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https://www.readbyqxmd.com/read/27932205/cold-induced-sympathetic-tone-modifies-the-impact-of-endothelium-dependent-vasodilation-in-the-finger-pulp
#1
Tone Kristin Bergersen, Maria Skytioti, Maja Elstad
OBJECTIVE: In thermoneutral and cold subjects, the sympathetic nervous system regulates skin blood flow by adjusting frequency of the tonic vasoconstrictor impulses. However, the way these thermoregulatory impulses influence the vascular endothelium is not well known. We studied how the sympathetic nervous system influences endothelium-dependent vasodilation (EDV) caused by shear stress in skin containing arteriovenous anastomoses (AVAs) and arterioles in healthy subjects. METHODS: Thirteen healthy subjects were exposed to thermoneutral (29°C) and cold (22°C) ambient temperatures on separate days...
November 30, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27912885/tetrandrine-an-alkaloid-from-s-tetrandra-exhibits-anti-hypertensive-and-sleep-enhancing-effects-in-shr-via-different-mechanisms
#2
Yuan-Li Huang, Su-Ying Cui, Xiang-Yu Cui, Qing Cao, Hui Ding, Jin-Zhi Song, Xiao Hu, Hui Ye, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang
BACKGROUND: Sleep disorders have been found to be associated with hypertension in both cross-sectional and longitudinal epidemiological studies. Tetrandrine, a major component of Stephania tetrandra, is well known as an antihypertensive agent. The anti-hypertension mechanism mainly relies on its L-type calcium channel blocking property. In the previous study, tetrandrine revealed both anti-hypertension and hypnotic effects in spontaneously hypertensive rats (SHRs). PURPOSE: This study aims to elucidate whether the antihypertensive mechanism of tetrandrine in SHRs is relevant to its hypnotic effect...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912161/a-prospective-randomized-trial-of-tapered-cuff-endotracheal-tubes-with-intermittent-subglottic-suctioning-in-preventing-ventilator-associated-pneumonia-in-critically-ill-patients
#3
Ata Mahmoodpoor, Hadi Hamishehkar, Masoud Hamidi, Kamran Shadvar, Sarvin Sanaie, Samad Ej Golzari, Zahid Hussain Khan, Nader D Nader
BACKGROUND: Endotracheal tube placement is necessary for the control of the airway in patients who are mechanically ventilated. However, prolonged duration of endotracheal tube placement contributes to the development of ventilator-associated pneumonias (VAPs). The aim of this study was to evaluate whether subglottic suctioning using TaperGuard EVAC tubes was effective in decreasing the frequency of VAP. METHODS: A total of 276 mechanically ventilated patients for more than 72 hours were randomly assigned to group E (EVAC tube) and group C (conventional tube)...
November 14, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27909668/triple-row-modification-of-the-suture-bridge-technique-for-arthroscopic-rotator-cuff-repair
#4
Roger V Ostrander, Jarrod Smith, Michael Saper
Recent advances to improve outcomes in rotator cuff repair include using arthroscopic double-row suture-bridge techniques in an effort to reconstruct the rotator cuff footprint and improve fixation. However, when using this technique for larger tears, it can be difficult to get the lateral portion of the rotator cuff into an anatomic position. This report describes a triple-row modification of the suture-bridge technique that results in significantly more footprint contact area and contact pressure compared with the double-row and standard suture-bridge techniques...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27902494/an-ultrasound-look-at-korotkoff-sounds-the-role-of-pulse-wave-velocity-and-flow-turbulence
#5
Amir Benmira, Antonia Perez-Martin, Iris Schuster, Florent Veye, Jean Triboulet, Nicolas Berron, Isabelle Aichoun, Sarah Coudray, Jérémy Laurent, Fethi Bereksi-Reguig, Michel Dauzat
AIMS: The aim of this study was to analyze the temporal relationships between pressure, flow, and Korotkoff sounds, providing clues for their comprehensive interpretation. MATERIALS AND METHODS: When measuring blood pressure in a group of 23 volunteers, we used duplex Doppler ultrasonography to assess, under the arm-cuff, the brachial artery flow, diameter changes, and local pulse wave velocity (PWV), while recording Korotkoff sounds 10 cm downstream together with cuff pressure and ECG...
