keyword
https://read.qxmd.com/read/38537236/comparison-of-perioperative-outcomes-in-obese-and-non-obese-patients-subjected-to-open-lumbar-spine-surgery
#1
JOURNAL ARTICLE
Parménides Guadarrama-Ortiz, César O Ruíz-Rivero, Deyanira Capi-Casillas, Alondra Román-Villagómez, Ulises Palacios-Zúñiga, Ángel D Prieto-Rivera, José A Choreño-Parra
OBJECTIVE: Obesity is a global epidemic affecting developing countries. The relationship between obesity and perioperative outcomes during elective lumbar spine surgery remains controversial, especially in those without morbid disease. MATERIALS AND METHODS: We retrospectively revised the medical records of patients with lumbar spine degeneration subjected to elective surgery. The data retrieved included demographic and clinical characteristics, body mass index (BMI), obesity status (BMI ≥ 30), surgical interventions, estimated blood loss (EBL), operative time, length of stay (LOS), and post-operative complications...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537073/the-role-of-robotic-assisted-surgery-in-the-management-of-rectal-cancer-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Chenxion Zhang, Hao Tan, Han Xu, Jiaming Ding
BACKGROUND: Rectal cancer poses a significant global health burden. There is a lack of concrete evidence concerning the benefits of robotic-assisted surgery (RAS) for rectal cancer surgery as compared to laparoscopic and open techniques. To address this gap, we conducted a meta-analysis to assess the intraoperative, postoperative, and safety outcomes of robotic surgery in this context. METHODS: MEDLINE, Scopus, and the Cochrane library were searched till May 2023 for randomized and non-randomized studies comparing robotic surgery with either laparoscopic or open approach for rectal cancers...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536861/predictors-for-participation-in-mass-treatment-and-female-genital-schistosomiasis-re-investigation-and-the-effect-of-praziquantel-treatment-in-south-african-adolescents
#3
JOURNAL ARTICLE
Takalani Girly Nemungadi, Elisabeth Kleppa, Hashini Nilushika Galappaththi-Arachchige, Pavitra Pillay, Svein Gunnar Gundersen, Birgitte Jyding Vennervald, Patricia Doris Ndhlovu, Myra Taylor, Saloshni Naidoo, Eyrun Floerecke Kjetland
OBJECTIVE: Female Genital Schistosomiasis (FGS) causes intravaginal lesions and symptoms that could be mistaken for sexually transmitted diseases or cancer. In adults, FGS lesions [grainy sandy patches (GSP), homogenous yellow patches (HYP), abnormal blood vessels and rubbery papules] are refractory to treatment. The effect of treatment has never been explored in young women; it is unclear if gynaecological investigation will be possible in this young age group (16-23 years). We explored the predictors for accepting anti-schistosomal treatment and/or gynaecological reinvestigation in young women, and the effects of anti-schistosomal mass-treatment (praziquantel) on the clinical manifestations of FGS at an adolescent age...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536168/persistent-cutaneous-lesions-of-darier-disease-and-second-hit-somatic-variants-in-atp2a2-gene
#4
JOURNAL ARTICLE
Lihi Atzmony, Fadia Zagairy, Banan Mawassi, Majd Shehade, Yasmin Tatour, Nada Danial-Farran, Morad Khayat, Nassim Warrour, Roni Dodiuk-Gad, Eran Cohen-Barak
IMPORTANCE: Darier disease (DD) is a rare genetic skin disorder caused by heterozygous variants in the ATP2A2 gene. Clinical manifestations include recurrent hyperkeratotic papules and plaques that occur mainly in seborrheic areas. Although some of the lesions wax and wane in response to environmental factors, others are severe and respond poorly to therapy. OBJECTIVE: To investigate the molecular mechanism underlying the persistency of skin lesions in DD. DESIGN, SETTING, AND PARTICIPANTS: In this case series, DNA was extracted from unaffected skin, transient and persistent lesional skin, and blood from 9 patients with DD...
March 27, 2024: JAMA Dermatology
https://read.qxmd.com/read/38535872/detection-and-phylogenetic-analysis-of-caprine-arthritis-encephalitis-virus-using-taqman-based-qpcr-in-eastern-china
#5
JOURNAL ARTICLE
Yutong Tian, Hailong Zhang, Yan Zhang, Xinya Zhang, Zhilei Guan, Junjie Zhang, Yafeng Qiu, Beibei Li, Ke Liu, Zongjie Li, Donghua Shao, Peng Li, Zhiyong Ma, Jianchao Wei
Caprine arthritis encephalitis is an infectious disease caused by the caprine arthritis encephalitis virus that infects goats, sheep, and other small ruminants. An outbreak of CAEV could be extremely harmful to the goat farming industry and could cause severe economic losses. We designed specific primers and probes for the gag gene and established a TaqMan real-time quantitative polymerase chain reaction assay. This method's correlation coefficient (R2 ) was >0.999, and the sensitivity of the assay to the plasmid-carried partial gag gene was approximately 10 copies/µL, 1000 times higher than that of conventional PCR...
