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Post herpetic neuralgia

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https://www.readbyqxmd.com/read/29757758/ultrasound-guided-pulsed-radiofrequency-in-the-management-of-thoracic-post-herpetic-neuralgia-a-randomized-double-blinded-controlled-trial
#1
Mohamed Y Makharita, Hanaa M El Bendary, Zainab M Sonbul, Salma El Sayed Ahmed, Mahmoud Abdel Latif
OBJECTIVES: This study was designed to evaluate the efficacy and safety of ultrasound-guided pulsed radiofrequency (PRF) for the intercostal nerves (ICNs) in the management of thoracic post-herpetic neuralgia (PHN). METHODS: After 2 weeks of treatment by pregabalin 150▒mg/12 hours, patients were randomly allocated into 2 groups. The PRF group, after ultrasound-guided localization of the ICN of the affected thoracic dermatome, sensory stimulation of the ICN was tested...
May 11, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29737410/executive-summary-of-the-clinical-guidelines-of-pharmacotherapy-for-neuropathic-pain-second-edition-by-the-japanese-society-of-pain-clinicians
#2
REVIEW
Masahiko Sumitani, Tetsuya Sakai, Yoichi Matsuda, Hiroaki Abe, Shigeki Yamaguchi, Toyoshi Hosokawa, Sei Fukui
Neuropathic pain has a substantial effect on quality of life (QOL). The Japanese Society of Pain Clinicians (JSPC) has developed clinical guidelines of pharmacotherapy for neuropathic pain. These guidelines offer clarity on recommendations based on both the most recent scientific evidence and expert opinions. Understanding the concept, disease entity, and burden of neuropathic pain, as well as its screening and diagnosis are important steps before starting pharmacotherapy. As well as other guidelines, the guidelines propose several lines of pharmacotherapies in a step-wise manner...
May 8, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29730833/assessing-and-improving-zoster-vaccine-uptake-in-a-homeless-population
#3
Laura Kaplan-Weisman, Eve Waltermaurer, Casey Crump
The herpes zoster (shingles) vaccine is recommended for all adults aged ≥ 60 years without contraindications to prevent shingles and post-herpetic neuralgia. There are no published studies on zoster vaccination rates, barriers, or workflows in adults who have experienced homelessness. Due to barriers specific to this vaccine, including difficulty determining insurance coverage, high upfront costs, need for storage in a freezer, and under-prescription by physicians, uptake is lower compared to other recommended vaccines for older adults...
May 5, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29707236/subacute-histopathological-features-in-a-case-of-varicella-zoster-virus-myelitis-and-post-herpetic-neuralgia
#4
Pouria Moshayedi, Diana Thomas, Charles R Rinaldo, John J Moossy, Joseph C Maroon, Geoffrey H Murdoch, Ronald L Hamilton, Houman Homayoun
Introduction: Post-herpetic neuralgia is a crippling complication of varicella zoster virus (VZV) reactivation, also known as zoster disease. In rare cases, VZV spreads to the spinal cord and causes myelitis. There is a paucity of data on spinal cord histopathology in the subacute phase of post-herpetic neuralgia and VZV myelitis. Case description: In this report, we present a case of post-herpetic neuralgia in a patient who died 5 weeks after initiation of symptoms...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29668453/the-skin-and-the-eye-herpes-zoster-ophthalmicus-in-a-healthy-18-month-old-toddler
#5
Radka T Komitova, Oliana B Boykinova, Nina S Stoyanova
Herpes zoster, caused by reactivation of varicella-zoster virus, is uncommon in infancy. Even more uncommon is herpes zoster ophthalmicus, defined as herpes zoster of the ophthalmic branch of the fifth cranial nerve. Among healthy children, primary varicella-zoster virus infection during gestation as a result of maternal varicella or the first year of life is the major risk factor for development of herpes zoster in a relatively young age. Here we present an unusual case of herpes zoster ophthalmicus with dissemination in an immunocompetent toddler with favorable outcome...
