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Heart Rate Variability and CAD

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https://www.readbyqxmd.com/read/28914638/long-term-risk-and-predictors-of-cardiovascular-death-in-stable-coronary-artery-disease-the-coronor-study
#1
Christophe Bauters, Olivier Tricot, Thibaud Meurice, Nicolas Lamblin
BACKGROUND: There is limited knowledge on the residual risk of cardiovascular death (CVD) in patients with stable coronary artery disease (CAD) who receive modern secondary prevention. Our aim was to analyze the causes of death and to determine predictors of CVD in the 5-year CORONOR registry. METHODS: We studied 4184 consecutive CAD outpatients who were free from any myocardial infarction (MI) or coronary revascularization for more than 1 year at inclusion. Antithrombotics were prescribed in 99%, statins in 92%, inhibitors of renin-angiotensin system in 82%, and β-blockers in 79%; 86% had prior coronary revascularization...
September 13, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28662007/-evaluation-of-sleep-apnea-detected-by-24-hour-ecg-holter-monitoring-analysis-in-patients-with-stable-coronary-artery-disease-and-ischemic-heart-failure-correlations-with-clinical-data
#2
Magdalena Frączek-Jucha, Paweł Rostoff, Jacek Łach, Jadwiga Nessler, Andrzej Gackowski
Obstructive sleep apnoea (OSA) is frequently undiagnosed in patients with heart failure (HF) and coronary artery disease (CAD). Simple and widely available screening tests are needed to diagnose patients with SA. Measurements of thoracic impedance and heart rate variability during 24-hour ECG Holter (H-EKG) monitoring allows to calculate estimated apnoea-hypopnoea index (eAHI). AIM: The aim of the research was to assess prevalence of OSA evaluated with the use of H-EKG and determination of its clinical relevance in patients with CAD and ischeamic HF...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28636505/the-effect-of-aerobic-interval-training-and-continuous-training-on-exercise-capacity-and-its-determinants
#3
Nele Pattyn, Paul J Beckers, Véronique A Cornelissen, Ellen Coeckelberghs, Catherine De Maeyer, Geert Frederix, Kaatje Goetschalckx, Nadine Possemiers, Dirk Schepers, Emeline M Van Craenenbroeck, Kurt Wuyts, Viviane M Conraads, Luc Vanhees
Objective We aimed to investigate (1) the effects of aerobic interval training (AIT) and aerobic continuous training (ACT) on (sub)maximal exercise measures and its determinants including endothelial function, muscle strength and cardiac autonomic function, and (2) the relationship between exercise capacity and these determinants. Methods Two-hundred coronary artery disease (CAD) patients (58.4 ± 9.1 years) were randomized to AIT or ACT for 12 weeks. All patients performed a cardiopulmonary exercise test and endothelial function measurements before and after the intervention; a subpopulation underwent muscle strength and heart rate variability (HRV) assessments...
June 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28536533/heart-rate-fragmentation-a-new-approach-to-the-analysis-of-cardiac-interbeat-interval-dynamics
#4
Madalena D Costa, Roger B Davis, Ary L Goldberger
Background: Short-term heart rate variability (HRV) is most commonly attributed to physiologic vagal tone modulation. However, with aging and cardiovascular disease, the emergence of high short-term HRV, consistent with the breakdown of the neuroautonomic-electrophysiologic control system, may confound traditional HRV analysis. An apparent dynamical signature of such anomalous short-term HRV is frequent changes in heart rate acceleration sign, defined here as heart rate fragmentation. Objective: The aims were to: (1) introduce a set of metrics designed to probe the degree of sinus rhythm fragmentation; (2) test the hypothesis that the degree of fragmentation of heartbeat time series increases with the participants' age in a group of healthy subjects; (3) test the hypothesis that the heartbeat time series from patients with advanced coronary artery disease (CAD) are more fragmented than those from healthy subjects; and (4) compare the performance of the new fragmentation metrics with standard time and frequency domain measures of short-term HRV...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28387685/investigation-of-heart-rate-variability-of-patients-undergoing-coronary-artery-bypass-grafting-cabg
#5
A Hossen, D Jaju, M Al-Abri, H Al-Sabti, M Mukaddirov, M Hassan, K Al-Hashmi
BACKGROUND: Myocardial revascularization by coronary artery bypass grafting (CABG) is an effective measure for reducing symptoms and mortality in patients with unstable or severe coronary artery disease (CAD). Autonomic function can be estimated non-invasively using heart rate variability (HRV). HRV of patients undergoing CABG is investigated before and after CABG using a soft-decision wavelet based spectral analysis. OBJECTIVE: The main purpose of this work is to evaluate non-invasively HRV in patients undergoing CABG before operation; and to monitor the status of patients through HRV investigation on day 6 and day 30 after the CABG operation...