November 29, 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27898185/perfusion-has-no-effect-on-the-in-vivo-cest-effect-from-cr-crcest-in-skeletal-muscle
#6
Feliks Kogan, Randall B Stafford, Erin K Englund, Garry E Gold, Hari Hariharan, John A Detre, Ravinder Reddy
Creatine, a key component of muscle energy metabolism, exhibits a chemical exchange saturation transfer (CEST) effect between its amine group and bulk water, which has been exploited to spatially and temporally map creatine changes in skeletal muscle before and after exercise. In addition, exercise leads to an increase in muscle perfusion. In this work, we determined the effects of perfused blood on the CEST effects from creatine in skeletal muscle. Experiments were performed on healthy human subjects (n = 5) on a whole-body Siemens 7T magnetic resonance imaging (MRI) scanner with a 28-channel radiofrequency (RF) coil...
November 29, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27893308/evaluation-of-hypotensive-and-antihypertensive-effects-of-velvet-bean-mucuna-pruriens-l-hydrolysates
#7
Luis Chel-Guerrero, Saulo Galicia-Martínez, Juan José Acevedo-Fernández, Jesus Santaolalla-Tapia, David Betancur-Ancona
Hypertension could cause significant worldwide health problems that affect 15-20% of all adults; according to National Health and Nutrition Examination Survey, about 29% of the adult population in the United States are hypertensive. Recent research has shown that peptides derived from the hydrolysis of food proteins can decrease blood pressure. This study was carried out to evaluate the hypotensive and antihypertensive potential of Mucuna pruriens protein hydrolysates in in vitro and in vivo models. M. pruriens protein concentrate was prepared by wet fractionation and enzymatically hydrolyzed using Alcalase(®), Flavourzyme(®), and the sequential system Alcalase-Flavourzyme at different times (5-120 min)...
November 28, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27890833/pulse-wave-analysis-after-treatment-of-abdominal-aortic-aneurysms-with-the-ovation-device
#8
Efstratios Georgakarakos, Christos Argyriou, George S Georgiadis, Miltos K Lazarides
BACKGROUND: Ovation Aortic Stent-Graft System is a new device for the endovascular treatment of Abdominal Aortic Aneurysms achieving fixation via a 35-mm long, rigid ancored suprarenal stent and sealing stent at the infrarenal level by a means of a polymer-filling pair of inflatable O-rings which cause narrowing of flow lumen and regional stenosis. Thus, concerns have been raised regarding hemodynamic consequences associated with this new desing . Our preliminary report showed no significant increase of aortic pulse wave velocity (aPWV) immediately after implantation of the Ovation in 3 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27888135/antihypertensive-effects-of-androgens-in-conscious-spontaneously-hypertensive-rats
#9
Mercedes Perusquía, Nieves Herrera, Mercedes Ferrer, John N Stallone
Androgens are vasoactive steroids that induce acute vasodilation in a number of isolated vascular beds from different species, but the effects of these hormones on systemic blood pressure (BP) have been studied little. Although it has been reported that androgens exert systemic hypotensive effects through peripheral vasodilation in normotensive rats, there have not been any reports of systemic hypotensive effects of androgens in animals with hypertension. This study was designed to evaluate the acute effects of testosterone (TES) and its 5-reduced metabolites on systemic BP in hypertensive rats and to test the hypothesis that hypotestosteronemia may be involved in the pathogenesis of hypertension...
