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Ocular injury

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https://www.readbyqxmd.com/read/28538072/surgical-treatment-of-posttraumatic-ophthalmoplegia-through-the-reconstruction-of-the-lateral-orbital-wall
#1
Pedro Henrique da Hora Sales, Suellen Sombra da Rocha, Paulo Henrique Carvalho Rodrigues, Edson Luiz Cetira Filho, Leonardo de Freitas Silva, Manoel de Jesus Rodrigues Mello
Orbital fractures are injuries frequently related to traumas of the midface. These fractures can be associated with ocular lesions, ranging from small abrasions on the cornea to serious complications such as hyphema and ocular globe rupture. Diplopia and ophthalmoplegia are common findings in orbital fractures. They can be caused by mechanical factors as bone fragments or muscle imprisonment. The aim of this study was to report a case of a 40-year patient, male showing diplopia and ophthalmoplegia due to the orbital fracture...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28532352/understanding-glaucomatous-optic-neuropathy-the-synergy-between-clinical-observation-and-investigation
#2
Harry A Quigley
Glaucoma is a complex disorder of aging defined by the death of retinal ganglion cells and remodeling of connective tissues at the optic nerve head. Intraocular pressure-induced axonal injury at the optic nerve head leads to apoptosis. Loss of retinal ganglion cells follows a slowly progressive sequence. Clinical features of the disease have suggested and corroborated pathological events. The death of retinal ganglion cells causes secondary loss of neurons in the brain, but only as a by-product of injury to the retinal ganglion cells...
October 14, 2016: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28530314/-presentation-of-ocular-problems-among-displaced-persons-from-sudan-and-eritrea-at-the-tel-aviv-medical-center
#3
Roy Schwartz, Michaella Goldstein, Anat Loewenstein, Adiel Barak
INTRODUCTION: Illegal immigration from Africa to Israel expanded in recent years, bringing illegal immigrants, mostly from Eritrea and Sudan. No data regarding the ophthalmic conditions of this population was previously published. AIMS: To delineate reasons for ophthalmologic emergency room visits and hospitalizations in the ophthalmology department at a tertiary center in Tel Aviv, Israel. METHODS: In this retrospective study we reviewed the records of patients of Eritrean and Sudanese origin arriving at the ophthalmic emergency room at the Tel Aviv Sourasky Medical Center between June 2012 and August 2012 and hospitalized in the ophthalmology ward between August 2011 and August 2012...
January 2017: Harefuah
https://www.readbyqxmd.com/read/28529481/topical-ophthalmic-formulation-of-trichostatin-a-and-surr9-c84a-for-quick-recovery-post-alkali-burn-of-corneal-haze
#4
Kislay Roy, Chun Hei Antonio Cheung, Rupinder K Kanwar, Rajat Sandhir, Jagat R Kanwar
Alkali burn injury is a true ocular emergency of the conjunctiva and cornea that requires immediate precision. Lack of an immediate therapy can lead to a substantial damage in the ocular surface and anterior segment further causing visual impairment and disfigurement. We explored the regenerative capability of dominant negative survivin protein (SurR9-C84A) and histone deacetylase inhibitor trichostatin-A (TSA) in vivo, in a rat alkali burn model. A topical insult in rat eyes with NaOH led to degradation of the conjunctival and corneal epithelium...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28524835/collapsin-response-mediator-protein-2-induced-retinal-ischemic-injury-in-a-novel-mice-model-of-ocular-ischemia-syndrome
#5
Yu Wang, Xiao-Lei Wang, Guo-Li Xie, Hong-Yang Li, Yan-Ling Wang
BACKGROUND: Collapsin response mediator protein-2 (CRMP2) has been shown to be involved in ischemia/hypoxia (IH) injury. We determined whether CRMP2 modulates ischemic injury in the retinal of Ocular ischemic syndrome (OIS). This study was to explore the molecular mechanisms underlying OIS in a novel mice model. METHODS: Experiments were performed on adult male C57/BL6 mice that received bilateral internal carotid arteries ligation for 1, 2, or 4 weeks. The mice received injection of calpeptin group before occlusion for 4 weeks or not...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28522972/recent-advances-in-the-study-of-bipolar-rod-shaped-microglia-and-their-roles-in-neurodegeneration