2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28381400/association-of-plasma-7-ketocholesterol-with-cardiovascular-outcomes-and-total-mortality-in-patients-with-coronary-artery-disease
#6
Jiayi Song, Duan Wang, Hongen Chen, Xiuwei Huang, Yuan Zhong, Nan Jiang, Chaogang Chen, Min Xia
RATIONALE: 7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models. OBJECTIVE: We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery disease. METHODS AND RESULTS: We measured the plasma 7-KC levels by high-performance liquid chromatography in a prospective cohort study of 1016 patients (mean age, 63...
May 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/28103324/use-of-proton-pump-inhibitors-predicts-heart-failure-and-death-in-patients-with-coronary-artery-disease
#7
Ana María Pello Lázaro, Carmen Cristóbal, Juan Antonio Franco-Peláez, Nieves Tarín, Álvaro Aceña, Rocío Carda, Ana Huelmos, María Luisa Martín-Mariscal, Jesús Fuentes-Antras, Juan Martínez-Millá, Joaquín Alonso, Óscar Lorenzo, Jesús Egido, Lorenzo López-Bescós, José Tuñón
OBJECTIVES: Proton-pump inhibitors (PPIs) seem to increase the incidence of cardiovascular events in patients with coronary artery disease (CAD), mainly in those using clopidogrel. We analysed the impact of PPIs on the prognosis of patients with stable CAD. METHODS: We followed 706 patients with CAD. Primary outcome was the combination of secondary outcomes. Secondary outcomes were 1) acute ischaemic events (any acute coronary syndrome, stroke, or transient ischaemic attack) and 2) heart failure (HF) or death...
2017: PloS One
https://www.readbyqxmd.com/read/28102898/a-composite-autonomic-index-as-unitary-metric-for-heart-rate-variability-a-proof-of-concept
#8
Roberto Sala, Mara Malacarne, Nadia Solaro, Massimo Pagani, Daniela Lucini
BACKGROUND: This study addresses whether a unitary cardiac autonomic nervous system index (ANSI), obtained combining multiple metrics from heart rate variability (HRV) into a radar plot could provide an easy appreciation of autonomic performance in a clinical setting. MATERIALS AND METHODS: Data are standardized using percentile ranking of autonomic proxies from a relatively large reference population (n = 1593, age 39 ± 13 years). Autonomic indices are obtained from autoregressive spectral analysis of (ECG derived) HRV at rest and during standing up...
March 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28068419/anxiety-level-and-cardiac-autonomic-modulations-in-coronary-artery-disease-and-cardiac-syndrome-x-patients
#9
Mohamed Faisal Lutfi
BACKGROUND: Anxiety and cardiac autonomic modulations (CAM) were thoroughly investigated in coronary artery disease (CAD) and cardiac syndrome X (CSX) patients worldwide, but not among Sudanese with similar pathology. AIMS: To compare levels of anxiety and CAM between Sudanese patients with CSX and CAD. MATERIALS AND METHODS: Anxiety was evaluated in 51 CAD and 26 CSX patients using Taylor Manifest anxiety score (TMAS) questionnaire while heart rate variability derived indices were used to assess CAM, namely natural logarithm of low frequency (LnLF), high frequency (LnHF) and LF/HF ratio (LnLF/HF)...
2017: PloS One
https://www.readbyqxmd.com/read/28052754/the-burden-of-major-adverse-cardiac-events-in-patients-with-coronary-artery-disease
#10
I-Ting Tsai, Chao-Ping Wang, Yung-Chuan Lu, Wei-Chin Hung, Cheng-Ching Wu, Li-Fen Lu, Fu-Mei Chung, Chia-Chang Hsu, Yau-Jiunn Lee, Teng-Hung Yu
BACKGROUND: Patients with a history of cardiovascular disease are at high risk of developing secondary major adverse cardiac events (MACE). This study aimed to identify independent predictors of MACE after hospital admission which could be used to identify of high-risk patients who may benefit from preventive strategies. METHODS: This study included 1,520 consecutive patients with coronary artery disease (CAD) (654 with acute coronary syndrome (ACS) and 866 with elective percutaneous coronary intervention (PCI) patients) who received PCI and/or stenting...
