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https://www.readbyqxmd.com/read/29656449/regimen-durability-in-hiv-infected-children-and-adolescents-initiating-first-line-art-in-a-large-public-sector-hiv-cohort-in-south-africa
#1
Rachael Bonawitz, Alana T Brennan, Lawrence Long, Timothy Heeren, Mhairi Maskew, Ian Sanne, Matthew P Fox
INTRODUCTION: In April 2010 tenofovir and abacavir replaced stavudine in public-sector first-line antiretroviral therapy (ART) for children under 20 years old in South Africa. The association of both abacavir and tenofovir with fewer side-effects and toxicities compared to stavudine could translate to increased durability of tenofovir or abacavir-based regimens. We evaluated changes over time in regimen durability for pediatric patients 3 to 19 years of age at 8 public sector clinics in Johannesburg, South Africa...
April 15, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29655517/integrating-pregnancy-prevention-into-an-hiv-counseling-and-testing-program-in-pediatric-primary-care
#2
Noah J Wheeler, Krishna K Upadhya, Marie-Sophie Tawe, Kathy Tomaszewski, Renata Arrington-Sanders, Arik V Marcell
PURPOSE: Certified health educator (CHE)-based HIV counseling and testing typically focus on HIV and sexually transmitted infection (STI) prevention only. A quality improvement initiative examined integrating assessment of reproductive life plans, counseling about pregnancy prevention, and contraception referral into a CHE-based HIV testing program. METHODS: Between February 2014 and January 2017, in one urban pediatric primary care clinic serving patients aged 0-25, CHEs assessed sexual history, HIV risk, short-term (i...
April 11, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29630021/changing-patterns-and-factors-associated-with-mode-of-delivery-among-pregnant-women-with-human-immunodeficiency-virus-infection-in-the-united-states
#3
Kartik K Venkatesh, Leavitt Morrison, Elizabeth G Livingston, Alice Stek, Jennifer S Read, David E Shapiro, Ruth E Tuomala
OBJECTIVE: To describe patterns and factors associated with mode of delivery among pregnant women with human immunodeficiency virus (HIV) infection in the United States in relation to evolving HIV-in-pregnancy guidelines. METHODS: We conducted an analysis of two observational studies, Pediatric AIDS Clinical Trials Group and International Maternal Pediatric Adolescent AIDS Clinical Trials Network Protocol P1025, which enrolled pregnant women with HIV infection from 1998 to 2013 at more than 60 U...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29604982/hiv-neuropathology
#4
Susan Morgello
Primary human immunodeficiency virus (HIV) neuropathologies can affect all levels of the neuraxis and occur in all stages of natural history disease. Some, like HIV encephalitis, HIV myelitis, and diffuse infiltrative lymphocytosis of peripheral nerve, reflect productive infection of the nervous system; others, like vacuolar myelopathy, distal symmetric polyneuropathy, and central and peripheral nervous system demyelination, are not clearly related to regional viral replication, and reflect more complex cascades of dysregulated host immunity and metabolic dysfunction...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29601404/letter-to-the-editor-financial-incentives-to-motivate-pediatric-hiv-testing-assessing-the-potential-for-coercion-inducement-and-voluntariness
#5
Anjuli D Wagner, Seema K Shah, Irene N Njuguna, Kathryn M Porter, Jillian Neary, Elizabeth Maleche-Obimbo, Rose Bosire, Dalton C Wamalwa, Grace C John-Stewart, Jennifer A Slyker
No abstract text is available yet for this article.
March 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29596217/financial-incentives-for-pediatric-hiv-testing-in-kenya
#6
Irene N Njuguna, Anjuli D Wagner, Vincent O Omondi, Verlinda A Otieno, Jillian Neary, Rose Bosire, Joseph B Babigumira, Carol Levin, Elizabeth Maleche-Obimbo, Dalton C Wamalwa, Grace John-Stewart, Jennifer Slyker
The acceptability of financial incentives for pediatric HIV testing was evaluated in Kenya. Sixty HIV-infected women with children of unknown status were randomized to receive $5, $10, or $15 conditional upon HIV testing. Forty-four (73%) completed child testing; with similar rates across arms. Uptake was significantly higher than a cohort with similar procedures but no incentives (73% vs. 14%, p<0.001).
