keyword
https://read.qxmd.com/read/37898904/intractable-abdominal-pain-as-the-sole-symptom-of-varicella-zoster-reactivation-after-allogeneic-stem-cell-transplantation-brief-case-report-and-review-of-the-literature
#21
JOURNAL ARTICLE
Yogi Chopra, Carly Hong, Tal Schechter, Muhammad Ali, Kuang-Yueh Chiang, Donna Wall, Joerg Krueger
After primary infection, Varicella Zoster (VZV) persists in sensory dorsal root ganglia and may be reactivated in periods of diminished T-cell immunity. Varicella Zoster reactivation post allogenic stem cell transplantation (HSCT) can be challenging to diagnose as it does not always present with characteristic skin lesions. We describe a pediatric patient who presented with isolated severe abdominal pain with no other symptoms. Cutaneous lesions appeared only 10 days later resulting in delayed diagnosis and treatment...
October 29, 2023: Pediatric Hematology and Oncology
https://read.qxmd.com/read/37886862/the-effectiveness-of-the-erector-spinae-plane-block-using-methylprednisolone-and-bupivacaine-in-post-herpetic-neuralgia-case-series
#22
Uğur Peksöz, Ümran Öner, Mine Çelik
Post-herpetic neuralgia (PHN) is the most common chronic complication of herpes zoster and the most common pain syndrome associated with infections. There are medical and interventional treatment options in PHN, and some patients may be resistant to the preferred medical treatments. This situation negatively affects the quality of life of the patient. Interventional treatments come to the fore, especially in patients in whom medical treatments are not sufficient, and systemic side effects such as hepatotoxicity and nephrotoxicity occur...
October 2023: Journal of the Turkish Society of Algology
https://read.qxmd.com/read/37880069/willingness-to-receive-herpes-zoster-vaccination-among-adults-and-older-people-a-cross-sectional-study-in-italy
#23
JOURNAL ARTICLE
Gabriella Di Giuseppe, Concetta Paola Pelullo, Annalisa Napoli, Francesco Napolitano
The objective of this study was to explore the Herpes Zoster (HZ) knowledge and the willingness to receive the HZ vaccination in adults and older people in Italy. The study was conducted on a sample of patients aged ≥65 years and over 50 years with chronic conditions who went to the clinics of general practitioners (GPs) in Campania region, Italy. Data was collected with a questionnaire administered through an interview. Multivariate logistic regression analysis was performed. 427 participants (83...
October 23, 2023: Vaccine
https://read.qxmd.com/read/37854543/conditions-and-factors-that-raise-the-risk-of-developing-skin-lesions-after-shingles
#24
JOURNAL ARTICLE
Qiao Xue, Jie Ji, Wen-Ge Fan, Jian-Peng Pan, Mei Wei, Hao Ding, Jun Zhao
OBJECTIVE: To understand the situation and risk factors of skin lesions following the eruption of shingles. METHODS: We selected 275 patients with shingles who had been diagnosed and treated in the Dermatology Department of Changshu No. 1 People's Hospital between July 2017 and March 2022. Age, gender, skin lesion site, skin lesion type, prodromal pain, history of diabetes, history of hypertension, history of other immune diseases, as well as other pertinent clinical data, were collected...
2023: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/37823492/effect-of-antivirals-plus-low-dose-short-term-glucocorticoids-on-post-herpetic-neuralgia
#25
JOURNAL ARTICLE
Yu Wang, Han Deng, Tudi Chen, Pinglu Li, Wanxing Zhao, Lu Wang, Congzhong Zhu, Huiping Wang, Shuping Hou
BACKGROUND: Post-herpetic neuralgia (PHN) is the most common complication of herpes zoster (HZ). It is unclear whether short-term and low-dose glucocorticoids combined with antivirals can reduce the incidence of PHN. OBJECTIVES: To investigate the effects of antivirals plus low-dose, short-term glucocorticoids on PHN. MATERIALS & METHODS: A total of 394 patients with HZ were divided into glucocorticoid and non-glucocorticoid groups, and the incidence of PHN was studied retrospectively...
