keyword
MENU ▼
Read by QxMD icon Read
search

antihypertensive

keyword
https://www.readbyqxmd.com/read/28742547/celiprolol-a-unique-selective-adrenoceptor-modulator
#1
James J Nawarskas, Angela Cheng-Lai, William H Frishman
Celiprolol is a β-blocker with a unique pharmacologic profile: it is a β1-andrenoceptor antagonist with partial β2 agonist activity. Given this combination of effects, celiprolol may be better described as a elective adrenoreceptor modulator. It has antihypertensive and antianginal properties and is indicated for those uses in various countries around the world. In the United States, however, the proposed indication for this drug will be for the treatment of vascular type Ehlers-Danlos syndrome, a rare connective tissue isorder haracterized by fragile arterial structure and an increased risk of life-threatening vascular complications...
July 20, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/28741243/the-pharmacogenomic-and-metabolomic-predictors-of-ace-inhibitor-and-angiotensin-ii-receptor-blocker-effectiveness-and-safety
#2
Hania K Flaten, Andrew A Monte
Hypertension (HTN) is the most common chronic disease in the USA. Hypertensive patients frequently require repeat primary care visits to find an effective drug or drug combination to control their disease. Currently, patients are prescribed drugs for HTN based on race, age, and comorbidities and although the current guidelines are reasonable starting points for prescribing, 50% of hypertensive patients still fail to achieve target blood pressures. Despite numerous strategies to improve compliance, drug effectiveness, and optimization of initial drug choice, effectiveness has remained largely unchanged over the past two decades...
July 24, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28739634/management-of-severe-hypertension-in-the-newborn
#3
REVIEW
Janis M Dionne, Joseph T Flynn
Blood pressure is considered a vital sign, as values too low or too high can be related with serious morbidity and mortality. In neonates, normal blood pressure values undergo rapid changes, especially in premature infants, making the recognition of abnormal blood pressures more challenging. Severe hypertension can occur in neonates and infants and is a medical emergency, often manifesting with congestive heart failure or other life-threatening complications. The cause or risk factors for the hypertension can usually be identified and may guide management...
July 24, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28738507/gender-specific-associations-between-serum-isomers-of-perfluoroalkyl-substances-and-blood-pressure-among-chinese-isomers-of-c8-health-project-in-china
#4
Wen-Wen Bao, Zhengmin Min Qian, Sarah Dee Geiger, Echu Liu, Yimin Liu, Si-Quan Wang, Wayne R Lawrence, Bo-Yi Yang, Li-Wen Hu, Xiao-Wen Zeng, Guang-Hui Dong
Previous studies have demonstrated associations of perfluoroalkyl substances (PFASs), a group of highly persistent chemicals ubiquitous in wildlife and humans, with hypertension, but the relationships are mixed. Furthermore, academic literature on the relationship between isomers of PFASs and blood pressure (BP) and hypertension in populations from a higher pollution area is scant. We studied 1612 Chinese adults, ages 22-96years old, from Shenyang, China, utilizing high performance liquid chromatography-mass spectrometry to analyze isomers of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and other PFASs in blood serum...
July 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28738502/formulation-and-optimization-of-lacidipine-loaded-niosomal-gel-for-transdermal-delivery-in-vitro-characterization-and-in-vivo-activity
#5
Mohd Qumbar, Ameeduzzafar, Syed Sarim Imam, Javed Ali, Javed Ahmad, Asgar Ali
The aim of the present research work is to formulate lacidipine (LAC) loaded niosomes formulation for the management of hypertension by thin film hydration technique. The developed formulations were statistically optimized by four factors, three levels Box-Behnken design and were evaluated for vesicle size, entrapment efficiency, and flux. The optimized LAC niosomes was further evaluated for permeation depth by confocal laser scanning microscopy (CLSM) and converted to gel formulation. Further, the optimized LAC niosomes gel was evaluated for ex-vivo permeation study, skin irritation study, stability study and pharmacodynamics study...