March 24, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29596110/cardiac-and-inflammatory-biomarkers-in-perinatally-hiv-infected-and-hiv-exposed-uninfected-children
#7
James D Wilkinson, Paige L Williams, Wendy Yu, Steven D Colan, Armando Mendez, Justin P V Zachariah, Russell B Van Dyke, William T Shearer, Renee E Margossian, Steven E Lipshultz
OBJECTIVES: To compare distributions of serum cardiac and inflammatory biomarkers between perinatally HIV-infected (PHIV) and perinatally HIV-exposed uninfected (PHEU) children, to evaluate their associations with echocardiographic measures, and among PHIV youth, with antiretroviral therapy (ART) and HIV disease severity measures. DESIGN: Cross-sectional analysis of temporally paired serum samples for biomarkers and echocardiograms in a prospective multicenter cohort study of PHIV and PHEU youth...
March 28, 2018: AIDS
https://www.readbyqxmd.com/read/29595649/next-generation-sequencing-provides-an-added-value-in-determining-drug-resistance-and-viral-tropism-in-cameroonian-hiv-1-vertically-infected-children
#8
Joseph Fokam, Maria C Bellocchi, Daniele Armenia, Aubin J Nanfack, Luca Carioti, Fabio Continenza, Desire Takou, Edith S Temgoua, Charlotte Tangimpundu, Judith N Torimiro, Paul N Koki, Charles N Fokunang, Giulia Cappelli, Alexis Ndjolo, Vittorio Colizzi, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Maria M Santoro
With limited and low-genetic barrier drugs used for the prevention of mother-to-child transmission (PMTCT) of HIV in sub-Saharan Africa, vertically transmitted HIV-1 drug-resistance (HIVDR) is concerning and might prompt optimal pediatric strategies.The aim of this study was to ascertain HIVDR and viral-tropism in majority and minority populations among Cameroonian vertically infected children.A comparative analysis among 18 HIV-infected children (7 from PMTCT-exposed mothers and 11 from mothers without PMTCT-exposure) was performed...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29593900/the-palatability-of-lopinavir-and-ritonavir-delivered-by-an-innovative-freeze-dried-fast-dissolving-tablet-formulation
#9
David W Pittman, Alexandra M Brantly, Alexandra L Drobonick, Hannah T King, Daniel C Mesta, Caroline G Richards, Manjari Lal, Manshun Lai
Negative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. This study examines the palatability of an innovative delivery mechanism utilizing a freeze-drying-in-blister approach to create fast-dissolving tablets (FDTs) containing a fixed-dose combination of lopinavir and ritonavir (LPV/r). Consumption patterns of solutions during brief-access and long-term testing and baby foodstuff consumption were analyzed to evaluate the orosensory detection and avoidance of placebo FDTs containing no LPV/r (FDT-) and FDTs containing LPV/r (FDT+)...
2018: AIDS Research and Treatment
https://www.readbyqxmd.com/read/29592818/social-support-needs-among-adolescents-living-with-hiv-in-transition-from-pediatric-to-adult-care-in-cambodia-findings-from-a-cross-sectional-study
#10
Graham Toth, Gitau Mburu, Sovannary Tuot, Vohith Khol, Chanrith Ngin, Pheak Chhoun, Siyan Yi
BACKGROUND: Understanding the circumstances of adolescents living with HIV is critical in designing adolescent-friendly services that will facilitate successful transition from pediatric to adult care. This study describes access, utilization and ongoing social support needs among adolescents living with HIV aged 15-17 in transition from pediatric to adult HIV care in Cambodia. METHODS: A cross-sectional study was conducted among 328 adolescents, randomly selected from 11 antiretroviral therapy (ART) clinics across the country...
March 28, 2018: AIDS Research and Therapy
https://www.readbyqxmd.com/read/29575050/impact-of-hiv-infection-and-highly-active-antiretroviral-therapy-haart-on-b-cell-subpopulations-in-children
#11
Ravinder Singh, Aparna Mukherjee, Mohit Singla, Madhu Vajpayee, Neema Negi, Sushil Kumar Kabra, Rakesh Lodha, Bimal Kumar Das
Background B-cells play an important role in defending children against various infections. In view of scare data, we undertook this prospective cohort study to describe B cell compartment in HIV infected children (<5 years of age) and the effect of HAART on B cell subpopulations. Methods HIV infected children (<5 years) from Pediatric HIV services of the Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, were recruited (April 2012 to December 2015). The enrolled HAART naive HIV-1 infected children (n = 59) were followed up regularly for 12 months; healthy controls (n = 51) included HIV uninfected children with no major illness...