August 1, 2023: European Journal of Dermatology: EJD
https://read.qxmd.com/read/37787418/impact-of-type-1-versus-type-2-diabetes-on-developing-herpes-zoster-and-post-herpetic-neuralgia-a-population-based-cohort-study
#26
JOURNAL ARTICLE
Su-Ying Wen, Chao Ou-Yang, Catherine Chang, Chu-Chieh Chen, Hung-Yu Chang
Type 2 diabetes is associated with an increased risk of herpes zoster and postherpetic neuralgia. However, the association of type 1 diabetes with herpes zoster or postherpetic neuralgia remains unclear. This retrospective cohort study using Taiwan's Health Insurance Research Database included 199,566 patients with type 1 diabetes and 1,458,331 with type 2 diabetes, identified during the period 2000 to 2012. Patients with type 1 diabetes had a significantly higher risk of developing herpes zoster than those with type 2 diabetes (p < 0...
October 3, 2023: Acta Dermato-venereologica
https://read.qxmd.com/read/37772682/the-value-of-herpes-zoster-prevention-in-patients-aging-with-hiv-a-narrative-review
#27
REVIEW
Nicolas Dauby, Christian Motet, Agnès Libois, Charlotte Martin
OBJECTIVE: Review the evidence on the incidence and impact of herpes zoster among people living with HIV and the potential impact of recombinant zoster vaccine for people aging with HIV. METHODS: Narrative review. RESULTS: Although antiretroviral therapy has substantially reduced the risk of herpes zoster among people living with HIV, they remain at an increased risk compared with the general population. Among people aging with HIV, aging per se is now the main risk factor for herpes zoster...
September 29, 2023: HIV Medicine
https://read.qxmd.com/read/37763662/disseminated-herpes-zoster-following-protein-subunit-and-mrna-covid-19-vaccination-in-immunocompetent-patients-report-of-two-cases-and-literature-review
#28
Chia-Shuen Lin, Chung-Hsing Chang
Disseminated herpes zoster (DHZ), resulting from the reactivation of the varicella-zoster virus (VZV), typically occurs in immunocompromised persons. To date, only four cases of DHZ following mRNA, viral vector, or inactivated COVID-19 vaccinations have been reported in immunocompetent patients. Herein, we present the first case of DHZ following the protein subunit COVID-19 vaccination (case 1, 64 years old) and a case of DHZ following mRNA COVID-19 vaccination (case 2, 67 years old) in elderly, immunocompetent male patients...
August 25, 2023: Medicina
https://read.qxmd.com/read/37755967/is-botulinum-toxin-effective-in-treating-orofacial-neuropathic-pain-disorders-a-systematic-review
#29
REVIEW
Matteo Val, Robert Delcanho, Marco Ferrari, Luca Guarda Nardini, Daniele Manfredini
BACKGROUND: The aim of this paper is to provide a systematic review of the literature regarding the clinical use of botulinum toxin (BTX) to treat various orofacial neuropathic pain disorders (NP). METHODS: A comprehensive literature search was conducted using Medline, Web of Science, and the Cochrane Library databases. Only randomized clinical trials (RCT) published between 2003 and the end of June 2023, investigating the use of BTX to treat NP, were selected. PICO guidelines were used to select and tabulate the articles...
September 1, 2023: Toxins
https://read.qxmd.com/read/37719532/clinical-and-epidemiological-profile-of-herpes-zoster-and-its-complications-in-a-tertiary-care-center-of-bihar-a-prospective-study
#30
JOURNAL ARTICLE
Rajesh Sinha, Pinki Kumari, U K Pallavi, Subhasree Sarkar
Background Herpes zoster is a common viral infection caused by reactivation of the varicella-zoster virus (VZV) characterized by the presence of a segmental distribution of painful grouped vesicles on an erythematous base. It is associated with several complications like zoster-associated pain (ZAP), postherpetic neuralgia (PHN), pigmentary changes, scarring, secondary infections, and dermatosis as well as severe systemic complications. Aims/objectives The aim of the study was to analyze the various clinical and epidemiological patterns of herpes zoster and post-herpetic complications...