November 23, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27884851/influence-of-preinfarction-angina-and-coronary-collateral-blood-flow-on-the-efficacy-of-remote-ischaemic-conditioning-in-patients-with-st-segment-elevation-myocardial-infarction-post-hoc-subgroup-analysis-of-a-randomised-controlled-trial
#10
Kasper Pryds, Morten Bøttcher, Astrid Drivsholm Sloth, Kim Munk, Michael Rahbek Schmidt, Hans Erik Bøtker
OBJECTIVES: Remote ischaemic conditioning (RIC) confers cardioprotection in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). We investigated whether preinfarction angina and coronary collateral blood flow (CCBF) to the infarct-related artery modify the efficacy of RIC. DESIGN: Post hoc subgroup analysis of a randomised controlled trial. PARTICIPANTS: A total of 139 patients with STEMI randomised to treatment with pPCI or RIC+pPCI...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27879379/performance-of-the-pneux-system-a-bench-study-comparison-with-4-other-endotracheal-tube-cuffs
#11
Christopher T Chenelle, Taiga Itagaki, Daniel F Fisher, Lorenzo Berra, Robert M Kacmarek
BACKGROUND: Cuff design affects microaspiration, a risk factor for pneumonia. We questioned whether the PneuX low-volume fold-free cuff design would prevent cuff leakage and maintain the same tracheal wall pressure as high-volume, low-pressure (HVLP) cuffs. METHODS: We evaluated 4 HVLP-cuffed endotracheal tubes (ETTs), Hi-Lo (polyvinyl chloride [PVC]), Microcuff (polyurethane [PU]), SealGuard (PU+tapered), and TaperGuard (PVC+tapered), and the PneuX with its dedicated tracheal seal monitor...
November 22, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27878503/evaluation-of-different-near-infrared-spectroscopy-technologies-for-assessment-of-tissue-oxygen-saturation-during-a-vascular-occlusion-test
#12
Kevin Steenhaut, Koen Lapage, Thierry Bové, Stefan De Hert, Annelies Moerman
An increasing number of NIRS devices are used to provide measurements of peripheral tissue oxygen saturation (StO2). The aim of the present study is to test the hypothesis that despite technological differences between devices, similar trend values will be obtained during a vascular occlusion test. The devices compared are NIRO-200NX, which measures StO2 and oxyhemoglobin by spatially resolved spectroscopy and the Beer-Lambert law, respectively, and INVOS 5100C and Foresight Elite, which both measure StO2 with the Beer-Lambert law, enhanced with the spatial resolution technique...
November 22, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27876841/accuracy-of-pulse-interval-timing-in-ambulatory-blood-pressure-measurement
#13
Sarah A Kane, James R Blake, Frank J McArdle, Philip Langley, Andrew J Sims
Blood pressure (BP) monitors rely on pulse detection. Some blood pressure monitors use pulse timings to analyse pulse interval variability for arrhythmia screening, but this assumes that the pulse interval timings detected from BP cuffs are accurate compared with RR intervals derived from ECG. In this study we compared the accuracy of pulse intervals detected using an ambulatory blood pressure monitor (ABPM) with single lead ECG. Twenty participants wore an ABPM for three hours and a data logger which synchronously measured cuff pressure and ECG...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872025/contemporary-review-of-artificial-urinary-sphincters-for-male-stress-urinary-incontinence
#14
REVIEW
Faysal A Yafi, Mary K Powers, Jonathan Zurawin, Wayne J G Hellstrom
INTRODUCTION: The most common cause of urinary incontinence in men after radical prostatectomy is intrinsic sphincter deficiency, which can affect long-term quality of life. The prevalence of stress urinary incontinence (SUI) after radical prostatectomy has been reported to be 2.5% to 90%. For patients with moderate to severe male SUI, the artificial urinary sphincter (AUS) is considered the gold standard in surgical treatment. AIM: To review the available literature on the development, patient selection, surgical technique, complications, and management of AUS for male SUI...
April 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27870648/facilitated-temporal-summation-of-pain-correlates-with-clinical-pain-intensity-after-hip-arthroplasty
#15
Masashi Izumi, Kristian Kjær Petersen, Mogens Berg Laursen, Lars Arendt-Nielsen, Thomas Graven-Nielsen
Widespread hyperalgesia has been found in patients with painful hip osteoarthritis (OA) which can be normalized after total hip arthroplasty (THA) if patients have no residual postoperative pain. This study characterized the preoperative somatosensory profiles and provided possible interpretation of underlying pain mechanisms that might influence the development of postoperative pain. Forty hip OA patients with unilateral pain were assessed before and 6 weeks post-THA and compared with forty asymptomatic control subjects...
