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https://www.readbyqxmd.com/read/29031233/forensic-and-clinical-significance-of-serum-amylase-lipase-and-gamma-glutamyl-transferase-as-predictors-of-outcome-in-head-injured-patients
#1
Mona Mohamed Abo El-Noor, Naema Mahmoud ElHosary, Hytham Ibrahim Elatrozy, Hussein Mohamed Abou Elgheit, Ahmed Mohamed Elbelkasy, Ahmed Gamal Fath, Ghada Hamed El-Shafy
Head trauma is one of the leading causes of death and disability worldwide. Combined head lesions consist of more than one form of lesions. Biochemical markers of brain injury are used in determining the extent of brain injury and predicting its outcomes. The aim of this study was to investigate the forensic and clinical significance of serum amylase, lipase and gamma glutamyl transferase (GGT) as predictors of the outcome in head injured patients. PATIENTS AND METHODS: Sixty head injured patients were enrolled and subjected to personal history taking, general and local physical examination...
October 4, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29029254/retrospective-proteomic-analysis-of-serum-after-akhmeta-virus-infection-new-suspect-case-identification-and-insights-into-poxvirus-humoral-immunity
#2
Michael B Townsend, Nadia F Gallardo-Romero, Ekaterine Khmaladze, Neil M Vora, Giorgi Maghlakelidze, Marika Geleishvili, Darin S Carroll, Ginny L Emerson, Mary G Reynolds, P S Satheshkumar
Serologic cross-reactivity, a hallmark of orthopoxvirus (OPXV) infection, makes species-specific diagnosis of infection difficult. In this study, we used a Variola virus (VARV) proteome microarray to characterize and differentiate antibody responses to non-vaccinia OPXV infections from smallpox vaccination. The profile of two-case patients infected with newly discovered OPXV, Akhmeta virus (AKMV), exhibited antibody responses of greater intensity and broader recognition of viral proteins and includes the B21/22 family glycoproteins not encoded by vaccinia virus (VACV) strains used as vaccines...
October 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029123/outcome-of-elevated-ca125-values-from-primary-care-following-implementation-of-ovarian-cancer-guidelines
#3
S Michael Crawford, Colin Evans
Background: Ovarian cancer presents later in the UK compared to economically similar countries. National guidance suggests measuring CA125 in primary care as a means of bringing patients to specialist attention. Aim: To investigate the outcome of CA125 values measured in accordance with this policy. Setting and design: Examination of the laboratory records of female patients from the usual catchment population of one general hospital in whom CA125 was measured from primary care in a calendar year...
September 28, 2017: Family Practice
https://www.readbyqxmd.com/read/29028938/impact-of-the-us-maternal-tetanus-diphtheria-and-acellular-pertussis-vaccination-program-on-preventing-pertussis-in-infants-2-months-of-age-a-case-control-evaluation
#4
Tami H Skoff, Amy E Blain, James Watt, Karen Scherzinger, Melissa McMahon, Shelley M Zansky, Kathy Kudish, Paul R Cieslak, Melissa Lewis, Nong Shang, Stacey W Martin
Background: Infants aged <1 year are at highest risk for pertussis-related morbidity and mortality. In 2012, Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) vaccine was recommended for women during each pregnancy to protect infants in the first months of life; data on effectiveness of this strategy are currently limited. Methods: We conducted a case-control evaluation among pertussis cases <2 months old with cough onset between 1 January 2011 and 31 December 2014 from 6 US Emerging Infection Program Network states...
September 28, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028736/superficial-and-deep-capillary-ischemia-as-a-presenting-sign-of-retinal-vasculopathy-with-cerebral-leukoencephalopathy-and-systemic-manifestations
#5
Aaron Nagiel, Robert A Lalane, Joanna C Jen, Allan E Kreiger
PURPOSE: The aim of this study was to investigate the presenting sign of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations, a rare autosomal dominant condition caused by mutations in the TREX1 gene, and to explore the potential efficacy of bevacizumab in preventing capillary occlusions. METHODS: Observational case report with the use of ultra-widefield fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography...
