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HMB pediatrics

Giuseppina Catanzaro, Zein Mersini Besharat, Neha Garg, Maurizio Ronci, Luisa Pieroni, Evelina Miele, Angela Mastronuzzi, Andrea Carai, Vincenzo Alfano, Agnese Po, Isabella Screpanti, Franco Locatelli, Andrea Urbani, Elisabetta Ferretti
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers. Among them, stem-like cells (hMB-SLCs) represent a fraction of the tumor cell population with the potential of self-renewal and proliferation and have been associated with tumor poor prognosis. In this context, microRNAs have been described as playing a pivotal role in stem cells differentiation. In our paper, we analyze microRNAs profile and genes expression of hMB-SLCs before and after Retinoic Acid- (RA-) induced differentiation...
2016: Stem Cells International
Abelardo Loya-Solis, Lucía Alemán-Meza, Luis Carlos Canales-Martínez, Rodolfo Franco-Márquez, Alim Adriana Rincón-Bahena, Karla María Nuñez-Barragán, Raquel Garza-Guajardo, Marco Antonio Ponce-Camacho
Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney...
2015: Case Reports in Pathology
Lakshmi V Srivaths, Jennifer E Dietrich, Donald L Yee, Haleh Sangi-Haghpeykar, Donald Mahoney
STUDY OBJECTIVE: To compare the efficacy of oral tranexamic acid (TA) with combined oral contraceptives (COC) in reducing menstrual blood loss (MBL) and improving quality of life in adolescent heavy menstrual bleeding (HMB). DESIGN, SETTING, AND PARTICIPANTS: A prospective randomized crossover trial with 17 postmenarchal girls aged 21 years and younger with HMB who were seen at our institution. INTERVENTIONS: Patients were randomized to group A (TA arm) or group B (COC arm), each for 3 cycles, with crossover to the second arm after 1-month washout...
August 2015: Journal of Pediatric and Adolescent Gynecology
Katsumi Mizuno, Motoichiro Sakurai, Kazuo Itabashi
BACKGROUND: If their own mother's milk (OMM) is not available, another mother's milk may be used for extremely low-birthweight (ELBW) infants. Human milk is a bodily fluid, however, therefore we have assumed that other mother's milk is currently seldom given to infants despite its superiority to formula. Although the World Health Organization and the American Academy of Pediatrics have recommended using donor human milk (DHM) from a human milk bank (HMB) in the case that OMM is not available, there is no HMB in Japan...
August 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
Sertac Arslanoglu, Willemijn Corpeleijn, Guido Moro, Christian Braegger, Cristina Campoy, Virginie Colomb, Tamas Decsi, Magnus Domellöf, Mary Fewtrell, Iva Hojsak, Walter Mihatsch, Christian Mølgaard, Raanan Shamir, Dominique Turck, Johannes van Goudoever
The Committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition aims to document the existing evidence of the benefits and common concerns deriving from the use of donor human milk (DHM) in preterm infants. The comment also outlines gaps in knowledge and gives recommendations for practice and suggestions for future research directions. Protection against necrotizing enterocolitis is the major clinical benefit deriving from the use of DHM when compared with formula...
October 2013: Journal of Pediatric Gastroenterology and Nutrition
Huilin Niu, F W Wang, Paul J Zhang, Zhanyong Bing
Cardiac PEComa is very rare. We reported two cases of epithelioid PEComas, one in an adult and one in a 2-year-old child. Both tumors were composed of sheets of epithelioid cells with coagulation necrosis. In addition, the adult case showed marked nuclear atypia and high mitotic activity with atypical mitosis and the pediatric case showed unusual clear cell features. Immunohistochemically, both tumors were positive for HMB-45 and SMA and negative for S100 and cytokeratin. Electron microscopy was performed in the pediatric case and showed premelanosomes...
2012: Case Reports in Medicine
Suchanan Hanamornroongruang, Jitsupa Treetipsatit, Bunchoo Pongtanakul, Napakorn Seangchai
Xp11.2 translocation renal cell carcinomas are rare tumors characterized by translocations involving chromosome Xp11.2. These tumors are predominantly reported in pediatric patients. The authors report Xp11.2 translocation renal cell carcinoma in a 13-year-old girl who presented with asymptomatic palpable right renal mass. Right radical nephrectomy was performed and revealed a well-defined solid mass at the lower pole of the kidney. Microscopically, the tumor was composed of sheets and nests of clear to pale eosinophilic cells with some alveolar growth pattern...