January 4, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28041575/the-impact-of-major-depression-on-heart-rate-variability-and-endothelial-dysfunction-in-patients-with-stable-coronary-artery-disease
#11
Esra Aydin Sunbul, Murat Sunbul, Huseyin Gulec
BACKGROUND: Depression is an independent risk factor in cardiovascular diseases. Changes in the cardiac autonomic functions and pro-inflammatory processes are potential biological factors. Endothelial dysfunction plays an important role in the etiopathogenesis of atherosclerosis. Our objective was to evaluate the impact of major depression on heart rate variability and endothelial dysfunction in patients with stable CAD. METHODS: The study group included 65 CAD patients with a diagnosis of major depression and 54 CAD patients without major depression...
January 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28017688/effect-of-position-on-the-residual-heart-rate-variability-in-patients-after-orthotopic-heart-transplantation
#12
Yi-Ying Lin, Wan-An Lu, Yuan-Chen Hsieh, Hsiao-Huang Chang, Chun-Che Shih, Mei-Jy Jeng, Cheng-Deng Kuo
BACKGROUND: This study investigated the effects of position on heart rate variability (HRV) in patients some years after orthotopic heart transplantation (OHT) surgery. METHODS: Spectral HRV analysis was performed on 15 patients after OHT and 16 patients with coronary artery disease (CAD). HRV measures were compared between OHT and CAD patients in four randomly ordered positions [supine, right lateral decubitus (RLD), left lateral decubitus (LLD), and upright]. Multivariable linear regression analysis was used to identify the factors associated with cardiac function and HRV of OHT patients in supine position, and the factors associated with the outcome (OHT or CAD) of the patients...
December 22, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27928211/use-of-heart-rate-variability-to-estimate-lactate-threshold-in-coronary-artery-disease-patients-during-resistance-exercise
#13
Rodrigo P Simões, Renata G Mendes, Viviane Castello-Simões, Aparecida M Catai, Ross Arena, Audrey Borghi-Silva
The aim of this study was to investigate whether it is possible to identify the first turn point of blood lactate (BL) concentration (1(st) lactate threshold - LT1) during a discontinuous resistance exercise protocol in coronary artery disease (CAD) patients and verify if heart rate variability (HRV) responses are consistent with BL responses. A total of 22 elderly men, 12 with CAD and 10 apparently healthy (control group = CG), underwent one-repetition maximum (1RM) testing on an inclined leg press. Discontinuous resistance exercise testing (DRET) was initiated at 10% of the 1RM with subsequent increases of 10% until 30% and after this percentage, 5% increments of 1RM was carried out...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27886710/automated-diagnosis-of-coronary-artery-disease-cad-patients-using-optimized-svm
#14
Azam Davari Dolatabadi, Siamak Esmael Zadeh Khadem, Babak Mohammadzadeh Asl
BACKGROUND AND OBJECTIVE: Currently Coronary Artery Disease (CAD) is one of the most prevalent diseases, and also can lead to death, disability and economic loss in patients who suffer from cardiovascular disease. Diagnostic procedures of this disease by medical teams are typically invasive, although they do not satisfy the required accuracy. METHODS: In this study, we have proposed a methodology for the automatic diagnosis of normal and Coronary Artery Disease conditions using Heart Rate Variability (HRV) signal extracted from electrocardiogram (ECG)...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27835972/the-association-of-functional-polymorphisms-in-genes-encoding-growth-factors-for-endothelial-cells-and-smooth-muscle-cells-with-the-severity-of-coronary-artery-disease
#15
Tadeusz Osadnik, Joanna Katarzyna Strzelczyk, Andrzej Lekston, Rafał Reguła, Kamil Bujak, Martyna Fronczek, Marcin Gawlita, Małgorzata Gonera, Jarosław Wasilewski, Bożena Szyguła-Jurkiewicz, Marek Gierlotka, Mariusz Gąsior
BACKGROUND: Despite the important roles of vascular smooth muscle cells and endothelial cells in atherosclerotic lesion formation, data regarding the associations of functional polymorphisms in the genes encoding growth factors with the severity of coronary artery disease (CAD) are lacking. The aim of the present study is to analyze the relationships between functional polymorphisms in genes encoding basic fibroblast growth factor (bFGF, FGF2), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), platelet derived growth factor-B (PDGFB), transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor A (VEGF-A) and the severity of coronary atherosclerosis in patients with stable CAD undergoing their first coronary angiography...