August 2023: Curēus
https://read.qxmd.com/read/37704912/varicella-zoster-virus-specific-hyperimmunoglobulin-in-the-adjuvant-treatment-of-immunocompromised-herpes-zoster-patients-a-case-series
#31
JOURNAL ARTICLE
Patrick Terheyden, Cord Sunderkötter, Franz-Dietmar Söhngen, Linda Golle, Sonja Schimo, Ralf Baron, Christian Maihöfner, Andreas Binder, Wolfram Pönisch
INTRODUCTION: Immunocompromised patients are at increased risk for herpes zoster (HZ)-associated complications. Despite standard therapy with systemic antiviral drugs and analgesics, complications are frequently encountered, including generalization of lesions or persistent neuropathic pain, so-called post-herpetic neuralgia (PHN). Given the scarcity of literature and awareness of therapeutic options to improve patient outcomes, especially for vulnerable patient groups, here we describe a strategy based on early intensification of treatment with a varicella zoster virus-specific hyperimmunoglobulin (VZV-IgG), which is approved in the adjuvant treatment of HZ...
September 13, 2023: Dermatology and Therapy
https://read.qxmd.com/read/37700336/a-novel-recombinant-orf7-sirna-delivered-by-flexible-nano-liposomes-inhibits-varicella-zoster-virus-infection
#32
JOURNAL ARTICLE
Jiawei Pei, Ye Tian, Wei Ye, Jiangfan Han, Yamei Dang, Tong Cheng, Wei Wang, Yipu Zhao, Weiliang Ye, Shuyuan Huangfu, Yu Li, Fanglin Zhang, Yingfeng Lei, Airong Qian
BACKGROUND: Varicella zoster virus (VZV), which is a human restricted alpha-herpesvirus, causes varicella (chickenpox) and zoster (shingles). The subsequent post-herpetic neuralgia (PHN) due to VZV infection is excruciating for most patients. Thus, developing specific therapeutics against VZV infection is imperative. RNA interference (RNAi) represents an effective approach for alternative antiviral therapy. This study aimed to develop a novel anti-VZV therapeutics based on RNAi. RESULTS: In this study, we screened and found the open reading frame 7 (ORF7) of the VZV genome was an ideal antiviral target based on RNAi...
September 12, 2023: Cell & Bioscience
https://read.qxmd.com/read/37697028/metabolomics-profiling-in-predicting-of-post-herpetic-neuralgia-induced-by-varicella-zoster
#33
JOURNAL ARTICLE
Lina Lu, Lihong Mei, Xushuo Li, Yanhua Lin, Hongfeng Wang, Gao Yang
To explore potential metabolomics biomarkers in predicting post-herpetic neuralgia (PHN) induced by herpes zoster (HZ). A total of 90 eligible patients were prospectively enrolled and assigned into an acute pain (ACP) group and a PHN group. Serum samples were collected before clinical intervention to perform metabolomics profiling analyses using gas chromatography mass spectrometry (GC-MS). Key metabolites were identified using partial least squares discriminant analysis (PLS-DA). A binary logistic regression was used to build a combined biomarker model to predict PHN from ACP...
September 11, 2023: Scientific Reports
https://read.qxmd.com/read/37641792/peripheral-nerve-stimulation-of-the-lesser-occipital-and-greater-auricular-nerve-for-post-herpetic-neuralgia-in-a-case-of-ramsay-hunt-syndrome-case-report
#34
JOURNAL ARTICLE
Brooks Johnson, Stephen Covington, Mostafa Maita, Natalie Strand
BACKGROUND: Post-herpetic neuralgia (PHN) is a painful condition that presents after herpes zoster reactivation in the peripheral and central nervous system. When medical treatment fails, options are limited, and patients may suffer with chronic pain indefinitely. CASE PRESENTATION: We present the case of a gentleman with a 3-year history of PHN in the distribution of the right lesser occipital and greater auricular nerves that failed to respond to medical treatment...
2023: Orthopedic Reviews
https://read.qxmd.com/read/37632006/the-spectrum-of-neurological-manifestations-of-varicella-zoster-virus-reactivation
#35
REVIEW
Peter G E Kennedy
Varicella-Zoster virus (VZV) is a pathogenic human alpha herpes virus that causes varicella (chicken pox) as a primary infection and, following a variable period of latency in different ganglionic neurons, it reactivates to produce herpes zoster (shingles). The focus of this review is on the wide spectrum of the possible neurological manifestations of VZV reactivation. While the most frequent reactivation syndrome is herpes zoster, this may be followed by the serious and painful post-herpetic neuralgia (PHN) and by many other neurological conditions...
