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Fetal liver

Camille Malouf, Katrin Ottersbach
No abstract text is available yet for this article.
June 14, 2018: Haematologica
David P Stonko, Jiancong Liang, Amy G Weeks, Raymond W Redline, Theonia K Boyd, Jaclyn C Watkins, Alexandra E Kovach
When an unusual intraplacental lesion is identified during pathologic examination, it becomes of substantial import to determine whether it represents a normal structure, metastasis from the mother, or a primary benign tumor, including those secondary to abnormal embryologic development versus a primary malignant placental tumor. In this case report, we identified an incidental nest of intraplacental cells with nondiagnostic morphology and negative initial Glypican-3 stain in a healthy 35-wk gestation. This negative result prompted a broadening of the differential before ultimately determining this lesion was indeed ectopic liver with positive Arginase-1 and HepPar-1 staining...
June 12, 2018: International Journal of Gynecological Pathology
Kyoko Hayakawa, Anthony M Formica, Yuka Nakao, Daiju Ichikawa, Susan A Shinton, Joni Brill-Dashoff, Mitchell R Smith, Herbert C Morse, Richard R Hardy
In mice, fetal/neonatal B-1 cell development generates murine CD5+ B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a VH 11/D/JH knock-in mouse line (VH 11t) that generates an autoreactive antiphosphatidylcholine BCR. Our study revealed that antiphosphatidylcholine B1a cells develop in liver, mature in spleen, and distribute in intestine/colon, mesenteric lymph node (mLN), and body cavity as the outcome of B-1 cell development before B-2 cell development. Throughout life, self-renewing B-1 B1a cells circulate through intestine, mesenteric vessel, and blood...
June 13, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón, Stefano Cianfarani
Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our aim was to evaluate liver UPR in an animal model of intrauterine growth restriction (IUGR). A significantly increased expression of X-box binding protein-1 spliced (XBP1s) mRNA (p<0.01), Endoplasmic Reticulum-localized DnaJ homologue (Erdj4) mRNA (p<0...
2018: PloS One
Tongjie Wang, Chengxiang Xia, Yong Dong, Xiaoli Chen, Jinyong Wang, Juan Du
Trim27 (Zinc finger protein RFP) is a potential regulator of hematopoietic stem cells (HSC), yet its role in hematopoiesis remains elusive. Here, we investigated the roles of Trim27 in hematopoiesis by enforcing its expression in mouse and human hematopoietic stem and progenitor cells (HSPC). Ectopic expression of Trim27 in mouse fetal liver (FL) HSPC confers repopulating advantage with myeloid dominance. However, the number of HSC from Trim27 group was comparable with empty vector control group, indicating that overexpression of Trim27 unlikely expanded HSC...
June 13, 2018: Journal of Leukocyte Biology
Rodney A Prell, Noel Dybdal, Akihiro Arima, Yutaka Chihaya, Ihsan Nijem, Wendy Halpern
Onartuzumab is an engineered single arm, monovalent monoclonal antibody that targets the MET receptor and prevents HGF signaling. Knockout mice have clearly demonstrated that HGF/MET signaling is developmentally critical. A pre- and post-natal development (PPND) study (enhanced design) was conducted in cynomolgus monkeys to evaluate the potential developmental consequences following onartuzumab administration. Control or onartuzumab, at loading/maintenance doses of 75/50 mg/kg (low) or 100/100 mg/kg (high), was administered intravenously once weekly to 12 confirmed pregnant female cynomolgus monkeys per group from gestation day (GD) 20 through GD 174...
June 8, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Jia Yin Soo, Michael D Wiese, Mary J Berry, I Caroline McMillen, Janna L Morrison
The effects of intrauterine growth restriction (IUGR) extend well into postnatal life. IUGR is associated with an increased risk of adverse health outcomes, which often leads to greater medication usage. Many medications require hepatic metabolism for activation or clearance, but hepatic function may be altered in IUGR fetuses. Using a sheep model of IUGR, we determined the impact of IUGR on hepatic drug metabolism and drug transporter expression, both important mediators of fetal drug exposure, in late gestation and in neonatal life...
June 8, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Çiğdem Ö Ecevit, Safiye Aktaş, Hülya Tosun Yildirim, Bengü Demirağ, Ayşe Erbay, İrfan Karaca, Ahmet Çelik, Ayşe Banu Demir, Ayşe Pinar Erçetin, Nur Olgun
Hepatoblastoma (HB) is the most common liver malignancy in children. The prognosis changes according to the histologic subtypes of HB. In the present study, we aimed to characterize the expression level of selected microRNAs (miRNAs) in HB as well as in histologic subtypes, and to consider the association with the prognosis. A total of 22 HB tumor samples, subtyped as fetal (n=16) and embryonal (n=6), and 10 nontumorous surrounding liver samples were evaluated in this study. Expressions of miR-17, miR-146a, miR-302d, and miR-19b were analyzed in 22 HB tumor samples and 10 nontumorous surrounding liver samples by quantitative real-time polymerase chain reaction...