March 25, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29566695/cerebrospinal-fluid-plasmodium-falciparum-histidine-rich-protein-2-in-pediatric-cerebral-malaria
#12
Kiran T Thakur, Jimmy Vareta, Kathryn A Carson, Samuel Kampondeni, Michael J Potchen, Gretchen L Birbeck, Ian MacCormick, Terrie Taylor, David J Sullivan, Karl B Seydel
BACKGROUND: Cerebral malaria (CM) causes a rapidly developing coma, and remains a major contributor to morbidity and mortality in malaria-endemic regions. This study sought to determine the relationship between cerebrospinal fluid (CSF) Plasmodium falciparum histidine rich protein-2 (PfHRP-2) and clinical, laboratory and radiographic features in a cohort of children with retinopathy-positive CM. METHODS: Patients included in the study were admitted (2009-2013) to the Pediatric Research Ward (Queen Elizabeth Central Hospital, Blantyre, Malawi) meeting World Health Organization criteria for CM with findings of malarial retinopathy...
March 23, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29558972/dolutegravir-based-anti-retroviral-therapy-is-effective-and-safe-in-hiv-infected-paediatric-patients
#13
Eugenia Bruzzese, Andrea Lo Vecchio, Andrea Smarrazzo, Orsola Tambaro, Giulia Palmiero, Giovanni Bonadies, Alfredo Guarino
BACKGROUND: Treatment of HIV infection in adolescents is challenging due to long duration of therapy and poor adherence. Recently, the integrase strand transfer inhibitor dolutegravir (DTG) has been approved for the use in adolescents with HIV, but evidence in clinical practice is very limited. METHODS: We describe six cases of HIV-infected children/adolescents successfully treated with DTG-based regimen. Data relative to children/adolescents managed at the Referral Center for Pediatric HIV/AIDS of the University of Naples were reviewed...
March 20, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29534693/severe-eye-complications-from-toxic-epidermal-necrolysis-following-initiation-of-nevirapine-based-haart-regimen-in-a-child-with-hiv-infection-a-case-from-cameroon
#14
Xavier Tchetnya, Calypse Asangbe Ngwasiri, Tiayah Munge, Leopold Ndemnge Aminde
BACKGROUND: Toxic epidermal necrolysis (TEN) is a rare life threatening dermatological disorder characterized by extensive epidermal detachment and erosion of mucous membranes. It is typically a side effect of some medications. Nevirapine, a nonnucleoside reverse transcriptase inhibitor (NNRTI) is one of the frequently used components of highly active antiretroviral therapy (HAART). Skin rash is its common adverse reaction, usually mild and rarely progressing to TEN. Ophthalmic involvement is common as well but rarely progresses to blindness especially in the pediatric population...
March 13, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29534241/clinical-features-and-outcome-of-children-with-severe-lower-respiratory-tract-infection-admitted-to-a-pediatric-intensive-care-unit-in-south-africa
#15
Hayley K Hutton, Heather J Zar, Andrew C Argent
Aim: Severe acute lower respiratory tract infection (ALRTI) remains an important cause of childhood morbidity and mortality. Methods: This is a 12-month retrospective cohort study of children (0-12 years) admitted to a pediatric intensive care unit (PICU) with ALRTI to investigate risk factors, clinical course and in-hospital survival. Results: In total, 265 patients (median age = 4 months [2-12 months]) were identified. In all,102 (38...
March 9, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29528944/rilpivirine-plasma-and-cervico-vaginal-concentrations-in-women-during-pregnancy-and-postpartum
#16
Ahizechukwu C Eke, Nahida Chakhtoura, Angela Kashuba, Brookie M Best, Craig Sykes, Jiajia Wang, Alice M Stek, Elizabeth Smith, Samantha Calabrese, Edmund V Capparelli, Mark Mirochnick
BACKGROUND: Concentrations of antiretrovirals (ARVs) in the genital tract play a key role in pre-exposure prophylaxis. This study aims to describe rilpivirine (Edurant) concentrations in the genital tract in pregnant and postpartum women. METHODS: International Maternal Pediatric Adolescent AIDS Clinical Trials Protocol P1026s is an ongoing, prospective study of antiretroviral pharmacokinetics (PK) in HIV infected pregnant women that include a cohort receiving rilpivirine combination regimen...
