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https://www.readbyqxmd.com/read/28442607/n-methyl-d-aspartate-nmda-receptor-blockade-prevents-neuronal-death-induced-by-zika-virus-infection
#1
Vivian V Costa, Juliana L Del Sarto, Rebeca F Rocha, Flavia R Silva, Juliana G Doria, Isabella G Olmo, Rafael E Marques, Celso M Queiroz-Junior, Giselle Foureaux, Julia Maria S Araújo, Allysson Cramer, Ana Luíza C V Real, Lucas S Ribeiro, Silvia I Sardi, Anderson J Ferreira, Fabiana S Machado, Antônio C de Oliveira, Antônio L Teixeira, Helder I Nakaya, Danielle G Souza, Fabiola M Ribeiro, Mauro M Teixeira
Zika virus (ZIKV) infection is a global health emergency that causes significant neurodegeneration. Neurodegenerative processes may be exacerbated by N-methyl-d-aspartate receptor (NMDAR)-dependent neuronal excitoxicity. Here, we have exploited the hypothesis that ZIKV-induced neurodegeneration can be rescued by blocking NMDA overstimulation with memantine. Our results show that ZIKV actively replicates in primary neurons and that virus replication is directly associated with massive neuronal cell death. Interestingly, treatment with memantine or other NMDAR blockers, including dizocilpine (MK-801), agmatine sulfate, or ifenprodil, prevents neuronal death without interfering with the ability of ZIKV to replicate in these cells...
April 25, 2017: MBio
https://www.readbyqxmd.com/read/28366425/osteoporosis-in-the-women-s-health-initiative-another-treatment-gap
#2
Maryam Sattari, Jane A Cauley, Cynthia Garvan, Karen C Johnson, Michael J LaMonte, Wenjun Li, Marian Limacher, Todd Manini, Gloria E Sarto, Shannon D Sullivan, Jean Wactawski-Wende, Rebecca J Beyth
BACKGROUND: Osteoporotic fractures are associated with high morbidity, mortality, and cost. METHODS: We performed a post hoc analysis of the Women's Health Initiative (WHI) clinical trials (CT) data to assess osteoporosis treatment and identify participant characteristics associated with utilization of osteoporosis medication(s) after new diagnoses of osteoporosis and/or fracture. Information from visits prior to and immediately subsequent to the first fracture event or osteoporosis diagnosis were evaluated for medication use...
March 30, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28335307/zinc-oxide-nanorods-decorated-graphene-nanoplatelets-a-promising-antimicrobial-agent-against-the-cariogenic-bacterium-streptococcus-mutans
#3
Elena Zanni, Chandrakanth Reddy Chandraiahgari, Giovanni De Bellis, Maria Rita Montereali, Giovanna Armiento, Paolo Ballirano, Antonella Polimeni, Maria Sabrina Sarto, Daniela Uccelletti
Nanomaterials are revolutionizing the field of medicine to improve the quality of life due to the myriad of applications stemming from their unique properties, including the antimicrobial activity against pathogens. In this study, the antimicrobial and antibiofilm properties of a novel nanomaterial composed by zinc oxide nanorods-decorated graphene nanoplatelets (ZNGs) are investigated. ZNGs were produced by hydrothermal method and characterized through field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) techniques...
September 29, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28330482/development-of-a-model-of-saint-louis-encephalitis-infection-and-disease-in-mice
#4
Rafael Elias Marques, Juliana L Del Sarto, Rebeca P F Rocha, Giovanni F Gomes, Allysson Cramer, Milene A Rachid, Danielle G Souza, Maurício L Nogueira, Mauro M Teixeira
BACKGROUND: Flaviviruses are a genre of closely related viral pathogens which emerged in the last decades in Brazil and in the world. Saint (St.) Louis encephalitis virus (SLEV) is a neglected flavivirus that can cause a severe neurological disease that may lead to death or sequelae. St. Louis encephalitis pathogenesis is poorly understood, which hinders the development of specific treatment or vaccine. METHODS: To address this problem, we developed a model of SLEV infection in mice to study mechanisms involved in the pathogenesis of severe disease...