June 8, 2018: Journal of Pediatric Hematology/oncology
Stephanie C Piekos, Liming Chen, Pengcheng Wang, Jian Shi, Sharon Yaqoob, Hao-Jie Zhu, Xiaochao Ma, Xiao-Bo Zhong
The induction of cytochrome P450 enzymes (CYPs) in response to drug treatment is a significant contributing factor to drug-drug interactions, which may reduce therapeutic efficacy and/or cause toxicity. As most studies on CYP induction are performed in adults, enzyme induction at neonatal, infant, and adolescent ages is not well understood. Previous work defined the postnatal ontogeny of drug-metabolizing CYPs in human and mouse livers; however, there are limited data on the ontogeny of the induction potential of each enzyme in response to drug treatment...
June 8, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Susan E Morarie-Kane, Natalia P Smirnova, Thomas R Hansen, Jessica Mediger, Lyle Braun, Christopher Chase
Non-cytopathic bovine viral diarrhea virus (ncp BVDV) can cause persistent infection (PI) in animals infected in utero during early gestation. PI animals shed the virus for life and are the major source of the virus in herds. The mechanism responsible for BVDV immune tolerance in the PI fetus is unknown. We assessed the impact of BVDV infection on the fetal liver. Dams were inoculated with ncp BVDV at gestational day 75. Fetal liver samples were collected at necropsy, 7 and 14 days post-maternal-BVDV inoculation...
June 6, 2018: Pathogens
Camillo Sargiacomo, Hoda El-Kehdy, Guillaume Pourcher, Bruno Stieger, Mustapha Najimi, Etienne Sokal
Sodium taurocholate cotransporter polypeptide (NTCP), mainly expressed on the sinusoidal membrane of hepatocytes, is one of the major transporters responsible for liver bile acid (BA) re-uptake. NTCP transports conjugated BA from the blood into hepatocytes and is crucial for correct enterohepatic circulation. Studies have shown that insufficient hepatic clearance of BA correlates with elevated serum BA in infants younger than 1 year of age. In the current study, we investigated human NTCP messenger RNA and protein expression by using reverse-transcription quantitative polymerase chain reaction and immunoblotting in isolated and cryopreserved human hepatocytes from two different age groups, below and above 1 year of age...
June 2018: Hepatology Communications
Natalia Mandiá, Alejandro Pérez-Muñuzuri, Olalla López-Suárez, Carolina López-Sanguos, Adolfo Bautista-Casanovas, Mariá-Luz Couce
INTRODUCTION: Hereditary multiple intestinal atresia associated with severe combined immunodeficiency (MIA-SCID) is a very rare disease caused by deleterious mutations in the tetratricopeptide repeat domain-containing protein 7A gene TTC7A. It is characterized by intestinal obstruction, sepsis, and a poor prognosis. Insights into phenotype-genotype correlations could help to guide genetic counseling and increase our knowledge of the natural history of this disease. CASE PRESENTATION: We report the case of a newborn in which his fetal magnetic resonance imaging showed jejunal atresia and microcolon and an abdominal x-ray at birth confirmed intestinal obstruction...
June 2018: Medicine (Baltimore)
Hillary F Huber, Anderson H Kuo, Cun Li, Susan L Jenkins, Kenneth G Gerow, Geoffrey D Clarke, Peter W Nathanielsz
INTRODUCTION: Women threatening premature delivery receive synthetic glucocorticoids (sGC) to accelerate fetal lung maturation, reducing neonatal mortality and morbidity. Few investigations have explored potential long-term offspring side effects. We previously reported increased pericardial fat and liver lipids in 10-year-old (human equivalent 40 years) male baboons exposed to 3 antenatal sGC courses. We hypothesized middle-aged sGC male offspring show obesity-related morphometric changes...
January 1, 2018: Reproductive Sciences
Joanna Stragierowicz, Krystyna Sitarek, Bartłomiej Grobelski, Anna Kilanowicz-Sapota
OBJECTIVES: Due to structural and toxicological similarities to 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD), polychlorinated naphthalenes (PCNs) were included in the Stockholm Convention on Persistent Organic Pollutants (POPs) in 2015. Hexachloronaphthalene (HxCN) is considered to be one of the most toxic congeners of PCNs. The objective of this study was to determine the maternal and fetal tissue concentrations of hexachloronaphthalene after a single administration...