March 1, 2018: Folia Medica
https://www.readbyqxmd.com/read/29656511/neuropathic-pain-a-patient-centred-approach-to-measuring-outcomes
#6
Steve Hwang, Floortje van Nooten, Ted Wells, Aisling Ryan, Bruce Crawford, Christopher Evans, Marci English
BACKGROUND: Neuropathic pain (NP) is a complex, chronic pain state initiated by a primary lesion or dysfunction of the nervous system and presents as a variety of symptoms across multiple disease states. OBJECTIVE: To develop a patient-centred conceptual model of symptoms and impacts in subjects with diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) that can inform the measurement strategy in clinical trials. METHOD: Thirty subjects with DPN or PHN participated in in-person interviews which were performed until saturation was achieved...
April 15, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29593042/vzv-orf63-protects-human-neuronal-and-keratinocyte-cell-lines-from-apoptosis-and-changes-its-localization-upon-apoptosis-induction
#7
Chelsea Gerada, Megan Steain, Brian P McSharry, Barry Slobedman, Allison Abendroth
There are many facets of varicella zoster virus (VZV) pathogenesis that are not fully understood, such as the mechanisms involved in the establishment of lifelong latency, reactivation and development of serious conditions such as post herpetic neuralgia (PHN). Virus-encoded modulation of apoptosis has been suggested to play an important role in these processes. VZV open reading frame (ORF) 63 has been shown to modulate apoptosis in a cell type specific manner, but the impact of ORF63 on cell death pathways has not been examined in isolation, in the context of human cells...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29587275/efficacy-analysis-of-capsaicin-8-patch-in-neuropathic-peripheral-pain-treatment
#8
Joana Tenreiro Pinto, Frederico C Pereira, Maria C Loureiro, Ricardo Gama, Hugo L Fernandes
BACKGROUND/AIMS: Several guidelines for neuropathic pain management and various effective drugs are available; however, neuropathic pain remains undertreated. This retrospective study aimed to evaluate the efficacy of topical capsaicin 8% in peripheral neuropathic pain in a routine clinical setting. METHODS: Therapeutic efficacy was evaluated through pain intensity, using numerical pain rating scale at baseline and 7-14 days after each treatment, and using pain treatment area (PTA) assessed immediately before each treatment...
March 27, 2018: Pharmacology
https://www.readbyqxmd.com/read/29565203/management-of-herpes-zoster-shingles-during-pregnancy
#9
Khalea Hayward, Abigail Cline, Angela Stephens, Linda Street
An infection with the varicella-zoster virus (VZV) causes both varicella and herpes zoster (HZ). Although rare, the development of HZ does occur during pregnancy. Maternal HZ does not result in increased foetal mortality, and the passage of VZV to the foetus rarely occurs. However, HZ does increase maternal morbidity. Upon infection with HZ, patients typically present with a viral prodrome preceding the appearance of the characteristic zoster rash. HZ is usually diagnosed clinically by the zoster rash, but can also be confirmed by a polymerase chain reaction and an enzyme-linked immunosorbent assay...
March 22, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29562396/-the-efficacy-of-ultrasound-guided-spinal-nerve-posterior-ramus-pulsed-radiofrequency-treatment-for-aged-lower-back-post-herpetic-neuralgia
#10
Z B Pi, J K Zhang, Y Peng, Y Jin, H Lin
Objective: To evaluate the efficacy of ultrasound-guided spinal nerve posterior ramus pulsed radiofrequency treatment of lower back post-herpetic neuralgia. Methods: One hundred and twenty-eight cases of lower back or anterior abdominal wall acute post-herpetic neuralgia patients were enrolled. They were randomly divided into two groups. Group A: oral treatment only with gabapentin+ celecoxib+ amitriptyline. Group B: while taking these drugs, patients were treated with radiofrequency pulses using a portable ultrasound device and the paravertebral puncture technique...
