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Ocular injury

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https://www.readbyqxmd.com/read/28910888/-endoscopic-salvage-treatment-for-optic-neuropathy-caused-by-sinonasal-fibro-osseous-lesions
#1
J Deng, F H Chen, Y Y Lai, J B Shi
Objective: To summarize the surgical techniques, benefits and limitations of transnasal endoscopic resection and optic nerve decompression for patients with optic neuropathy caused by fibro-osseous lesions. Methods: Eight patients with optic neuropathy caused by fibro-osseous lesions who accepted endoscopic surgery of either resection of the lesion or decompression of optic nerve in Otorhinolaryngology Hospital, First Affiliated Hospital of Sun Yat-sen University from 2007 to 2016 were retrospectively reviewed and followed until April, 2017...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28906020/diagnostic-impact-of-anterior-segment-angiography-of-limbal-stem-cell-insufficiency-in-pax6-related-aniridia
#2
Barbara Käsmann-Kellner, Lorenz Latta, Fabian Fries, Arne Viestenz, Berthold Seitz
BACKGROUND: PAX6 is a master gene of ocular development and postnatal ocular equilibrium. Congenital aniridia is the hallmark of PAX6 gene haploinsufficiency (Chr. 11 p. 13), but PAX6-associated aniridia is a profound, progressive pan-ocular developmental disorder often leading to blindness. Limbal stem cell insufficiency and corneal findings in PAX6 syndrome: There is congenital visual impairment with advancing loss of vision mainly due to secondary glaucoma and to corneal blindness caused by limbal stem cell insufficiency (LSCI)...
September 14, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28905831/primary-prevention-of-ocular-injury-in-agricultural-workers-with-safety-eyewear
#3
Samrat Chatterjee, Deepshikha Agrawal
PURPOSE: The purpose of this study was to determine the effectiveness of preventing eye injury with the use of safety eyewear in agriculture workers. METHODS: A sample group of 575 agricultural workers (Group A) engaged in harvesting paddy were provided with goggles with side covers. Following harvesting, a questionnaire-based survey was carried out to determine the frequency of their eye injuries. Workers with goggles were asked about the duration for which they used the goggles and also list barriers or difficulties with the same...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903152/nuclear-respiratory-factor-1-nrf-1-regulates-transcription-of-the-cxc-receptor-4-cxcr4-in-the-rat-retina
#4
Pei Chen, Xiaoxiao Cai, Ying Yang, Zhao Chen, Jin Qiu, Na Yu, Mingjun Tang, Qiyun Wang, Jian Ge, Keming Yu, Jing Zhuang
Purpose: The CXC receptor 4 (CXCR4) is required for various physiologic and pathologic processes in the eye, including stem cell trafficking, neuronal development, immune responses, and ocular neovascularization. Here, we used the rat retina models to determine the mechanisms driving CXCR4 transcription. Methods: The expression pattern of CXCR4 and nuclear respiratory factor-1 (NRF-1) were profiled in the rat retina during the course of development. Chromatin immunoprecipitation (CHiP) assay determined the transcriptional mechanism of CXCR4 in rat retina...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28901515/vulnerability-study-of-myelinated-and-unmyelinated-nerve-fibers-in-acute-ocular-hypertension-in-rabbit
#5
Jiying Shen, Qiang Yang, Daoyi Yu, Jihong Wu, Yuanfang Zhu, Wenyi Guo
In the current study, it was aimed to evaluate the changes in myelinated and unmyelinated nerve fibers in retinal ischemia‑reperfusion injuries caused by acute ocular hypertension and to determine the sequence of these changes. Adult healthy New Zealand white rabbits were randomized to the hemodynamic group [n=12; used to determine the optimal intraocular pressure (IOP) for the subsequent experiments] and the hypertension group (n=6; 70‑mmHg hypertension induced in one eye). IOP was adjusted using a cannula and saline...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28887879/orbital-floor-fracture-repair-the-endonasal-approach
#6
T Kuhnel, H Jagle, W Hosemann, R Weber, V Vielsmeier
To avoid the dangers associated with lower eyelid approaches to the orbital floor and to improve visualization, we propose an endoscopic procedure for orbital floor fracture reduction and osteosynthesis using endonasal access via the medial maxillary sinus wall. The technique of endoscopic, endonasal transantral surgery is described, together with a retrospective analysis of 17 patients who had undergone this surgical procedure in the Department of Otorhinolaryngology, University of Regensburg, between July 2013 and June 2016...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28883787/investigations-into-hypoxia-and-oxidative-stress-at-the-optic-nerve-head-in-a-rat-model-of-glaucoma
#7
Glyn Chidlow, John P M Wood, Robert J Casson
The vascular hypothesis of glaucoma proposes that retinal ganglion cell axons traversing the optic nerve head (ONH) undergo oxygen and nutrient insufficiency as a result of compromised local blood flow, ultimately leading to their degeneration. To date, evidence for the hypothesis is largely circumstantial. Herein, we made use of an induced rat model of glaucoma that features reproducible and widespread axonal transport disruption at the ONH following chronic elevation of intraocular pressure. If vascular insufficiency plays a role in the observed axonal transport failure, there should exist a physical signature at this time point...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28878627/optic-nerve-degeneration-after-retinal-ischemia-reperfusion-in-a-rodent-model
