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https://www.readbyqxmd.com/read/29775089/detection-of-perimacular-red-dots-and-blots-when-screening-for-diabetic-retinopathy-refer-or-not-refer
#1
Anatolie Baltatescu, Elio Striglia, Marina Trento, Aurora Mazzeo, Franco Cavallo, Lorena Charrier, Massimo Porta
PURPOSE: Detection of microaneurysms and/or microhaemorrhages near the fovea when screening for diabetic retinopathy poses a problem because referral to retinal specialists may alarm patients and unnecessarily burden ophthalmologists. METHODS: Six-month prospective study of patients found to have minimal red lesions within one disc diameter of the fovea when screened for diabetic retinopathy. Two 45° digital photographs, one centred on the macula and the other nasal including the optic disc, were taken for each eye...
May 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29774002/on-the-drive-specificity-of-freudian-drives-for-the-generation-of-seeking-activities-the-importance-of-the-underestimated-imperative-motor-factor
#2
Michael Kirsch, Wolfgang Mertens
Doubters of Freud's theory of drives frequently mentioned that his approach is outdated and therefore cannot be useful for solving current problems in patients with mental disorders. At present, many scientists believe that affects rather than drives are of utmost importance for the emotional life and the theoretical framework of affective neuroscience, developed by Panksepp, strongly underpinned this view. Panksepp evaluated seven so-called command systems and the SEEKING system is therein of central importance...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29770927/a-review-of-existing-and-potential-computer-user-interfaces-for-modern-radiology
#3
REVIEW
Antoine Iannessi, Pierre-Yves Marcy, Olivier Clatz, Anne-Sophie Bertrand, Maki Sugimoto
The digitalization of modern imaging has led radiologists to become very familiar with computers and their user interfaces (UI). New options for display and command offer expanded possibilities, but the mouse and keyboard remain the most commonly utilized, for usability reasons. In this work, we review and discuss different UI and their possible application in radiology. We consider two-dimensional and three-dimensional imaging displays in the context of interventional radiology, and discuss interest in touchscreens, kinetic sensors, eye detection, and augmented or virtual reality...
May 16, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29769759/a-p2p-botnet-detection-scheme-based-on-decision-tree-and-adaptive-multilayer-neural-networks
#4
Mohammad Alauthaman, Nauman Aslam, Li Zhang, Rafe Alasem, M A Hossain
In recent years, Botnets have been adopted as a popular method to carry and spread many malicious codes on the Internet. These malicious codes pave the way to execute many fraudulent activities including spam mail, distributed denial-of-service attacks and click fraud. While many Botnets are set up using centralized communication architecture, the peer-to-peer (P2P) Botnets can adopt a decentralized architecture using an overlay network for exchanging command and control data making their detection even more difficult...
2018: Neural Computing & Applications
https://www.readbyqxmd.com/read/29769298/induced-expression-of-a-vestigial-sexual-signal
#5
David A Gray, Scherezade Hormozi, Fritz R Libby, Randy W Cohen
Vestigial morphological traits are common and well known in a variety of taxa. Identification of vestigial genes has illustrated the potential for evolutionary reversals and the re-expression of atavistic traits. Here we induce expression of a behavioural sexual signal, male calling song, in a cricket species, Gryllus ovisopis, which lacks a functional calling song. We successfully used acetylcholine injections in the frontal space of the head of male crickets to activate cerebral command neurons for cricket calling, and we recorded calling songs with a temporal chirp pattern similar to that of G...
May 2018: Biology Letters
https://www.readbyqxmd.com/read/29768990/control-of-a-7-dof-robotic-arm-system-with-an-ssvep-based-bci
#6
Xiaogang Chen, Bing Zhao, Yijun Wang, Shengpu Xu, Xiaorong Gao
Although robot technology has been successfully used to empower people who suffer from motor disabilities to increase their interaction with their physical environment, it remains a challenge for individuals with severe motor impairment, who do not have the motor control ability to move robots or prosthetic devices by manual control. In this study, to mitigate this issue, a noninvasive brain-computer interface (BCI)-based robotic arm control system using gaze based steady-state visual evoked potential (SSVEP) was designed and implemented using a portable wireless electroencephalogram (EEG) system...
April 12, 2018: International Journal of Neural Systems
https://www.readbyqxmd.com/read/29768634/perceived-burden-of-ehrs-on-physicians-at-different-stages-of-their-career
#7
Saif Khairat, Gary Burke, Heather Archambault, Todd Schwartz, James Larson, Raj M Ratwani
OBJECTIVE:  The purpose of this study was to further explore the effect of EHRs on emergency department (ED) attending and resident physicians' perceived workload, satisfaction, and productivity through the completion of six EHR patient scenarios combined with workload, productivity, and satisfaction surveys. METHODS:  To examine EHR usability, we used a live observational design combined with post observation surveys conducted over 3 days, observing emergency physicians' interactions with the EHR during a 1-hour period...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29764915/remote-physiological-monitoring-in-an-austere-environment-a-future-for-battlefield-care-provision
#8
Matthew J Smyth, J A Round, A J Mellor
Wearable technologies are making considerable advances into the mainstream as they become smaller and more user friendly. The global market for such devices is forecasted to be worth over US$5 billion in 2018, with one in six people owning a device. Many professional sporting teams use self-monitoring to assess physiological parameters and work rate on the pitch, highlighting the potential utility for military command chains. As size of device reduces and sensitivity improves, coupled with remote connectivity technology, integration into the military environment could be relatively seamless...