March 22, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28330129/the-recombinant-pea-defensin-drr230a-is-active-against-impacting-soybean-and-cotton-pathogenic-fungi-from-the-genera-fusarium-colletotrichum-and-phakopsora
#5
Ariane Ferreira Lacerda, Rafael Perseghini Del Sarto, Marilia Santos Silva, Erico Augusto Rosas de Vasconcelos, Roberta Ramos Coelho, Vanessa Olinto Dos Santos, Claudia Vieira Godoy, Claudine Dinali Santos Seixas, Maria Cristina Mattar da Silva, Maria Fatima Grossi-de-Sa
Plant defensins are antifungal peptides produced by the innate immune system plants developed to circumvent fungal infection. The defensin Drr230a, originally isolated from pea, has been previously shown to be active against various entomopathogenic and phytopathogenic fungi. In the present study, the activity of a yeast-expressed recombinant Drr230a protein (rDrr230a) was tested against impacting soybean and cotton fungi. First, the gene was subcloned into the yeast expression vector pPICZαA and expressed in Pichia pastoris...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28178286/sexual-communication-in-castniid-moths-males-mark-their-territories-and-appear-to-bear-all-chemical-burden
#6
Carmen Quero, Victor Sarto I Monteys, Gloria Rosell, Marc Puigmartí, Angel Guerrero
Castniid moths (Lepidoptera: Castniidae) display a butterfly-like reproductive behavior, i.e., they use visual stimuli for mate location and females have apparently lost their pheromone glands in an evolutionary context. In this paper we report for the first time the identification of three new compounds, namely n-octadecyl acetate, (Z)-9-octadecenyl acetate and (E,Z)-2,13-octadecadienyl acetate, in males of the Castniid Palm Borer, Paysandisia archon, which could be involved in its short-range courtship behavior, and also shed light on recent controversies on the sexual behavior of the species...
2017: PloS One
https://www.readbyqxmd.com/read/28152055/post-diagnosis-body-mass-index-and-mortality-among-women-diagnosed-with-endometrial-cancer-results-from-the-women-s-health-initiative
#7
Hannah Arem, Ruth M Pfeiffer, Steven C Moore, Melinda L Irwin, Michael J LaMonte, Gloria E Sarto, Rami Nassir, Juhua Luo, Rowan T Chlebowski, Louise A Brinton, Charles E Matthews
Higher body mass index (BMI) measured before endometrial cancer diagnosis has been associated with greater risk of developing endometrial cancer and higher mortality, but the association between BMI measured after diagnosis and mortality risk is unclear. We identified 467 women (91 deaths) in the Women's Health Initiative (WHI) with information on BMI measured after diagnosis and used Cox proportional hazards regression to generate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality...
2017: PloS One
https://www.readbyqxmd.com/read/28095783/genome-wide-expression-profiling-in-muscle-and-subcutaneous-fat-of-lambs-in-response-to-the-intake-of-concentrate-supplemented-with-vitamin-e
#8
Laura González-Calvo, Elda Dervishi, Margalida Joy, Pilar Sarto, Roberto Martin-Hernandez, Magdalena Serrano, Jose M Ordovás, Jorge H Calvo
BACKGROUND: The objective of this study was to acquire a broader, more comprehensive picture of the transcriptional changes in the L. Thoracis muscle (LT) and subcutaneous fat (SF) of lambs supplemented with vitamin E. Furthermore, we aimed to identify novel genes involved in the metabolism of vitamin E that might also be involved in meat quality. In the first treatment, seven lambs were fed a basal concentrate from weaning to slaughter (CON). In the second treatment, seven lambs received basal concentrate from weaning to 4...
January 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28095125/nitrate-in-drinking-water-and-risk-of-colorectal-cancer-in-yogyakarta-indonesia
#9
Fathmawati, Jajah Fachiroh, Evi Gravitiani, Sarto, Adi Heru Husodo
Nitrate concentration in well water in Yogyakarta, Indonesia, and its surroundings tended to increase rapidly from time to time, and it may be associated with an elevated risk for several types of cancer. The purpose of this study was to examine the association between nitrate in drinking water and colorectal cancer (CRC) risk occurrence. A case-control study was conducted in Yogyakarta Special Province. Pathologically confirmed 75 CRC patients and 75 controls were consulted and their individual well water was sampled and examined for nitrate concentrations...