July 30, 2023: Viruses
https://read.qxmd.com/read/37593290/herpes-zoster-ophthalmicus-discovered-during-pain-consult-possibly-complicated-with-dural-sinus-thrombosis-and-refractory-headache-managed-with-ketamine-a-case-report
#36
Laura Furtado Pessoa de Mendonca, Alejandro Hallo-Carrasco, Christian C Prusinski, Christine Hunt
Pain is a common symptom associated with shingles and may precede the onset of the characteristic rash. In the context of herpes zoster ophthalmicus, pain can manifest with severe headaches, posing challenges due to other potentially life-threatening conditions such as stroke and intracranial hypertension. In this report, we present the case of a 51-year-old male with severe headache and imaging findings of dural sinus thrombosis. He was later diagnosed with herpes zoster ophthalmicus and required aggressive inpatient management of neuropathic pain...
July 2023: Curēus
https://read.qxmd.com/read/37588338/zoster-sine-herpete-confirmatory-diagnosis-using-varicella-zoster-virus-dna-polymerase-chain-reaction-analysis-of-intact-skin-scrapings
#37
Sean Ho Yoon, Renuka Shetty-Das
Zoster, commonly known as shingles, is a syndrome caused by the reactivation of the varicella-zoster virus (VZV) that results in characteristic vesicular eruptions in a unilateral dermatomal distribution. Timely diagnosis of zoster sine herpete (ZSH), a variant of shingles without the typical vesicular rash, can be challenging due to the absence of visual cues and limited application of traditional diagnostic methods. Recent case reports have demonstrated the utility of VZV DNA polymerase chain reaction (PCR) analysis of involved skin exudates for confirming ZSH...
July 2023: Curēus
https://read.qxmd.com/read/37540900/increased-risk-of-herpes-zoster-in-adult-patients-with-inflammatory-bowel-disease-after-sars-cov2-infection-a-propensity-matched-cohort-study
#38
JOURNAL ARTICLE
Aakash Desai, Aakriti Soni, Mary S Hayney, Jana G Hashash, Gursimran S Kochhar, Francis A Farraye, Freddy Caldera
BACKGROUND: There is evidence that SARS-CoV2 infection can increase the risk of herpes zoster (HZ) in the general population. However, the risk in patients with inflammatory bowel disease (IBD) is not known. METHODS: The TriNetX database was utilized to conduct a retrospective cohort study in patients with IBD after SARS-CoV2 infection and patients without a SARS-CoV2 infection (IBD control cohort). The primary outcome was to evaluate the risk of HZ between the 2 cohorts...
August 4, 2023: Inflammatory Bowel Diseases
https://read.qxmd.com/read/37513958/global-research-trends-and-hotspots-analysis-of-the-scientific-production-of-amitriptyline-a-bibliometric-approach
#39
JOURNAL ARTICLE
Cristian Dos Santos Pereira, Jorddy Neves Cruz, Maria Karolina Martins Ferreira, Daiane Claydes Baia-da-Silva, Eneas Andrade Fontes-Junior, Rafael Rodrigues Lima
Amitriptyline was first introduced as a medication to treat depression. Over time, this substance has been used to treat other conditions, such as gastrointestinal disorders, fibromyalgia, neuropathic pain, and analgesia, among others. However, there are no published studies that provide a broad view of the possible motivations that have led to changes in the use of amitriptyline. In this study, we have identified the landscape of use for amitriptyline based on knowledge mapping of the 100 most-cited articles about this drug...
July 24, 2023: Pharmaceuticals
https://read.qxmd.com/read/37505177/effect-of-extracorporeal-shock-wave-combined-with-pregabalin-on-patients-with-post-herpetic-neuralgia
#40
JOURNAL ARTICLE
Haoliang Sun, Zhou Yu
Post-herpetic neuralgia (PHN) is a chronic pain that is difficult to treat and lasts a long time, which poses a threat to patients' physical and mental health (MH) and quality of life. To analyze the effectiveness of extracorporeal shock wave (ESW) combined with pregabalin on PHN and its impact on PHN patients' quality of life with the help of a random number table. Totally 164 PHN patients were assigned to a control group (n = 82) or an observation group (n = 82). The observation group was given pregabalin combined with ESW treatment, while the control group was only given pregabalin...
July 28, 2023: Medicine (Baltimore)
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