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https://www.readbyqxmd.com/read/28231470/rapid-integration-of-artificial-sensory-feedback-during-operant-conditioning-of-motor-cortex-neurons
#1
Mario Prsa, Gregorio L Galiñanes, Daniel Huber
Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-time optogenetic stimulation were used to train mice to activate a single neuron in motor cortex (M1), while continuous feedback of its activity level was provided by proportionally stimulating somatosensory cortex...
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28231289/rehr-an-r-package-for-manipulating-and-analysing-electronic-health-record-data
#2
David A Springate, Rosa Parisi, Ivan Olier, David Reeves, Evangelos Kontopantelis
Research with structured Electronic Health Records (EHRs) is expanding as data becomes more accessible; analytic methods advance; and the scientific validity of such studies is increasingly accepted. However, data science methodology to enable the rapid searching/extraction, cleaning and analysis of these large, often complex, datasets is less well developed. In addition, commonly used software is inadequate, resulting in bottlenecks in research workflows and in obstacles to increased transparency and reproducibility of the research...
2017: PloS One
https://www.readbyqxmd.com/read/28228272/commanding-cns-invasion-gm-csf
#3
Junjie Zhao, Lillian Sun, Xiaoxia Li
Granulocyte-macrophage colony-stimulating factor (GM-CSF or Csf-2) is a pro-inflammatory mediator implicated in the pathogenesis of various autoimmune diseases. In this issue of Immunity, Spath et al. (2017) show that the dysregulated production of GM-CSF rather than IL-17 induces spontaneous immunopathology in a mouse model of CNS inflammation.
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28227970/combining-a-hybrid-robotic-system-with-a-bain-machine-interface-for-the-rehabilitation-of-reaching-movements-a-case-study-with-a-stroke-patient
#4
F Resquin, J Ibanez, J Gonzalez-Vargas, F Brunetti, I Dimbwadyo, S Alves, L Carrasco, L Torres, Jose Luis Pons, F Resquin, J Ibañez, J Gonzalez-Vargas, F Brunetti, I Dimbwadyo, S Alves, L Carrasco, L Torres, Jose Luis Pons, S Alves, Jose Luis Pons, F Brunetti, J Gonzalez-Vargas, F Resquin, I Dimbwadyo, L Carrasco, L Torres, J Ibanez
Reaching and grasping are two of the most affected functions after stroke. Hybrid rehabilitation systems combining Functional Electrical Stimulation with Robotic devices have been proposed in the literature to improve rehabilitation outcomes. In this work, we present the combined use of a hybrid robotic system with an EEG-based Brain-Machine Interface to detect the user's movement intentions to trigger the assistance. The platform has been tested in a single session with a stroke patient. The results show how the patient could successfully interact with the BMI and command the assistance of the hybrid system with low latencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227967/a-stimulation-driven-exoskeleton-for-walking-after-paraplegia
#5
Sarah R Chang, Mark J Nandor, Lu Li, Kevin M Foglyano, John R Schnellenberger, Rudi Kobetic, Roger D Quinn, Ronald J Triolo, Sarah R Chang, Mark J Nandor, Lu Li, Kevin M Foglyano, John R Schnellenberger, Rudi Kobetic, Roger D Quinn, Ronald J Triolo, Mark J Nandor, Rudi Kobetic, Roger D Quinn, John R Schnellenberger, Sarah R Chang, Kevin M Foglyano, Lu Li, Ronald J Triolo
An untethered version of a stimulation-driven exoskeleton was evaluated for its ability to restore walking after paralysis from spinal cord injury. The hybrid neuroprosthesis (HNP) combined a passive variable-constraint exoskeleton for stability and support with functional neuromuscular stimulation (FNS) to contract the paralyzed muscles to drive limb movement. This self-contained HNP was operated by an onboard controller that sampled sensor signals, generated appropriate commands to both the exoskeletal constraints and integrated stimulator, and transmitted data wirelessly via Bluetooth to an off-board computer for real-time monitoring and recording for offline analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227966/real-time-evaluation-of-a-myoelectric-control-method-for-high-level-upper-limb-amputees-based-on-homologous-leg-movements
#6
Kenneth R Lyons, Sanjay S Joshi, Kenneth R Lyons, Sanjay S Joshi, Sanjay S Joshi, Kenneth R Lyons