July 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28737303/comparing-cardiovascular-risk-factors-disease-and-treatment-in-participants-with-rheumatoid-arthritis-and-without-arthritis-in-a-population-based-stud
#6
N O'Driscoll, N Kennedy, S Amjum, A Fraser, A Hannigan
Rheumatoid Arthritis (RA) is associated with a significant increase in mortality compared to the general population, with cardiovascular disease (CVD) the leading cause of death. The aim of this study is to compare the prevalence and treatment of modifiable CV risk factors and history of CVD in those with RA and those without arthritis in Ireland. Data from the Irish Longitudinal Study on Ageing (TILDA), a population-representative cohort study of people in Ireland aged 50 or over, was used. Participants with RA (n=457) were twice as likely to be obese (OR 2...
May 10, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28736962/diagnosis-and-management-of-white-coat-hypertension-in-children-and-adolescents-a-midwest-pediatric-nephrology-consortium-study
#7
Yosuke Miyashita, Joseph T Flynn, Coral D Hanevold
Although the definition of white-coat hypertension (WCH) in children and adolescents is clearly defined, little is known about how this condition is actually approached clinically. To better understand the contemporary approach to the diagnosis and management of WCH in pediatric patients, the authors surveyed the membership of the Midwest Pediatric Nephrology Consortium. Seventy-four faculty pediatric nephrologists responded to the survey. The survey results demonstrated uniformity in diagnosing WCH, including ambulatory blood pressure monitoring use in 93% of the respondents and a 75% adherence rate according to the 2014 American Heart Association scientific statement on pediatric ambulatory blood pressure monitoring...
July 23, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28736560/nonparallel-progression-of-left-ventricular-structure-and-function-in-long-term-peritoneal-dialysis-patients
#8
Qiuhong Shi, Jing Zhu, Sheng Feng, Huaying Shen, Jianchang Chen, Kai Song
BACKGROUND/AIMS: Left ventricular hypertrophy and dysfunction are key cardiovascular risk factors of patients on peritoneal dialysis (PD). The purpose of this study was to investigate the dynamic changes of left ventricular (LV) structure and function in patients on long-term PD. METHODS: Patients who underwent PD catheter insertions from January 2010 to December 2012 in our PD center were enrolled into this study. Cardiac structure and function of those patients were determined by echocardiography (4 times) at 12-month intervals...
June 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28736381/-efficacy-of-acei-in-the-treatment-of-hypertension-and-the-effect-of-secondary-prevention-in-patients-complicated-with-coronary-heart-disease-and-stroke
#9
Yang Li, Jun-Fa Liu, Ya-Feng Hao, Xue-Zhi Wang
OBJECTIVE: To investigate the efficacy of ACEI drugs in the treatment of hypertension patients and the effect of two levels of prevention of hypertension complicated with coronary heart disease and stroke. METHDOS: 210 cases of hypertension patients in our hospital from January 2012 to December 2015 were randomly divided into experimental group and control group, 105 cases in each group. According to the conventional symptomatic treatment, the experimental group was given lisinopril treatment, while control group was given the captopril treatment...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28735987/estimated-nephron-number-of-the-donor-kidney-impact-on-allograft-kidney-outcomes
#10
T Schachtner, P Reinke
BACKGROUND: Low birth weights have been associated with a reduction in nephron number with compensatory hypertrophy of existing glomeruli. The impact of donor birth weight as an estimate of nephron number on allograft function, however, has not been examined. METHODS: We collected donor birth weight, kidney weight, and volume from 91 living kidney donor-recipient pairs before nephrectomy and after 12, 36, and 60 months. Nephron number was calculated from donor birth weight and age...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735892/clinical-and-echocardiographic-correlates-of-left-atrial-function-index-the-framingham-offspring-study
#11
Mayank Sardana, Gregory Nah, Connie W Tsao, Adedotun A Ogunsua, Eric Vittinghoff, Randell C Thomas, Susan Cheng, Aditya Vaze, Jayashri R Aragam, Gary F Mitchell, Emelia J Benjamin, Ramachandran S Vasan, Gerard P Aurigemma, Nelson B Schiller, David D McManus, Nisha I Parikh
BACKGROUND: Left atrial (LA) remodeling is a predictor of cardiovascular disease (CVD). We performed measurement of the LA function index (LAFI), a composite measure of LA structure and function, in a community-based cohort and here report the distribution and cross-sectional correlates of LAFI. METHODS: In 1,719 Framingham Offspring Study participants (54% women, mean age 66 ± 9 years), we derived LAFI from the LA emptying fraction, left ventricular (LV) outflow tract velocity time integral, and indexed maximal LA volume...