March 8, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29516883/a-comparison-of-intradermal-test-with-recombinant-tuberculosis-allergen-diaskintest-with-other-immunologic-tests-in-the-diagnosis-of-tuberculosis-infection
#17
Anna Starshinova, Viacheslav Zhuravlev, Irina Dovgaluk, Alexandr Panteleev, Vera Manina, Ulia Zinchenko, Evgenia Istomina, Maria Pavlova, Piotr Yablonskiy
Background: The WHO strategy for eradication of tuberculosis (TB) by 2035 (The End TB Strategy) is aimed at an early and precise diagnosis and subsequent effective treatment of TB patients. Currently, there is no gold standard for the diagnosis of latent TB infection. This study evaluated the diagnostic capabilities of a new intradermal test using recombinant TB allergen (Diaskintest) compared with tuberculin skin test (TST) and commercial TB interferon-gamma release assays (IGRAs). Methods: A post-hoc data analysis that involved examining 860 HIV-negative, bacillus Calmette-Guérin (BCG)-vaccinated persons aged 1-65 years who visited the TB health-care institutions of Saint Petersburg to rule out or confirm an active TB was conducted from 2011 to 2016...
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29514237/priorities-for-decreasing-morbidity-and-mortality-in-children-with-advanced-hiv-disease
#18
Lisa Frigati, Moherdran Archary, Helena Rabie, Martina Penazzato, Nathan Ford
Early mortality and morbidity remain high in children initiating antiretroviral therapy (ART), especially in sub-Saharan Africa. Many children still present with advanced human immunodeficiency virus (HIV) disease. Tuberculosis, pneumonia, and severe bacterial infections are the main causes of hospital admission in HIV-infected children. In contrast to adults with advanced HIV disease, cryptococcal disease is not common in childhood, although there is a peak in infancy and adolescence. Interventions such as TB screening in symptomatic children, and isoniazid and cotrimoxazole prophylaxis should be implemented...
March 4, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29509759/sexual-risk-during-pregnancy-and-postpartum-periods-among-hiv-infected-and-uninfected-south-african-women-implications-for-primary-and-secondary-hiv-prevention-interventions
#19
Dvora Joseph Davey, Elise Farley, Yolanda Gomba, Thomas Coates, Landon Myer
BACKGROUND: HIV acquisition in pregnancy and breastfeeding contributes significantly toward pediatric HIV infection. However, little is known about how sexual behavior changes during pregnancy and postpartum periods which will help develop targeted HIV prevention and transmission interventions, including pre-exposure prophylaxis (PrEP). METHODS: Cross-sectional study in HIV-infected and uninfected pregnant and postpartum women in Cape Town, South Africa. Interviewers collected survey data on demographic, sexual behaviors, and alcohol use among pregnant and post-partum women...
2018: PloS One
https://www.readbyqxmd.com/read/29509590/time-to-first-line-art-failure-and-time-to-second-line-art-switch-in-the-iedea-pediatric-cohort
#20
Kara Wools-Kaloustian, Irene Marete, Samuel Ayaya, Annette H Sohn, Lam Van Nguyen, Shanshan Li, Valériane Leroy, Beverly S Musick, Jamie E Newman, Andrew Edmonds, Mary-Ann Davies, François Tanoh Eboua, Marie-Thérèse Obama, Marcel Yotebieng, Shobna Sawry, Lynne M Mofenson, Constantin T Yiannoutsos
BACKGROUND: Globally, 49% of the estimated 1.8 million children living with HIV are accessing antiretroviral therapy (ART). There are limited data concerning long-term durability of first-line ART regimens and time to transition to second-line. METHODS: Children initiating their first ART regimen between 2-14 years of age and enrolled in one of 208 sites in 30 Asia-Pacific and African countries participating in the Pediatric International Epidemiology Databases to Evaluate AIDS consortium were included in this analysis...
March 2, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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