#6
Ngan Pan Bennett Au, Chi Him Eddie Ma
Microglia are the resident immune cells of the central nervous system (CNS) and they contribute to primary inflammatory responses following CNS injuries. The morphology of microglia is closely associated with their functional activities. Most previous research efforts have attempted to delineate the role of ramified and amoeboid microglia in the pathogenesis of neurodegenerative diseases. In addition to ramified and amoeboid microglia, bipolar/rod-shaped microglia were first described by Franz Nissl in 1899 and their presence in the brain was closely associated with the pathology of infectious diseases and sleeping disorders...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28511872/impairment-of-tear-film-and-the-ocular-surface-in-patients-with-facial-burns
#7
Sang Ouk Choi, Tae-Young Chung, Young Joo Shin
AIM: The aim of this study is to investigate the factors affecting tear film and ocular surface in patients with facial burns. METHODS: A total of 273 patients with facial burns, treated at Hallym University Hangang Sacred Heart Hospital from November 2012 to July 2015, were included. Tear break-up time (TBUT), Schirmer's tear secretion test, fluorescein staining score (FSS), ocular surface disease index (OSDI), and visual analogue pain score (VAS) were compared according to burned surface area, burn site, burn cause, time since burn injury, or lid abnormality...
May 13, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28509425/methods-of-fixation-of-intraocular-lenses-according-to-the-anatomical-structures-in-trauma-eyes
#8
REVIEW
Miltiadis Fiorentzis, Anja Viestenz, Jens Heichel, Berthold Seitz, Thomas Hammer, Arne Viestenz
Ocular trauma can lead to severe visual impairment and morbidity, depending on the anatomical structures affected. The main causes of ocular trauma include foreign bodies, impact by an object, falls, and chemicals. Most ocular traumas occur in children or young male adults. A meticulous slit lamp examination is crucial for assessing all anatomical structures. Trauma to the crystalline lens can result in dislocation, an intralenticular foreign body, cataract, fragmentation, and capsular breach. An intraocular lens (IOL) can endure subluxation or luxation under the conjunctiva, into the anterior chamber or the vitreous, or can be extruded...
May 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28502469/hepatocyte-growth-factor-suppresses-inflammation-and-promotes-epithelium-repair-in-corneal-injury
#9
Masahiro Omoto, Kunal Suri, Afsaneh Amouzegar, Mingshun Li, Kishore R Katikireddy, Sharad K Mittal, Sunil K Chauhan
Corneal injuries are among the major causes of ocular morbidity and vision impairment. Optimal epithelial wound healing is critical for the integrity and transparency of the cornea after injury. Hepatocyte growth factor (HGF) is a mitogen and motility factor that primarily regulates epithelial cell function. Herein, we investigate the effect of HGF on proliferation of corneal epithelial cells (CECs) in inflamed conditions both in vitro and in vivo. We demonstrate that HGF not only promotes CEC proliferation in homeostatic conditions but also reverses the anti-proliferative effect of the inflammatory environment on these cells...
May 10, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28501766/therapeutic-effects-of-zerumbone-in-an-alkali-burned-corneal-wound-healing-model
#10
Jong Won Kim, Hyuneui Jeong, Myeon-Sik Yang, Chae Woong Lim, Bumseok Kim
Cornea is an avascular transparent tissue. Ocular trauma caused by a corneal alkali burn induces corneal neovascularization (CNV), inflammation, and fibrosis, leading to vision loss. The purpose of this study was to examine the effects of Zerumbone (ZER) on corneal wound healing caused by alkali burns in mice. CNV was induced by alkali-burn injury in BALB/C female mice. Topical ZER (three times per day, 3μl each time, at concentrations of 5, 15, and 30μM) was applied to treat alkali-burned mouse corneas for 14 consecutive days...