November 17, 2016: Pain
https://www.readbyqxmd.com/read/27864919/using-a-novel-assessment-of-procedural-proficiency-provides-medical-educators-insight-into-blood-pressure-measurement
#16
Michael Holmstrup, Brock Jensen, Rebecca Burkart, Malorie Levis
Objective: This investigation was performed to determine how students in a health sciences program utilize and explain techniques within blood pressure measurement using a novel assessment, and changes associated with greater curricular exposure. Methods: An exploratory, qualitative and quantitative study was conducted using a 'Think Aloud' design with protocol analysis. Following familiarization, participants performed the task of measuring blood pressure on a reference subject while stating their thought processes...
November 19, 2016: International Journal of Medical Education
https://www.readbyqxmd.com/read/27864167/testing-the-feasibility-of-remote-patient-monitoring-in-prenatal-care-using-a-mobile-app-and-connected-devices-a-prospective-observational-trial
#17
Kathryn I Marko, Jill M Krapf, Andrew C Meltzer, Julia Oh, Nihar Ganju, Anjali G Martinez, Sheetal G Sheth, Nancy D Gaba
BACKGROUND: Excessive weight gain and elevated blood pressure are significant risk factors for adverse pregnancy outcomes such as gestational diabetes, premature birth, and preeclampsia. More effective strategies to facilitate adherence to gestational weight gain goals and monitor blood pressure may have a positive health benefit for pregnant women and their babies. The impact of utilizing a remote patient monitoring system to monitor blood pressure and weight gain as a component of prenatal care has not been previously assessed...
November 18, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27859944/user-independent-assessment-of-conditioning-pain-modulation-by-cuff-pressure-algometry
#18
T Graven-Nielsen, M Izumi, K K Petersen, L Arendt-Nielsen
BACKGROUND: The use of conditioning pain modulation (CPM) is hampered by poor reproducibility and lack of user-independent paradigms. This study refined the CPM paradigm by applying user-independent cuff algometry. METHODS: In 20 subjects, the CPM effect of conditioning with cuff stimulation on the arm was investigated by pain test stimuli on the contralateral leg before and in parallel with different cuff conditionings (10, 30, 60 kPa/60 s; 30, 60 kPa/10 s)...
November 11, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27859264/inwardly-rectifying-k-channels-are-major-contributors-to-flow-induced-vasodilation-in-resistance-arteries
#19
Sang Joon Ahn, Ibra S Fancher, Jing-Tan Bian, Chong Xu Zhang, Sarah Schwab, Robert Gaffin, Shane A Phillips, Irena Levitan
AIMS: Inwardly rectifying K(+) (Kir) channels are known to be sensitive to flow, but their role in flow-induced endothelial responses is not known. The goal of this study is to establish the role of Kir channels in flow-induced vasodilation and to provide first insights into the mechanisms responsible for Kir signaling in this process. METHODS AND RESULTS: First, we establish that primary endothelial cells isolated from murine mesenteric arteries express functional Kir2...
November 17, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27856718/central-and-peripheral-responses-to-static-and-dynamic-stretch-of-skeletal-muscle-mechano-and-metabo-reflex-implications
#20
Massimo Venturelli, Emiliano Cé, Eloisa Limonta, Angela V Bisconti, Michela Devoto, Susanna Rampichini, Fabio Esposito
Passive static stretching (SS), circulatory cuff occlusion (CCO), and the combination of both (SS+CCO) have been used to investigate the mechano- and metabo-reflex, respectively. However, the effects of dynamic stretching (DS) alone or in combination with CCO (DS+CCO) on the same reflexes have never been explored. The aim of the study was to compare central and peripheral hemodynamic responses to DS, SS, DS+CCO, and SS+CCO. In ten participants, femoral blood flow (FBF), heart rate (HR), cardiac output (CO), and mean arterial pressure (MAP) were assessed during DS and SS of the quadriceps muscle with and without CCO...
November 17, 2016: Journal of Applied Physiology
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