July 2012: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Shanon R Lacy, Matthew Kuhar
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare and diagnostically challenging neoplasm typically presenting in the bones of the maxilla, skull, or mandible. Only 6 of approximately 357 reported cases have involved the subcutis. We describe a case of MNTI presenting as a palpable, subcutaneous, thigh mass in a 5-month-old girl. By ultrasound, the mass was round with well-defined borders, minimal vascularity, and heterogeneous echogenicity. Microscopically, the tumor consisted of nested foci of primitive-appearing small round blue cells with an increased nuclear to cytoplasmic ratio, stippled chromatin, and occasional mitotic figures...
May 2010: American Journal of Dermatopathology
Shih-Hwa Chiou, Chung-Lan Kao, Han-Tso Lin, Wen-Ser Tseng, Ren-Shyan Liu, Chen-Fun Chung, Hung-Hai Ku, Ching-Po Lin, Tai-Tong Wong
INTRODUCTION: Medulloblastoma (MB) is one of the most common malignant brain tumors in children. It is a radiosensitive tumor. At 5 years after radical surgical excision and craniospinal axis irradiation, the tumor-free survival rate is from 50 to 70% [Halperin EC, Constine LS, Tarbell NJ, Kun LE. Pediatric radiation oncology (2005)]. CASE REPORT: In this study, we established xenotransplanted human MB (hMB) cells - isochromosome 17q - in a severe combined immunodeficiency (SCID) mouse model...
May 2006: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Weiming Yu, Robert B Fraser, David A Gaskin, Conrad V Fernandez, James R Wright
We report the first pediatric case of malignant pigmented epithelioid clear-cell tumor arising from kidney; the lesion occurred in a 12-year-old girl without tuberous sclerosis. The tumor was widely metastatic to the retroperitoneum and chest, and the patient died of the disease 9 months after diagnosis, despite active chemotherapy. Pigmented epithelioid clear-cell tumor of the kidney is a rare variant of epithelioid angiomyolipoma and a member of the family of perivascular epithelioid cell tumors (PEComas)...
December 2005: Annals of Diagnostic Pathology
Ismail H Tekkök, Aydin Sav
This paper presents the case of an eight-year-old girl who presented with headache and vomiting and was found to harbor a right fronto-temporo-parietal, partially cystic and centrally solid tumor that measured 11 x 8 x 7 cm. This vascular tumor was gross totally removed. The initial histopathologic diagnosis was hemangiopericytoma and the patient received a total dose of 5330 cGy of external cranial radiation. Twelve months later, the patient presented with left lower quadrant pain and limping and the spinal MR scans showed metastases at T4-5, T7, T12-L1 and L3 levels...
July 2005: Journal of Neuro-oncology
Mai P Hoang, Dinesh Rakheja, Robin H Amirkhan
Rosette formation is a feature that has not been described as occurring in melanocytic neoplasms. We present such a unique case. A 59-year-old man presented with an asymptomatic, soft, hairy 3.0 x 2.0-cm pigmented lesion that had been present for many years in the right external ear, extending from the conchal bowl onto the antitragus area. Examination of histologic sections showed a proliferation of nonatypical and heavily pigmented melanocytes in the superficial dermis and around deep adnexal structures, characteristic of a congenital nevus...
February 2003: American Journal of Dermatopathology
R Delgado, B de Leon Bojorge, J Albores-Saavedra
BACKGROUND: The purpose of this study was to fully characterize and emphasize the salient features of an unusual variant of angiomyolipoma that the authors believe has been underrecognized. METHODS: Five cases of atypical angiomyolipoma (AAML) of the kidney, two of which were reported previously, were retrieved from the consultation files of one of the authors. In one patient a small extrarenal tumor was examined in addition to the primary renal tumor. The histopathologic features of all six tumors, the immunohistochemical findings of five tumors (including the extrarenal tumor), and the ultrastructure of three tumors were analyzed...
October 15, 1998: Cancer
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