keyword
https://read.qxmd.com/read/37088371/randomised-controlled-trial-of-omalizumab-in-treatment-resistant-systemic-and-cutaneous-mastocytosis-roam
#1
JOURNAL ARTICLE
Jeremy S McComish, Charlotte A Slade, Luke Buizen, Sanjoy K Paul, Josh W Chatelier, Gary Unglik, Katherine A Nicholls, Kymble Spriggs, Samantha S Chan, Jack Godsell, Priscilla Auyeung, Zi Hao Tan, Joseph DeLuca, Mittal Patel, Lin Eon Kuek BBiomed Hons, Yang Tran, Johannes S Kern, Laura Scardamaglia, George A Varigos, Surender Juneja, Julian A Grabek, Michael Christie, Graham A Mackay, Jo A Douglass
No abstract text is available yet for this article.
April 21, 2023: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/33762089/immature-platelet-fraction-as-a-predictor-of-platelet-count-recovery-following-allogeneic-bone-marrow-transplantation
#2
JOURNAL ARTICLE
Julian Grabek, Nic D'Elia, Giles Kelsey
The immature platelet fraction (IPF) is a marker of increased platelet production. An increase in IPF is associated with increased marrow production; therefore, a subsequent increase in a bone marrow transplant recipient during the pancytopenic phase may correlate with platelet recovery and engraftment. We performed a retrospective cohort study and evaluated 32 patients who underwent allogeneic bone marrow transplantation. Patients had platelet count, neutrophil count, platelet transfusion and IPF recorded over a period extending from stem cell infusion, day 0, to day 30...
June 2021: Pathology
https://read.qxmd.com/read/32823933/mpn-the-molecular-drivers-of-disease-initiation-progression-and-transformation-and-their-effect-on-treatment
#3
REVIEW
Julian Grabek, Jasmin Straube, Megan Bywater, Steven W Lane
Myeloproliferative neoplasms (MPNs) constitute a group of disorders identified by an overproduction of cells derived from myeloid lineage. The majority of MPNs have an identifiable driver mutation responsible for cytokine-independent proliferative signalling. The acquisition of coexisting mutations in chromatin modifiers, spliceosome complex components, DNA methylation modifiers, tumour suppressors and transcriptional regulators have been identified as major pathways for disease progression and leukemic transformation...
August 14, 2020: Cells
https://read.qxmd.com/read/26377291/the-ama-specialist-trainee-survey-2014-a-survey-of-hospital-based-specialty-trainees-and-general-practice-registrars
#4
JOURNAL ARTICLE
Julian Grabek, James A Churchill, Sally Banfield
No abstract text is available yet for this article.
September 21, 2015: Medical Journal of Australia
https://read.qxmd.com/read/24300731/chronic-myeloid-leukaemia-masquerading-as-primary-myelofibrosis
#5
JOURNAL ARTICLE
Muhajir Mohamed, Michael Beamish, Julian Grabek
No abstract text is available yet for this article.
January 2014: Pathology
https://read.qxmd.com/read/24014332/atypical-features-in-a-patient-with-acute-promyelocytic-leukaemia-a-potential-diagnostic-pitfall
#6
JOURNAL ARTICLE
Muhajir Mohamed, Karen Dun, Julian Grabek
Acute promyelocytic leukaemia (APML) is a malignancy with a high cure rate; however, delay in diagnosis or treatment can result in morbidity and mortality. APML has characteristic clinical, morphological, immunophenotypic and molecular features. In patients with acute leukaemia, a high index of suspicion is required to exclude APML. Very rarely APML patients at diagnosis can demonstrate atypical features. We reported a patient whose bone marrow features resembled acute myeloid leukaemia with predominantly agranular blasts, devoid of Auer rods and expressing CD34 and HLA-DR on flow cytometry...
September 6, 2013: BMJ Case Reports
https://read.qxmd.com/read/23921688/bleeding-associated-with-acquired-factor-v-inhibitor-in-a-patient-on-warfarin-treated-successfully-with-prednisolone
#7
JOURNAL ARTICLE
Alhossain Khalafallah, Julian Grabek, Robert Hayes, Muhajir Mohamed
An 85-year-old man on warfarin for atrial fibrillation presented with skin bleeding. International normalised ratio (INR) and activated partial thromboplastin time (APTT) were elevated and did not correct even after warfarin reversal with vitamin K, prothrombin complex concentrate (PCC) and fresh frozen plasma. Mixing coagulation studies with normal plasma suggested the presence of an inhibitor rather than the multiple coagulation factor deficiencies expected with warfarin. Assays of the common-pathway coagulation factors revealed factor V concentration <2% with inhibitor level elevated to 11 Bethesda units...
August 6, 2013: BMJ Case Reports
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