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https://www.readbyqxmd.com/read/28102774/interactions-between-c-reactive-protein-and-traditional-risk-factors-in-predicting-mortality-of-older-adults
#1
Henrik Rudolf, Naemi Wall, Renate Klaassen-Mielke, Ulrich Thiem, Curt Diehm, Hans-Joachim Trampisch, Dietmar Krause
BACKGROUND: Elevated levels of C-reactive protein (CRP) are known to be associated with cardiovascular (CV) morbidity and mortality in older adults, however, there seems to be heterogeneity of this association across subsets of individuals. We aim to assess the effects of interactions between CRP and one of the following traditional CV risk factors regarding all-cause mortality in unselected elderly men and women: age, sex, body mass index, diabetes, and hypertension. PATIENTS AND METHODS: Three hundred and forty-four general practitioners all over Germany enrolled 6,817 unselected participants, aged 65 years or older, and performed thorough examinations, including CRP measurement at baseline (getABI study)...
January 19, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28102435/effects-of-tryptophan-containing-peptides-on-angiotensin-converting-enzyme-activity-and-vessel-tone-ex-vivo-and-in-vivo
#2
Sherif Khedr, Andreas Deussen, Irakli Kopaliani, Birgit Zatschler, Melanie Martin
PURPOSE: Over-activation of the renin-angiotensin axis and worsening of vascular function are critical contributors to the development of hypertension. Therefore, inhibition of angiotensin-converting enzyme (ACE), a key factor of the renin-angiotensin axis, is a first line treatment of hypertension. Besides pharmaceutical ACE inhibitors, some natural peptides have been shown to exert ACE-inhibiting properties with antihypertensive effects and potentially beneficial effects on vascular function...
January 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28102195/positive-association-between-kcnj5-rs2604204-a-c-polymorphism-and-plasma-aldosterone-levels-but-also-plasma-renin-and-angiotensin-i-and-ii-levels-in-newly-diagnosed-hypertensive-chinese-a-case-control-study
#3
H Wang, C Weng, H Chen
Variants in G protein-coupled inward rectifier K(+) channels 4 (GIRK4 also known as KCNJ5) gene are associated with primary aldosteronism, which is the most common cause of secondary hypertension. The KCNJ5 rs2604204 variant was shown to be common (minor allele frequency=32.5%) in Chinese patients with essential hypertension (EH). The relationship between KCNJ5 variant and plasma aldosterone (ALD) levels in EH patients has not been reported. We collected 229 patients with newly diagnosed EH without any antihypertensive agents...
January 19, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28101724/drug-drug-multicomponent-solid-forms-cocrystal-coamorphous-and-eutectic-of-three-poorly-soluble-antihypertensive-drugs-using-mechanochemical-approach
#4
Jamshed Haneef, Renu Chadha
The present study deals with the application of mechanochemical approach for the preparation of drug-drug multicomponent solid forms of three poorly soluble antihypertensive drugs (telmisartan, irbesartan and hydrochlorothiazide) using atenolol as a coformer. The resultant solid forms comprise of cocrystal (telmisartan-atenolol), coamorphous (irbesartan-atenolol) and eutectic (hydrochlorothiazide-atenolol). The study emphasizes that solid-state transformation of drug molecules into new forms is a result of the change in structural patterns, diminishing of dimers and creating new facile hydrogen bonding network based on structural resemblance...
January 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28100922/the-effects-of-missed-doses-of-amlodipine-and-losartan-on-blood-pressure-in-older-hypertensive-patients
#5
Peter W de Leeuw, Robert Fagard, Abraham A Kroon
This randomized, double-blind, parallel-group, multicenter study compared the efficacy of amlodipine and losartan in an older hypertensive population, focusing on therapeutic coverage in the case of missed doses. Following a 4-week, single-blind, placebo washout period, 211 patients were randomly assigned to receive either 5 mg of amlodipine once daily or 50 mg of losartan once daily. Doses were doubled after 6 weeks of treatment if the diastolic blood pressure exceeded 90 mm Hg. After the 12-week treatment period, patients received the placebo for 2 days (drug holiday) to simulate two missed doses of antihypertensive medication...