January 17, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28076636/body-dysmorphic-symptoms-scale-for-patients-seeking-esthetic-surgery-cross-cultural-validation-study
#10
Tatiana Dalpasquale Ramos, Maria José Azevedo de Brito, Mônica Sarto Piccolo, Maria Fernanda Normanha da Silva Martins Rosella, Miguel Sabino, Lydia Masako Ferreira
CONTEXT AND OBJECTIVE: Rhinoplasty is one of the most sought-after esthetic operations among individuals with body dysmorphic disorder. The aim of this study was to cross-culturally adapt and validate the Body Dysmorphic Symptoms Scale. DESIGN AND SETTING: Cross-cultural validation study conducted in a plastic surgery outpatient clinic of a public university hospital. METHODS: Between February 2014 and March 2015, 80 consecutive patients of both sexes seeking rhinoplasty were selected...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28065634/association-between-dietary-energy-density-and-incident-type-2-diabetes-in-the-women-s-health-initiative
#11
Melanie D Hingle, Betsy C Wertheim, Marian L Neuhouser, Lesley F Tinker, Barbara V Howard, Karen Johnson, Simin Liu, Lawrence S Phillips, Lihong Qi, Gloria Sarto, Tami Turner, Molly E Waring, Cynthia A Thomson
BACKGROUND: Dietary energy density, or energy available in relation to gram intake, can inform disease risk. OBJECTIVE: The objective of this study was to investigate the association between baseline dietary energy density and risk of incident type 2 diabetes in postmenopausal women. DESIGN: Dietary energy density, weight status, and type 2 diabetes incidence were prospectively characterized in a large cohort of postmenopausal women participating in one or more clinical trials or an observational study...
January 5, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27999251/a-flexible-and-highly-sensitive-pressure-sensor-based-on-a-pdms-foam-coated-with-graphene-nanoplatelets
#12
Andrea Rinaldi, Alessio Tamburrano, Marco Fortunato, Maria Sabrina Sarto
The demand for high performance multifunctional wearable devices is more and more pushing towards the development of novel low-cost, soft and flexible sensors with high sensitivity. In the present work, we describe the fabrication process and the properties of new polydimethylsiloxane (PDMS) foams loaded with multilayer graphene nanoplatelets (MLGs) for application as high sensitive piezoresistive pressure sensors. The effective DC conductivity of the produced foams is measured as a function of MLG loading...
December 16, 2016: Sensors
https://www.readbyqxmd.com/read/27833052/dietary-calcium-supplementation-in-adult-rats-reverts-brown-adipose-tissue-dysfunction-programmed-by-postnatal-early-overfeeding
#13
Ellen Paula Santos Conceição, Egberto Gaspar Moura, Elaine Oliveira, Deysla Sabino Guarda, Mariana Sarto Figueiredo, Fernanda Torres Quitete, Camila Calvino, Rosiane Aparecida Miranda, Paulo Cezar Freitas Mathias, Alex Christian Manhães, Patricia Cristina Lisboa
Brown adipose tissue (BAT) dysfunction is associated with obesity and its comorbidities, such as hypertension, and the improvement of BAT function seems important for obesity management. Here we investigated the effects of dietary calcium supplementation on BAT autonomic nerve activity, sympathoadrenal function and cardiovascular parameters in adult obese rats that were raised in small litters (SL group). Three days after birth, SL litters were adjusted to three pups to induce early overfeeding. The control group remained with 10 pups/litter until weaning (NL group)...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27792153/electro-mechanical-properties-of-multilayer-graphene-based-polymeric-composite-obtained-through-a-capillary-rise-method
#14
Chiara Acquarelli, Licia Paliotta, Alessio Tamburrano, Giovanni De Bellis, Maria Sabrina Sarto
A new sensor made of a vinyl-ester polymer composite filled with multilayer graphene nanoplatelets (MLG) is produced through an innovative capillary rise method for application in strain sensing and structural health monitoring. The new sensor is characterized by high stability of the piezoresistive response under quasi-static consecutive loading/unloading cycles and monotonic tests. This is due to the peculiarity of the fabrication process that ensures a smooth and clean surface of the sensor, without the presence of filler agglomerates acting as micro- or macro-sized defects in the composite...
October 25, 2016: Sensors
https://www.readbyqxmd.com/read/27749739/estrogen-alone-and-health-outcomes-in-black-women-by-african-ancestry-a-secondary-analyses-of-a-randomized-controlled-trial
#15
Rowan T Chlebowski, Wendy Barrington, Aaron K Aragaki, JoAnn E Manson, Gloria Sarto, Mary J OʼSullivan, Daniel Wu, Jane A Cauley, Lihong Qi, Robert L Wallace, Ross L Prentice
OBJECTIVE: In postmenopausal black women in the Women's Health Initiative randomized trial, estrogen alone reduced breast cancers but its comprehensive influence on health outcomes in black women is unknown. Therefore, we examined this issue in the Women's Health Initiative overall and by African ancestry. METHODS: A total of 1,616 black women with prior hysterectomy, including 1,061 with percent African ancestry determination, at 40 US centers were randomly assigned to conjugated equine estrogen (0...
