keyword
https://read.qxmd.com/read/38498020/outcomes-and-costs-of-the-transition-from-a-paper-based-immunization-system-to-a-digital-immunization-system-in-vietnam-mixed-methods-study
#21
JOURNAL ARTICLE
Thi Thanh Huyen Dang, Emily Carnahan, Linh Nguyen, Mercy Mvundura, Sang Dao, Thi Hong Duong, Trung Nguyen, Doan Nguyen, Tu Nguyen, Laurie Werner, Tove K Ryman, Nga Nguyen
BACKGROUND: The electronic National Immunization Information System (NIIS) was introduced nationwide in Vietnam in 2017. Health workers were expected to use the NIIS alongside the legacy paper-based system. Starting in 2018, Hanoi and Son La provinces transitioned to paperless reporting. Interventions to support this transition included data guidelines and training, internet-based data review meetings, and additional supportive supervision visits. OBJECTIVE: This study aims to assess (1) changes in NIIS data quality and use, (2) changes in immunization program outcomes, and (3) the economic costs of using the NIIS versus the traditional paper system...
March 18, 2024: Journal of Medical Internet Research
https://read.qxmd.com/read/38498017/fin-bayes-a-multi-objective-bayesian-optimization-framework-for-soft-robotic-fingers
#22
JOURNAL ARTICLE
Xing Wang, Bing Wang, Joshua Pinskier, Yue Xie, James Brett, Richard Scalzo, David Howard
Computational design is a critical tool to realize the full potential of Soft Robotics, maximizing their inherent benefits of high performance, flexibility, robustness, and safe interaction. Practically, computational design entails a rapid iterative search process over a parameterized design space, with assessment using (frequently) computational modeling and (more rarely) physical experimentation. Bayesian approaches work well for these expensive-to-analyze systems and can lead to efficient exploration of design space than comparative algorithms...
March 18, 2024: Soft Robotics
https://read.qxmd.com/read/38498014/cannabinoid-receptor-2-gene-polymorphism-and-the-risk-of-developing-rheumatoid-arthritis-in-lebanese-patients
#23
JOURNAL ARTICLE
Morouj Ismail, Ghada Khawaja
Objective: Evidence supports a role of cannabinoid receptor 2 (CB2) in regulating the immune response. Some variations in the CB2 receptor gene (CB2) were linked to the susceptibility of developing rheumatoid arthritis (RA). The aim of this study is to assess the relationship between CNR2 rs2501431 and the risk of developing RA in Lebanese patients. Methods: A total of one hundred five Lebanese RA patients and one hundred five controls participated in the study. CNR2 was genotyped and analyzed. Results: Using χ 2 test, our results show that the CC genotype was the most common (47...
March 18, 2024: Cannabis and Cannabinoid Research
https://read.qxmd.com/read/38498012/3d-analysis-of-the-cranial-and-facial-shape-in-craniosynostosis-patients-a-systematic-review
#24
JOURNAL ARTICLE
Melissa S I C Kurniawan, Pauline A E Tio, Tareq Abdel Alim, Gennady Roshchupkin, Clemens M F Dirven, Mieke M Pleumeekers, Irene M J Mathijssen, Marie-Lise C van Veelen
With increasing interest in 3D photogrammetry, diverse methods have been developed for craniofacial shape analysis in craniosynostosis patients. This review provides an overview of these methods and offers recommendations for future studies. A systematic literature search was used to identify publications on 3D photogrammetry analyses in craniosynostosis patients until August 2023. Inclusion criteria were original research reporting on 3D photogrammetry analyses in patients with craniosynostosis and written in English...
March 18, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38498004/potential-i-nos-arg-1-switch-with-nlrp3-and-parasitic-load-down-regulation-in-experimental-schistosoma-mansoni-infection-via-chloroquine-repurposing
#25
JOURNAL ARTICLE
Marwa A Hasby Saad, Esraa G El-Saadi, Dareen A Ali, Mona M Watany, Mohammed M Eid
In previous studies, the inhibitory effect of chloroquine on NLRP3 inflammasome and heme production was documented. This may be employed as a double-bladed sword in schistosomiasis (anti-inflammatory and parasiticidal). In this study, chloroquine's impact on schistosomiasis mansoni was investigated. The parasitic load (worm/egg counts and reproductive capacity index [RCI]), i-Nos/Arg-1 expression, splenomegaly, hepatic insult and NLRP3-immunohistochemical expression were assessed in infected mice after receiving early and late repeated doses of chloroquine alone or dually with praziquantel...