November 11, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27797930/effects-of-liraglutide-on-heart-rate-and-heart-rate-variability-a-randomized-double-blind-placebo-controlled-crossover-study
#16
Preman Kumarathurai, Christian Anholm, Bjørn S Larsen, Rasmus Huan Olsen, Sten Madsbad, Ole Kristiansen, Olav W Nielsen, Steen B Haugaard, Ahmad Sajadieh
OBJECTIVE: Reduced heart rate variability (HRV) and increased heart rate (HR) have been associated with cardiovascular mortality. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) increase HR, and studies have suggested that they may reduce HRV. We examined the effect of the GLP-1 RA liraglutide on HRV and diurnal variation of HR in overweight patients with newly diagnosed type 2 diabetes (T2D) and stable coronary artery disease (CAD). RESEARCH DESIGN AND METHODS: Liraglutide or placebo was administrated to a backbone therapy of metformin in this double-blind, placebo-controlled 12 + 12-week crossover study...
January 2017: Diabetes Care
https://www.readbyqxmd.com/read/27737597/coronary-artery-disease-prevalence-and-outcome-in-patients-hospitalized-with-acute-heart-failure-an-observational-report-from-seven-middle-eastern-countries
#17
Amar M Salam, Kadhim Sulaiman, Ibrahim Al-Zakwani, Alawi Alsheikh-Ali, Mohammed Aljaraallah, Husam Al Faleh, Abdelfatah Elasfar, Prasanth Panduranga, Rajvir Singh, Charbel Abi Khalil, Jassim Al Suwaidi
OBJECTIVES: The purpose of this study was to report prevalence, clinical characteristics, precipitating factors, management and outcome of patients with coronary artery disease (CAD) among patients hospitalized with heart failure (HF) in seven Middle Eastern countries and compare them to non-CAD patients. METHODS: Data were derived from Gulf CARE (Gulf aCute heArt failuRe rEgistry), a prospective multicenter study of 5005 consecutive patients hospitalized with acute HF during February-November 2012 in 7 Middle Eastern countries...
December 2016: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/27693051/high-density-lipoprotein-subclass-profile-and-mortality-in-patients-with-coronary-artery-disease-results-from-the-genes-study
#18
Meyer Elbaz, Julien Faccini, Vanina Bongard, Cécile Ingueneau, Dorotea Taraszkiewicz, Bertrand Perret, Jean Ferrières, Jean-Bernard Ruidavets, Cécile Vindis
BACKGROUND: High-density lipoproteins (HDLs) are highly heterogeneous particles, and the specific contribution of each subclass to the prediction of clinical outcome in coronary artery disease (CAD) remains controversial. OBJECTIVE: To examine the relationship between HDL subclass profile and mortality in patients with CAD, using a new and rapid electrophoretic quantitative method for the assessment of HDL particle size phenotype. METHODS: We investigated 403 patients with CAD admitted for cardiovascular examination in the context of evaluation and management of CAD...
November 2016: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/27573599/predictors-of-significant-coronary-artery-disease-in-atrial-fibrillation-are-cardiac-troponins-a-useful-measure
#19
Alaa Alghamry, Joseph Hanna, Anita Pelecanos, Stephen Kyranis, Vinod Khelgi, Peter O'Rourke, Oran Carroll, Cassie Oxenford, Swetha Rangaswamaiah, Christopher Tan
BACKGROUND: Cardiac Troponin I (cTnI) is frequently measured in patients presenting with symptomatic atrial fibrillation (AF). The significance of elevated cTnI levels in this patient cohort is unclear. We investigated the value of cTnI elevation in this setting and whether it is predictive for significant coronary artery disease (sCAD). METHODS: We conducted a retrospective, single-center, case-control study of 231 patients who presented with symptomatic AF to The Prince Charles Hospital emergency department, Brisbane, Australia between 2006 and 2014...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27556384/is-heart-rate-variability-a-feasible-method-to-determine-anaerobic-threshold-in-progressive-resistance-exercise-in-coronary-artery-disease
#20
Milena P R Sperling, Rodrigo P Simões, Flávia C R Caruso, Renata G Mendes, Ross Arena, Audrey Borghi-Silva
BACKGROUND: Recent studies have shown that the magnitude of the metabolic and autonomic responses during progressive resistance exercise (PRE) is associated with the determination of the anaerobic threshold (AT). AT is an important parameter to determine intensity in dynamic exercise. OBJECTIVES: To investigate the metabolic and cardiac autonomic responses during dynamic resistance exercise in patients with Coronary Artery Disease (CAD). METHOD: Twenty men (age = 63±7 years) with CAD [Left Ventricular Ejection Fraction (LVEF) = 60±10%] underwent a PRE protocol on a leg press until maximal exertion...
July 2016: Brazilian Journal of Physical Therapy
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