February 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27469994/maternal-flaxseed-oil-intake-during-lactation-changes-body-fat-inflammatory-markers-and-glucose-homeostasis-in-the-adult-progeny-role-of-gender-dimorphism
#16
Deysla Sabino Guarda, Egberto Gaspar de Moura, Janaíne Cavalcanti Carvalho, Adelina Martha Dos Reis, Patricia Novaes Soares, Patricia Cristina Lisboa, Mariana Sarto Figueiredo
We evaluated maternal flaxseed oil intake during lactation on body composition, lipid profile, glucose homeostasis and adipose tissue inflammation in male and female progeny at adulthood. Lactating rats were divided into the following: control 7% soybean oil (C), hyper 19% soybean oil (HS) and hyper 17% flaxseed oil+2% soybean oil (HF). Weaned pups received a standard diet. Offspring were killed in PN180. Male HF presented higher visceral adipose tissue (VAT) and triacylglycerol, and female HF showed insulin resistance...
September 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27463406/body-dysmorphic-symptoms-scale-for-patients-seeking-esthetic-surgery-cross-cultural-validation-study
#17
Tatiana Dalpasquale Ramos, Maria José Azevedo de Brito, Mônica Sarto Piccolo, Maria Fernanda Normanha da Silva Martins Rosella, Miguel Sabino, Lydia Masako Ferreira
CONTEXT AND OBJECTIVE: Rhinoplasty is one of the most sought-after esthetic operations among individuals with body dysmorphic disorder. The aim of this study was to cross-culturally adapt and validate the Body Dysmorphic Symptoms Scale. DESIGN AND SETTING: Cross-cultural validation study conducted in a plastic surgery outpatient clinic of a public university hospital. METHODS: Between February 2014 and March 2015, 80 consecutive patients of both sexes seeking rhinoplasty were selected...
July 21, 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27448147/endoscopic-ultrasound-guided-fna-of-pelvic-lesions-a-large-single-center-experience
#18
Galab M Hassan, Sarto C Paquin, Roula Albadine, Gilles Gariépy, Geneviève Soucy, Bich N Nguyen, Anand V Sahai
BACKGROUND: Pelvic endoscopic ultrasound-guided fine-needle aspiration (PEUS-FNA) of rectal or perirectal lesions is safe, minimally invasive, and well tolerated. It provides valuable information, which can greatly influence patient management. Herein, the authors present what to their knowledge is the largest series to date of PEUS-FNA. METHODS: PEUS-FNA specimens were retrieved from the archives of the study institution from January 2001 to March 2015. Only patients with solid pelvic lesions were examined...
November 2016: Cancer
https://www.readbyqxmd.com/read/27440911/low-birth-weight-and-risk-of-later-life-physical-disability-in-women
#19
Cassandra N Spracklen, Kelli K Ryckman, Jennifer G Robinson, Marcia L Stefanick, Gloria E Sarto, Stephen D Anton, Robert B Wallace
Background: There is strong evidence that low and high birth weight due to in-utero programming results in elevated risk for adult diseases, though less research has been performed examining the influence of birth weight and physical disability later in life. Methods: Baseline data from 76,055 postmenopausal women in the Women's Health Initiative, a large multi-ethnic cohort, were used to examine the association between self-reported birth weight category (<6 lbs, 6-7 lbs 15 oz, 8-9 lbs 15 oz, and ≥10 lbs) and the self-reported physical functioning score on the RAND 36-item Health Survey...
April 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27390211/nonischemic-left-ventricular-scar-as-a-substrate-of-life-threatening-ventricular-arrhythmias-and-sudden-cardiac-death-in-competitive-athletes
#20
Alessandro Zorzi, Martina Perazzolo Marra, Ilaria Rigato, Manuel De Lazzari, Angela Susana, Alice Niero, Kalliopi Pilichou, Federico Migliore, Stefania Rizzo, Benedetta Giorgi, Giorgio De Conti, Patrizio Sarto, Luis Serratosa, Giampiero Patrizi, Elia De Maria, Antonio Pelliccia, Cristina Basso, Maurizio Schiavon, Barbara Bauce, Sabino Iliceto, Gaetano Thiene, Domenico Corrado
BACKGROUND: The clinical profile and arrhythmic outcome of competitive athletes with isolated nonischemic left ventricular (LV) scar as evidenced by contrast-enhanced cardiac magnetic resonance remain to be elucidated. METHODS AND RESULTS: We compared 35 athletes (80% men, age: 14-48 years) with ventricular arrhythmias and isolated LV subepicardial/midmyocardial late gadolinium enhancement (LGE) on contrast-enhanced cardiac magnetic resonance (group A) with 38 athletes with ventricular arrhythmias and no LGE (group B) and 40 healthy control athletes (group C)...
July 2016: Circulation. Arrhythmia and Electrophysiology
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