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Open globe injury

Shohei Morikawa, Yoshifumi Okamoto, Fumiki Okamoto, Naoki Inomoto, Hiroto Ishikawa, Kozo Harimoto, Tetsuo Ueda, Taiji Sakamoto, Tetsuro Oshika
PURPOSE: To investigate the clinical characteristics and visual outcomes in patients with fall-related open globe injuries and to evaluate differences between fall-related and non-fall-related open globe injuries in Japan. METHODS: A retrospective review of patients with open globe injury who presented to Japan-Clinical Research of Study (J-CREST) hospitals between 2005 and 2015 was enrolled. Clinical information including age, sex, initial visual acuity, final visual acuity, type of injury, status of the crystalline lens, zone of injury, wound length, presence of retinal detachment, proliferative vitreoretinopathy, expulsive hemorrhage, and endophthalmitis was recorded...
March 15, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Peng Zhang, Guannan Zhao, Liang Ji, Jinggang Yin, Lu Lu, Wei Li, Guomin Zhou, Edward Chaum, Junming Yue
Proliferative vitreoretinopathy (PVR) is a common complication of open globe injury and the most common cause of failed retinal detachment surgery. The response by retinal pigment epithelial (RPE) cells liberated into the vitreous includes proliferation and migration; most importantly, epithelial to mesenchymal transition (EMT) of RPE plays a central role in the development and progress of PVR. For the first time, we show that knockdown of BIRC5, a member of the inhibitor of apoptosis family, using either lentiviral vector based CRISPR/Cas9 nickase gene editing or inhibition of survivin using the small-molecule inhibitor YM155, results in the suppression of EMT in RPE cells...
March 6, 2018: Biochemical and Biophysical Research Communications
Anne-Marie Yardley, Asim Ali, Nasrin Najm-Tehrani, Kamiar Mireskandari
PURPOSE: To describe refractive and visual outcomes of pediatric traumatic cataract requiring surgery and evaluate the factors influencing success. SETTING: Hospital for Sick Children, Toronto, Ontario, Canada. DESIGN: Retrospective case series. METHODS: Charts of children having lensectomy for traumatic cataract between January 1, 2000, and June 30, 2015, were reviewed for demographic information, visual and refractive outcomes, complications, and surgical details...
January 2018: Journal of Cataract and Refractive Surgery
Robert B Garoon, Darlene Miller, Harry W Flynn
Purpose: To report a series of patients with acute-onset bacterial endophthalmitis caused by culture proven Staphylococcus lugdunensis , and to characterize clinical outcomes and microbiologic susceptibilities of this organism. Observations: The study included six eyes of 6 patients. The etiologies included cataract surgery (3), open globe injury (2), and intravitreal injection (1). Isolates of S. lugdunensis demonstrated sensitivity to vancomycin in all cases reported...
March 2018: American Journal of Ophthalmology Case Reports
Sevinc Sahin Atik, Seyda Ugurlu, Emine Deniz Egrilmez
BACKGROUND: Open globe injuries (OGIs) are the main cause of visual impairment worldwide. The aim of this study was to evaluate the clinical features and the visual outcome of OGIs presented to the largest Teaching Hospital in Western part of Turkey. METHODS: The study included patients presented with OGI between Jan 2009 and Dec 2013. Data including patient demographics, causes of injury, visual acuity (VA) at presentation, and final VA were collected. Ocular Trauma Scores (OTS) were calculated...
January 29, 2018: Journal of Craniofacial Surgery
Işıl Kutlutürk Karagöz, Esin Söğütlü Sarı, Anıl Kubaloğlu, Ahmet Elbay, Ümit Çallı, David P Pinero, Yusuf Özertürk, Titap Yazıcıoğlu
BACKGROUND: This study aimed to evaluate 1-year follow-up results of cases that were diagnosed with open globe injury (OGI), to compare trauma-related characteristics between pediatric and adult cases, and to determine risk factors for a poor final visual acuity. METHODS: This study enrolled 294 cases that met the OGI definition and were followed up for at least 1 year. Demographic and clinical features regarding ocular trauma were recorded. The cases were divided into two groups according to age: pediatric (≤16 years) and adult (>16 years) groups...
