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Post herpetic neuralgia

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https://www.readbyqxmd.com/read/28078530/evaluation-of-the-population-pharmacokinetic-properties-of-lidocaine-and-its-metabolites-after-long-term-multiple-applications-of-a-lidocaine-plaster-in-post-herpetic-neuralgia-patients
#1
Roberta Bursi, Chiara Piana, Joachim Grevel, Dymphy Huntjens, Irmgard Boesl
BACKGROUND AND OBJECTIVES: Lidocaine 5% medicated plaster is the first lidocaine containing product for chronic use. As no previous investigations have been conducted to evaluate the population pharmacokinetics of long-term exposure to lidocaine 5% medicated plasters, further insights into the evaluation of the pharmacokinetic properties of lidocaine and its metabolites were needed for the assessment of its safety. METHODS: The population pharmacokinetic properties of lidocaine and its metabolites were evaluated after multiple applications of lidocaine 5% medicated plasters based on data collected for up to 14...
January 12, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28042075/topical-treatment-of-peripheral-neuropathic-pain-applying-the-evidence
#2
REVIEW
Claudia Sommer, Giorgio Cruccu
CONTEXT: Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief with currently recommended first-line oral treatments, which are also associated with systemic adverse events. Topical treatments are currently considered second- or third-line options, but a recent pharmacological treatment algorithm has called for broader first-line use of these agents. This has highlighted a need to communicate the benefits associated with topical agents, in particular around the efficacy, targeted local action and limited systemic availability resulting in minimal systemic adverse events and drug-drug interactions...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28005560/capsaicin-8-patch-repeat-treatment-in-non-diabetic-peripheral-neuropathic-pain-a-52-week-open-label-single-arm-safety-study
#3
Rafael Gálvez, Marie-Louise Navez, Graeme Moyle, Christian Maihöfner, Malcolm Stoker, Etienne Ernault, Turo J Nurmikko, Nadine Attal
OBJECTIVES: To investigate long-term safety and tolerability of capsaicin 8% patch repeat treatment in non-diabetic patients with peripheral neuropathic pain (NP). METHODS: Prospective, open-label, observational study in patients with post-herpetic neuralgia, post-traumatic or post-surgical nerve injury, HIV-associated distal sensory polyneuropathy, or other peripheral NP, and average daily pain score ≥4, received ≤6 capsaicin 8% patch treatments over 52 weeks according to clinical need (retreatment at 9-12 wk intervals)...
December 21, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27977069/biological-mechanism-of-post-herpetic-neuralgia-evidence-from-multiple-patho-psychophysiological-measures
#4
W W Peng, X L Guo, Q Q Jin, H Wei, X L Xia, Y Zhang, P C Huang, W C Wang, S L Li, J S Wang, J Chen, L Hu
BACKGROUND: Post-herpetic neuralgia (PHN), which develops after the resolution of a herpes zoster eruption, is an exceptionally drug-resistant neuropathic pain. The unsatisfactory management of PHN partly results from the difficulty in dissecting out its contributing factors due to the complexity of PHN mechanism. METHODS: Here, to elaborate our understanding of the PHN mechanism and to establish a basis for effective therapeutic strategies, we comprehensively investigated the contributions of multiple factors to PHN severity...
December 15, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27943311/fv-100-versus-valacyclovir-for-the-prevention-of-post-herpetic-neuralgia-and-the-treatment-of-acute-herpes-zoster-associated-pain-a-randomized-controlled-trial
#5
Stephen K Tyring, Patricia Lee, Gordon T Hill, Joel C Silverfield, Angela Yen Moore, Theresa Matkovits, John Sullivan-Bolyai
This prospective, parallel-group, randomized, double-blind, multicenter study compared the efficacy and safety of FV-100 with valacyclovir for reducing pain associated with acute herpes zoster (HZ). Patients, ≥50 years of age, diagnosed with HZ within 72 h of lesion appearance who had HZ-associated pain, were randomized 1:1:1 to a 7-day course of either FV-100 200 mg QD (n = 117), FV-100 400 mg QD (n = 116), or valacyclovir 1000 mg TID (n =117). Efficacy was evaluated on the basis of the burden of illness (BOI; Zoster Brief Pain Inventory scores); incidence and duration of clinically significant pain (CSP); pain scores; incidence and severity of post-herpetic neuralgia (PHN); and times to full lesion crusting and to lesion healing...