#8
Marina Renner, Gesa Stute, Mohammad Alzureiqi, Jacqueline Reinhard, Susanne Wiemann, Heiko Schmid, Andreas Faissner, H Burkhard Dick, Stephanie C Joachim
Retinal ischemia is a common pathomechanism in many ocular disorders such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma or retinal vascular occlusion. Several studies demonstrated that ischemia/reperfusion (I/R) leads to morphological and functional changes of different retinal cell types. However, little is known about the ischemic effects on the optic nerve. The goal of this study was to evaluate these effects. Ischemia was induced by raising the intraocular pressure (IOP) in one eye of rats to 140 mmHg for 1 h followed by natural reperfusion...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28878269/caveolin-1-protects-retinal-ganglion-cells-against-acute-ocular-hypertension-injury-via-modulating-microglial-phenotypes-and-distribution-and-activating-akt-pathway
#9
Liwei Zhang, Jiazhou Xu, Ran Liu, Wei Chen, Qishan Chen, Wenjie Hu, Lan Zhou, Ruting Zhang, Hongping Xu, Dongyue Lin, Xuri Li, Zhongshu Tang
Glaucoma, a group of eye diseases, causes gradual loss of retinal ganglion cells (RGCs) and ultimately results in irreversible blindness. Studies of the underlying mechanisms of glaucoma and clinical trial are far from satisfactory. Results from a genome-wide association study have suggested that the CAV1/CAV2 locus is associated with glaucoma, but this association and its potential underlying mechanisms need to be confirmed and further explored. Here, we studied the function of caveolin-1 (Cav1) in an acute ocular hypertension glaucoma model...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28877146/eye-protection-survey-of-dermatologists-and-office-staff
#10
David A Pate, Jeremy T Kampp
BACKGROUND: Splash injuries to mucosal membranes during procedures have been well documented in dermatology and carry a potential risk of blood-borne virus transmission. The risk to the ocular mucosa can be minimized with proper eye protection. OBJECTIVE: To examine the prevalence of wearing eye protection during dermatologic procedures by physicians, trainees, and office staff in dermatology. METHODS: A Cross-sectional observational study of US dermatologists, residents, nurses, and medical assistants was performed regarding eye protection during dermatologic procedures...
September 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28875742/medicated-ocular-bandages-and-corneal-health-potential-excipients-and-active-pharmaceutical-ingredients
#11
Ghada Zidan, Ilva D Rupenthal, Carol Greene, Ali Seyfoddin
Corneal blindness can occur due to improper healing of the corneal tissues after induced injury or abrasion which can be accidental, pathogenic or after corneal surgery. Abnormal regulation of the healing mechanisms can lead to corneal opacity. Reducing inflammation and promoting epithelial wound healing is crucial for scar-free corneal recovery without eyesight complications. Current approaches for corneal wound healing involve amniotic membrane (AM) bandages, bandage contact lenses (BCL) and collagen shields in conjunction with frequent administration of therapeutic eye drops...
September 6, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28874911/a-ligation-of-the-lacrimal-excretory-duct-in-mouse-induces-lacrimal-gland-inflammation-with-proliferative-cells
#12
Ying Liu, Masatoshi Hirayama, Tetsuya Kawakita, Kazuo Tsubota
The lacrimal gland secretes tear fluids to ocular surface, which plays an indispensable role in maintaining the health of the ocular epithelia and protecting the ocular surface from the external environment. The dysfunction of the lacrimal glands causes dry eye disease due to a reduction in tear volume. The dry eye disease is becoming a popular public disease, for the number of patients is increasing, who have subjective symptom and loss of vision, which affect the quality of life. Inflammatory change in the damaged lacrimal gland has been reported; however, a major challenge is to establish a simple animal model to observe the changes...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28855772/patterns-of-ocular-trauma-among-the-elderly-in-a-south-american-urban-area-and-the-association-between-eye-traumas-with-sleep-disorders
#13
Sergio Henrique N Moreira, Niro Kasahara
AIMS: Eye trauma in the older population can lead to blindness. Sleep deterioration is associated with increased risk of occupational injuries. The purpose of the study was to assess the epidemiology of ocular trauma in the elderly population and to evaluate the relationship between eye trauma and sleep quality. SETTINGS AND DESIGN: This was a cross-sectional, observational hospital based study done in a Sao Paulo, Brazil. SUBJECTS AND METHODS: Patients with ocular trauma aged 60 years who attended the Eye Trauma Service of the Santa Casa de Sao Paulo Central Hospital were included...
