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Ocular injury

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https://www.readbyqxmd.com/read/28802684/-management-of-post-traumatic-aphakia-and-aniridia-retrospective-study-of-17-patients-undergoing-scleral-sutured-artificial-iris-intraocular-lens-implantation-management-of-aphakia-aniridia-with-scleral-sutured-artificial-iris-intraocular-lenses
#1
A-S Villemont, V Kocaba, H Janin-Manificat, L Abouaf, M Poli, A-S Marty, M Rabilloud, J Fleury, C Burillon
PURPOSE: To evaluate the long-term outcomes of artificial iris intraocular lenses sutured to the sclera for managing traumatic aphakia and aniridia. METHODS: All consecutive cases receiving a Morcher(®) combination implant from June 2008 to February 2016 in Edouard-Herriot Hospital (Lyon, France) were included in this single-center retrospective study. Visual acuity, subjective degree of glare, quality of life and surgical complications were evaluated. RESULTS: Seventeen eyes of 17 patients were included, among which 82% were male...
August 9, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28799757/immobilization-of-growth-factors-to-collagen-surfaces-using-visible-light
#2
Gabriella Maria Fernandes Cunha, Hyun Jong Lee, Alisha Kumar, Alexander Kreymerman, Sarah Christine Heilshorn, David Myung
In the treatment of traumatic injuries, burns, and ulcers of the eye, inadequate epithelial tissue healing remains a major challenge. Wound healing is a complex process involving the temporal and spatial interplay between cells and their extracellular milieu. It can be impaired by a variety of causes including infection, poor circulation, loss of critical cells and/or proteins, and a deficiency in normal neural signaling (e.g. neurotrophic ulcers). Ocular anatomy is particularly vulnerable to lasting morbidity from delayed healing, whether it be scarring or perforation of the cornea, destruction of the conjunctival mucous membrane, or cicatricial changes to the eyelids and surrounding skin...
August 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28797041/repeat-low-level-blast-exposure-increases-transient-receptor-potential-vanilloid-1-trpv1-and-endothelin-1-et-1-expression-in-the-trigeminal-ganglion
#3
Elaine D Por, Melody L Sandoval, Chiquita Thomas-Benson, Teresa A Burke, Allison Doyle Brackley, Nathaniel A Jeske, Jeffery M Cleland, Brian J Lund
Blast-associated sensory and cognitive trauma sustained by military service members is an area of extensively studied research. Recent studies in our laboratory have revealed that low-level blast exposure increased expression of transient receptor potential vanilloid 1 (TRPV1) and endothelin-1 (ET-1), proteins well characterized for their role in mediating pain transmission, in the cornea. Determining the functional consequences of these alterations in protein expression is critical to understanding blast-related sensory trauma...
2017: PloS One
https://www.readbyqxmd.com/read/28796783/myd88-contribution-to-ocular-surface-homeostasis
#4
Rose Y Reins, Justin Courson, Carolina Lema, Rachel L Redfern
The cornea must maintain homeostasis, enabling rapid response to injury and microbial insult, to protect the eye from insult and infection. Toll-like receptors (TLRs) are critical to this innate immune response through the recognition and response to pathogens. Myeloid differentiation primary response (MyD88) is a key signaling molecule necessary for Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R)-mediated immune defense and has been shown to be necessary for corneal defense during infection. Here, we examined the intrinsic role of TLR signaling in ocular surface tissues by determining baseline levels of inflammatory mediators, the response to mechanical stimuli, and corneal infection in MyD88-deficient mice (MyD88-/-)...
2017: PloS One
https://www.readbyqxmd.com/read/28789573/the-protective-effect-of-fish-oil-against-cisplatin-induced-eye-damage-in-rat
#5
Burcu Gul Baykalir, Osman Ciftci, Aslı Cetin, Nese Basak Turkmen
Ocular toxicity induced by anticancer chemotherapy is not uncommon, but underestimated and under-reported. Visual changes have been attributed to a number of chemotherapeutic agents in humans. Cisplatin (CP), a heavy metal compound, is used in the treatment of many types of tumors. CP is known to produce non-specific blurred vision, papilledema and optic neuritis for high doses as well as cumulative dose regimens. The aim of this study was to investigate the possible beneficial effects of fish oil (FO) on eye tissue oxidative status and histological alterations against CP-induced in the rats...