December 12, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27925894/prevention-of-herpes-zoster-and-its-complications-from-clinical-evidence-to-real-life-experience
#6
Giovanni Gabutti, Paolo Bonanni, Michele Conversano, Guido Fanelli, Elisabetta Franco, Donato Greco, Giancarlo Icardi, Marzia Lazzari, Alessandro Rossi, Silvestro Scotti, Antonio Volpi
Herpes zoster (HZ) is an acute viral illness characterized by a vesicular rash with unilateral distribution, which can also result in severe complications such as post-herpetic neuralgia (PHN), ophthalmic zoster, stroke or other neurological complications. The estimate incidence in Europe ranges between 2.0 and 4.6 cases per 1,000 person-years, with a sharp increase in >50 year-old subjects. Currently, treatment options for HZ are only partially effective in limiting the acute phase, while the management of complications is complex and often unsatisfactory...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925856/clinical-and-economic-impact-of-herpes-zoster-vaccination-in-elderly-in-italy
#7
Sara Boccalini, Cristiano Alicino, Domenico Martinelli, Angela Bechini, Emilia Tiscione, Barbara Pellizzari, Rosa Prato, Giancarlo Icardi, Stefania Iannazzo, Paolo Bonanni
Herpes zoster (HZ) is a very relevant pathology among elderly people (≥ 60 years of age), with a considerable disease burden and loss of quality of life. In the last years a new vaccine against HZ became available in Italy. Therefore, the Italian decision makers are now confronted with the decision whether that vaccination should be implemented. Pharmaco-economic analyses represent useful tools to value the feasibility of new immunization programs and their sustainability. To this aim, an ad hoc population model was developed in order to value the clinical and economic impact of HZ vaccination program for the elderly in Italy...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925843/incidence-of-herpes-zoster-and-post-herpetic-neuralgia-in-italy-results-from-a-three-years-population-based-study
#8
Cristiano Alicino, Cecilia Trucchi, Chiara Paganino, Ilaria Barberis, Sara Boccalini, Domenico Martinelli, Barbara Pellizzari, Angela Bechini, Andrea Orsi, Paolo Bonanni, Rosa Prato, Stefania Iannazzo, Giancarlo Icardi
Herpes Zoster (HZ) and its main complication, post-herpetic neuralgia (PHN), represent important public health issues because of their relevant burden among older adults. However, data on the epidemiology of HZ and PHN in Italy are very limited. A population-based study was performed by seeking for cases of HZ and PHN, occurred in the period 2013-2015, in the clinical charts of 56 General Practitioners working in four Italian Regions (Liguria, Puglia, Toscana and Veneto). The main objective of the study was to estimate the incidence of HZ and the proportion of PHN (at 1 and 3 months from the onset of HZ; PHN1 and PHN3) among people aged ≥ 50 years...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27902409/prevention-of-herpes-zoster-and-its-complications-from-the-clinic-to-the-real-life-experience-with-the-vaccine
#9
Gabutti Giovanni, Valente Nicoletta, Kuhdari Parvanè, Lupi Silvia, Stefanati Armando
The erpes zoster is an acute viral illness characterized by a vesicular rash of unilateral distribution, which can eventually cause severe complications, such as post-herpetic neuralgia, ophthalmic zoster, stroke or other neurological complications. In Europe, an incidence of between 2.0 and 4.6 cases per 1000 person-years is estimated, with an increase after 50 years of age. Currently, the therapeutic options for are only partially effective in limiting the acute phase, while the management of complications is frequently complex and not satisfactory...
December 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27765026/increasing-incidence-associated-with-herpes-zoster-infection-in-british-columbia-canada
#10
Fawziah Marra, Mei Chong, Mehdi Najafzadeh
BACKGROUND: Recent studies have shown an increasing incidence of herpes zoster (HZ) infection, which may be related to the introduction of varicella vaccination programs in children. We examined the epidemiology and treatment costs of HZ and post-herpetic neuralgia (PHN) over time in British Columbia, Canada. METHODS: The cohort consisted of all cases with HZ infection from January 1, 1997 and December 31, 2012. Incident zoster was defined as a case (ICD-9 053 or ICD-10 B02) without a previous episode of HZ or PHN in the previous 12 months...
