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Split prep

Michael P DeMicco, Lucy B Clayton, Jeff Pilot, Michael S Epstein
BACKGROUND AND AIMS: NER1006 is the first 32 fluid ounce (1L) polyethylene glycol-based bowel preparation. This randomized, multicenter, colonoscopist/central reader-blinded Phase 3 non-inferiority trial assessed the efficacy, safety, and tolerability of NER1006 versus trisulfate for bowel cleansing. METHODS: Patients undergoing colonoscopy were randomized (1:1) to receive NER1006 or trisulfate, using evening/morning split-dosing administration. Blinded central readers used the validated Harefield Cleansing Scale (HCS) to evaluate 2 alternative primary endpoints: overall bowel cleansing success and high-quality cleansing of the ascending colon/cecum...
August 10, 2017: Gastrointestinal Endoscopy
Rui Hao, Yunshan Fan, Bo Zhang
The electrochemical interface is an ultrathin interfacial region between the electrode surface and the electrolyte solution and is often characterized by numerous dynamic processes, such as solvation and desolvation, heterogeneous electron transfer, molecular adsorption and desorption, diffusion, and surface rearrangement. Many of these processes are driven and modulated by the presence of a large interfacial potential gradient. The study and better understanding of the electrochemical interface is important for designing better electrochemical systems where their applications may include batteries, fuel cells, electrocatalytic water splitting, corrosion protection, and electroplating...
August 11, 2017: Journal of the American Chemical Society
Geng Zhang, Ping Wang, Wang-Ting Lu, Cao-Yu Wang, Yong-Ke Li, Cong Ding, Jiangjiang Gu, Xin-Sheng Zheng, Fei-Fei Cao
The development of high-performance electrocatalyst with earth-abundant elements for water-splitting is a key factor to improve its cost efficiency. Here, a noble metal free bi-functional electrocatalyst was synthesized by a facile pyrolysis method using sucrose, urea, Co(NO3)2 and sulfur powder as raw materials. During the fabrication process, Co, S co-doped graphitic carbon nitride (g-C3N4) was firstly produced, and then this in-situ formed template further induced the generation of a Co, N, S tri-doped graphene coupled with Co nanoparticles...
August 10, 2017: ACS Applied Materials & Interfaces
Aasma Shaukat, Ashish Malhotra, Nancy Greer, Roderick MacDonald, Joseph Wels, Timothy J Wilt
BACKGROUND/AIMS: Variation exists among anesthesia providers as to acceptable timing of NPO ("nothing by mouth") for elective colonoscopy procedures. There is a need to balance optimal colonic preparation, patient convenience, and scheduling efficiency with anesthesia safety concerns. We reviewed the evidence for the relationship between NPO timing and aspiration incidence and colonoscopy rescheduling. METHODS: We searched MEDLINE (1990-April 2015) for English language studies of any design and included them if at least one bowel preparation regimen was completed within 8 hours of colonoscopy...
2017: Gastroenterology Research and Practice
Katherine Serrano, Chantale Pambrun, Elena Levin, Dana V Devine
BACKGROUND: In neonate transfusion, the use of a dedicated red blood cell (RBC) unit decreases donor exposure. A separate safety measure involves gamma irradiation of the RBCs to abrogate the possibility of transfusion-associated graft-versus-host disease. However, in combination, storage of gamma-irradiated RBCs leads to accumulation of potentially harmful substances in the supernatant. STUDY DESIGN AND METHODS: For this study, RBCs were pooled and split into three study arms...
August 7, 2017: Transfusion
Carrie L Pierce, Tracie L Williams, Wanda I Santana, Marnie Levine, Li-Mei Chen, Hans C Cooper, Maria I Solano, Adrian R Woolfitt, Wayne A Marasco, He Fang, Ruben O Donis, John R Barr
As a result of recent advances in mass spectrometry-based protein quantitation methods, these techniques are now poised to play a critical role in rapid formulation of pandemic influenza vaccines. Analytical techniques that have been developed and validated on seasonal influenza strains can be used to increase the quality and decrease the time required to deliver protective pandemic vaccines to the global population. The emergence of a potentially pandemic avian influenza A (H7N9) virus in March of 2013, prompted the US public health authorities and the vaccine industry to initiate production of a pre-pandemic vaccine for preparedness purposes...