Electromyography-based gesture classification methods for control of advanced upper limb prostheses are limited either to individuals with amputations distal to the elbow or to those willing to undergo targeted muscle reinnervation surgery. Based on the natural similarity between gestures of the lower leg and the arm and on established methods in electromyography-based gesture classification, we propose a noninvasive system with which users control an upper limb prosthesis via homologous movements of the leg and foot...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227845/high-performance-wearable-two-channel-hybrid-bci-system-with-eye-closure-assist
#7
Yubing Jiang, Hyeonseok Lee, Gang Li, Wan-Young Chung, Yubing Jiang, Hyeonseok Lee, Gang Li, Wan-Young Chung, Wan-Young Chung, Gang Li, Hyeonseok Lee, Yubing Jiang
Generally, eye closure (EC) and eye opening (EO)-based alpha blocking has widely recognized advantages, such as being easy to use, requiring little user training, while motor imagery (MI) is difficult for some users to have concrete feelings. This study presents a hybrid brain-computer interface (BCI) combining MI and EC strategies - such an approach aims to overcome some disadvantages of MI-based BCI, improve the performance and universality of the BCI. The EC/EO is employed to control the machine to switch in different states including forward, stop, changing direction motions, while the MI is used to control the machine to turn left or right for 90° by imagining the hands grasp motions when the system is switched into "changing direction" state...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227634/design-and-validation-of-a-wearable-drl-less-eeg-using-a-novel-fully-reconfigurable-architecture
#8
Ruhi Mahajan, Bashir I Morshed, Gavin M Bidelman, Ruhi Mahajan, Bashir I Morshed, Gavin M Bidelman, Bashir I Morshed, Ruhi Mahajan, Gavin M Bidelman
The conventional EEG system consists of a driven-right-leg (DRL) circuit, which prohibits modularization of the system. We propose a Lego-like connectable fully reconfigurable architecture of wearable EEG that can be easily customized and deployed at naturalistic settings for collecting neurological data. We have designed a novel Analog Front End (AFE) that eliminates the need for DRL while maintaining a comparable signal quality of EEG. We have prototyped this AFE for a single channel EEG, referred to as Smart Sensing Node (SSN), that senses brain signals and sends it to a Command Control Node (CCN) via an I(2)C bus...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227535/skills-based-evaluation-of-alternative-input-methods-to-command-a-semi-autonomous-electric-wheelchair
#9
Mario Rojas, Pedro Ponce, Arturo Molina, Mario Rojas, Pedro Ponce, Arturo Molina, Pedro Ponce, Mario Rojas, Arturo Molina
This paper presents the evaluation, under standardized metrics, of alternative input methods to steer and maneuver a semi-autonomous electric wheelchair. The Human-Machine Interface (HMI), which includes a virtual joystick, head movements and speech recognition controls, was designed to facilitate mobility skills for severely disabled people. Thirteen tasks, which are common to all the wheelchair users, were attempted five times by controlling it with the virtual joystick and the hands-free interfaces in different areas for disabled and non-disabled people...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227510/feasibility-of-an-ultra-low-power-digital-signal-processor-platform-as-a-basis-for-a-fully-implantable-brain-computer-interface-system
#10
Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, An H Do, Zoran Nenadic, Colin M McCrimmon, Keulanna Gandasetiawan, Payam Heydari, Alireza Karimi-Bidhendi, Po T Wang, Charles Y Liu
A fully implantable brain-computer interface (BCI) can be a practical tool to restore independence to those affected by spinal cord injury. We envision that such a BCI system will invasively acquire brain signals (e.g. electrocorticogram) and translate them into control commands for external prostheses. The feasibility of such a system was tested by implementing its benchtop analogue, centered around a commercial, ultra-low power (ULP) digital signal processor (DSP, TMS320C5517, Texas Instruments). A suite of signal processing and BCI algorithms, including (de)multiplexing, Fast Fourier Transform, power spectral density, principal component analysis, linear discriminant analysis, Bayes rule, and finite state machine was implemented and tested in the DSP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227162/a-non-linear-mapping-algorithm-shaping-the-control-policy-of-a-bidirectional-brain-machine-interface