March 13, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29555217/effectiveness-of-herpes-zoster-vaccination-in-an-older-united-kingdom-population
#11
Jemma L Walker, Nick J Andrews, Gayatri Amirthalingam, Harriet Forbes, Sinead M Langan, Sara L Thomas
BACKGROUND: Vaccination against herpes zoster was introduced in the United Kingdom in 2013 for individuals aged 70 years, with a phased catch-up campaign for 71-79 year olds. Vaccine introduction has resulted in a marked fall in incident herpes zoster and in post-herpetic neuralgia (PHN), but formal evaluation of vaccine effectiveness is needed. METHODS: In a population-based cohort study of older individuals born between 1933 and 1946, we used linked UK anonymised primary care health records for the first three years of the vaccination programme (01/09/2013-31/08/2016) and multivariable Poisson regression to obtain incidence rates and vaccine effectiveness (VE) against zoster and PHN...
March 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29520743/herpes-zoster-and-diabetes-mellitus-a-review
#12
REVIEW
Marianthi Papagianni, Symeon Metallidis, Konstantinos Tziomalos
Accumulating evidence suggests that diabetes mellitus (DM) represents an important risk factor for both herpes zoster and post-herpetic neuralgia. Moreover, post-herpetic neuralgia appears to be more severe and persistent in diabetic patients. On the other hand, a novel vaccine against varicella-zoster virus (VZV) was recently introduced in clinical practice. Given the increased risk and severity of herpes zoster infection in patients with DM, this vaccine might be useful in this population. However, there are limited data regarding the efficacy and safety of vaccination against herpes zoster in the diabetic population...
April 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29516900/epidemiology-treatment-and-prevention-of-herpes-zoster-a-comprehensive-review
#13
REVIEW
Elsam Koshy, Lu Mengting, Hanasha Kumar, Wu Jianbo
Herpes zoster is a major health burden that can affect individuals of any age. It is seen more commonly among individuals aged ≥50 years, those with immunocompromised status, and those on immunosuppressant drugs. It is caused by a reactivation of varicella zoster virus infection. Cell-mediated immunity plays a role in this reactivation. Fever, pain, and itch are common symptoms before the onset of rash. Post-herpetic neuralgia is the most common complication associated with herpes zoster. Risk factors and complications associated with herpes zoster depend on the age, immune status, and the time of initializing treatment...
May 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29512282/a-randomized-placebo-controlled-phase-i-trial-of-live-attenuated-herpes-zoster-vaccine-in-subjects-with-end-stage-renal-disease-immunized-prior-to-renal-transplantation
#14
Geraldine Miller, Heidi Schaefer, Sandra Yoder, Rachel Miller, Patricia Winokur, Karen Kotloff, David Klassen, Michael Wierzbicki, Cyrille Amegashie, Kathryn Edwards
BACKGROUND: Solid organ transplant recipients are at increased risk for reactivation of herpes zoster, or shingles, and have a higher frequency of serious complications including post-herpetic neuralgia. A live, attenuated shingles vaccine is effective and approved for individuals 50 years and older. The vaccine is contraindicated following transplantation, but may be used in patients with renal failure. Utilization of the vaccine has been poor in patients with end-stage renal disease, including those awaiting transplant, owing to concerns for safety, efficacy, and potential sensitization prior to transplant...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29430195/computed-tomography-guided-percutaneous-ozone-injection-of-the-gasserian-ganglion-for-the-treatment-of-trigeminal-neuralgia
#15
Jian-Xiong An, Hui Liu, Ruo-Wen Chen, Yong Wang, Wen-Xing Zhao, Derek Eastwood, John P Williams
Objective: The aim of this study was to evaluate the therapeutic effect of computed tomography (CT)-guided percutaneous ozone injection for refractory trigeminal neuralgia. Design: A retrospective evaluation was performed in the study. Setting: The study was conducted at a university hospital pain center. Patients and methods: A total of 29 patients with a clinical diagnosis of refractory trigeminal neuralgia were enrolled...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29409817/botulinum-toxin-treatment-of-pain-syndromes-an-evidence-based-review
#16
Yasaman Safarpour, Bahman Jabbari
This review evaluates the existing level of evidence for efficacy of BoNTs in different pain syndromes using the recommended efficacy criteria from the Assessment and Therapeutic Subcommittee of the American Academy of Neurology. There is a level A evidence (effective) for BoNT therapy in post-herpetic neuralgia, trigeminal neuralgia, and posttraumatic neuralgia. There is a level B evidence (probably effective) for diabetic neuropathy, plantar fasciitis, piriformis syndrome, pain associated with total knee arthroplasty, male pelvic pain syndrome, chronic low back pain, male pelvic pain, and neuropathic pain secondary to traumatic spinal cord injury...