July 20, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28734791/association-between-nocturnal-blood-pressure-variation-and-wake-up-ischemic-stroke
#12
Hyuk Sung Kwon, Ji Young Kim, Hojin Choi, Seok Joon Lee, Seong-Ho Koh, Young Joo Lee, Hyun Young Kim, Hee-Tae Kim, Juhan Kim, Young Seo Kim
Ischemic stroke during nocturnal sleep, known as wake-up stroke (WUS), has been reported to have more severe symptoms and worse outcomes than non-WUS. However, studies on risk factors for WUS are scarce and the association between nocturnal blood pressure (BP) and WUS is unclear. In this study, we used ambulatory blood pressure monitoring (ABPM) to examine the association between WUS and variation in nocturnal BP. A total of 369 patients with ischemic stroke within one week were consecutively enrolled. ABPM was applied 1-2weeks after the ictus because of possible reactive increments of BP; antihypertensive medications were delayed until ABPM...
July 19, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28733880/effect-of-asiatic-acid-on-the-ang-ii-at1r-nadph-oxidase-nf-%C3%AE%C2%BAb-pathway-in-renovascular-hypertensive-rats
#13
Putcharawipa Maneesai, Sarawoot Bunbupha, Upa Kukongviriyapan, Laddawan Senggunprai, Veerapol Kukongviriyapan, Parichat Prachaney, Poungrat Pakdeechote
Asiatic acid, a triterpenoid compound derived from Centella asiatica, has been demonstrated to have antioxidant and anti-inflammatory effects. The present study evaluated the effects of asiatic acid on hemodynamic alterations, renin-angiotensin system (RAS), oxidative stress, and inflammation in 2K-1C hypertensive rats. Renovascular hypertension was induced in male Sprague-Dawley rats and treated with vehicle, asiatic acid (30 mg/kg/day), or captopril (5 mg/kg/day) for 4 weeks. We observed that 2K-1C hypertensive rats exhibited hemodynamic alterations such as high blood pressure, heart rate, hindlimb vascular resistance, and low hindlimb blood flow...
July 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28733751/evaluation-of-the-safety-and-efficacy-of-metoprolol-infusion-for-children-and-adolescents-with-hypertensive-crises-a-retrospective-case-series
#14
Rola Saqan, Hanan Thiabat
BACKGROUND: Acute severe hypertension occurs infrequently in pediatric patients and, consequently, data on the efficacy and safety of most antihypertensive agents, as well as the adverse events associated with these agents, are very limited in this population. In this case series, we evaluated the use of metoprolol infusion in children with hypertensive emergencies. METHODS: The study population comprised children younger than 18 years who had been admitted to the pediatric intensive care unit at King Abdullah University Hospital with blood pressure above the 99th percentile for age, height, and sex and who were symptomatic at the time of presentation...
July 21, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28733707/angiotensin-ii-type-1-receptor-blockers-inhibit-kat-ii-activity-in-the-brain-its-possible-clinical-applications
#15
Izabela Zakrocka, Katarzyna M Targowska-Duda, Artur Wnorowski, Tomasz Kocki, Krzysztof Jóźwiak, Waldemar A Turski
Angiotensin II receptor blockers (ARBs) are one of the most frequently recommended antihypertensive drugs. Apart from their activity towards the circulatory system, ARBs also penetrate the blood-brain barrier and display neuroprotective effects. Kynurenic acid (KYNA) is an endogenous metabolite of tryptophan produced by kynurenine aminotransferase II (KAT II) in the brain. Antagonism towards all ionotropic glutamate (GLU) receptors is the main mechanism of KYNA action. An elevated brain level of KYNA is linked with memory impairment and psychotic symptoms...