March 21, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535581/extensive-countrywide-molecular-identification-and-high-genetic-diversity-of-haemonchus-spp-in-domestic-ruminants-in-greece
#6
JOURNAL ARTICLE
Konstantinos V Arsenopoulos, Styliani Minoudi, Isaia Symeonidou, Alexandros Triantafyllidis, George C Fthenakis, Elias Papadopoulos
The gastrointestinal nematode parasite Haemonchus spp. is one of the most pathogenic parasites of ruminants, due to its blood-sucking activity, which causes large economic losses in the ruminant industry. The latest epizootiological data recorded an increase in the infection, not only in Greece but also in other countries, mainly attributed to climatic changes. The study of the population structure and the investigation of the phylogenetic relationships of Haemonchus spp. are essential for the understanding of its biology and epizootiology to implement appropriate control and prevention strategies...
March 8, 2024: Pathogens
https://read.qxmd.com/read/38535532/advances-in-the-immunology-of-the-host-parasite-interactions-in-african-trypanosomosis-including-single-cell-transcriptomics
#7
REVIEW
Boyoon Choi, Hien Thi Vu, Hai Thi Vu, Magdalena Radwanska, Stefan Magez
Trypanosomes are single-celled extracellular parasites that infect mammals, including humans and livestock, causing global public health concerns and economic losses. These parasites cycle between insect vectors, such as tsetse flies and vertebrate hosts, undergoing morphological, cellular, and biochemical changes. They have remarkable immune evasion mechanisms to escape the host's innate and adaptive immune responses, such as surface coat antigenic variation and the induction of the loss of specificity and memory of antibody responses, enabling the prolongation of infection...
February 20, 2024: Pathogens
https://read.qxmd.com/read/38534614/hydrogels-for-cardio-and-vascular-tissue-repair-and-regeneration
#8
REVIEW
Ilenia Motta, Michelina Soccio, Giulia Guidotti, Nadia Lotti, Gianandrea Pasquinelli
Cardiovascular disease (CVD), the leading cause of death globally, affects the heart and arteries with a variety of clinical manifestations, the most dramatic of which are myocardial infarction (MI), abdominal aortic aneurysm (AAA), and intracranial aneurysm (IA) rupture. In MI, necrosis of the myocardium, scar formation, and loss of cardiomyocytes result from insufficient blood supply due to coronary artery occlusion. Beyond stenosis, the arteries that are structurally and functionally connected to the cardiac tissue can undergo pathological dilation, i...
March 13, 2024: Gels
https://read.qxmd.com/read/38534183/what-factors-can-affect-the-occurrence-of-vertigo-in-patients-after-craniofacial-surgery-in-china
#9
JOURNAL ARTICLE
Sainan Zhang, Jun Zhuang, Wenhong Wu, Lan Huang, Mei Tian, Li Guo, Mengjin Sun, Jintian Hu, Na Liu
Vertigo is a complication of craniomaxillofacial contour plastic surgery characterized by dizziness from hypovolemia in the cerebral hemispheres and brainstem. The authors analyzed the current status and influencing factors of postoperative vertigo in patients who undergo craniomaxillofacial contouring and discussed improvements in nursing strategies. The authors investigated 418 patients admitted to the authors' hospital who underwent craniomaxillofacial contouring between November 2020 and October 2023 and divided them into asymptomatic and symptomatic groups based on syncopal precursors or vertigo...
March 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38533994/mobile-phone-text-messaging-for-medication-adherence-in-secondary-prevention-of-cardiovascular-disease
#10
REVIEW
Julie Redfern, Qiang Tu, Karice Hyun, Matthew A Hollings, Nashid Hafiz, Clara Zwack, Caroline Free, Pablo Perel, Clara K Chow
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death globally, accounting for almost 18 million deaths annually. People with CVDs have a five times greater chance of suffering a recurrent cardiovascular event than people without known CVDs. Although drug interventions have been shown to be cost-effective in reducing the risk of recurrent cardiovascular events, adherence to medication remains suboptimal. As a scalable and cost-effective approach, mobile phone text messaging presents an opportunity to convey health information, deliver electronic reminders, and encourage behaviour change...