October 12, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29028677/are-people-with-a-history-of-disease-more-susceptible-to-a-short-term-exposure-to-asian-dust-a-case-crossover-study-among-the-elderly-in-japan
#6
Saori Kashima, Takashi Yorifuji, Etsuji Suzuki
BACKGROUND: Factors influencing the susceptibility of the elderly to the adverse health effects of short-term exposure to desert dust have yet to be explored. We aimed to identify the disease histories that increase the susceptibility of the elderly to disease onset induced by dust events. METHODS: We used a time-stratified case-crossover design using data on 17,874 elderly residents (≥65 years) of Okayama, Japan, who were transported to hospital emergency rooms because of cardiovascular and respiratory diseases between 2006 and 2010...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028228/preventing-emergence-of-drug-resistant-tuberculosis-in-myanmar-s-transitioning-health-system
#7
Mishal S Khan, Coll Hutchison, Richard J Coker, Joanne Yoong, Khaung M Hane, Anh L Innes, Tin M Khaing, Sithu Aung
Multidrug-resistant tuberculosis (MDR-TB) is a particular threat to the populations of resource-limited countries. Although inadequate treatment of TB has been identified as a major underlying cause of drug resistance, essential information to inform changes in health service delivery and policy is missing. We investigate factors that may be driving the emergence of MDR-TB in Myanmar, a country where investment and health system reforms are ongoing to address the unexplained, high occurrence of MDR-TB. We conducted a multi-centre, retrospective case-control study in 10 townships across Yangon...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29027331/when-does-it-pay-to-invest-in-a-patch-the-evolution-of-intentional-niche-construction
#8
Kathryn A Mohlenhoff, Brian F Codding
Humans modify their environments in ways that significantly transform the earth's ecosystems. Recent research suggests that such niche-constructing behaviors are not passive human responses to environmental variation, but instead should be seen as active and intentional management of the environment. Although such research is useful in highlighting the interactive dynamics between humans and their natural world, the niche-construction framework, as currently applied, fails to explain why people would decide to modify their environments in the first place...
September 2017: Evolutionary Anthropology
https://www.readbyqxmd.com/read/29027319/pregnancy-in-immunoglobulin-m-nephropathy
#9
Meryem Hocaoğlu, Sabahat Alışır Ecder, Abdulkadir Turgut, Ateş Karateke
Immunoglobulin nephropathy is an uncommon glomerular disease and a relatively less recognized clinico-immunopathological entity in the domain of glomerulonephritis, often thought to be a bridge between minimal change disease and focal segmental glomerulosclerosis. It is characterized by asymptomatic hematuria, episodes of macroscopic hematuria and proteinuria. Corticosteroids remain the mainstay of therapeutic strategies for such patients. We present what we believe to be the first known case of successful pregnancy in a 40-year-old woman with a 12-year history of underlying immunoglobulin nephropathy...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29027270/the-yerba-mate-intake-has-a-neutral-effect-on-bone-a-case-control-study-in-postmenopausal-women
#10
Denise T A da Veiga, Raísa Bringhenti, Aline A Bolignon, Etiane Tatsh, Rafael N Moresco, Fabio V Comim, Melissa O Premaor
Nutritional factors have been associated with osteoporosis and fractures. The intake of coffee may increase the risk of fracture whereas the intake of black and green tea is associated with its reduction. Recently, consumption of yerba mate was associated with increased bone mineral density in postmenopausal women. Nonetheless, its influence on fracture is not known. The aim of this study was to evaluate the effect of yerba mate tea intake on fractures, bone markers, calcium homeostasis, and oxidative stress in postmenopausal women...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29027221/abscopal-immunological-effects-of-radiotherapy-narrowing-the-gap-between-clinical-and-preclinical-experiences