August 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28782783/poly-%C3%AE%C2%B5-caprolactone-nanocapsule-carriers-with-sustained-drug-release-single-dose-for-long-term-glaucoma-treatment
#6
Chih-Hung Lee, Yu-Jia Li, Chih-Ching Huang, Jui-Yang Lai
Glaucoma is an eye-related disease accompanied by highly elevated intraocular pressure (IOP), which causes damage to the optic nerve and results in vision loss and even blindness. Although the treatment of glaucoma with eye drops may reduce the IOP, eye drops have some limitations, such as poor patient compliance and short duration. To develop drug carriers that facilitate the sustained and long-term release of drugs for glaucoma therapy, we synthesized poly(ε-caprolactone) nanoparticles (PCL NPs) capable of loading pilocarpine, a widely used drug for the treatment of dry eye and glaucoma...
August 7, 2017: Nanoscale
https://www.readbyqxmd.com/read/28782018/hierarchies-in-light-sensing-and-dynamic-interactions-between-ocular-and-extraocular-sensory-networks-in-a-flatworm
#7
Nishan Shettigar, Asawari Joshi, Rimple Dalmeida, Rohini Gopalkrishna, Anirudh Chakravarthy, Siddharth Patnaik, Manoj Mathew, Dasaradhi Palakodeti, Akash Gulyani
Light sensing has independently evolved multiple times under diverse selective pressures but has been examined only in a handful among the millions of light-responsive organisms. Unsurprisingly, mechanistic insights into how differential light processing can cause distinct behavioral outputs are limited. We show how an organism can achieve complex light processing with a simple "eye" while also having independent but mutually interacting light sensing networks. Although planarian flatworms lack wavelength-specific eye photoreceptors, a 25 nm change in light wavelength is sufficient to completely switch their phototactic behavior...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28774513/evaluation-of-occupational-ocular-trauma-are-we-doing-enough-to-promote-eye-safety-in-the-workplace
#8
Helena Zakrzewski, Helen Chung, Emi Sanders, Christopher Hanson, Bryce Ford
OBJECTIVE: The aim of this study was to document the use of eye personal protective equipment (PPE) by patients who had sustained an eye injury in the workplace and to evaluate the characteristics and outcomes of these patients. DESIGN: Case-control study. PARTICIPANTS: All adult patients who had sustained an eye injury in the workplace and presented to the urgent ophthalmology clinic of a tertiary care hospital from October 1, 2013, to November 30, 2014, were eligible for inclusion...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28774512/impact-of-lens-densitometry-on-phacoemulsification-parameters-and-usage-of-ultrasound-energy-in-femtosecond-laser-assisted-lens-surgery
#9
Ghada Al-Khateeb, Mehdi Shajari, Krishnapoojita Vunnava, Kerstin Petermann, Thomas Kohnen
OBJECTIVE: The aim of this study was to find the correlation between lens densitometry measurements using Pentacam Scheimpflug imaging system with equivalent average ultrasound power and cumulative dissipated energy (CDE) in femtosecond laser-assisted lens surgery (FLALS). METHODS: One hundred and twenty-four eyes were analyzed retrospectively, of which 109 had undergone cataract surgery and 15 had received refractive lens exchange with FLALS. Using the Pentacam Nucleus Staging (PNS) lens densitometry program, preoperative mean lens density and cataract grading score were evaluated...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28771946/prophylactic-intravitreal-antibiotics-reduce-the-risk-of-post-traumatic-endophthalmitis-after-repair-of-open-globe-injuries
#10
Marwan A Abouammoh, Abdullah Al-Mousa, Mohammad Gogandi, Hani Al-Mezaine, Essam Osman, Abdulrahman M Alsharidah, Abdullah Al-Kharashi, Ahmed M Abu El-Asrar
PURPOSE: To investigate efficacy of prophylactic intravitreal antibiotics in reducing incidence of endophthalmitis after repair of open globe injuries. At King Abdulaziz University Hospital, a standard protocol of intravenous vancomycin and ceftazidime was used in all cases. METHODS: Charts of 353 patients who presented between January 2010 and January 2014 with open globe injury were retrospectively reviewed. In addition, the standard protocol in this cohort included prophylactic intravitreal antibiotics in high-risk cases at time of primary repair...
