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HMB supplementation

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https://www.readbyqxmd.com/read/27897391/a-systematic-review-on-the-role-of-vitamins-minerals-proteins-and-other-supplements-for-the-treatment-of-cachexia-in-cancer-a-european-palliative-care-research-centre-cachexia-project
#1
REVIEW
Mochamat, Henning Cuhls, Milka Marinova, Stein Kaasa, Christiane Stieber, Rupert Conrad, Lukas Radbruch, Martin Mücke
We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27887984/impact-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-on-age-related-functional-deficits-in-mice
#2
Michael Munroe, Yair Pincu, Jennifer Merritt, Adam Cobert, Ryan Brander, Tor Jensen, Justin Rhodes, Marni D Boppart
β-Hydroxy β-methylbutyrate (HMB) is a metabolite of the essential amino acid leucine. Recent studies demonstrate a decline in plasma HMB concentrations in humans across the lifespan, and HMB supplementation may be able to preserve muscle mass and strength in older adults. However, the impact of HMB supplementation on hippocampal neurogenesis and cognition remains largely unexplored. The purpose of this study was to simultaneously evaluate the impact of HMB on muscle strength, neurogenesis and cognition in young and aged mice...
November 22, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27820726/%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-supplementation-effects-on-body-mass-and-performance-in-elite-male-rugby-union-players
#3
Nicholas D McIntosh, Thomas D Love, Jillian Haszard, Hamish Osborne, Katherine E Black
Pre-season is characterized by high training volumes with short recovery periods β-hydroxy β-methylbutyrate (HMB) has been postulated to assist with recovery. HMB has been shown to improve strength and body composition amongst untrained groups the benefits of HMB amongst trained populations are unclear due to the methodologies employed. This randomized control trail determined the effects of 11 weeks HMB supplementation on body mass and performance measures in 27 elite rugby players. HMB group (n=13) mean±SD age 20...
October 27, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27726925/the-effect-of-hmb-ingestion-on-the-igf-i-and-igf-binding-protein-response-to-high-intensity-military-training
#4
Michael J Redd, Jay R Hoffman, Yftach Gepner, Jeffrey R Stout, Mattan W Hoffman, Daniel Ben-Dov, Shany Funk, David D Church, Guy Avital, Yacov Chen, Hagai Frankel, Ishay Ostfeld
OBJECTIVE: Insulin-like growth factor-I (IGF-I) is a metabolic and anabolic biomarker that has been proposed to reflect physiological adaptations resulting from multistressor environments. The bioactivity of IGF-I is regulated by seven different insulin-like growth factor binding proteins (IGFBPs) which act not only as carriers of IGF-1, but also function as a modulator of IGF-I availability and activity. Supplementing with β-hydroxy-β-methylbutyrate (HMB) has been shown to enhance physiological outcomes associated with intense training, and has been reported to augment the IGF-1 response...
October 5, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27691998/characterisation-of-equine-satellite-cell-transcriptomic-profile-response-to-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb
#5
Katarzyna A Szcześniak, Anna Ciecierska, Piotr Ostaszewski, Tomasz Sadkowski
β-Hydroxy-β-methylbutyrate (HMB) is a popular ergogenic aid used by human athletes and as a supplement to sport horses, because of its ability to aid muscle recovery, improve performance and body composition. Recent findings suggest that HMB may stimulate satellite cells and affect expressions of genes regulating skeletal muscle cell growth. Despite the scientific data showing benefits of HMB supplementation in horses, no previous study has explained the mechanism of action of HMB in this species. The aim of this study was to reveal the molecular background of HMB action on equine skeletal muscle by investigating the transcriptomic profile changes induced by HMB in equine satellite cells in vitro...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27648945/downregulation-of-mir-150-expression-by-dna-hypermethylation-is-associated-with-high-2-hydroxy-4-methylthio-butanoic-acid-induced-hepatic-cholesterol-accumulation-in-nursery-piglets
#6
Yimin Jia, Mingfa Ling, Luchu Zhang, Shuxia Jiang, Yusheng Sha, Ruqian Zhao
Excess 2-hydroxy-(4-methylthio)butanoic acid (HMB) supplementation induces hyperhomocysteinemia, which contributes to hepatic cholesterol accumulation. However, it is unclear whether and how high levels of HMB break hepatic cholesterol homeostasis in nursery piglets. In this study, HMB oversupplementation suppressed food intake and decreased body weight in nursery piglets. Hyperhomocysteinemia and higher hepatic cholesterol accumulation were observed in HMB groups. Accordingly, HMB significantly increased the protein content of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and glycine N-methyltransferase (GNMT) but decreased that of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1)...