July 31, 2017: Vaccine
Shintaro Sukegawa, Takahiro Kanno, Yoshiki Manabe, Kenichi Matsumoto, Yuka Sukegawa-Takahashi, Masanori Masui, Yoshihiko Furuki
OSTEOTRANS MX(®) (Takiron Co., Ltd., Osaka, Japan) is a bioactive resorbable maxillofacial osteosynthetic material composed of an unsintered hydroxyapatite/poly-l-lactide composite, and its effective osteoconductive capacity has been previously documented. However, the mechanical strength of this plate system is unclear. Thus, the aim of this in vitro study was to assess its tensile and shear strength and evaluate the biomechanical intensity of different osteosynthesis plate designs after sagittal split ramus osteotomy by simulating masticatory forces in a clinical setting...
July 7, 2017: Materials
Tzu Hsuan Chiang, Tso-Ming Chen
The study investigated photocatalytic water splitting for O₂ production under visible light irradiation using neodymium vanadium oxide (NdVO₄) and vanadium oxide (V₂O₅) hybrid powders. The results in a sacrificial agent of 0.01 M AgNO₃ solution were obtained, and the highest photocatalytic O₂ evolution was 2.63 μmol/h, when the hybrid powders were prepared by mixing Nd and V at a volume ratio of 1:3 at a calcination temperature of 350 °C for 1 h. The hybrid powders were synthesized by neodymium nitrate and ammonium metavanadate using the glycothermal method in ethylene glycol at 120 °C for 1 h...
March 23, 2017: Materials
Yan Li, Zaicheng Wang, Chunlan Jiang, Haohao Niu
Metal/fluoropolymer composites are a category of energetic structural materials that release energy through exothermic chemical reactions initiated under highly dynamic loadings. In this paper, the chemical reaction mechanism of PTFE (polytetrafluoroethylene)/Ti/W composites is investigated through thermal analysis and composition analysis. These composites undergo exothermic reactions at 510 °C to 600 °C, mainly producing TiFx. The tungsten significantly reduces the reaction heat due to its inertness. In addition, the dynamic compression properties and impact-induced reaction behaviors of PTFE/Ti/W composites with different W content prepared by pressing and sintering are studied using Split Hopkinson Pressure Bar and high speed photography...
February 13, 2017: Materials
Shaomao Xu, Yanan Chen, Yiju Li, Aijiang Lu, Yonggang Yao, Jiaqi Dai, Yanbin Wang, Boyang Liu, Steven D Lacey, Glenn R Pastel, Yudi Kuang, Valencia A Danner, Feng Jiang, Kun Kelvin Fu, Liangbing Hu
The synthesis of nanoscale metal compound catalysts has attracted much research attention in the past decade. The challenges of preparation of the metal compound include the complexity of the synthesis process and difficulty of precise control of the reaction conditions. Herein, we report an in situ synthesis of nanoparticles via a high-temperature pulse method where the bulk material acts as the precursor. During the process of rapid heating and cooling, swift melting, anchoring, and recrystallization occur, resulting in the generation of high-purity nanoparticles...
August 8, 2017: Nano Letters
Malkeshkumar Patel, Wang-Hee Park, Abhijit Ray, Joondong Kim, Jung-Ho Lee
In this data article, we presented the electrochemical data of the working electrode made of Co3O4 semi-transparent film. Electrochemically stable, porous nature of Kirkendall-diffusion grown Co3O4 films were applied to generate hydrogen from the seawater splitting (Patel et al., 2017) [1]. The data presented in this article includes the photograph of prepared samples, polarization curves for water oxidation and Tafel plot, linear sweep voltammetry measurements under the pulsed light condition in 0.1 M Na2S2O3 electrolyte, and transient photoresponses with natural sea water...
October 2017: Data in Brief
Gyanendra Kumar, Jatinder Kaur Dhillon, Ferah Rehman
Aim: The aim of this study was to compare the retention rates of sealant placed either with conventional acid etching or Er,Cr:YSGG laser pretreatment of enamel surface. Materials and methods: This is a prospective, single blind randomised controlled clinical trial enrolling 200 permanent first molars in 50 patients, aged 6-12 years for sealant placement. Study followed split mouth design where each side of the arch was randomly allocated to the two treatment group. Group A(Acid etch group): 37 % phosphoric acid (Scotchbond, 3M ESPE, Seefeld, Germany) was applied for 15 seconds, rinsed with water for 20 seconds and then air-dried using air spray...
December 30, 2016: Laser Therapy
Sakineh Chabi, Andrew G Wright, Steven Holdcroft, Michael S Freund
This study describes the use of a benzimidazolium-based anion exchange membrane for creating bipolar membranes and the assessment of their suitability for solar-driven water splitting. Bipolar membranes were prepared by laminating anion exchange membrane with Nafion NR-211 membrane without modification of the interface. Under acidic and basic conditions, proton and hydroxide ion conductivities of 103 and 102 mS cm(-1) were obtained for Nafion and benzimidazolium-based membranes, respectively. The fabricated bipolar membranes have an average thickness of 90 μm and show high transmittance, up to 75% of the visible light...