August 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28769866/eye-control-deficits-coupled-to-hand-control-deficits-eye-hand-incoordination-in-chronic-cerebral-injury
#11
John-Ross Rizzo, James K Fung, Maryam Hosseini, Azadeh Shafieesabet, Edmond Ahdoot, Rosa M Pasculli, Janet C Rucker, Preeti Raghavan, Michael S Landy, Todd E Hudson
It is widely accepted that cerebral pathology can impair ocular motor and manual motor control. This is true in indolent and chronic processes, such as neurodegeneration and in acute processes such as stroke or those secondary to neurotrauma. More recently, it has been suggested that disruptions in these control systems are useful markers for prognostication and longitudinal monitoring. The utility of examining the relationship or the coupling between these systems has yet to be determined. We measured eye and hand-movement control in chronic, middle cerebral artery stroke, relative to healthy controls, in saccade-to-reach paradigms to assess eye-hand coordination...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28761031/indications-for-enucleation-and-evisceration-in-a-tertiary-eye-hospital-in-riyadh-over-a-10-year-period
#12
Saad A Al-Dahmash, Sawsan Saad Bakry, Nada H Almadhi, Lolwah M Alashgar
BACKGROUND: Enucleation and evisceration are eye removal procedures considered as palliative treatment when all other therapeutic options are exhausted. OBJECTIVE: Describe the causes and histopathological findings leading to enucleation/evisceration, and correlate the clinical findings with the histopathological findings. DESIGN: Retrospective, descriptive study. SETTINGS: Tertiary care hospital, Riyadh, Saudi Arabia...
July 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28760885/the-neonatal-fc-receptor-and-complement-fixation-facilitate-prophylactic-vaccine-mediated-humoral-protection-against-viral-infection-in-the-ocular-mucosa
#13
Derek J Royer, Meghan M Carr, Hem R Gurung, William P Halford, Daniel J J Carr
The capacity of licensed vaccines to protect the ocular surface against infection is limited. Common ocular pathogens, such as HSV-1, are increasingly recognized as major contributors to visual morbidity worldwide. Humoral immunity is an essential correlate of protection against HSV-1 pathogenesis and ocular pathology, yet the ability of Ab to protect against HSV-1 is deemed limited due to the slow IgG diffusion rate in the healthy cornea. We show that a live-attenuated HSV-1 vaccine elicits humoral immune responses that are unparalleled by a glycoprotein subunit vaccine vis-à-vis Ab persistence and host protection...
July 31, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28760643/reactive-oxygen-species-oxidative-stress-glaucoma-and-hyperbaric-oxygen-therapy
#14
Charles McMonnies
This review examines the role of oxidative stress in damage to cells of the trabecular meshwork and associated impaired aqueous drainage as well as damage to retinal ganglion cells and associated visual field losses. Consideration is given to the interaction between vascular and mechanical explanations for pathological changes in glaucoma. For example, elevated intraocular pressure (IOP) forces may contribute to ischaemia but there is increasing evidence that altered blood flow in a wider sense is also involved...