July 2017: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/28852825/incarceration-of-the-inferior-oblique-muscle-branch-of-the-oculomotor-nerve-in-patients-with-orbital-floor-trapdoor-fracture
#14
Yasuhiro Takahashi, Maria Suzanne Sabundayo, Hidetaka Miyazaki, Hidenori Mito, Hirohiko Kakizaki
PURPOSE: To examine the clinical characteristics of patients with concomitant incarceration of the inferior oblique muscle branch of the oculomotor nerve who had suffered from an orbital floor trapdoor fracture with orbital fat incarceration. METHODS: Fifty-nine patients were retrospectively reviewed. Concomitant inferior oblique muscle branch incarceration was diagnosed by inferior oblique muscle underaction on the Hess chart and a missing inferior oblique muscle branch on computed tomographic images on baseline examination...
August 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28844048/traumatic-brain-injury-dry-eye-and-comorbid-pain-diagnoses-in-us-veterans
#15
Charity J Lee, Elizabeth R Felix, Roy C Levitt, Christopher Eddy, Elizabeth A Vanner, William J Feuer, Constantine D Sarantopoulos, Anat Galor
AIMS: The purpose of the study is to evaluate the relationship between dry eye (DE) and pain diagnoses in US veterans with and without traumatic brain injury (TBI). METHODS: Retrospective cohort study of veterans who were seen in the Veterans Administration Hospital (VA) between 1 January 2010 and 31 December 2014. Veterans were separated into two groups by the presence or absence of an International Classification of Diseases, Ninth Revision diagnosis of TBI and assessed for DE and other comorbidities...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28835428/oral-mucosal-grafting-combined-with-tenonplasty-for-ocular-surface-and-lid-margin-reconstruction-in-an-atypical-sectorial-chemical-burn
#16
Swati Singh, Purvasha Narang, Vikas Mittal
A 46-year-old woman presented with chemical injury in both eyes after the instillation of undefined eye-drops prescribed by quack. She had an atypical presentation in the form of bilateral severe necrosis of both lids and whole palpebral conjunctiva. Extensive debridement with conjunctival epitheliectomy, tenonplasty and amniotic membrane transplantation (AMT) was performed. Characteristic differences from typical chemical injuries were a sectorial involvement of ocular surface and keratinisation over distorted lid margins...
August 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28820158/systematic-analysis-of-ocular-trauma-by-a-new-proposed-ocular-trauma-classification
#17
Bhartendu Shukla, Rupesh Agrawal, Dhananjay Shukla, Sophia Seen
PURPOSE: The current classification of ocular trauma does not incorporate adnexal trauma, injuries that are attributable to a nonmechanical cause and destructive globe injuries. This study proposes a new classification system of ocular trauma which is broader-based to allow for the classification of a wider range of ocular injuries not covered by the current classification. METHODS: A clinic-based cross-sectional study to validate the proposed classification. We analyzed 535 cases of ocular injury from January 1, 2012 to February 28, 2012 over a 4-year period in an eye hospital in central India using our proposed classification system and compared it with conventional classification...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28811503/lacrimal-gland-repair-after-short-term-obstruction-of-excretory-duct-in-rabbits
#18
Hui Lin, Ying Liu, Hong He, Benjamin Botsford, Samuel Yiu
Aqueous tear-deficient dry eye is a multifactorial chronic disorder in which the lacrimal glands fail to produce enough tears to maintain a healthy ocular surface. The existence of lacrimal gland stem/progenitor cells was proposed in several species, yet their origin and characteristics are not very clear. Here, we investigated the presence of resident progenitor cells and their regenerative potential in a rabbit model with lacrimal gland main excretory duct ligation-induced injury. The ligation-injured lacrimal glands temporarily decreased in weight and had impaired tear secretion...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810572/diffusion-weighted-imaging-of-injuries-to-the-visual-centers-of-the-brain-in-patients-with-type-2-diabetes-and-retinopathy
#19
Ming Liang, Xing Chen, Feng Xue, Lingna Meng, Yunfeng Cong
The present study aimed to investigate the ability of diffusion-weighted imaging (DWI) to identify injury to the visual centers of the brain in patients with type 2 diabetes with retinopathy. The study included 84 cases (63 patients with type 2 diabetic retinopathy and 21 healthy individuals) that were assessed using DWI. Diabetic patients were equally divided into three groups: Proliferative diabetic retinopathy (PDR), non-proliferative diabetic retinopathy (NPDR) and diabetic without retinopathy. The results demonstrated that individuals in the PDR group had significantly higher disease duration and glycated hemoglobin levels than the diabetic without retinopathy group (P<0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807717/myofibroblast-transdifferentiation-the-dark-force-in-ocular-wound-healing-and-fibrosis
#20
REVIEW
Daisy Y Shu, Frank J Lovicu
Wound healing is one of the most complex biological processes to occur in life. Repair of tissue following injury involves dynamic interactions between multiple cell types, growth factors, inflammatory mediators and components of the extracellular matrix (ECM). Aberrant and uncontrolled wound healing leads to a non-functional mass of fibrotic tissue. In the eye, fibrotic disease disrupts the normally transparent ocular tissues resulting in irreversible loss of vision. A common feature in fibrotic eye disease is the transdifferentiation of cells into myofibroblasts that can occur through a process known as epithelial-mesenchymal transition (EMT)...
September 2017: Progress in Retinal and Eye Research
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