#11
REVIEW
Nikko Brix, Anna Tiefenthaller, Heike Anders, Claus Belka, Kirsten Lauber
Radiotherapy-despite being a local therapy that meanwhile is characterized by an impressively high degree of spatial accuracy-can stimulate systemic phenomena which occasionally lead to regression and rejection of non-irradiated, distant tumor lesions. These abscopal effects of local irradiation have been observed in sporadic clinical case reports since the beginning of the 20th century, and extensive preclinical work has contributed to identify systemic anti-tumor immune responses as the underlying driving forces...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29027191/tha-conversion-rate-comparing-decompression-alone-with-autologous-bone-graft-or-stem-cells-in-osteonecrosis
#12
Francisco J Nally, Gerardo Zanotti, Martín A Buttaro, Fernando D Dilernia, Ignacio G Mansilla, Fernando M Comba, Francisco Piccaluga
INTRODUCTION: Core decompression (CD) with or without the addition of autologous bone graft (CDBG) is currently the most widely accepted treatment for hip osteonecrosis in stages of pre-collapse. The use of bone marrow mesenchymal stem cells (CDSC) is emerging as a promising biological alternative. We sought to determine the total hip arthroplasty (THA) conversion rate for patients treated with CD, CDBG or CDSC. MATERIAL AND METHODS: Between 1996 and 2012, 97 cases were evaluated in 72 patients: 47 CD cases, 34 CDGB cases and 16 CDSC cases...
October 9, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29027153/conflicting-data-on-the-incidence-of-leukopenia-and-neutropenia-after-heated-intraperitoneal-chemotherapy-with-mitomycin-c
#13
Yael Feferman, Shanel Bhagwandin, Joseph Kim, Samantha N Aycart, Daniela Feingold, Daniel M Labow, Umut Sarpel
BACKGROUND: During heated intraperitoneal chemotherapy (HIPEC), neutropenia rates of 20 to 40% have been reported when mitomycin C (MMC) is dosed by weight or body surface area (BSA). This study investigated the authors' HIPEC experience using a fixed 40-mg dose of MMC, per consensus guidelines, and analyzed predictors for severe leukopenia and neutropenia. METHODS: Patients who underwent MMC-HIPEC from 2007 to 2016 at a single tertiary care center were retrospectively reviewed...
October 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29027063/inflammatory-myofibroblastic-tumors-of-the-breast-with-simultaneous-intracranial-lung-and-pancreas-involvement-ultrasonographic-findings-and-a-review-of-the-literature
#14
Mari Inoue, Tomoyuki Ohta, Hisashi Shioya, Shun Sato, Hiroyuki Takahashi, Norio Nakata, Chiaki Taniguchi, Megumi Hirano, Makiko Nishioka, Hironori Yamakawa
We encountered a case of inflammatory myofibroblastic tumor (IMT) of the breast with simultaneous intracranial, lung, and pancreas involvement. Here, we present the clinical imaging results and report the significance of sonographic findings of breast IMT along with a review of the literature. A 16-year-old girl with a history of subarachnoidal hemorrhage was admitted to our hospital due to tonic-clonic seizure. Computed tomography (CT) and magnetic resonance imaging (MRI) showed multiple intracranial, lung, and pancreas mass lesions and a solitary mass lesion in the right breast...
October 12, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29026877/prolonged-delayed-renal-graft-function-secondary-to-venous-hypertension
#15
Suraj Mishra, Gaurav Gupta, I Moinuddin, Brian Strife, Uma Prasad, D Massey, Anne King, Dhiren Kumar, Chandra S Bhati
The case of a 39-year-old highly sensitized woman who underwent second renal transplantation after being on warfarin because of a history of frequent thromboses of her left femoral arteriovenous graft (AVG) is reported here. The patient received a flow cytometric positive crossmatch kidney transplant from a deceased donor. Her posttransplant course was complicated by prolonged delayed graft function (DGF) lasting for 9 months. Antibody-mediated rejection occurred in the immediate postoperative period. This resolved after treatment, and resolution was confirmed by repeat biopsy...