January 19, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28100465/prevalence-of-masked-hypertension-among-us-adults-with-nonelevated-clinic-blood-pressure
#6
Y Claire Wang, Daichi Shimbo, Paul Muntner, Andrew E Moran, Lawrence R Krakoff, Joseph E Schwartz
Masked hypertension (MHT), defined as nonelevated blood pressure (BP) in the clinic setting and elevated BP assessed by ambulatory monitoring, is associated with increased risk of target organ damage, cardiovascular disease, and mortality. Currently, no estimate of MHT prevalence exists for the general US population. After pooling data from the Masked Hypertension Study (n = 811), a cross-sectional clinical investigation of systematic differences between clinic BP and ambulatory BP (ABP) in a community sample of employed adults in the New York City metropolitan area (2005-2012), and the National Health and Nutrition Examination Survey (NHANES; 2005-2010; n = 9,316), an ongoing nationally representative US survey, we used multiple imputation to impute ABP-defined hypertension status for NHANES participants and estimate MHT prevalence among the 139 million US adults with nonelevated clinic BP, no history of overt cardiovascular disease, and no use of antihypertensive medication...
January 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28099662/effects-of-neighborhood-socioeconomic-status-on-blood-pressure-in-older-adults
#7
Katia Jakovljevic Pudla Wagner, Antonio Fernando Boing, S V Subramanian, Doroteia Aparecida Höfelmann, Eleonora D'Orsi
OBJECTIVE: To test if the neighborhood socioeconomic status is associated with systolic blood pressure and hypertension in older adults. METHODS: A cross-sectional population-based study with a sample of 1,705 older adults from Florianópolis, SC, Southern Brazil. The contextual variable used was the average years of schooling of the head of the household in census tracts. Participants were considered hypertensive when the systolic blood pressure was ≥ 140 mmHg, diastolic ≥ 90 mmHg, or both...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28099659/factors-associated-with-the-use-of-antihypertensives-among-seniors
#8
Kaio Henrique Correa Massa, José Leopoldo Ferreira Antunes, Maria Lúcia Lebrão, Yeda Aparecida Oliveira Duarte, Alexandre Dias Porto Chiavegatto
OBJECTIVE: Analyze the use of antihypertensives among seniors and the association with socioeconomic and behavioral characteristics. METHODS: In this seriate cross-sectional study, we used data from the Saúde, Bem Estar e Envelhecimento study (SABE - Health, Well-being, and Aging), conducted in 2000, 2006, and 2010 in the city of São Paulo. Association between the use of antihypertensives and the demographic, behavioral, and socioeconomic characteristics and risk factors was analyzed by using multilevel logistic regression models...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28099657/quality-of-life-and-treatment-adherence-in-hypertensive-patients-systematic-review-with-meta-analysis
#9
Ana Célia Caetano de Souza, José Wicto Pereira Borges, Thereza Maria Magalhães Moreira
OBJECTIVE: To verify the effects of antihypertensive treatment (pharmacological and non-pharmacological) on the health-related quality of life of individuals with hypertension. METHODS: We conducted a systematic review with meta-analysis using the following databases: IBECS, LILACS, SciELO, Medline, Cochrane, Science Direct, Scopus and the Brazilian Capes Theses and Dissertations Database. The statistical analysis was performed using Review Manager, version 5.2...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28098848/identification-of-phenolic-compounds-from-hancornia-speciosa-apocynaceae-leaves-by-uhplc-orbitrap-hrms
#10
Katherine Xavier Bastos, Clarice Noleto Dias, Yuri Mangueira Nascimento, Marcelo Sobral da Silva, Silvana Maria Zucolotto Langassner, Ludger A Wessjohann, Josean Fechine Tavares
Apocynaceae is a botanical family distributed mainly in tropical and subtropical regions of the world. In Brazil, they comprise about 90 genera and 850 species, inhabiting various types of vegetation. Within this large botanical family, the genus Hancornia is considered monotypic, with its only species Hancornia speciosa Gomes. Antihypertensive, antidiabetic, and antiviral activities are described for this species. Despite having been the target of some studies, knowledge of its chemical composition is still limited...
