keyword
MENU ▼
Read by QxMD icon Read
search

Provoke epilepsy

keyword
https://www.readbyqxmd.com/read/29414595/safety-and-efficiency-of-medication-withdrawal-at-home-prior-to-long-term-eeg-video-monitoring
#1
Renate van Griethuysen, Wytske A Hofstra, Sandra M A van der Salm, Mireille D Bourez-Swart, Al W de Weerd
PURPOSE: Long-term video-EEG monitoring (LTM) is frequently used for diagnostic purposes and in the workup of epilepsy surgery to determine the seizure onset zone. Different strategies are applied to provoke seizures during LTM, of which withdrawal of anti-epileptic drugs (AED) is most effective. Remarkably, there is no standardized manner of AED withdrawal. For instance, the majority of clinics taper medication during clinical admission, whereas we prefer to taper medication at home prior to admission...
January 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29414547/stress-seizures-and-epilepsy-patient-narratives
#2
Johannes D Lang, David C Taylor, Burkhard S Kasper
In epilepsy, individual seizures can be triggered by a variety of external and internal stimuli. One of the most common trigger factors reported by patients is stress. However prevalent, stress-related triggering of episodes seems underappreciated in epilepsy for various reasons, and its misinterpretation often leads to other diagnoses, e.g., psychogenic nonepileptic seizures (PNES) or normal reactions. This article illustrates the significant role of stress as a seizure-provoking factor by referring to nine patient narratives...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29327348/respiratory-dysfunction-progresses-with-age-in-kcna1-null-mice-a-model-of-sudden-unexpected-death-in-epilepsy
#3
Kristina A Simeone, Jodi Hallgren, Charles S Bockman, Ankita Aggarwal, Vikash Kansal, Lauren Netzel, Shruthi H Iyer, Stephanie A Matthews, Malavika Deodhar, Peter J Oldenburg, Peter W Abel, Timothy A Simeone
OBJECTIVE: Increased breathing rate, apnea, and respiratory failure are associated with sudden unexpected death in epilepsy (SUDEP). We recently demonstrated the progressive nature of epilepsy and mortality in Kcna1 -/- mice, a model of temporal lobe epilepsy and SUDEP. Here we tested the hypothesis that respiratory dysfunction progresses with age in Kcna1 -/- mice, thereby increasing risk of respiratory failure and sudden death (SD). METHODS: Respiratory parameters were determined in conscious mice at baseline and following increasing doses of methacholine (MCh) using noninvasive airway mechanics (NAM) systems...
February 2018: Epilepsia
https://www.readbyqxmd.com/read/29317612/gamma-oscillatory-activity-in-vitro-a-model-system-to-assess-pathophysiological-mechanisms-of-comorbidity-between-autism-and-epilepsy
#4
D Subramanian, E Pralong, R T Daniel, A G Chacko, R Stoop, K S Babu
Autism spectrum disorder (ASD) and temporal lobe epilepsy exhibit remarkable comorbidity, but for reasons not clearly understood. To reveal a common pathophysiological mechanism, we here describe and characterize an in vitro epileptiform activity in the rat hippocampus that exhibits common features with in vivo activity in rodent ASD models. We discovered the development of this activity in the CA1 region of horizontal slices after prolonged interictal-like epileptiform activity in the CA3 region that was provoked by incubation in high potassium artificial cerebrospinal fluid...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29234274/neuronal-nitric-oxide-synthase-contributes-to-ptz-kindling-epilepsy-induced-hippocampal-endoplasmic-reticulum-stress-and-oxidative-damage
#5
Xinjian Zhu, Jingde Dong, Bing Han, Rongrong Huang, Aifeng Zhang, Zhengrong Xia, Huanhuan Chang, Jie Chao, Honghong Yao
Epilepsy is one of the most common chronic neurological disorders which provoke progressive neuronal degeneration. Endoplasmic reticulum (ER) stress has recently been recognized as pivotal etiological factors contributing to epilepsy-induced neuronal damage. However, the specific contribution of epilepsy made to ER stress remains largely elusive. Here we use pentylenetetrazole (PTZ) kindling, a chronic epilepsy model, to identify neuronal nitric oxide synthase (nNOS) as a signaling molecule triggering PTZ kindling epilepsy-induced ER stress and oxidative damage...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29213036/-pathomorphosis-of-idiopathic-generalized-epilepsy-juvenile-forms