July 21, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28733551/antihypertensive-drug-use-and-breast-cancer-risk-a-meta-analysis-of-observational-studies
#16
Haibo Ni, Qin Rui, Xiaojue Zhu, Zhenquan Yu, Rong Gao, Huixiang Liu
We conducted a meta-analysis of observational studies to examine the hypothesized association between breast cancer and antihypertensive drug (AHT) use. Fixed- or random- effect models were used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs) for all AHTs and individual classes (i.e., angiotensin-converting enzyme inhibitors, [ACEi]; angiotensin-receptor blockers, [ARBs]; calcium channel blockers, [CCBs]; beta-blockers, [BBs], and diuretics). Twenty-one studies with 3,116,266 participants were included...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733135/centrally-mediated-cardiovascular-actions-of-the-angiotensin-ii-type-2-receptor
#17
REVIEW
U Muscha Steckelings, Annette de Kloet, Colin Sumners
Sustained increases in the activity of the sympathetic neural pathways that exit the brain and which increase blood pressure (BP) are a major underlying factor in resistant hypertension. Recently available information on the occurrence of angiotensin II type 2 receptors (AT2Rs) within or adjacent to brain cardiovascular control centers is consistent with findings that stimulation of these receptors lowers BP, particularly during hypertension of neurogenic origin. Until recently brain AT2R had not been considered by many to play a role in the central control of BP...
July 18, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28731439/antihypertensive-treatment-is-associated-with-mri-derived-markers-of-neurodegeneration-and-impaired-cognition-a-propensity-weighted-cohort-study
#18
Jodi D Edwards, Joel Ramirez, Brandy L Callahan, Sheldon W Tobe, Paul Oh, Courtney Berezuk, Krista Lanctôt, Walter Swardfager, Sean Nestor, Alexander Kiss, Stephen Strother, Sandra E Black
BACKGROUND: Hypertension is an important risk factor for Alzheimer's disease (AD) and cerebral small vessel disease. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are common anti-hypertensive treatments, but have differential effects on cortical amyloid. OBJECTIVE: The objective of this study was to evaluate associations between anti-hypertensive treatment, brain volume, and cognition, using a propensity-weighted analysis to account for confounding by indication...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731289/current-status-of-achieving-blood-pressure-target-and-its-clinical-correlates-in-japanese-type-2-diabetes
#19
Hiroki Yokoyama, Shin-Ichi Araki, Koichi Kawai, Koichi Hirao, Yoshio Kurihara, Hiroaki Seino, Hiroshi Takamura, Hidekatsu Sugimoto, Akira Okada, Hiroshi Maegawa
AIMS/INTRODUCTION: To investigate the current status of achieved blood pressure levels in association with the number of antihypertensive drug classes as of 2013, and to explore the clinical correlates with achievement of target blood pressure in a large-scale cohort of Japanese subjects with type 2 diabetes. MATERIALS AND METHODS: A nationwide survey was conducted including 12,811 subjects with type 2 diabetes. Subjects were divided by achieved blood pressure, <130/80 or 140/90 mmHg, and the number of drug classes taken...
July 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28730828/the-effect-of-hypertension-on-adult-hippocampal-neurogenesis-in-young-adult-spontaneously-hypertensive-rats-and-dahl-rats
#20
A Pistikova, H Brozka, M Bencze, D Radostova, K Vales, A Stuchlik
The dentate gyrus of the hippocampus is one of the few places in the brain where neurogenesis occurs in adulthood. Nowadays, an increasing number of children and young adults are affected by hypertension, one of the factors in the development of cerebrovascular diseases and age-related cognitive deficits. Since these cognitive deficits are often hippocampus-dependent, it is possible that hypertension exerts this effect via decreasing adult neurogenesis which has been shown to be essential for a range of cognitive tasks...
July 18, 2017: Physiological Research
keyword
keyword
77835
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"