July 28, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28760404/retinal-toxicity-after-accidental-intravitreal-injection-of-mepivacaine-and-adrenaline
#15
F López-Herrero, J L Sánchez-Vicente, J Monge-Esquivel, E Parra-Oviedo, A Martínez-Borrego, A Muñoz-Morales
CASE REPORT: The case is presented of a 32 year-old male with no medical history of interest who suffered a traffic accident with mild traumatic brain injury. He had a left supraciliary incised and contused wound that extended to the left upper eyelid, with no loss of vision. After palpebral anaesthetic injection, there was a sudden visual acuity decrease in the left eye and hyposphagma located between I-III at 4mm from the limbus, with increased intraocular pressure. A whitish lesion with a central haemorrhagic focus was observed in the ocular fundus, corresponding to the area where the hyposphagma was located...
July 28, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28759511/chemical-burns-of-the-eye
#16
Denise R Ramponi
Chemical burns of the eye are one of the most common eye injuries. The extent of the ocular surface damage is influenced by the type, temperature, volume, and pH of the corrosive substance and duration of exposure. Limbal ischemia found on eye assessment is the primary determinant of eventual visual outcome. Eye irrigation must be instituted immediately at the scene of exposure and continued in the emergency department to reduce visual impairment. Traditionally lactated Ringer's and normal saline have been used as irrigation fluids, although one systematic review demonstrates similar outcomes with other irrigation fluids...
July 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/28757688/ocular-trauma-a-tertiary-hospital-experience-from-oman
#17
Haitham H Al-Mahrouqi, Naila Al-Harthi, Maryam Al-Wahaibi, Kishore Hanumantharayappa
PURPOSE: To describe the epidemiology of ocular trauma in a tertiary hospital setting in Muscat, Oman. METHODS: Medical records of all cases of ocular trauma which presented to the Emergency Department at Al-Nahdha Hospital and were seen by the ophthalmology service from January 1, 2013 to June 30, 2013 (6 months) were reviewed to collect data on ocular trauma according to the World Eye Injury Registry initial reporting form which uses the Birmingham Eye Trauma Terminology System...
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28753216/strabismus-after-ocular-surgery
#18
Ethan K Sobol, Jamie B Rosenberg
Many types of ocular surgery can cause diplopia, including eyelid, conjunctival, cataract, refractive, glaucoma, retinal, and orbital surgery. Mechanisms include direct injury to the extraocular muscles from surgery or anesthesia, scarring of the muscle complex and/or conjunctiva, alteration of the muscle pulley system, mass effects from implants, and muscle displacement. Diplopia can also result from a loss of fusion secondary to long-standing poor vision in one eye or from a decompensation of preexisting strabismus that was not recognized preoperatively...
July 28, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28740387/apatinib-loaded-nanoparticles-suppress-vascular-endothelial-growth-factor-induced-angiogenesis-and-experimental-corneal-neovascularization
#19
Jung Eun Lee, Koung Li Kim, Danbi Kim, Yeongju Yeo, Hyounkoo Han, Myung Goo Kim, Sun Hwa Kim, Hyuncheol Kim, Ji Hoon Jeong, Wonhee Suh
Pathological angiogenesis is one of the major symptoms of severe ocular diseases, including corneal neovascularization. The blockade of vascular endothelial growth factor (VEGF) action has been recognized as an efficient strategy for treating corneal neovascularization. In this study, we aimed to investigate whether nanoparticle-based delivery of apatinib, a novel and selective inhibitor of VEGF receptor 2, inhibits VEGF-mediated angiogenesis and suppresses experimental corneal neovascularization. Water-insoluble apatinib was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28737601/new-ways-to-detect-pediatric-sickle-cell-retinopathy-a-comprehensive-review
#20
Daniel A Pahl, Nancy S Green, Monica Bhatia, Royce W S Chen
Sickle retinopathy reflects disease-related vascular injury of the eye, which can potentially result in visual loss from vitreous hemorrhage or retinal detachment. Here we review sickle retinopathy among children with sickle cell disease, describe the epidemiology, pediatric risk factors, pathophysiology, ocular findings, and treatment. Newer, more sensitive ophthalmological imaging modalities are available for retinal imaging, including ultra-widefield fluorescein angiography, spectral-domain optical coherence tomography, and optical coherence tomography angiography...
July 21, 2017: Journal of Pediatric Hematology/oncology
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