June 1, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29258938/prospective-study-of-neuroendoscopy-versus-microscopy-213-cases-of-microvascular-decompression-for-trigeminal-neuralgia-performed-by-one-neurosurgeon
#17
Hui Xiang, Guangyong Wu, Jia Ouyang, Ruen Liu
OBJECTIVE: To compare the efficacy and complications of microvascular decompression (MVD) by complete neuroendoscopy versus microscopy for 213 cases of trigeminal neuralgia (TN). METHODS: Between January 2014 and January 2016, 213 patients with TN were randomly assigned to the neuroendoscopy (n = 105) or microscopy (n = 114) group for MVD via the suboccipital retrosigmoid approach. All procedures were performed by the same neurosurgeon. Follow-up was conducted by telephone interview...
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29258169/botulinum-toxin-in-the-field-of-dermatology-novel-indications
#18
REVIEW
Yoon Seob Kim, Eun Sun Hong, Hei Sung Kim
Since its approval by the US Food and Drug Administration in 2002 for glabellar wrinkles, botulinum toxin (BTX) has been widely used to correct facial wrinkles. As a result, many consider BTX synonymous with cosmetic dermatology. Recent studies indicate that BTX elicits biological effects on various skin cell types via the modulation of neurotransmitter release, and it seems that BTX has a wider zone of dermatologic influence than originally understood. Clinicians and researchers are now beginning to explore the potential of BTX beyond the amelioration of facial lines and encouraging results are seen with BTX in a variety of skin conditions...
December 16, 2017: Toxins
https://www.readbyqxmd.com/read/29244612/letter-to-the-editor-regarding-the-role-of-age-sex-interaction-in-the-development-of-post-herpetic-neuralgia
#19
Cintia Muñoz-Quiles, Mónica López-Lacort, Alejandro Orrico-Sánchez, Javier Díez-Domingo
The objective of the study was to evaluate the role of age and sex and their combined effect in the development of post-herpetic neuralgia (PHN) in a large population-based study, in order to confirm the results published previously by Amicizia et al. Data were extracted from population and healthcare databases from the Valencia Region (2009-2014). Logistic regressions were implemented to estimate the effect of increasing age on the probability of developing PHN stratified by sex. From a cohort of 2,289,485 subjects ≥ 50 years, 87,086 cases of HZ were registered and 13,658 (15...
December 15, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29218466/acute-herpes-zoster-and-post-herpetic-neuralgia-in-primary-care-a-study-of-diagnosis-treatment-and-cost
#20
Brendan Crosbie, Sinead Lucey, Lesley Tilson, Lisa Domegan, Jennifer Kieran
Acute herpes zoster and its complication post herpetic neuralgia represent a significant challenge to primary care physicians in their care of an ageing population of patients. This was a cross-sectional observational study by means of a quantitative survey of 1,000 general practitioners registered in Ireland exploring the frequency of diagnosis, methods of treatment and cost of AHZ and PHN in primary care. We recorded an 18% response rate (n = 184) with an 83% completion rate (n = 152/184). 80% of cases of AHZ occurred in patients aged 50 years or more with 81% of study participants encountering cases at a rate of 1-3 patients per month...
December 7, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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