#11
Fabio Boi, Marianna Semprini, Alessandro Vato, Fabio Boi, Marianna Semprini, Alessandro Vato, Fabio Boi, Marianna Semprini, Alessandro Vato
Motor brain-machine interfaces (BMIs) transform neural activities recorded directly from the brain into motor commands to control the movements of an external object by establishing an interface between the central nervous system (CNS) and the device. Bidirectional BMIs are closed-loop systems that add a sensory channel to provide the brain with an artificial feedback signal produced by the interaction between the device and the external world. Taking inspiration from the functioning of the spinal cord in mammalians, in our previous works we designed and developed a bidirectional BMI that uses the neural signals recorded form rats' motor cortex to control the movement of an external object...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227077/optimal-control-of-inspired-perfluorocarbon-temperature-for-induction-of-hypothermia-by-total-liquid-ventilation-in-juvenile-lamb-model
#12
Mathieu Nadeau, Michael Sage, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau, Mathieu Nadeau, Michael Sage, Jean-Paul Praud, Renaud Tissier, Herve Walti, Philippe Micheau, Michael Sage, Philippe Micheau, Jean-Paul Praud, Mathieu Nadeau, Herve Walti, Renaud Tissier
Mild hypothermia is well known for its therapeutic value in cardio- and neuroprotection. Many recent experimental studies have shown that the swiftness of the cooling offered by total liquid ventilation (TLV) holds great promise in achieving maximal therapeutic effect. TLV is an emerging ventilation technique in which the lungs are filled with breathable liquids, namely perfluorocarbons (PFCs). A liquid ventilator ensures subject ventilation by periodically renewing a volume of oxygenated, CO2-free and temperature-controlled breathable PFC...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227058/iproprio-a-smartphone-based-system-to-measure-and-improve-proprioceptive-function
#13
Q Mourcou, A Fleury, B Diot, N Vuillerme, Q Mourcou, A Fleury, B Diot, N Vuillerme, Q Mourcou, A Fleury, B Diot, N Vuillerme
It is well known that proprioception is necessary to maintain balance control. Although proprioceptive exercices have shown to have beneficial effects on balance, the joint position sense is not easy to measure and patient cannot practise self-measurement. This article proposes a new system specifically desinged to allow measure and improve proprioceptive function. This so-called `iProprio' system uses inertial sensors included in a smartphone, wireless communication and voice command to allow joint position sense measurment in autonomous way and provide a configurable vibrotactile biofeedback for end-users at home...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227001/mechanism-for-safe-remote-activation-of-networked-surgical-and-poc-devices-using-dynamic-assignable-controls
#14
Martin Kasparick, Max Rockstroh, Stefan Schlichting, Frank Golatowski, Dirk Timmermann, Martin Kasparick, Max Rockstroh, Stefan Schlichting, Frank Golatowski, Dirk Timmermann, Stefan Schlichting, Martin Kasparick, Max Rockstroh, Frank Golatowski, Dirk Timmermann
The number of devices within an operating room (OR) increases continuously as well as the complexity of the complete system. One key enabler to handle the complexity is an interoperable and vendor independent system of networked medical devices. To build up such an interoperable system we use the proposed IEEE 11073 SDC standards (IEEE P11073-10207, -20701, -20702) for networked point-of-care (PoC) and surgical devices. One of the major problems within the OR is that typically every device has its own control unit...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226857/development-of-a-closed-loop-system-for-tremor-suppression-in-patients-with-parkinson-s-disease
#15
F L Xu, M Z Hao, S Q Xu, Z X Hu, Q Xiao, N Lan, F L Xu, M Z Hao, S Q Xu, Z X Hu, Q Xiao, N Lan, S Q Xu, Z X Hu, Q Xiao, M Z Hao, N Lan, F L Xu