May 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28499464/prospective-study-on-ocular-motility-limitation-due-to-orbital-muscle-entrapment-or-impingement-associated-with-orbital-wall-fracture
#11
Babak Alinasab, Abdul Rashid Qureshi, Pär Stjärne
INTRODUCTION: The recommended urgent surgical management of ocular motility restriction due to orbital muscle entrapment or impingement associated with orbital wall fracture needs to be elucidated. AIM: To evaluate the importance of the time from injury to surgery for the outcome in ocular motility and diplopia, the time lapse of ocular motility, diplopia and hypesthesia recovery. MATERIAL AND METHODS: Patients with entrapment or impingement of orbital contents due to orbital wall fracture were followed up prospectively over 1year regarding ocular motility, diplopia, hypesthesia and cosmetic deformity...
April 21, 2017: Injury
https://www.readbyqxmd.com/read/28495906/emergency-corneal-grafting-in-the-uk-a-6-year-analysis-of-the-uk-transplant-registry
#12
Parwez Hossain, Abdo Karim Tourkmani, Dimitri Kazakos, Mark Jones, David Anderson
BACKGROUND: Corneal graft (CG) surgery is the most common and successful tissue transplant worldwide. A small and important group of patients are operated in emergency situations, typically to save a perforated eye. Our knowledge of the indications and outcomes of emergency corneal graft (eCG) is limited. METHODS: Retrospective, multifactorial analysis of all CGs registered by the UK Transplant Service from April 1999 to March 2005. RESULTS: A total of 12 976 CGs were performed...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28494699/lens-capsule-perforation-without-inflammation-in-4-rabbits-from-intravitreal-injection-studies
#13
Cindy Farman, Chris Schuetz, Florence Lorget, Vladimir Bantseev, David Calise, Evan A Thackaberry
Historically, it was thought that lens protein was sequestered, and injury to the lens capsule causing release of lens material into the eye would always result in ocular inflammation. Currently, it is believed that lens antigens are recognized as self, subject to normal T-cell tolerance. Three different single-dose intravitreal injection/implantation studies of 4 different test materials, ranging from 4 to 6 weeks in length, were performed in New Zealand White rabbits. The test materials included polymer microspheres, polymer rods, a solvent, and a hydrogel...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28491019/shared-and-differential-retinal-responses-against-optic-nerve-injury-and-ocular-hypertension
#14
REVIEW
Manuel Vidal-Sanz, Caridad Galindo-Romero, Francisco J Valiente-Soriano, Francisco M Nadal-Nicolás, Arturo Ortin-Martinez, Giuseppe Rovere, Manuel Salinas-Navarro, Fernando Lucas-Ruiz, Maria C Sanchez-Migallon, Paloma Sobrado-Calvo, Marcelino Aviles-Trigueros, María P Villegas-Pérez, Marta Agudo-Barriuso
Glaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage to RGC axons at the optic nerve head plays a major role. Rodent models to study glaucoma include those that mimic either ocular hypertension or optic nerve injury. Here we review the anatomical loss of the general population of RGCs (that express Brn3a; Brn3a(+)RGCs) and of the intrinsically photosensitive RGCs (that express melanopsin; m(+)RGCs) after chronic (LP-OHT) or acute (A-OHT) ocular hypertension and after complete intraorbital optic nerve transection (ONT) or crush (ONC)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28489786/bilateral-carotid-cavernous-fistula-with-spontaneous-resolution-a-case-report-and-literature-review
#15
Lan Ke, Yan-Ning Yang, Jing Yuan
RATIONALE: Bilateral carotid-cavernous fistula (CCF) is rare and serious extra-ocular disease occurring in clinical which may result in severe complication. Unique manifestations and imaging examinations are important to the diagnosis. PATIENT CONCERNS: A case of bilateral carotid-cavernous fistula in an 60-year-old healthy man caused by a head injury is reported. Further clinical symptoms and signs and imaging examinations lead to the correct diagnosis. DIAGNOSES: Computed tomography angiography of the brain aroused suspicion of bilateral CCF...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28487369/n-glycosylation-affects-the-stability-and-barrier-function-of-the-muc16-mucin