#6
A S Kotov, Yu V Eliseev, Yu V Tokareva
AIM: To investigate the pathomorphosis of idiopathic generalized epilepsy (IGE) in the aspect of prognosis. MATERIAL AND METHODS: The study involved 1480 patients with epilepsy including 281 patients with IGE. RESULTS AND CONCLUSION: 'Juvenile' forms were diagnosed in 228 patients. Relapse of seizures in anamnesis occurred in 19% out of 105 patients with juvenile myoclonic epilepsy (JME). Remission was achieved in 59.2% out of 76 patients with long-term follow-up...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29208406/macrophage-depletion-by-liposome-encapsulated-clodronate-suppresses-seizures-but-not-hippocampal-damage-after-acute-viral-encephalitis
#7
Inken Waltl, Christopher Käufer, Sonja Bröer, Chintan Chhatbar, Luca Ghita, Ingo Gerhauser, Muneeb Anjum, Ulrich Kalinke, Wolfgang Löscher
Viral encephalitis is a major risk factor for the development of seizures and epilepsy, but the underlying mechanisms are only poorly understood. Mouse models such as viral encephalitis induced by intracerebral infection with Theiler's virus in C57BL/6 (B6) mice allow advancing our understanding of the immunological and virological aspects of infection-induced seizures and their treatment. Previous studies using the Theiler's virus model in B6 mice have indicated that brain-infiltrating inflammatory macrophages and the cytokines released by these cells are key to the development of acute seizures and hippocampal damage in this model...
December 5, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29161897/status-epilepticus-and-multiple-sclerosis-a-case-presentation-and-literature-review
#8
Murat Mert Atmaca, Candan Gurses
PURPOSE: To search the literature for the frequency, pathogenesis, prognosis, and treatment of seizures and status epilepticus (SE) in patients with multiple sclerosis (MS). METHODS: We report 2 patients with MS who presented with SE and review the literature. RESULTS: Seizures and SE episodes worsened during MS relapses in the first patient. SE episodes and MS relapses significantly decreased after initiation of natalizumab treatment but she still had seizures and was taking 4 antiepileptic drugs (AEDs)...
January 1, 2017: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29105060/cannabinoid-receptor-1-2-double-knockout-mice-develop-epilepsy
#9
Shane Rowley, Xiaofei Sun, Isabel V Lima, Alexandra Tavenier, Antonio Carlos Pinheiro de Oliveira, Sudhansu K Dey, Steve C Danzer
The endocannabinoid system has gained attention as an important modulator of activity in the central nervous system. Initial studies focused on cannabinoid receptor 1 (CB1), which is widely expressed in the brain, but recent work also implicates cannabinoid receptor 2 (CB2) in modulating neuronal activity. Both receptors are capable of reducing neuronal activity, generating interest in cannabinoid receptor agonists as potential anticonvulsants. CB1 (Cnr1) and CB2 (Cnr2) single-knockout mice have been generated, with the former showing heightened seizure sensitivity, but not overt seizures...
November 3, 2017: Epilepsia
https://www.readbyqxmd.com/read/29104044/calcitonin-potentiates-the-anticonvulsant-and-antinociceptive-effects-of-valproic-acid-and-pregabalin-in-pentylenetetrazole-kindled-mice
#10
Nada M Hamada, Rehab H Ashour, Amany A Shalaby, Hussien M El-Beltagi
Antiepileptic drugs are the backbone for epilepsy management. Epilepsy may be accompanied by decreased pain threshold. Thus, anticonvulsant agents with antinociceptive properties are of great importance. This study investigated the possible anticonvulsant and antinociceptive effects of calcitonin in combination with either valproic acid or pregabalin and whether these effects might occur through γ-aminobutyric acid (GABA) modulation. Eighty-four male Balb/C mice were divided into 7 groups: control-naïve, pentylenetetrazole (PTZ)-induced seizures, PTZ-calcitonin, PTZ-valproic acid, PTZ-pregabalin, PTZ-calcitonin-valproic acid (PCV) combination, and PTZ-calcitonin-pregabalin (PCP) combination...