May 14, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29764437/caring-for-parents-an-evolutionary-rationale
#9
J Garay, S Számadó, Z Varga, E Szathmáry
BACKGROUND: The evolutionary roots of human moral behavior are a key precondition to understanding human nature. Investigations usually start with a social dilemma and end up with a norm that can provide some insight into the origin of morality. We take the opposite direction by investigating whether the cultural norm that promotes helping parents and which is respected in different variants across cultures and is codified in several religions can spread through Darwinian competition...
May 15, 2018: BMC Biology
https://www.readbyqxmd.com/read/29763490/climate-change-and-skin-disease
#10
Ashley D Lundgren
Despite commanding essentially universal scientific consensus, climate change remains a divisive and poorly understood topic in the United States. Familiarity with this subject is not just for climate scientists. The impact of climate change on human morbidity and mortality may be considerable; thus, physicians also should be knowledgeable in this realm. Climate change science can seem opaque and inferential, creating fertile ground for political polemics and undoubtedly contributing to confusion among the general public...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29762782/metaboanalyst-4-0-towards-more-transparent-and-integrative-metabolomics-analysis
#11
Jasmine Chong, Othman Soufan, Carin Li, Iurie Caraus, Shuzhao Li, Guillaume Bourque, David S Wishart, Jianguo Xia
We present a new update to MetaboAnalyst (version 4.0) for comprehensive metabolomic data analysis, interpretation, and integration with other omics data. Since the last major update in 2015, MetaboAnalyst has continued to evolve based on user feedback and technological advancements in the field. For this year's update, four new key features have been added to MetaboAnalyst 4.0, including: (1) real-time R command tracking and display coupled with the release of a companion MetaboAnalystR package; (2) a MS Peaks to Pathways module for prediction of pathway activity from untargeted mass spectral data using the mummichog algorithm; (3) a Biomarker Meta-analysis module for robust biomarker identification through the combination of multiple metabolomic datasets and (4) a Network Explorer module for integrative analysis of metabolomics, metagenomics, and/or transcriptomics data...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29762716/crispor-intuitive-guide-selection-for-crispr-cas9-genome-editing-experiments-and-screens
#12
Jean-Paul Concordet, Maximilian Haeussler
CRISPOR.org is a web tool for genome editing experiments with the CRISPR-Cas9 system. It finds guide RNAs in an input sequence and ranks them according to different scores that evaluate potential off-targets in the genome of interest and predict on-target activity. The list of genomes is continuously expanded, with more 150 genomes added in the last two years. CRISPOR tries to provide a comprehensive solution from selection, cloning and expression of guide RNA as well as providing primers needed for testing guide activity and potential off-targets...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29761993/-design-and-implementation-of-real-time-continuous-glucose-monitoring-instrument
#13
Yonghong Huang, Hongying Liu, Senfu Tian, Ziru Jia, Zi Wang, Xitian Pi
Real-time continuous glucose monitoring can help diabetics to control blood sugar levels within the normal range. However, in the process of practical monitoring, the output of real-time continuous glucose monitoring system is susceptible to glucose sensor and environment noise, which will influence the measurement accuracy of the system. Aiming at this problem, a dual-calibration algorithm for the moving-window double-layer filtering algorithm combined with real-time self-compensation calibration algorithm is proposed in this paper, which can realize the signal drift compensation for current data...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29760853/emergency-physicians-at-war
#14
REVIEW
Andrew E Muck, Melissa Givens, Vikhyat S Bebarta, Phillip E Mason, Craig Goolsby
Operation Enduring Freedom (OEF-A) in Afghanistan and Operation Iraqi Freedom (OIF) represent the first major, sustained wars in which emergency physicians (EPs) fully participated as an integrated part of the military's health system. EPs proved invaluable in the deployments, and they frequently used the full spectrum of trauma and medical care skills. The roles EPs served expanded over the years of the conflicts and demonstrated the unique skill set of emergency medicine (EM) training. EPs supported elite special operations units, served in medical command positions, and developed and staffed flying intensive care units...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29759829/acute-and-3-month-performance-of-a-communicating-leadless-antitachycardia-pacemaker-and-subcutaneous-implantable-defibrillator
#15
Fleur V Y Tjong, Tom F Brouwer, Brendan Koop, Brian Soltis, Allan Shuros, Brian Schmidt, Bryan Swackhamer, Anne-Floor E B Quast, Arthur A M Wilde, Martin C Burke, Reinoud E Knops
