delivery due to the cornea's unique structure. Therefore, in this study a novel drug delivery system using minocycline-loaded nano-hydroxyapatite/poly (lactic-co-glycolic acid) (nHAP/PLGA) nanoparticles was developed to improve treatment outcomes for CoNV...
March 28, 2024: Journal of Nanobiotechnology