November 2, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29033340/nonepileptic-seizure-provoked-by-cardiac-dysrhythmia-with-stemi
#11
A Pourmand, S Davis, K Yensen
Acute seizures represent 1% of all visits to emergency departments in the United States. While many acute seizures are correctly attributable to underlying epilepsy, approximately one-third of acute seizures are provoked by underlying and potentially life-threatening acute conditions. Many clinical syndromes associated with seizure-like activity are well-established and readily identified in the acute setting. Cardiac dysrhythmias are known causes of acute seizure-like activity and, if transient and not captured by electrocardiogram tracings during acute episodes, may be incorrectly diagnosed as epileptic seizures...
January 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29021759/effects-of-gladiolus-dalenii-on-the-stress-induced-behavioral-neurochemical-and-reproductive-changes-in-rats
#12
David Fotsing, Gwladys T Ngoupaye, Agnes C Ouafo, Stephanie K J Njapdounke, Yongabi A Kenneth, Elisabeth Ngo Bum
Gladiolus dalenii is a plant commonly used in many regions of Cameroon as a cure for various diseases like headaches, epilepsy, schizophrenia, and mood disorders. Recent studies have revealed that the aqueous extract of G. dalenii (AEGD) exhibited antidepressant-like properties in rats. Therefore, we hypothesized that the AEGD could protect from the stress-induced behavioral, neurochemical, and reproductive changes in rats. The objective of the present study was to elucidate the effect of the AEGD on behavioral, neurochemical, and reproductive characteristics, using female rats subjected to chronic immobilization stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28977140/air-pollution-and-risk-of-hospitalization-for-epilepsy-the-role-of-farm-use-of-nitrogen-fertilizers-and-emissions-of-the-agricultural-air-pollutant-nitrous-oxide
#13
Keith Fluegge, Kyle Fluegge
The link between various air pollutants and hospitalization for epilepsy has come under scrutiny. We have proposed that exposure to air pollution and specifically the pervasive agricultural air pollutant and greenhouse gas, nitrous oxide (N2O), may provoke susceptibility to neurodevelopmental disorders. Evidence supports a role of N2O exposure in reducing epileptiform seizure activity, while withdrawal from the drug has been shown to induce seizure-like activity. Therefore, we show here that the statewide use of anthropogenic nitrogen fertilizers (the most recognized causal contributor to environmental N2O burden) is significantly negatively associated with hospitalization for epilepsy in all three pre-specified hospitalization categories, even after multiple pollutant comparison correction (p<...
September 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28966642/spreading-depression-and-focal-venous-cerebral-ischemia-enhance-cortical-neurogenesis
#14
Ryo Tamaki, Samuel Ige Orie, Beat Alessandri, Oliver Kempski, Axel Heimann
Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or "enriched environment" as well as pathological conditions such as ischemia, epilepsy or cortical spreading depression. Whether all these conditions use a common trigger to set off endogenous neurogenesis is yet unclear. We hypothesized that cortical spreading depression (CSD) induces neurogenesis in the cerebral cortex and dentate gyrus after cerebral venous ischemia. Forty-two Wistar rats alternatively underwent sham operation (Sham), induction of ten CSDs or venous ischemia provoked via occlusion of two adjacent superficial cortical vein followed by ten induced CSDs (CSD + 2-VO)...
August 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28946181/localization-of-musicogenic-epilepsy-to-heschl-s-gyrus-and-superior-temporal-plane-case-report
#15
Yasunori Nagahama, Christopher K Kovach, Michael Ciliberto, Charuta Joshi, Ariane E Rhone, Adam Vesole, Phillip E Gander, Kirill V Nourski, Hiroyuki Oya, Matthew A Howard, Hiroto Kawasaki, Brian J Dlouhy
Musicogenic epilepsy (ME) is an extremely rare form of the disorder that is provoked by listening to or playing music, and it has been localized to the temporal lobe. The number of reported cases of ME in which intracranial electroencephalography (iEEG) has been used for seizure focus localization is extremely small, especially with coverage of the superior temporal plane (STP) and specifically, Heschl's gyrus (HG). The authors describe the case of a 17-year-old boy with a history of medically intractable ME who underwent iEEG monitoring that involved significant frontotemporal coverage as well as coverage of the STP with an HG depth electrode anteriorly and a planum temporale depth electrode posteriorly...