OBJECTIVES: The primary objective was to assess the acute and 3-month performance of the modular antitachycardia pacing (ATP)-enabled leadless pacemaker (LP) and subcutaneous implantable cardioverter-defibrillator (S-ICD) system, particularly device-device communication and ATP delivery. BACKGROUND: Transvenous pacemakers and implantable cardioverter-defibrillators (ICDs) have considerable rates of lead complications. We examined the next step in multicomponent leadless cardiac rhythm management: feasibility of pacing (including ATP) by a LP, commanded by an implanted S-ICD through wireless, intrabody, device-device communication...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29757913/association-between-muscle-wasting-and-muscle-strength-in-patients-who-developed-severe-sepsis-and-septic-shock
#16
Rodrigo Cerqueira Borges, Francisco Garcia Soriano
PURPOSE: To evaluate the association between the rectus femoris cross-sectional area (RFCSA) and the muscular strength obtained at the bedside in patients forwarded to the intensive care unit (ICU) for severe sepsis and septic shock. METHODS: A prospective cohort study. RFCSA was assessed by ultrasound on the following day of the ICU admission and monitored during hospitalization. The patients performed clinical tests of muscle strength (Medical Research Council (MRC) scale and handgrip dynamometry), when they could understand the verbal commands of the examiners...
May 11, 2018: Shock
https://www.readbyqxmd.com/read/29757269/combining-quantitative-food-intake-assays-and-forcibly-activating-neurons-to-study-appetite-in-drosophila
#17
Lifen Jiang, Yinpeng Zhan, Yan Zhu
Food consumption is under the tight control of the brain, which integrates the physiological status, palatability, and nutritional contents of the food, and issues commands to start or stop feeding. Deciphering the processes underlying the decision-making of timely and moderate feeding carries major implications in our understanding of physiological and psychological disorders related to feeding control. Simple, quantitative, and robust methods are required to measure the food ingestion of animals after experimental manipulation, such as forcibly increasing the activities of certain target neurons...
April 24, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29757057/-necessary-and-sufficient-in-biology-is-not-necessarily-necessary-confusions-and-erroneous-conclusions-resulting-from-misapplied-logic-in-the-field-of-biology-especially-neuroscience
#18
Motojiro Yoshihara, Motoyuki Yoshihara
In this article, we describe an incorrect use of logic which involves the careless application of the 'necessary and sufficient' condition originally used in formal logic. This logical fallacy is causing frequent confusion in current biology, especially in neuroscience. In order to clarify this problem, we first dissect the structure of this incorrect logic (which we refer to as 'misapplied-N&S') to show how necessity and sufficiency in misapplied-N&S are not matching each other. Potential pitfalls of utilizing misapplied-N&S are exemplified by cases such as the discrediting of command neurons and other potentially key neurons, the distorting of truth in optogenetic studies, and the wrongful justification of studies with little meaning...
May 14, 2018: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29755854/neuroanatomical-autonomic-substrates-of-brainstem-gut-circuitry-identified-using-transsynaptic-tract-tracing-with-pseudorabies-virus-recombinants
#19
Zhi-Gang He, Quan Wang, Run-Shan Xie, Yong-Sheng Li, Qing-Xiong Hong, Hong-Bing Xiang
To investigate autonomic substrates of brainstem-gut circuitry identified using trans-synaptic tracing with pseudorabies virus (PRV)-152, a strain that expresses enhanced green fluorescent protein, and PRV-614, a strain that expresses enhanced red fluorescent protein, injecting into the rat rectum wall. 3-7 days after PRV-152 injection, spinal cord and brainstem were removed and sectioned, and processed for PRV-152 visualization using immunofluorescence labeling against PRV-152. 6 days after PRV-614 injection, brainstem was sectioned and the neurochemical phenotype of PRV-614-positive neurons was identified using double immunocytochemical labeling against PRV-614 and TPH...
2018: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29753536/wasp-write-a-scientific-paper-doctors-in-star-trek-correctly-compassionate-caring-kantian-zampolit
#20
Victor Grech, Elizabeth Grech, Jason T Eberl
Doctors in Star Trek are vital and central characters, often crucial in helping their captains to reach command decisions. They are also interdisciplinarians, performing not only medical tasks but also any form of work related to all fields of biology. Furthermore, these doctors also carry out any required research that pertains to the biological sciences. It is perhaps this unique blend of skills, combined with a fundamental orientation towards humanism and compassion, that leads to their default position, de facto, if not de jure, as the crew's ethics officers, a role that they embrace with as much dedication and zeal as the former Soviet communist political officers/commissars (the Zampolit) did theirs...
May 9, 2018: Early Human Development
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