March 27, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38533896/synthesis-of-novel-hydrazide-schiff-bases-with-anti-diabetic-and-anti-hyperlipidemic-effects-in-vitro-in-vivo-and-in-silico-approaches
#11
JOURNAL ARTICLE
Waseem Ul Islam, Abad Khan, Faizullah Khan, Saeed Ullah, Muhammad Waqas, Hammad Khan, Momin Khan, Shaikh Mizanoor Rahman, Shaukat Ali, Abdul Mateen, Asaad Khalid, Ajmal Khan, Ahmed Al-Harrasi
The increasing global incidence of non-insulin-dependent diabetes mellitus (NIDDM) necessitates innovative therapeutic solutions. This study focuses on the design, synthesis and biological evaluation of Schiff base derivatives from 2-bromo-2-(2-chlorophenyl) acetic acid, particularly hydrazone compounds 4a and 4b . Both in-vitro and in-vivo assays demonstrate these derivatives' strong antidiabetic and anti-hyperlipidemic properties. In a 15-d experiment, we administered 4a and 4b at doses of 2.5 and 5 mg/kg body weight, which effectively improved symptoms of alloxan-induced diabetes in mice...
March 27, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38533664/blood-kinetics-of-lipophilic-and-proteinophilic-pollutants-during-two-types-of-long-term-fast-in-king-penguins
#12
JOURNAL ARTICLE
Margaux Mollier, Paco Bustamante, Ignacio Martinez-Alvarez, Quentin Schull, Pierre Labadie, Hélène Budzinski, Yves Cherel, Alice Carravieri
In vertebrates, fasting is an intricate physiological process associated with strong metabolic changes, yet its effect on pollutant residue variation is poorly understood. Here, we quantified long-term changes in plasma concentrations of 20 organochlorine and 16 perfluoroalkyl pollutants in king penguins Aptenodytes patagonicus during the breeding and molting fasts, which are marked by low and high levels of protein catabolism, respectively, and by strong lipid use. The profile of measured pollutants in plasma was dominated by perfluorooctanesulfonic acid (PFOS, initial relative contribution of 60%)...
March 27, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38533322/immunological-risk-factors-in-recurrent-pregnancy-loss-in-patients-with-hereditary-thrombophilia
#13
JOURNAL ARTICLE
Zlatko Kirovakov, Emiliana Konova, Nadezhda Hinkova, Stefani Markova, Plamen Penchev
BACKGROUND: Recurrent pregnancy loss (RPL) is a complicated reproductive disorder with underlying genetic and immunological causes. RPL may be influenced by hereditary thrombophilia, a class of blood clotting-related genetic abnormalities, via the vascular and immune systems. This study examines the immunological characteristics that hereditary thrombophilia patients have in common with RPL. METHODS: A prospective cohort study included 300 patients split into two groups: a control group without hereditary thrombophilia and a group with the condition...
March 2024: Curēus
https://read.qxmd.com/read/38533279/sglt2-inhibitors-paradigm-shift-from-diabetes-care-to-metabolic-care-an-indian-perspective
#14
REVIEW
K M Prasanna Kumar, A G Unnikrishnan, Pankaj Jariwala, Ashwani Mehta, Richa Chaturvedi, Sagar Panchal, Preet Lakhani, Rachana Acharya, Jitendra Dixit
The prevalence and burden of diabetes are on the rise in India, making it 'the diabetes capital of the world'. Comorbidities such as obesity, cardiovascular (CV) complications, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and neurodegenerative diseases are common in patients with diabetes. Recent breakthroughs in diabetes medications and continuous glucose monitoring have resulted in a paradigm shift in diabetes care. Hence, a review in the Indian context is warranted. This review focuses on the existing evidence (gathered by a systematic literature search utilising online databases such as PubMed) on the metabolic, cardio-renoprotective, and hepatoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibition, particularly in the Indian setting...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533141/the-effect-of-tranexamic-acid-with-or-without-tourniquet-on-blood-loss-in-total-knee-arthroplasty-at-a-community-hospital
#15
JOURNAL ARTICLE
Elise N Ketelaar, Michael Wagner, Adam Lorenzo, Robert Comrie, Carolina Restini, Grace D Brannan, Roger Corvasce, Saad Mohammad
Tourniquets have long been used in total knee arthroplasty due to the theoretical improvement of bleeding control, integration of cement-bone interface, visibility, and efficiency of the overall surgery. However, this has become increasingly disputed. Comparative studies in total knee arthroplasty employing chemical prophylaxis, i.e., tranexamic acid, have been conducted. This retrospective cohort study evaluated the effect of tranexamic with or without a tourniquet on mean blood loss, hemoglobin, and length of stay in total knee arthroplasty patients...