January 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098840/comparative-solid-state-stability-of-perindopril-active-substance-vs-pharmaceutical-formulation
#11
Valentina Buda, Minodora Andor, Adriana Ledeti, Ionut Ledeti, Gabriela Vlase, Titus Vlase, Carmen Cristescu, Mirela Voicu, Liana Suciu, Mirela Cleopatra Tomescu
This paper presents the results obtained after studying the thermal stability and decomposition kinetics of perindopril erbumine as a pure active pharmaceutical ingredient as well as a solid pharmaceutical formulation containing the same active pharmaceutical ingredient (API). Since no data were found in the literature regarding the spectroscopic description, thermal behavior, or decomposition kinetics of perindopril, our goal was the evaluation of the compatibility of this antihypertensive agent with the excipients in the tablet under ambient conditions and to study the effect of thermal treatment on the stability of perindopril erbumine...
January 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098801/a-novel-antihypertensive-derived-from-adlay-coix-larchryma-jobi-l-var-ma-yuen-stapf-glutelin
#12
Bin Li, Liansheng Qiao, Lingling Li, Yanling Zhang, Kai Li, Lingzhi Wang, Yanjiang Qiao
Our previous studies have shown that Coix glutelin pepsin hydrolysate can effectively inhibit angiotensin converting enzyme (ACE) activity in vitro. The main purpose of this study was to obtain potent anti-hypertensive peptides from Coix glutelin. The Coix glutelin hydrolysates (CGH) were prepared by pepsin catalysis and further separated by an ultrafitration (UF) system, gel filtration chromatography (GFC) and reversed-phase high performance liquid chromatography (RP-HPLC). As a result, the sub-fraction F5-3 had the highest ACE-inhibitory activity...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28097883/is-angiotensin-3-4-val-tyr-the-shortest-angiotensin-ii-derived-peptide-opening-new-vistas-on-the-renin-angiotensin-system
#13
Juliana Dias, Flavia Axelband, Lucienne S Lara, Humberto Muzi-Filho, Adalberto Vieyra
Angiotensin-(3-4) (Ang-(3-4) or Val-Tyr) is the shorter angiotensin (Ang) II-derived peptide, formed through successive hydrolysis that culminates with the release of Val-Tyr as a dipeptide. It is formed both in plasma and in kidney from Ang II and Ang III, and can be considered a component of the systemic and organ-based renin-angiotensin system. It is potently antihypertensive in humans and rats, and its concerted actions on proximal tubule cells culminate in the inhibition of fluid reabsorption, hyperosmotic urinary excretion of Na(+)...
January 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28096206/racial-and-ethnic-differences-in-antihypertensive-medication-use-and-blood-pressure-control-among-us-adults-with-hypertension-the-national-health-and-nutrition-examination-survey-2003-to-2012
#14
Anna Gu, Yu Yue, Raj P Desai, Edgar Argulian
BACKGROUND: A key to reduce and eradicate racial disparities in hypertension outcomes is to understand their causes. We aimed at evaluating racial differences in antihypertensive drug utilization patterns and blood pressure control by insurance status, age, sex, and presence of comorbidities. METHODS AND RESULTS: A total of 8796 hypertensive individuals ≥18 years of age were identified from the National Health and Nutrition Examination Survey (2003-2012) in a repeated cross-sectional study...
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28096205/effect-of-prepublication-results-on-trends-in-prescribing-of-antihypertensive-medication-impact-of-the-altitude-aliskiren-trial-in-type-2-diabetes-using-cardio-renal-disease-endpoints-trial-on-aliskiren-prescribing
#15
Sahar S Othman, Peter C Austin, Jack V Tu, Douglas S Lee
No abstract text is available yet for this article.