March 2024: Parasite Immunology
https://read.qxmd.com/read/38498001/in-hospital-outcomes-of-autologous-and-implant-based-breast-reconstruction-in-patients-with-diabetes-mellitus-a-population-based-study-of-2015-2020-national-inpatient-sample
#26
JOURNAL ARTICLE
Renxi Li, Bharat Ranganath
BACKGROUND: Breast reconstruction encompasses autologous (ABR) and implant-based breast reconstruction (IBR) each with its own sets of potential complications. Diabetes mellitus (DM) is associated with breast reconstruction complications, although most of the studies did not differentiate between the reconstruction procedures. This study conducted a population-based study examining impact of DM on inhospital outcomes in ABR and IBR. METHODS: Patients underwent ABR or IBR were identified in National Inpatient Sample from Q4 2015 to 2020...
March 18, 2024: World Journal of Surgery
https://read.qxmd.com/read/38497997/pyroptosis-tuning-in-intestinal-cryptosporidiosis-via-the-natural-histone-deacetylase-inhibitor-romidepsin
#27
JOURNAL ARTICLE
Noha E Shalaby, Zeinab S Shoheib, Nabila A Yassin, Heba H El-Kaliny, Marwa A Hasby Saad
Cryptosporidium is an opportunistic protozoan, with many species of cross-human infectivity. It causes life-threatening diarrhoea in children and CD4-defective patients. Despite its limited efficacy, nitazoxanide remains the primary anti-cryptosporidial drug. Cryptosporidium infects the intestinal brush border (intracellular-extracytoplasmic) and down-regulates pyroptosis to prevent expulsion. Romidepsin is a natural histone deacetylase inhibitor that triggers pyroptosis. Romidepsin's effect on cryptosporidiosis was assessed in immunocompromised mice via gasdermin-D (GSDM-D) immunohistochemical expression, IFN-γ, IL-1β and IL-18 blood levels by ELISA, and via parasite scanning by modified Ziehl-Neelsen staining and scanning electron microscopy (SEM)...
March 2024: Parasite Immunology
https://read.qxmd.com/read/38497990/risk-of-major-congenital-malformations-and-exposure-to-antiseizure-medication-monotherapy
#28
JOURNAL ARTICLE
Dina Battino, Torbjörn Tomson, Erminio Bonizzoni, John Craig, Emilio Perucca, Anne Sabers, Sanjeev Thomas, Silje Alvestad, Piero Perucca, Frank Vajda
IMPORTANCE: Women with epilepsy (WWE) require treatment with antiseizure medications (ASMs) during pregnancy, which may be associated with an increased risk of major congenital malformations (MCMs) in their offspring. OBJECTIVE: To investigate the prevalence of MCMs after prenatal exposure to 8 commonly used ASM monotherapies and changes in MCM prevalence over time. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, observational, longitudinal cohort study conducted from June 1999 to October 2022...
March 18, 2024: JAMA Neurology
https://read.qxmd.com/read/38497981/basic-environmental-supports-for-positive-brain-and-cognitive-development-in-the-first-year-of-life
#29
JOURNAL ARTICLE
Joan L Luby, Max P Herzberg, Caroline Hoyniak, Rebecca Tillman, Rachel E Lean, Rebecca Brady, Regina Triplett, Dimitrios Alexopoulos, David Loseille, Tara Smyser, Cynthia E Rogers, Barbara Warner, Christopher D Smyser, Deanna M Barch
IMPORTANCE: Defining basic psychosocial resources to facilitate thriving in the first year of life could tangibly inform policy and enhance child development worldwide. OBJECTIVE: To determine if key environmental supports measured as a thrive factor (T-factor) in the first year of life positively impact brain, cognitive, and socioemotional outcomes through age 3. DESIGN, SETTING, AND PARTICIPANTS: This prospective longitudinal cohort study took place at a Midwestern academic medical center from 2017 through 2022...
March 18, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38497979/probiotics-in-autism-spectrum-disorders-a-systematic-review-of-clinical-studies-and-future-directions
#30
JOURNAL ARTICLE
Olga Barba-Vila, Helena García-Mieres, Belén Ramos
CONTEXT: It is hypothesized that gut dysbiosis, a typical feature of patients with autism spectrum disorder (ASD), could be involved in the origin of this neurodevelopmental disorder. Therefore, the use of probiotics to restore gastrointestinal (GI) equilibrium might be a promising therapeutic strategy due to its capacity to balance the gut-brain axis and behavioral responses. OBJECTIVE: To summarize current knowledge on the use of probiotics to treat core clinical ASD symptoms and concomitant GI signs, compare the design of published studies with those of ongoing trials, assess the near future of this field, and provide recommendations for improving novel studies...