June 4, 2018: International Journal of Occupational Medicine and Environmental Health
Kíssila Rabelo, Luiz J Souza, Natália G Salomão, Edson R A Oliveira, Lynna de Paula Sentinelli, Marcelle S Lacerda, Pedro B Saraquino, Fernando C Rosman, Rodrigo Basílio-de-Oliveira, Jorge J Carvalho, Marciano V Paes
Zika virus (ZIKV) is an emerging virus involved in recent outbreaks in Brazil. The association between the virus and Guillain-Barré syndrome (GBS) or congenital disorders has raised a worldwide concern. In this work, we investigated a rare Zika case, which was associated with GBS and spontaneous retained abortion. Using specific anti-ZIKV staining, the virus was identified in placenta (mainly in Hofbauer cells) and in several fetal tissues, such as brain, lungs, kidneys, skin and liver. Histological analyses of the placenta and fetal organs revealed different types of tissue abnormalities, which included inflammation, hemorrhage, edema and necrosis in placenta, as well as tissue disorganization in the fetus...
2018: Frontiers in Microbiology
Jinglong Guo, Yang Li, Yanhong Shan, Chang Shu, Feng Wang, Xue Wang, Ge Zheng, Jin He, Zheng Hu, Yong-Guang Yang
The liver is an immunological organ with a distinct immune cell profile. Although the composition and function of liver immune cells have been widely investigated, the mechanisms regulating the development and homeostasis of the specialized immune system, especially in humans, remain largely unknown. Herein, we address this question in humanized mice (hu-mice) that were constructed by transplantation of human fetal thymus and CD34+ hematopoietic stem/progenitor cells in immunodeficient mice with or without autologous human hepatocyte engraftment...
June 4, 2018: Cell Death & Disease
Charles Thomas, Antoine Jalil, Charlène Magnani, Minako Ishibashi, Ronan Queré, Thibaut Bourgeois, Victoria Bergas, Louise Ménégaut, Danish Patoli, Naig Le Guern, Jérôme Labbé, Thomas Gautier, Jean Paul Pais de Barros, Laurent Lagrost, David Masson
BACKGROUND AND AIMS: LPCAT3 plays a major role in phospholipid metabolism in the liver and intestine. However, the impact of LPCAT3 on hematopoietic cell and macrophage functions has yet to be described. Our aim was to understand the functions of LPCAT3 in macrophages and to investigate whether LPCAT3 deficiency in hematopoietic cells may affect atherosclerosis development. METHODS: Mice with constitutive Lpcat3 deficiency (Lpcat3-/- ) were generated. We used fetal hematopoietic liver cells to generate WT and Lpcat3-/- macrophages in vitro and to perform hematopoietic cell transplantation in recipient Ldlr-/- mice...
May 18, 2018: Atherosclerosis
Sarah Dubaisi, Kathleen G Barrett, Hailin Fang, Jorge Guzman-Lepe, Alejandro Soto-Gutierrez, Thomas A Kocarek, Melissa Runge-Morris
Cytosolic sulfotransferases (SULTs) are expressed during early life and therefore metabolize endogenous and xenobiotic chemicals during development. Little is currently known about the regulation of individual SULTs in the developing human liver. We characterized SULT expression in primary cultures of human fetal hepatocytes and the HepaRG model of liver cell differentiation. SULT1A1 (transcript variants 1 - 4), SULT1C2, SULT1C4, SULT1E1, and SULT2A1 were the most abundant transcripts in human fetal hepatocytes...
June 1, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Xiaochuan Liu, Yuwei Yang, Ping Jiang, Xiaohui Li, Yanliang Ge, Yang Cao, Zhihui Zhao, Xibi Fang, Xianzhong Yu
QSOX1 (quiescin-sulfhydryl oxidase 1) is involved in various processes, including apoptosis and the development of breast diseases. Here, we investigated the effect of QSOX1 on the meat quality of Simmental cattle by analyzing the correlation between QSOX1 single nucleotide polymorphisms (SNPs), I2 204 C>T and I2 378 C>T, and certain meat quality traits. The effects of QSOX1 on triglyceride synthesis and cell apoptosis were further validated by gene silencing or overexpression in bovine fetal fibroblasts and mammary epithelial cells...
May 30, 2018: Journal of Veterinary Medical Science
Jeffrey Barminko, Brad M Reinholt, Alexander Emmanuelli, Alannah N Lejeune, Margaret H Baron
The pathways that regulate the growth of erythroid progenitors are incompletely understood. In a computational analysis of gene expression changes during erythroid ontogeny, the vitamin D receptor ( Vdr ) nuclear hormone receptor transcription factor gene was identified in fetal and adult stages, but not at the embryonic stage of development. Vdr was expressed in definitive erythroid (EryD) progenitors and was downregulated during their maturation. Activation of Vdr signaling by the vitamin D3 agonist calcitriol increased the outgrowth of EryD colonies from fetal liver and adult bone marrow, maintained progenitor potential, and delayed erythroid maturation, as revealed by clonogenic assays, suspension culture, cell surface phenotype, and gene expression analyses...
June 12, 2018: Blood Advances
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