Cong-Min Tang, Zhen Zhang, Yan Sun, Wen-Jing Ding, Xue-Chun Yang, Yi-Ping Song, Ming-Ying Ling, Xue-Hui Li, Rong Yan, Yu-Jing Zheng, Na Yu, Wen-Hua Zhang, Yong Wang, Shao-Peng Wang, Hai-Qing Gao, Chuan-Li Zhao, Yan-Qiu Xing
Aging is associated with gradual changes in liver structure, altered metabolites and other physiological/pathological functions in hepatic cells. However, its characterized phenotypes based on altered metabolites and the underlying biological mechanism are unclear. Advancements in high-throughput omics technology provide new opportunities to understand the pathological process of aging. Here, in our present study, both metabolomics and phosphoproteomics were applied to identify the altered metabolites and phosphorylated proteins in liver of young (the WTY group) and naturally aged (the WTA group) mice, to find novel biomarkers and pathways, and uncover the biological mechanism...
November 2023: Heliyon