#16
Takazumi Taniguchi, Ashley M Woodward, Paula Magnelli, Nicole M McColgan, Sylvain Lehoux, Sarah Melissa P Jacobo, Jérôme Mauris, Pablo Argüeso
Transmembrane mucins are highly O-glycosylated glycoproteins that coat the apical glycocalyx on mucosal surfaces and represent the first line of cellular defense against infection and injury. Relatively low levels of N-glycans are found on transmembrane mucins, and their structure and function remains poorly characterized. We previously reported that carbohydrate-dependent interactions of transmembrane mucins with galectin-3 contribute to maintain the epithelial barrier at the ocular surface. Now, using MALDI-TOF mass spectrometry, we report that transmembrane mucin N-glycans in differentiated human corneal epithelial cells contain primarily complex-type structures with N-acetyllactosamine, a preferred galectin ligand...
May 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28480312/spatially-and-temporally-regulated-nrf2-gene-therapy-using-mcp-1-promoter-in-retinal-ganglion-cell-injury
#17
Kosuke Fujita, Koji M Nishiguchi, Yukihiro Shiga, Toru Nakazawa
Retinal ganglion cell degeneration triggered by axonal injury is believed to underlie many ocular diseases, including glaucoma and optic neuritis. In these diseases, retinal ganglion cells are affected unevenly, both spatially and temporally, such that healthy and unhealthy cells coexist in different patterns at different time points. Herein, we describe a temporally and spatially regulated adeno-associated virus gene therapy aiming to reduce undesired off-target effects on healthy retinal neurons. The Mcp-1 promoter previously shown to be activated in stressed retinal ganglion cells following murine optic nerve injury was combined with the neuroprotective intracellular transcription factor Nrf2...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28480151/efficacy-of-topical-analgesics-in-pain-control-for-corneal-abrasions-a-systematic-review
#18
REVIEW
Bryan Thiel, Alexandra Sarau, Daniel Ng
Corneal abrasions are one of the most common ocular injuries seen in the emergency department. While most patients with corneal abrasions complain of excruciating pain, permanent sequelae may develop if not managed properly. The use of topical antibiotics and other standards of treatment have greatly reduced the incidence of complications. However, there is still a lack of consensus regarding the proper management of pain in corneal abrasions. Proposed analgesics for the control of corneal abrasion pain include topical nonsteroidal anti-inflammatory drugs (NSAIDs), topical anesthetics, and topical cycloplegics...
March 27, 2017: Curēus
https://www.readbyqxmd.com/read/28457309/ocular-injuries-secondary-to-alexandrite-laser-assisted-hair-removal
#19
Mohammed S Asiri, Majed Alharbi, Trad Alkadi, Marwan Abouammoh, Mohammed Al-Amry, Yahya ALZahrani, Sulaiman M Alsulaiman
PURPOSE: The aim of this study was to describe the clinical manifestations and outcomes of 4 patients who had sustained eye injury during alexandrite laser-assisted hair removal. METHODS: This was a retrospective case series of 4 patients who presented to 2 tertiary eye care hospitals over 2 years. Data on ophthalmic examination, spectral domain optical coherence tomography (Heidelberg Engineering, Heidelberg, Germany), and fundus fluorescein angiography were collected...
April 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28448352/laundry-detergent-pods-linked-to-increased-eye-injuries-in-children
#20
Lucy Wang Halpern
Pods are responsible for over a quarter of toddlers' chemical ocular burns.
May 2017: American Journal of Nursing
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