October 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29026845/osteonecrosis-of-the-jaws-in-patient-received-bisphosphonates-and-sunitinib-separately-a-case-report
#16
Farzaneh Ashrafi, Ali Derakhshandeh, Bijan Movahedian, Azadeh Moghaddas
Recently published reports have suggested that antiangiogenic drugs such as sunitinib could potentiate the osteonecrosis of the jaw (ONJ) induced by bisphosphonates (BPs) and even induce this adverse effect per se. We reported a case of ONJ with renal cell carcinoma under sunitinib medication and history of BPs therapy. A 53-year-old man was referred to the oral surgery clinic complaining of painful exposed oral lesion and bone extraction from right lower jaw in the mouth. He underwent nephrectomy followed by 5 months treatment with cycles of 50 mg sunitinib (Sutent(®)) once a day for 4 weeks followed by 2 weeks drug free before lesion exposure in October 2016...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29026834/conservative-approach-to-the-acute-management-of-a-large-mesenteric-cyst
#17
Billy C Leung, Ruth Sankey, Matteo Fronza, Mohamed Maatouk
Mesenteric cysts are rare, benign gastrointestinal cystic lesions, which are often non-troublesome and present as an incidental radiological finding. However, surgery is often performed in the acute setting to remove lesions that are symptomatic. This report highlights the case of a large, symptomatic mesenteric cyst managed successfully with initial conservative measures followed by planned elective surgery. A 44-year-old female presented with a four-day history of generalised abdominal pain associated with distension, fever, diarrhoea and vomiting...
September 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29026813/immediate-nerve-transfer-for-the-treatment-of-peroneal-nerve-palsy-secondary-to-an-intraneural-ganglion-case-report-and-review
#18
I Ratanshi, T A Clark, Jennifer L Giuffre
Intraneural ganglion cysts that occur within the common peroneal nerve are a rare cause of foot drop. The current standard of treatment for intraneural ganglion cysts involving the common peroneal nerve involves (1) cyst decompression and (2) ligation of the articular nerve branch to prevent recurrence. Nerve transfers are a time-dependent strategy for recovering ankle dorsiflexion in cases of high peroneal nerve palsy; however, this modality has not been performed for intraneural ganglion cysts involving the common peroneal nerve...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29026764/a-case-control-study-on-environmental-and-biological-risk-factors-for-renal-calculi-persisting-in-a-coastal-union-territory-india
#19
Prakash Mathiyalagen, Anand Neelakantan, Karthik Balusamy, Kavita Vasudevan, Johnson Cherian, Bhuvaneswary Sunderamurthy
BACKGROUND AND OBJECTIVES: Renal stone disease is a common disorder of the urinary tract and also a significant problem because of incidence, recurrence, and severe consequences. The complex pathogenetic mechanisms of renal stone formation involve both biologic and environmental risk factors. The present study was performed to identify the role of these parameters among renal stone patients and normal individuals from a coastal union territory region in South India. METHODS: The authors conducted a case-control study of renal stone disease among outpatient department patients more than 30 years of age using systematic random sampling procedure with 100 study participants (50 subjects for each group)...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026744/profile-of-drug-resistant-tuberculosis-in-western-maharashtra
#20
Sudhakar W More, Malangori Abdulgani Parande, Sanjeev W Kamble, Manjunath S Kamble
CONTEXT: Drug-resistant tuberculosis (TB) strains have evolved mainly due to incomplete or improper treatment of TB patients and are one of the hurdles in controlling TB problem. It is better to understand the magnitude and comorbidities associated with drug-resistant TB. AIM AND OBJECTIVES: (1) To study some of the sociodemographic profile and history of TB treatment of drug-resistant TB cases. (2) To study their drug-resistance pattern and their comorbidity profile...
January 2017: Journal of Family Medicine and Primary Care
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