January 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
Edita Puodžiuvienė, Giedrė Jokūbauskienė, Monika Vieversytė, Kirwan Asselineau
BACKGROUND: Pediatric trauma can lead to serious visual impairment as a result of the trauma itself or secondary to amblyopia. Precise data on epidemiological characteristics and visual outcomes of pediatric ocular injuries are valuable for the prevention of monocular blindness. METHODS: A total of 268 cases of pediatric ocular trauma admitted to the Department of Ophthalmology of the Lithuanian University of Health Sciences Hospital from January 2008 to December 2013 were retrospectively reviewed...
January 18, 2018: BMC Ophthalmology
Hany Mahmoud Yassin, Ahmed Tohamy Abdel Moneim, Ahmed Sherin Mostafa Bayoumy, Hasan Metwally Bayoumy, Sameh Galal Taher
Background: The use of succinylcholine for rapid sequence induction in patients with open globe injuries may be detrimental to the eye. Aim: The aim of this study is to determine if the premedication with magnesium sulfate (MgSO4) could attenuate the increase in intraocular pressure (IOP) associated with succinylcholine injection and intubation. Setting: Operation theaters in a tertiary care University Hospital between December 2014 and July 215...
October 2017: Anesthesia, Essays and Researches
Nidhi Relhan, Richard K Forster, Harry W Flynn
PURPOSE: To report historically evolving strategies (then and now) in prevention and management of endophthalmitis. DESIGN: A perspective on relevant topics in the prophylaxis and management of endophthalmitis. METHODS: This is an author-selected review of studies leading to changes in strategies for endophthalmitis management over the last 100 years. RESULTS: The current perspective discusses the trends and strategies over the past century...
March 2018: American Journal of Ophthalmology
Xiangjia Zhu, Yinglei Zhang, Wenwen He, Hongfei Ye, Chunhui Jiang, Yi Lu
Purpose: To evaluate the tilt, decentration, and internal higher-order aberrations (HOAs) of sutured posterior-chamber intraocular lenses (IOLs) in patients with open globe injuries. Methods: 46 consecutive patients (47 eyes) who underwent transsclerally sutured IOL implantation were enrolled in this prospective cohort study. Nineteen eyes had a history of open globe injury. The tilt and decentration of the IOLs and the visual quality were measured 1 month after surgery...
2017: Journal of Ophthalmology
Niki Bayat, Yi Zhang, Paulo Falabella, Roby Menefee, John J Whalen, Mark S Humayun, Mark E Thompson
Open globe injuries are full-thickness injuries sustained to the eye wall (cornea or sclera), which cause immediate drops in intraocular pressure that may lead to retinal detachment and permanent vision loss if not treated rapidly after injury. The current standard of care for open globe injuries consists of suturing the margins closed, but the technique can be time-consuming, requires specialized training and equipment, and can lead to patient discomfort, abrasion, and infection from eye rubbing. We engineered an injectable, thermoresponsive sealant (TRS) and a custom tool to occlude open globe injuries...
December 6, 2017: Science Translational Medicine
João Beato, António B Melo, Pedro A Faria, Luís Torrão, Fernando Falcão-Reis
No abstract text is available yet for this article.
2017: International Journal of Ophthalmology
Varsha R Kadaba, Jayshree Menon
INTRODUCTION: Endophthalmitis after anti-vascular endothelial growth factor injection is a rare complication but may lead to rapid destruction of structures within the eye. Infection with Clostridium perfringens has not previously been reported in this context. CASE REPORT: A 90-year-old woman presented with endophthalmitis of the right eye, 2 days after an intravitreal injection of ranibizumab. Initial examination showed a high intraocular pressure, refractive to topical treatment, reduced vision, and a hypopyon...
November 22, 2017: Retinal Cases & Brief Reports
Jacob S Martin, Devasis N Reddy, Heather A D Potter, Cat N Burkat
The authors report the case of a 2-year-old girl who presented with an acute ruptured globe secondary to penetration by the casing of a .22 caliber cartridge that was ignited by a car cigarette lighter. Although penetrating injuries are a common mechanism of ocular trauma, open globe induced by cartridge casing represents an unusual and preventable cause. [J Pediatr Ophthalmol Strabismus. 2017;54:e88-e90.].