January 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28095040/consensus-statement-by-the-american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-on-the-comprehensive-type-2-diabetes-management-algorithm-2017-executive-summary
#16
Alan J Garber, Martin J Abrahamson, Joshua I Barzilay, Lawrence Blonde, Zachary T Bloomgarden, Michael A Bush, Samuel Dagogo-Jack, Ralph A DeFronzo, Daniel Einhorn, Vivian A Fonseca, Jeffrey R Garber, W Timothy Garvey, George Grunberger, Yehuda Handelsman, Irl B Hirsch, Paul S Jellinger, Janet B McGill, Jeffrey I Mechanick, Paul D Rosenblit, Guillermo E Umpierrez
EXECUTIVE SUMMARY This algorithm for the comprehensive management of persons with type 2 diabetes (T2D) was developed to provide clinicians with a practical guide that considers the whole patient, their spectrum of risks and complications, and evidence-based approaches to treatment. It is now clear that the progressive pancreatic beta-cell defect that drives the deterioration of metabolic control over time begins early and may be present before the diagnosis of diabetes (1). In addition to advocating glycemic control to reduce microvascular complications, this document highlights obesity and prediabetes as underlying risk factors for the development of T2D and associated macrovascular complications...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28093700/postdiagnostic-use-of-%C3%AE-blockers-and-other-antihypertensive-drugs-and-the-risk-of-recurrence-and-mortality-in-head-and-neck-cancer-patients-an-observational-study-of-10-414-person-years-of-follow-up
#17
S-A Kim, H Moon, J-L Roh, S-B Kim, S-H Choi, S Y Nam, S Y Kim
INTRODUCTION: Growing evidence indicates that norepinephrine promotes cancer growth and metastasis whereas β-blockers decrease these risks. This study aimed to examine the clinical impact of β-blockers and other hypertensive drugs on disease recurrence and survival in patients with head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: This study analyzed a cohort of 1274 consecutive patients who received definitive treatments for previously untreated HNSCC at our tertiary referral center between January 2001 and December 2012...
January 16, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28093466/effects-of-sacubitril-valsartan-versus-olmesartan-on-central-hemodynamics-in-the-elderly-with-systolic-hypertension-the-parameter-study
#18
Bryan Williams, John R Cockcroft, Kazuomi Kario, Dion H Zappe, Patrick C Brunel, Qian Wang, Weinong Guo
Effective treatment of systolic hypertension in elderly patients remains a major therapeutic challenge. A multicenter, double-blind, randomized controlled trial with sacubitril/valsartan (LCZ696), a first-in-class angiotensin receptor neprilysin inhibitor, was conducted to determine its effects versus olmesartan (angiotensin receptor blocker) on central aortic pressures, in elderly patients (aged ≥60 years) with systolic hypertension and pulse pressure >60 mm Hg, indicative of arterial stiffness. Patients (n=454; mean age, 67...
January 16, 2017: Hypertension
https://www.readbyqxmd.com/read/28091909/modes-of-hypotensive-action-of-dihydroquercetin-in-arterial-hypertension
#19
M B Plotnikov, O I Aliev, A V Sidekhmenova, A Yu Shamanaev, A M Anishchenko, A V Nosarev, E A Pushkina
We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28091867/arterial-aortic-stiffness-in-patients-with-resistant-hypertension-from-assessment-to-treatment
#20
REVIEW
James E Sharman, Pierre Boutouyrie, Stéphane Laurent
PURPOSE OF REVIEW: The purpose of the review is to examine whether measurement of aortic stiffness could be especially value-adding for risk stratification and treatment among patients with resistant hypertension (RH). RECENT FINDINGS: Adverse arterial remodeling and increased aortic stiffness is associated with RH, and it may be of additional clinical benefit to measure aortic stiffness in these patients. However, there is insufficient evidence to determine whether aortic stiffness is excessively high relative to the level of blood pressure (BP) among people with RH...
January 2017: Current Hypertension Reports
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