October 12, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27584245/hmb-supplementation-may-affect-cytokine-and-inflammatory-response-during-high-intensity-military-training-631-board-3-june-1-1-00-pm-3-00-pm
#7
Jay R Hoffman, Yiftach Gepner, Jeffrey R Stout, Mattan W Hoffman, Daniel Ben-Dov, Shany Funk, Ido Daimont, Adam J Jajtner, Jeremy R Townsend, Ilan Shelef, Guy Avital, Yacov Chen, Hagai Frankel, Ishay Ostfeld
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27474977/the-effect-of-increasing-concentrations-of-dl-methionine-and-2-hydroxy-4-methylthio-butanoic-acid-on-hepatic-genes-controlling-methionine-regeneration-and-gluconeogenesis
#8
Qian Zhang, Sandra J Bertics, N Daniel Luchini, Heather M White
Metabolizable methionine (Met) concentrations can be increased by feeding rumen-protected dl-Met or the isopropyl ester of 2-hydroxy-4-(methylthio) butanoic acid (HMBi). Hepatic responses to increasing concentrations of metabolizable Met as a result of supplementation of different Met sources have not been comparatively examined. The objective of this experiment was to examine the regulation of key genes for Met metabolism, gluconeogenesis, and fatty acid oxidation in response to increasing concentrations of dl-Met or 2-hydroxy-4-(methylthio) butanoic acid (HMB) in bovine primary hepatocytes...
October 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27359494/effect-of-14-days-hmb-supplement-on-osteoclastogenesis-related-protein-expression-and-bone-metabolism-regulate-cytokines-level-in-healthy-college-male-239-board-76-june-1-9-30-am-11-00-am
#9
Yao-Hung Kuo, Yu-Wen Weng, Chih-Li Lin, Chen-Kang Chang, Wei Hung
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27324808/skeletal-muscle-regulates-metabolism-via-interorgan-crosstalk-roles-in-health-and-disease
#10
REVIEW
Josep M Argilés, Nefertiti Campos, José M Lopez-Pedrosa, Ricardo Rueda, Leocadio Rodriguez-Mañas
Skeletal muscle is recognized as vital to physical movement, posture, and breathing. In a less known but critically important role, muscle influences energy and protein metabolism throughout the body. Muscle is a primary site for glucose uptake and storage, and it is also a reservoir of amino acids stored as protein. Amino acids are released when supplies are needed elsewhere in the body. These conditions occur with acute and chronic diseases, which decrease dietary intake while increasing metabolic needs. Such metabolic shifts lead to the muscle loss associated with sarcopenia and cachexia, resulting in a variety of adverse health and economic consequences...
September 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27302563/efficacy-of-beta-hydroxy-beta-methylbutyrate-supplementation-in-maintenance-hemodialysis-patients
#11
Peter J Fitschen, Annabel Biruete, Jinny Jeong, Kenneth R Wilund
Introduction Maintenance hemodialysis (MHD) patients suffer from a number of co-morbidities including declines in muscle mass and physical function. Beta-hydroxy-beta-methylbutyrate (HMB) is a metabolite of the amino acid leucine that has been shown to improve lean mass and physical function in elderly and clinical populations, but had not been studied in MHD patients. The purpose of this study was to investigate the efficacy of HMB in this population. Methods We performed a double-blind, placebo-controlled, randomized trial to assess the effects of daily HMB supplementation on co-morbidities in MHD patients...