November 17, 2017: Journal of Pediatric Ophthalmology and Strabismus
Satendra Singh, Bhavana Sharma, Kavita Kumar, Aditi Dubey, Kanchan Ahirwar
PURPOSE: Ocular trauma constitutes an important cause of preventable visual morbidity worldwide. This study was done to study the incidence, sociodemographic pattern, and clinical profile of ocular trauma in pediatric age group. Also to evaluate the factors influencing final visual outcome in these patients. METHODS: This was a prospective interventional study concerning ocular trauma in pediatric patients up to 16 years of age of either sex. Various variables having an impact on final visual outcome were studied, and results were analyzed using statistical indices - relative risk, Chi-square test, P value, and linear regression analysis...
November 2017: Indian Journal of Ophthalmology
Thanigasalam Thevi, Adinegara Lutfi Abas
Traumatic endophthalmitis is a devastating condition that can occur following an open globe injury and result in loss of vision. The use of prophylactic antibiotics is empirical as most surgeons fear complications associated with the same. No systematic review has been performed in English on the role of intravitreal/intracameral antibiotics in preventing traumatic endophthalmitis. We searched for randomized controlled trials and controlled clinical trials comparing intracameral/intravitreal antibiotics with placebos on PubMed, Google Scholar, Science Direct, and Cochrane Library using keywords open globe/trauma/penetrating/perforating injuries endophthalmitis...
October 2017: Indian Journal of Ophthalmology
Hua Wang, Ting Chen, Lei Ye, Qi-Chen Yang, Rong Wei, Ying Zhang, Nan Jiang, Yi Shao
The present study aimed to investigate functional networks underlying brain‑activity alterations in patients with acute unilateral open globe injury (OGI) and associations with their clinical features using the voxel‑wise degree centrality (DC) method. In total, 18 patients with acute OGI (16 males and 2 females), and 18 healthy subjects (16 males and 2 females), closely matched in age, sex and education, participated in the present study. Each subject underwent a resting‑state functional magnetic resonance imaging scan...
December 2017: Molecular Medicine Reports
Muhammed Batur, Erbil Seven, Mahmut Nedim Akaltun, Serek Tekin, Tekin Yasar
PURPOSE: The purpose of this study was to evaluate the epidemiology and outcomes of pediatric open globe injury (OGI). METHOD: The medical records of all patients diagnosed with OGI in the authors' clinic between 1996 and 2015 were screened retrospectively. A total of 893 eyes of 892 patients aged 16 years or younger were included in the study. Open globe injury was classified according to the ocular trauma classification (OTS). Age, sex, history, cause and month of trauma, treatment received, visual acuity at presentation, final visual acuity, and cause of vision loss were recorded...
November 2017: Journal of Craniofacial Surgery
Andrew J McClellan, Jacquelyn J Daubert, Nidhi Relhan, Kimberly D Tran, Harry W Flynn, Steven Gayer
PURPOSE: This study compares the clinical features and physician selection of either Regional Anesthesia (peribulbar or retrobulbar block) with Monitored Anesthesia Care (RA-MAC) or General Anesthesia (GA) for open globe injury repair. DESIGN: A non-randomized, comparative, retrospective case series at a University Referral Center. PARTICIPANTS: All adult repairable open globe injuries receiving primary repair between January 1st, 2004 and December 31st, 2014 (11 years)...
May 2017: Ophthalmology Retina
Yong-Rong Ji, Dong-Qing Zhu, Hui-Fang Zhou, Xian-Qun Fan
AIM: To investigate the epidemiologic characteristics and outcomes of open globe injury in Shanghai. METHODS: A retrospective study was conducted for 148 unilateral open globe injury cases presenting to a tertiary referral hospital of Shanghai. Electronic medical records were reviewed and phone surveys were conducted to collect and analyze 1) background of patient; 2) setting of injury and clinical signs at presentation; 3) treatment procedure and outcome; 4) quality of life after injury...
2017: International Journal of Ophthalmology
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