October 20, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27764706/management-of-postoperative-pain-after-lumbar-surgery-pregabalin-for-one-day-and-14-days-a-randomized-triple-blinded-placebo-controlled-study
#11
Mohammad Zarei, Arvin Najafi, Pejman Mansouri, Sadaf Sadeghi-Yazdankhah, Houshang Saberi, Mehran Moradi, Mahmoud Farzan
OBJECTIVES: Despite the progress in understanding acute pain physiology during recent decade, eighty percent of patients still suffer from post-operative discomfort. Pregabalin is an anticonvulsant agent that is approved for painful neuropathies in diabetic patients and post herpetic neuralgia. The main objective of the present study was to compare the improvement in post-operative pain management and patient lifestyle in 3 groups, as first group received placebo, second who received Pregabalin for one day and the last group those who received it for 14 days...
October 17, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27697147/the-pharmacological-therapy-of-chronic-neuropathic-pain
#12
Andreas Binder, Ralf Baron
BACKGROUND: Chronic neuropathic pain, including painful peripheral polyneuropathy and post-herpetic neuralgia, affects 6.9-10% of the general population. METHODS: In this article, we present current treatment recommendations on the basis of a selective review of the literature. RESULTS: Neuropathic pain does not respond consistently to classic non-opioid analgesic drugs and is better treated with co-analgesic, antidepressant, and anticonvulsant drugs and topical agents...
September 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27611178/cutaneous-involvement-of-pre-existing-rosai-dorfman-disease-via-post-herpetic-isotopic-response
#13
Neeta Malviya, Alexander Marzuka, Mokhtar Maamed-Tayeb, Lu Le, Travis Vandergriff
We report the case of a patient with a long-standing history of extranodal, sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and no evidence of original cutaneous involvement as well as a history of herpes zoster of the left flank with post-herpetic neuralgia who went on to develop multiple, round-to-oval, red-brown, atrophic macules and thin papules at the sites of herpes zoster scars on the left flank. Histopathology showed a dense nodular infiltrate of lymphocytes with some plasma cells and numerous large pale-staining histiocytes (S100+/CD68+), consistent with Rosai-Dorfman disease...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27551429/efficacy-of-varicella-vzv-vaccination-an-update-for-the-clinician
#14
Lili Wang, Lucy Zhu, Hua Zhu
Varicella-zoster virus (VZV) infection causes two distinct clinical conditions. Primary varicella infection results in chickenpox, a contagious rash illness typically seen among children. VZV can reactivate years after the initial infection to cause herpes zoster (HZ) and lead to post-herpetic neuralgia, a common complication resulting in persistent pain that may last for years after the zoster rash resolves. A person's risk of having longer lasting and more severe pain associated with HZ increases with age...
January 2016: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/27504334/herpes-zoster-infection-involving-mandibular-division-of-trigeminal-nerve-and-ramsay-hunt-syndrome-with-meningitis-in-an-immunocompetent-patient-a-rare-association
#15
Vijayan Ganesan, Dhrubajyoti Bandyopadhyay, Suvrendu Sankar Kar, Cankatika Choudhury, Vivek Choudhary
Herpes zoster is a unilateral painful vesicular cutaneous eruption caused by the reactivation of the Varicella zoster virus. It commonly affects the older people and immunocompromised individuals. The dermatomes from T3 to L3 are most frequently involved. Its three stages include prodromal stage, active stage and chronic stage. The common complications of the infection include post-herpetic neuralgia, Ramsay Hunt syndrome, Guillain-Barre syndrome, transverse myelitis and encephalomyelitis. This case report summarizes a very rare association of herpes zoster meningitis with the involvement of mandibular division of the trigeminal nerve and facial nerve...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27492741/effect-of-repetitive-intracutaneous-injections-with-local-anesthetics-and-steroids-for-acute-thoracic-herpes-zoster-and-incidence-of-postherpetic-neuralgia
#16
Ji-Zheng Cui, Xiao-Bao Zhang, Pin Zhu, Zhi-Bin Zhao, Zhu-Sheng Geng, Yun-Hai Zhang, Liang Tian, Heng-Fei Luan, Ji-Ying Feng
BACKGROUND: Treatment of established postherpetic neuralgia (PHN) is difficult and often disappointing. In this study, we assessed the efficacy of repetitive intracutaneous injections with local anesthetics and steroids in acute thoracic herpes zoster (HZ) pain, herpetic eruption, and incidence of PHN. METHODS: Ninety-three patients with acute thoracic HZ were randomly assigned to receive a standard treatment of antiviral medication with p.o. analgesics or the standard treatment with the addition of repetitive intracutaneous injections of a local anesthetic and steroid mixture...