June 14, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27300492/prenatally-administered-hmb-modifies-the-enamel-surface-roughness-in-spiny-mice-offspring-an-atomic-force-microscopy-study
#12
Izabela Świetlicka, Siemowit Muszyński, Ewa Tomaszewska, Piotr Dobrowolski, Anita Kwaśniewska, Michał Świetlicki, Anna Skic, Krzysztof Gołacki
OBJECTIVE: The aim of this research was to check the effect of the prenatally administered β-hydroxy β-methylbutyrate (HMB) on the development of enamel surface of the spiny mice offspring. DESIGN: The spiny mice dams were randomly assigned into three groups: control group (not supplemented with HMB) and two experimental groups in which powdered HMB was given at the daily dosage of 0.2g/kg of body weight (group I) and 0.02g/kg of body weight (group II) during the last period of gestation...
June 2, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27274715/the-effects-of-phosphatidic-acid-supplementation-on-strength-body-composition-muscular-endurance-power-agility-and-vertical-jump-in-resistance-trained-men
#13
Guillermo Escalante, Michelle Alencar, Bryan Haddock, Phillip Harvey
BACKGROUND: Phosphatidic acid (PA) is a lipid messenger that has been shown to increase muscle protein synthesis via signaling stimulation of the mammalian target of rapamycin (mTOR). MaxxTOR® (MT) is a supplement that contains PA as the main active ingredient but also contains other synergistic mTOR signaling substances including L-Leucine, Beta-Hydroxy-Beta-Methylbutyrate (HMB), and Vitamin D3. METHODS: Eighteen healthy strength-trained males were randomly assigned to a group that either consumed MT (n = 8, 22...
2016: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/27188901/%C3%AE-hydroxy-%C3%AE-methylbutyrate-attenuates-cytokine-response-during-sustained-military-training
#14
Jay R Hoffman, Yiftach Gepner, Jeffrey R Stout, Mattan W Hoffman, Daniel Ben-Dov, Shany Funk, Ido Daimont, Adam R Jajtner, Jeremy R Townsend, David D Church, Ilan Shelef, Philip Rosen, Guy Avital, Yacov Chen, Hagai Frankel, Ishay Ostfeld
This study tested the hypothesis that of 23 days of β-hydroxy-β-methylbutyrate (HMB) supplementation can maintain muscle mass and attenuate the immune and inflammatory response in combat soldiers during highly intense military training. Soldiers were randomly assigned to either a HMB (n = 6) or placebo (PL; n = 7) group and provided with 3 g · day(-1) of either HMB or PL. During the final week of supplementation soldiers participated in extreme physical training, which included night navigation of 6-8 hours across difficult terrain carrying heavy loads combined with sleep deprivation (3...
June 2016: Nutrition Research
https://www.readbyqxmd.com/read/27143558/enteral-%C3%AE-hydroxy-%C3%AE-methylbutyrate-supplementation-increases-protein-synthesis-in-skeletal-muscle-of-neonatal-pigs
#15
Michelle Kao, Daniel A Columbus, Agus Suryawan, Julia Steinhoff-Wagner, Adriana Hernandez-Garcia, Hanh V Nguyen, Marta L Fiorotto, Teresa A Davis
Many low-birth weight infants are at risk for poor growth due to an inability to achieve adequate protein intake. Administration of the amino acid leucine stimulates protein synthesis in skeletal muscle of neonates. To determine the effects of enteral supplementation of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB) on protein synthesis and the regulation of translation initiation and degradation pathways, overnight-fasted neonatal pigs were studied immediately (F) or fed one of five diets for 24 h: low-protein (LP), high-protein (HP), or LP diet supplemented with 4 (HMB4), 40 (HMB40), or 80 (HMB80) μmol HMB·kg body wt(-1)·day(-1) Cell replication was assessed from nuclear incorporation of BrdU in the longissimus dorsi (LD) muscle and jejunum crypt cells...
June 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27108228/levonorgestrel-releasing-intra-uterine-device-use-in-adolescent-females-with-heavy-menstrual-bleeding-and-bleeding-disorders-single-institution-review
#16
Oluyemisi A Adeyemi-Fowode, Xiomara M Santos, Jennifer E Dietrich, Lakshmi Srivaths
STUDY OBJECTIVE: Identify complications and efficacy of Levonorgestrel-releasing intrauterine device (LNgIUD) in adolescents with heavy menstrual bleeding (HMB) and bleeding disorders (BD). DESIGN, SETTING, PARTICIPANTS: A retrospective chart review of 13 post-menarchal adolescent girls with HMB/BD who underwent placement of LNgIUD. INTERVENTIONS: Placement of LNgIUD MAIN OUTCOME MEASURE(S): Primary outcome was to identify complications from placement of LNgIUD...