March 18, 2024: Nutrition Reviews
https://read.qxmd.com/read/38497975/in-hospital-outcomes-of-autologous-and-implant-based-breast-reconstruction-in-patients-with-chronic-obstructive-pulmonary-disease
#31
JOURNAL ARTICLE
Renxi Li, Bharat Ranganath
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common comorbid condition that can be associated with postoperative mortality and morbidity. However, the outcome profile of patients with COPD after breast reconstruction has yet to be established. Therefore, this study aimed to assess the postoperative outcomes in patients with COPD who underwent autologous (ABR) and implant-based breast reconstruction (IBR). METHODS: National Inpatient Sample was used to identify patients who underwent ABR or IBR from Q4 2015 to 2020...
March 18, 2024: World Journal of Surgery
https://read.qxmd.com/read/38497974/urgent-versus-elective-surgical-disparities-among-american-indian-and-alaska-native-patients
#32
JOURNAL ARTICLE
Benjamin Brown, Sarah Holt, Kassandra Dindinger-Hill, Erika M Wolff, Sara Javid, Yaw Nyame, John L Gore
BACKGROUND: American Indian and Alaska Native (AIAN) health issues are understudied despite documentation of lower-than-average life expectancy. Urgent surgery is associated with higher rates of postsurgical complications and postoperative death. We assess whether American Indian and Alaska Native (AIAN) patients in Washington State are at greater risk of requiring urgent rather than elective surgery compared with non-Hispanic Whites (NHW). METHODS: We accessed data for the period 2009-2014 from the Washington State Comprehensive Hospital Abstract Reporting System (CHARS) database, which captures all statewide hospital admissions, to examine three common surgeries that are performed both urgently and electively: hip replacements, aortic valve replacements, and spinal fusions...
March 18, 2024: World Journal of Surgery
https://read.qxmd.com/read/38497965/development-and-validation-of-a-machine-learning-based-model-of-mortality-risk-in-first-episode-psychosis
#33
JOURNAL ARTICLE
Johannes Lieslehto, Jari Tiihonen, Markku Lähteenvuo, Stefan Leucht, Christoph U Correll, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Heidi Taipale
IMPORTANCE: There is an absence of mortality risk assessment tools in first-episode psychosis (FEP) that could enable personalized interventions. OBJECTIVE: To examine the feasibility of machine learning (ML) in discerning mortality risk in FEP and to assess whether such risk predictions can inform pharmacotherapy choices. DESIGN, SETTING, AND PARTICIPANTS: In this prognostic study, Swedish nationwide cohort data (from July 1, 2006, to December 31, 2021) were harnessed for model development and validation...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38497964/lymph-node-isolated-tumor-cells-in-patients-with-endometrial-cancer
#34
JOURNAL ARTICLE
Koji Matsuo, Ling Chen, Monica K Neuman, Maximilian Klar, Joseph W Carlson, Lynda D Roman, Jason D Wright
IMPORTANCE: Isolated tumor cells (ITCs) are the histopathological finding of small clusters of cancer cells no greater than 0.2 mm in diameter in the regional lymph nodes. For endometrial cancer, the prognostic significance of ITCs is uncertain. OBJECTIVE: To assess clinico-pathological characteristics and oncologic outcomes associated with ITCs in endometrial cancer. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study using the National Cancer Database included patients with endometrial cancer who had primary hysterectomy and nodal evaluation from 2018 to 2020...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38497962/factors-associated-with-use-of-the-preventive-health-inventory-in-us-veterans
#35
JOURNAL ARTICLE
Chelle L Wheat, Edwin S Wong, Kristen E Gray, Susan E Stockdale, Karin M Nelson, Ashok Reddy
IMPORTANCE: The COVID-19 pandemic caused significant declines in the quality of preventive and chronic disease care. The Veterans Health Administration (VHA) used the Preventive Health Inventory (PHI), a multicomponent care management intervention, to catch up on care disrupted by the pandemic. OBJECTIVE: To identify key factors associated with PHI use. DESIGN, SETTING, AND PARTICIPANTS: This cohort study of veterans receiving primary care used administrative data from national VHA primary care clinics for February 1, 2021, through February 1, 2022...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38497958/leveraging-large-language-models-for-generating-responses-to-patient-messages-a-subjective-analysis
#36
JOURNAL ARTICLE
Siru Liu, Allison B McCoy, Aileen P Wright, Babatunde Carew, Julian Z Genkins, Sean S Huang, Josh F Peterson, Bryan Steitz, Adam Wright
OBJECTIVE: This study aimed to develop and assess the performance of fine-tuned large language models for generating responses to patient messages sent via an electronic health record patient portal. MATERIALS AND METHODS: Utilizing a dataset of messages and responses extracted from the patient portal at a large academic medical center, we developed a model (CLAIR-Short) based on a pre-trained large language model (LLaMA-65B). In addition, we used the OpenAI API to update physician responses from an open-source dataset into a format with informative paragraphs that offered patient education while emphasizing empathy and professionalism...