More than 70% of patients suffering Parkinson's disease (PD) exhibit resting tremor in their extremities, hampering their ability to perform daily activities. Based on our earlier studies on corticospinal transmission of tremor signals [10,11], we hypothesize that cutaneous afferents evoked by surface stimulation can produce an inhibitory effect on propriospinal neurons (PN), which in turn will suppress tremor signals passing through the PN. This paper presents the development of a closed-loop system for tremor suppression by transcutaneous electrical nerve stimulation (TENS) of sensory fibers beneath the skin...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226840/effects-of-input-frequency-content-and-signal-to-noise-ratio-on-the-parametric-estimation-of-surface-emg-torque-dynamics
#16
Mahsa A Golkar, Robert E Kearney, Mahsa A Golkar, Robert E Kearney, Mahsa A Golkar, Robert E Kearney
The dynamic relationship between surface EMG (sEMG) and torque can be estimated from data acquired while subjects voluntarily modulate joint torque. We have shown that for such data, the input (EMG) contains a feedback component from the output (torque) and so accurate estimates of the dynamics require the use of closed-loop identification algorithms. Moreover, this approach has several other limitations since the input is controlled indirectly and so the frequency content and signal-to-noise ratio cannot be controlled...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226788/decoding-of-responses-to-mixed-frequency-and-phase-coded-visual-stimuli-using-multiset-canonical-correlation-analysis
#17
Kaori Suefusa, Toshihisa Tanaka, Kaori Suefusa, Toshihisa Tanaka, Toshihisa Tanaka, Kaori Suefusa
Brain-computer interfacing (BCI) based on steady-state visual evoked potentials (SSVEPs) is one of the most practical BCIs because of its high recognition accuracies and little training of a user. Mixed frequency and phase coding which can implement a number of commands and achieve a high information transfer rate (ITR) has recently been gaining much attention. In order to implement mixed-coded SSVEP-BCI as a reliable interface, it is important to detect commands fast and accurately. This paper presents a novel method to recognize mixed-coded SSVEPs which achieves high performance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224266/design-process-and-tools-for-dynamic-neuromechanical-models-and-robot-controllers
#18
Nicholas S Szczecinski, Alexander J Hunt, Roger D Quinn
We present a serial design process with associated tools to select parameter values for a posture and locomotion controller for simulation of a robot. The controller is constructed from dynamic neuron and synapse models and simulated with the open-source neuromechanical simulator AnimatLab 2. Each joint has a central pattern generator (CPG), whose neurons possess persistent sodium channels. The CPG rhythmically inhibits motor neurons that control the servomotor's velocity. Sensory information coordinates the joints in the leg into a cohesive stepping motion...
February 21, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/28222846/planning-for-the-leicester-city-football-club-victory-parade
#19
Martin Halse
This paper details the multiagency planning for and delivery of the Leicester City Football Club victory parade at the end of the 2015/16 football season to celebrate the team winning the Barclays Premier League. This is compared and contrasted with the planning and delivery of the reinterment of the mortal remains of King Richard III, which took place in Leicester a little more than 12 months prior. Both events were unprecedentedly high-profile for a comparatively small city and the routes involved had much in common...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28222683/manananggal-a-novel-viewer-for-alternative-splicing-events
#20
Matthias Barann, Ralf Zimmer, Fabian Birzele
BACKGROUND: Alternative splicing is an important cellular mechanism that can be analyzed by RNA sequencing. However, identification of splicing events in an automated fashion is error-prone. Thus, further validation is required to select reliable instances of alternative splicing events (ASEs). There are only few tools specifically designed for interactive inspection of ASEs and available visualization approaches can be significantly improved. RESULTS: Here, we present Manananggal, an application specifically designed for the identification of splicing events in next generation sequencing data...
February 21, 2017: BMC Bioinformatics
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