April 20, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27065075/conversion-of-leucine-to-%C3%AE-hydroxy-%C3%AE-methylbutyrate-by-%C3%AE-keto-isocaproate-dioxygenase-is-required-for-a-potent-stimulation-of-protein-synthesis-in-l6-rat-myotubes
#17
María D Girón, José D Vílchez, Rafael Salto, Manuel Manzano, Natalia Sevillano, Nefertiti Campos, Josep M Argilés, Ricardo Rueda, José M López-Pedrosa
BACKGROUND: L-Leu and its metabolite β-hydroxy-β-methylbutyrate (HMB) stimulate muscle protein synthesis enhancing the phosphorylation of proteins that regulate anabolic signalling pathways. Alterations in these pathways are observed in many catabolic diseases, and HMB and L-Leu have proven their anabolic effects in in vivo and in vitro models. The aim of this study was to compare the anabolic effects of L-Leu and HMB in myotubes grown in the absence of any catabolic stimuli. METHODS: Studies were conducted in vitro using rat L6 myotubes under normal growth conditions (non-involving L-Leu-deprived conditions)...
March 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/26973106/beta-hydroxy-beta-methylbutyrate-ameliorates-aging-effects-in-the-dendritic-tree-of-pyramidal-neurons-in-the-medial-prefrontal-cortex-of-both-male-and-female-rats
#18
Daniel G Kougias, Suzanne O Nolan, Wendy A Koss, Taehyeon Kim, Emily R Hankosky, Joshua M Gulley, Janice M Juraska
Beta-hydroxy-beta-methylbutyrate (HMB), a supplement commonly used to maintain muscle in elderly and clinical populations, has been unexplored in the aging brain. In both healthy aging humans and rat models, there are cognitive deficits associated with age-related dendritic shrinkage within the prefrontal cortex. The present study explores the effects of relatively short- and long-term (7 and 31 weeks) oral HMB supplementation starting at 12 months of age in male and female rats on the dendritic tree of layer 5 pyramidal neurons in the medial prefrontal cortex...
April 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/26953693/cellular-and-physiological-effects-of-dietary-supplementation-with-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-and-%C3%AE-alanine-in-late-middle-aged-mice
#19
Julian Vallejo, Madoka Spence, An-Lin Cheng, Leticia Brotto, Neile K Edens, Sean M Garvey, Marco Brotto
There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects of the leucine catabolite, beta-hydroxy-beta-methylbutyrate (HMB), in C2C12 myoblasts and myotubes, and to investigate the effects of dietary supplementation with HMB, the amino acid β-alanine and the combination thereof, on muscle contractility in a preclinical model of pre-sarcopenia...
2016: PloS One
https://www.readbyqxmd.com/read/26917333/dietary-supplementation-with-%C3%AE-hydroxy-%C3%AE-methylbutyrate-calcium-during-the-early-postnatal-period-accelerates-skeletal-muscle-fibre-growth-and-maturity-in-intra-uterine-growth-retarded-and-normal-birth-weight-piglets
#20
Haifeng Wan, Jiatao Zhu, Guoqi Su, Yan Liu, Lun Hua, Liang Hu, Caimei Wu, Ruinan Zhang, Pan Zhou, Yong Shen, Yan Lin, Shengyu Xu, Zhengfeng Fang, Lianqiang Che, Bin Feng, De Wu
Intra-uterine growth restriction (IUGR) impairs postnatal growth and skeletal muscle development in neonatal infants. This study evaluated whether dietary β-hydroxy-β-methylbutyrate Ca (HMB-Ca) supplementation during the early postnatal period could improve muscle growth in IUGR neonates using piglets as a model. A total of twelve pairs of IUGR and normal-birth-weight (NBW) male piglets with average initial weights (1·85 (sem 0·36) and 2·51 (sem 0·39) kg, respectively) were randomly allotted to groups that received milk-based diets (CON) or milk-based diets supplemented with 800 mg/kg HMB-Ca (HMB) during days 7-28 after birth...
April 2016: British Journal of Nutrition
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