August 4, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27448285/pregabalin-for-neuropathic-pain-why-benefits-could-be-expected-for-multiple-pain-conditions
#17
Setsuro Ogawa, Akio Arakawa, Kazuhiro Hayakawa, Tamotsu Yoshiyama
BACKGROUND AND OBJECTIVE: Limited research exists to support the extrapolation of the analgesic efficacy of pregabalin from one neuropathic pain condition to another. This retrospective analysis evaluated similarities in the efficacy of pregabalin for treating neuropathic pain associated with post-herpetic neuralgia (PHN), diabetic peripheral neuropathy (DPN), and spinal cord injury (SCI) in a Japanese population, as a basis for considering the extrapolation of these data to other neuropathic pain conditions...
November 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27440893/varicella-zoster-virus-activates-creb-and-inhibition-of-the-pcreb-p300-cbp-interaction-inhibits-viral-replication-in-vitro-and-skin-pathogenesis-in-vivo
#18
Sylvie François, Nandini Sen, Bryan Mitton, Xiangshu Xiao, Kathleen M Sakamoto, Ann Arvin
UNLABELLED: Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella upon primary infection and zoster upon reactivation from latency in sensory ganglion neurons. The replication of herpesviruses requires manipulation of cell signaling pathways. Notably, CREB, a factor involved in the regulation of several cellular processes, is activated upon infection of T cells with VZV. Here, we report that VZV infection also induced CREB phosphorylation in fibroblasts and that XX-650-23, a newly identified inhibitor of the phosphorylated-CREB (pCREB) interaction with p300/CBP, restricted cell-cell spread of VZV in vitro CREB phosphorylation did not require the viral open reading frame 47 (ORF47) and ORF66 kinases encoded by VZV...
October 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27428548/safety-and-efficacy-of-a-topical-sodium-channel-inhibitor-tv-45070-in-patients-with-post-herpetic-neuralgia-phn-a-randomized-controlled-proof-of-concept-crossover-study-with-a-subgroup-analysis-of-the-nav1-7-r1150w-genotype
#19
Nicola Price, Rostam Namdari, Judith Neville, Katie J W Proctor, Samer Kaber, Jeffery Vest, Michael Fetell, Richard Malamut, Robin Sherrington, Simon N Pimstone, Yigal P Goldberg
OBJECTIVES: To evaluate the safety and efficacy of TV-45070 ointment, as a treatment for PHN, and to explore the response in patients with the Nav1.7 R1150W gain-of-function polymorphism. METHODS: This was a randomized, placebo-controlled, 2-period, 2-treatment crossover trial. Patients with PHN with moderate or greater pain received TV-45070 and Placebo ointments, each applied twice daily for 3 weeks. The primary efficacy measure was the difference in change in mean daily pain score from baseline compared to the last week of placebo and active treatment...
July 15, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27413505/favorable-long-term-prognosis-of-cataract-surgery-in-herpes-zoster-ophthalmicus
#20
Kulbhushan Prakash Chaudhary, Deepti Mahajan, Praveen Panwar
PURPOSE: Scleritis is a rare presentation of herpes zoster ophthalmicus, complicated most commonly by iridocyclitis and raised intraocular pressure. These complications can recur in subsequent years, therefore they should be managed well. CASE REPORT: We describe a female patient who developed scleritis, complicated cataract and secondary glaucoma 2 years after being diagnosed by HZO. Secondary glaucoma was managed medically, and the patient underwent extracapsular cataract extraction for the complicated cataract...
April 2016: Journal of Ophthalmic & Vision Research
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