February 2024: Curēus
https://read.qxmd.com/read/38533089/novel-lipid-mediator-7-s-14-r-docosahexaenoic-acid-biogenesis-and-harnessing-mesenchymal-stem-cells-to-ameliorate-diabetic-mellitus-and-retinal-pericyte-loss
#16
JOURNAL ARTICLE
Yan Lu, Haibin Tian, Hongying Peng, Quansheng Wang, Bruce A Bunnell, Nicolas G Bazan, Song Hong
Introduction: Stem cells can be used to treat diabetic mellitus and complications. ω3-docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and protective. This study found novel DHA-derived 7 S ,14 R -dihydroxy-4 Z ,8 E ,10 Z ,12 E ,16 Z ,19 Z -docosahexaenoic acid (7 S ,14 R -diHDHA), a maresin-1 stereoisomer biosynthesized by leukocytes and related enzymes. Moreover, 7 S ,14 R -diHDHA can enhance mesenchymal stem cell (MSC) functions in the amelioration of diabetic mellitus and retinal pericyte loss in diabetic db/db mice...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38533056/molecular-identification-of-different-toxinogenic-strains-of-clostridium-perfringens-and-histo-pathological-observations-of-camels-died-of-per-acute-entero-toxaemia
#17
JOURNAL ARTICLE
Hafiz Muhammad Ali, Shujaat Hussain, Muhammad Zishan Ahmad, Abu Baker Siddique, Sultan Ali, Mudassar Mohiuddin, Muhammad Ehsan, Muhammad Nadeem, Abdul Qayyum, Riaz Hussain, Iahtasham Khan, Dunia A Al Farraj, Enshad Alzaidi
Enterotoxaemia is a severe disease caused by Clostridium perfringens and render high mortality and huge economic losses in livestock. However, scanty information and only few cases are reported about the presence and patho-physiology of enterotoxaemia in camels. The bacterium induces per-acute death in animals due to rapid production of different lethal toxins. The necropsy of camels (per-acute = 15, acute = 3) was conducted at 18 outbreaks of enterotoxaemia in camels in the desert area of Bahawalpur region...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532704/causes-of-intraoperative-neuromonitoring-events-in-adult-spine-deformity-surgery-a-systematic-review
#18
REVIEW
Chloe Cottone, David Kim, Christopher Lucasti, Maxwell M Scott, Benjamin C Graham, Nell Aronoff, Bilal Hasanspahic, David Kowalski, Justin Bird, Dil Patel
STUDY DESIGN: Systematic review. OBJECTIVES: Intraoperative neuromonitoring (IOMN) has become a standard practice in the detection and prevention of nerve damage and postoperative deficit. While multicenter studies have addressed this inquiry, there have been no systematic reviews to date. This systematic review identifies the leading causes of IONM alerts during adult spinal deformity (ASD) surgeries. METHODS: Following PRISMA guidelines, a literature search was performed in PubMed and Embase...
March 27, 2024: Global Spine Journal
https://read.qxmd.com/read/38532497/robotic-portal-resection-for-mediastinal-tumours-a-prospective-observational-study
#19
JOURNAL ARTICLE
Wei Gan, Mu-Zi Yang, Zi-Hui Tan, Chu-Long Xie, Tian-Yu Sun, Hao-Xian Yang
BACKGROUND: To demonstrate the effectiveness and feasibility of robotic portal resection (RPR) for mediastinal tumour using a prospectively collected database. METHODS: Data from 73 consecutive patients with mediastinal tumours who underwent RPRs were prospectively collected from August 2018 to April 2023. All patients underwent chest and abdominal enhanced computed tomography (CT) and preoperative multidisciplinary team (MDT) discussion. The patients were stratified into two groups based on tumour size: Group A (tumour size < 4 cm) and Group B (tumour size ≥ 4 cm)...
March 26, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38532371/minimally-invasive-cytoreductive-radical-prostatectomy-exploring-the-safety-and-feasibility-of-a-single-port-or-multi-port-robotic-platform
#20
JOURNAL ARTICLE
Daniel J Lama, Kyle Thomas, Simone L Vernez, Oluwatimilehin Okunowo, Clayton S Lau, Bertram E Yuh
BACKGROUND: Consolidative resection or cytoreductive radical prostatectomy (CRP) may benefit men with non-organ confined prostate cancer. We report the safety, feasibility, and outcomes of robot-assisted laparoscopic CRP using a single-port (SP) or multi-port (MP) platform. METHODS: We reviewed consecutive men with clinical node positive or metastatic castrate-sensitive prostate cancer who underwent IRB-approved CRP and extended pelvic lymph node dissection using the da Vinci SP or MP Surgical Systems (Intuitive Surgical, Sunnyvale, CA) from 2015-2022...
March 26, 2024: BMC Urology
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