August 1, 2017: ACS Applied Materials & Interfaces
Robert J Hilsden, Ronald Bridges, Catherine Dube, Steven J Heitman, Alaa Rostom
BACKGROUND & AIMS: An adequate bowel preparation for colonoscopy is best achieved by giving the cleansing regimen as a split-dose with the second dose given 4-6 hours before the procedure. This can be difficult to administer to diabetics who are preferentially scheduled for early morning procedures. We examined the impact on bowel preparation quality of scheduling diabetics for mid-morning (9:30 am or later) procedures rather than early morning procedures (7:30-9:00 AM) to facilitate a split-dose preparation...
2017: PloS One
Julian A Michely, Markus R Meyer, Hans H Maurer
Reliable, sensitive, and comprehensive urine screening procedures by GC-MS or LC-MS with low or high resolution (HR) are of high importance for drug testing, adherence monitoring, or detection of toxic compounds. Besides conventional urine sampling, dried urine spots are of increasing interest. In the present study, the power of LC-HR-MS/MS was investigated for comprehensive drug testing in urine with or without conjugate cleavage or using dried urine spots after on-spot cleavage in comparison to established LC-MS(n) or GC-MS procedures...
July 29, 2017: Drug Testing and Analysis
Chunyang Yin, Liyang Chen, Nan Song, Yan Lv, Fengrui Hu, Chun Sun, William W Yu, Chunfeng Zhang, Xiaoyong Wang, Yu Zhang, Min Xiao
Here we show that, in single perovskite CsPbI_{3} nanocrystals synthesized from a colloidal approach, a bright-exciton fine-structure splitting as large as hundreds of μeV can be resolved with two orthogonally and linearly polarized photoluminescence peaks. This doublet could switch to a single peak when a single CsPbI_{3} nanocrystal is photocharged to eliminate the electron-hole exchange interaction. The above findings have prepared an efficient platform suitable for probing exciton and spin dynamics of semiconductor nanostructures at the visible-wavelength range, from which a variety of practical applications such as in entangled photon-pair source and quantum information processing can be envisioned...
July 14, 2017: Physical Review Letters
Qing Zhao, Zhenhua Yan, Chengcheng Chen, Jun Chen
Spinels with the formula of AB2O4 (where A and B are metal ions) and the properties of magnetism, optics, electricity, and catalysis have taken significant roles in applications of data storage, biotechnology, electronics, laser, sensor, conversion reaction, and energy storage/conversion, which largely depend on their precise structures and compositions. In this review, various spinels with controlled preparations and their applications in oxygen reduction/evolution reaction (ORR/OER) and beyond are summarized...
August 9, 2017: Chemical Reviews
Anne L Høyland, Geir Øgrim, Stian Lydersen, Sigrun Hope, Morten Engstrøm, Tonje Torske, Terje Nærland, Ole A Andreassen
Executive functions are often affected in autism spectrum disorders (ASD). The underlying biology is however not well known. In the DSM-5, ASD is characterized by difficulties in two domains: Social Interaction and Repetitive and Restricted Behavior, RRB. Insistence of Sameness is part of RRB and has been reported related to executive functions. We aimed to identify differences between ASD and typically developing (TD) adolescents in Event Related Potentials (ERPs) associated with response preparation, conflict monitoring and response inhibition using a cued Go-NoGo paradigm...
2017: Frontiers in Neuroscience
Khurshid Anwar, Muhammad Raihan Sajid, Peter Cahusac, Abdul Ahad Shaikh, Ahmad Elgammal, Ahlam Alshedoukhy, Junaid Kashir
The aim of this study was to examine the potential of a self-designed Facebook page on Neuroscience, to supplement in-class teaching as a mode of blended learning. Posts were split into multiple choice questions (MCQs), general interest articles, neuroscience-related external links and resources, and lecture notes and PowerPoint presentations. The study was divided into three distinct phases: before, during, and after the Neuroscience block. Student responses were evaluated via a self-developed questionnaire...
September 1, 2017: Advances in Physiology Education
Ajish Pillai, Radha Menon, David Oustecky, Asyia Ahmad
BACKGROUND: Quality of bowel preparation and patient knowledge remains a major barrier for completing colorectal cancer screening. Few studies have tested unique ways to impact patient understanding centering on interactive computer programs, pictures, and brochures. Two studies explored instructional videos but focused on patient compliance and anxiety as endpoints. Furthermore, excessive video length and content may limit their impact on a broad patient population. No study so far has studied a video's impact on preparation quality and patient understanding of the colonoscopy procedure...
July 24, 2017: Journal of Clinical Gastroenterology
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