March 18, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38497944/estimated-childhood-lead-exposure-from-drinking-water-in-chicago
#37
JOURNAL ARTICLE
Benjamin Q Huynh, Elizabeth T Chin, Mathew V Kiang
IMPORTANCE: There is no level of lead in drinking water considered to be safe, yet lead service lines are still commonly used in water systems across the US. OBJECTIVE: To identify the extent of lead-contaminated drinking water in Chicago, Illinois, and model its impact on children younger than 6 years. DESIGN, SETTING, AND PARTICIPANTS: For this cross-sectional study, a retrospective assessment was performed of lead exposure based on household tests collected from January 2016 to September 2023...
March 18, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38497942/the-edmonton-symptom-assessment-system-is-a-valid-reliable-and-responsive-tool-to-assess-symptom-burden-in-decompensated-cirrhosis
#38
JOURNAL ARTICLE
John Donlan, Chengbo Zeng, Teresa Indriolo, Lucinda Li, Enya Zhu, Joyce Zhou, Kedie Pintro, Nora Horick, Maria Edelen, Raymond T Chung, Areej El-Jawahri, Nneka N Ufere
BACKGROUND: While there is a growing need for interventions addressing symptom burden in patients with decompensated cirrhosis (DC), the lack of validated symptom assessment tools is a critical barrier. We investigated the psychometric properties of the revised Edmonton Symptom Assessment System (ESAS-r) in a longitudinal cohort of patients with DC. METHODS: Adult outpatients with DC were prospectively recruited from a liver transplant center and completed ESAS-r at baseline and week 12...
April 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38497939/serologic-response-to-the-epstein-barr-virus-peptidome-and-the-risk-for-multiple-sclerosis
#39
JOURNAL ARTICLE
Marianna Cortese, Yumei Leng, Kjetil Bjornevik, Moriah Mitchell, Brian C Healy, Michael J Mina, James D Mancuso, David W Niebuhr, Kassandra L Munger, Stephen J Elledge, Alberto Ascherio
IMPORTANCE: It remains unclear why only a small proportion of individuals infected with the Epstein-Barr virus (EBV) develop multiple sclerosis (MS) and what the underlying mechanisms are. OBJECTIVE: To assess the serologic response to all EBV peptides before the first symptoms of MS occur, determine whether the disease is associated with a distinct immune response to EBV, and evaluate whether specific EBV epitopes drive this response. DESIGN, SETTING, AND PARTICIPANTS: In this prospective, nested case-control study, individuals were selected among US military personnel with serum samples stored in the US Department of Defense Serum Repository...
March 18, 2024: JAMA Neurology
https://read.qxmd.com/read/38497933/bullet-holes-a-novel-model-to-identify-the-most-impactful-gaps-in-the-firearm-homicide-prevention-laws-of-each-state
#40
JOURNAL ARTICLE
Aksel D Laudon, Elizabeth S Davis, Xuewei Zhao, Kelly Kenzik, Crisanto Torres, Sabrina E Sanchez, Tejal S Brahmbhatt, Dane R Scantling
BACKGROUND: Firearm homicides (FH) are a major cause of mortality in the United States (US). Firearm law implementation is variable across states, and legislative gaps may represent opportunities for FH prevention. For each state, we sought to identify which firearm law category would have been most effective if implemented and how effective it would have been. METHODS: We conducted a retrospective cohort study examining the effects of firearm laws on FH rates in the 48 contiguous US states 2010-2019...
March 18, 2024: Journal of Trauma and Acute Care Surgery
keyword
keyword
77914
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.