September 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28885121/epilepsy-headache-and-abdominal-pain-after-shunt-surgery-for-idiopathic-normal-pressure-hydrocephalus-the-inph-crash-study
#16
Jenny Larsson, Hanna Israelsson, Anders Eklund, Jan Malm
OBJECTIVE Adverse events related to shunt surgery are common and might have a negative effect on outcome in patients with idiopathic normal pressure hydrocephalus (INPH). The authors' objectives were to establish the frequencies of epilepsy, headache, and abdominal pain and determine their impact on patient quality of life (QOL), in long-term follow-up after shunt surgery for INPH. METHODS One hundred seventy-six shunt-treated patients with INPH (mean age 74 years) and 368 age- and sex-matched controls from the population were included...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28859565/neuroplasticity-and-the-brain-connectome-what-can-jean-talairach-s-reflections-bring-to-modern-psychosurgery
#17
Pierre Bourdillon, Caroline Apra, Marc Lévêque, Fabien Vinckier
Contrary to common psychosurgical practice in the 1950s, Dr. Jean Talairach had the intuition, based on clinical experience, that the brain connectome and neuroplasticity had a role to play in psychosurgery. Due to the remarkable progress of pharmacology at that time and to the technical limits of neurosurgery, these concepts were not put into practice. Currently, these concepts are being confirmed by modern techniques such as neuroimaging and computational neurosciences, and could pave the way for therapeutic innovation in psychiatry...
September 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28833036/treatment-with-lacosamide-impedes-generalized-seizures-in-a-rodent-model-of-cortical-dysplasia
#18
Ashley D Nemes, Rebecca O'Dwyer, Imad M Najm, Zhong Ying, Jorge Gonzalez-Martinez, Andreas V Alexopoulos
OBJECTIVE: Epilepsy is a common neurologic disorder resulting in spontaneous, recurrent seizures. About 30-40% of patients are not responsive to pharmacologic therapies. This may be due to the differences between individual patients such as etiology, underlying pathophysiology, and seizure focus, and it highlights the importance of new drug discovery and testing in this field. Our goal was to determine the efficacy of lacosamide (LCM), a drug approved for the treatment of focal seizures, in a model of generalized epilepsy with cortical dysplasia (CD)...
October 2017: Epilepsia
https://www.readbyqxmd.com/read/28659857/a-new-rat-model-of-epileptic-spasms-based-on-methylazoxymethanol-induced-malformations-of-cortical-development
#19
Eun-Hee Kim, Mi-Sun Yum, Minyoung Lee, Eun-Jin Kim, Woo-Hyun Shim, Tae-Sung Ko
Malformations of cortical development (MCDs) can cause medically intractable epilepsies and cognitive disabilities in children. We developed a new model of MCD-associated epileptic spasms by treating rats prenatally with methylazoxymethanol acetate (MAM) to induce cortical malformations and postnatally with N-methyl-d-aspartate (NMDA) to induce spasms. To produce cortical malformations to infant rats, two dosages of MAM (15 mg/kg, intraperitoneally) were injected to pregnant rats at gestational day 15. In prenatally MAM-exposed rats and the controls, spasms were triggered by single (6 mg/kg on postnatal day 12 (P12) or 10 mg/kg on P13 or 15 mg/kg on P15) or multiple doses (P12, P13, and P15) of NMDA...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28584610/the-usefulness-of-nap-sleep-recording-during-routine-electroencephalography-an-audit-study
#20
Sami Farah Al-Rawas, Khidir M Abdelbasit, Huda Hussain Al-Lawati, Rajesh Poothrikovil, Amal Khalfan Al-Rawahi, Abdul Aleem Khan, Robert Shane Delamont
OBJECTIVES: A measure to increase the electroencephalogram (EEG) outcome includes a short period of nap sleep during a routine standard EEG with the aim of increasing its sensitivity to interictal abnormalities or provoking seizures. As part of an ongoing auditing of our EEG data, we aimed to investigate the contribution of nap sleep during routine outpatient department based EEGs requested for a variety of reasons. METHODS: EEG data at the Department of Clinical Physiology at Sultan Qaboos University Hospital, Oman, from July 2006 to December 2007 and from January 2009 to December 2010 (total 42 months) were reviewed...
May 2017: Oman Medical Journal
keyword
keyword
77913
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"