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Aspirin with preeclampsia

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https://www.readbyqxmd.com/read/29229321/the-role-of-aspirin-heparin-and-other-interventions-in-the-prevention-and-treatment-of-fetal-growth-restriction
#1
REVIEW
Katie M Groom, Anna L David
Fetal growth restriction and related placental pathologies such as preeclampsia, stillbirth, and placental abruption are believed to arise in early pregnancy when inadequate remodeling of the maternal spiral arteries leads to persistent high-resistance and low-flow uteroplacental circulation. The consequent placental ischaemia, reperfusion injury, and oxidative stress are associated with an imbalance in angiogenic/antiangiogenic factors. Many interventions have centered on the prevention and/or treatment of preeclampsia with results pertaining to fetal growth restriction and small-for-gestational-age pregnancy often included as secondary outcomes because of the common pathophysiology...
December 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215518/angiogenic-factor-profiles-in-pregnant-women-with-a-history-of-early-onset-severe-preeclampsia-receiving-low-molecular-weight-heparin-prophylaxis
#2
Edouard Lecarpentier, Jean Christophe Gris, Eva Cochery-Nouvellon, Erick Mercier, Cyril Touboul, Ravi Thadhani, S Ananth Karumanchi, Bassam Haddad
OBJECTIVE: To evaluate whether daily low-molecular-weight (LMW) heparin prophylaxis during pregnancy alters profile of circulating angiogenic factors that have been linked with the pathogenesis of preeclampsia and fetal growth restriction. METHODS: This is a planned ancillary study of the Heparin-Preeclampsia trial, a randomized trial in pregnant women with a history of severe early-onset preeclampsia (less than 34 weeks of gestation). In the parent study, all women were treated with aspirin and then randomized to receive LMW heparin or aspirin alone...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29179589/aspirin-or-heparin-or-both-in-the-treatment-of-recurrent-spontaneous-abortion-in-women-with-antiphospholipid-antibody-syndrome-a-meta-analysis-of-randomized-controlled-trials
#3
Chang Lu, Yong Liu, Hai-Li Jiang
OBJECTIVE: This study was designed to evaluate the efficacy of aspirin or heparin or both in the treatment for recurrent spontaneous abortion (RSA) in women with antiphospholipid antibody syndrome (APS). METHODS: Systematic searches for randomized clinical trials (RCTs) evaluating on live birth and preterm delivery, preeclampsia, intrauterine growth restriction, gestational diabetes, bleeding of RSA with APS patients receiving aspirin and heparin therapy were carried out, from PubMed, EMBASE, ScienceDirect and CNKI...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29138036/aspirin-for-the-prevention-of-preterm-and-term-preeclampsia-systematic-review-and-meta-analysis
#4
Stephanie Roberge, Emmanuel Bujold, Kypros H Nicolaides
BACKGROUND: Meta-analyses of randomized controlled trials have reported contradictory results concerning the effect of aspirin in the prevention of preeclampsia both in terms of the gestational age at the onset of treatment and the dose of the drug. The controversy may be resolved by a meta-analysis that includes several recently published trials and particularly the large Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention (ASPRE) trial and by examining whether there is a difference of the effect of aspirin on preterm vs...
November 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29079078/maternal-characteristics-for-the-prediction-of-preeclampsia-in-nulliparous-women-the-great-obstetrical-syndromes-gos-study
#5
Amélie Boutin, Cédric Gasse, Suzanne Demers, Yves Giguère, Amélie Tétu, Emmanuel Bujold
OBJECTIVE: Low-dose aspirin started in early pregnancy significantly reduces the risk of preeclampsia (PE) in high-risk women, especially preterm PE. This study aimed to evaluate the influence of maternal characteristics on the risk of PE in nulliparous women. METHODS: The Great Obstetrical Syndromes (GOS) study recruited nulliparous women with singleton pregnancies at 11 to 13 weeks. The following maternal characteristics were collected: age, BMI, ethnicity, chronic diseases, smoking, and assisted reproductive technologies...
October 24, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29055792/the-effect-of-acetyl-salicylic-acid-aspirin-on-trophoblast-endothelial-interaction-in-vitro
#6
Bei Xu, Renuka Shanmugalingam, Katrina Chau, Suzanne Pears, Annemarie Hennessy, Angela Makris
Early administration of low dose acetyl salicylic acid (Aspirin) in high risk women reduces the risk of early onset preeclampsia. This study aims to investigate the effect of aspirin on trophoblast integration and the its effect on angiogenic and invasive pathways in an in-vitro model of preeclampsia. Red fluorescent-labeled human uterine myometrial microvascular endothelial cells (UtMVECs) were seeded on matrigel to form endothelial networks. Green fluorescent-labeled trophoblastic HTR-8/SVneo cells were co-cultured with the endothelial networks with/without TNF-a (0...
October 18, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29039130/aspirin-for-prevention-of-preeclampsia
#7
A Atallah, E Lecarpentier, F Goffinet, M Doret-Dion, P Gaucherand, V Tsatsaris
Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications. The indications for the use of aspirin during pregnancy are, however, the subject of much controversy. Since the first evidence of the obstetric efficacy of aspirin in 1985, numerous studies have tried to determine the effect of low-dose aspirin on the incidence of preeclampsia, with very controversial results. Large meta-analyses including individual patient data have demonstrated that aspirin is effective in preventing preeclampsia in high-risk patients, mainly those with a history of preeclampsia...
November 2017: Drugs
https://www.readbyqxmd.com/read/29034064/personalized-therapy-against-preeclampsia-by-replenishing-placental-protein-13-pp13-targeted-to-patients-with-impaired-pp13-molecule-or-function
#8
REVIEW
Hamutal Meiri, George Osol, Irene Cetin, Sveinbjörn Gizurarson, Berthold Huppertz
Hypertensive disorders affect about one third of all people aged 20 and above, and are treated with anti-hypertensive drugs. Preeclampsia (PE) is one form of such disorders that only develops during pregnancy. It affects ten million pregnant women globally and additionally causes fetal loss and major newborn disabilities. The syndrome's origin is multifactorial, and anti-hypertensive drugs are ineffective in treating it. Biomarkers are helpful for predict its development. Generic drugs, such as low dose aspirin, were proven effective in preventing preterm PE...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28974130/impact-of-early-supplementation-with-low-dose-aspirin-on-functional-first-trimester-parameters-in-low-risk-pregnancies
#9
Mona Elena Zvanca, Mihaela Bot, Dan Radu, Nicoleta Radu, Aida Petca
INTRODUCTION: There is recent evidence that prophylaxis with 150 mg of aspirin given before 14-16 weeks significantly reduces preeclampsia rates and may improve pregnancy outcome. We conducted an observational study that investigates the effect of low-dose aspirin initiated early in pregnancy or in preconception on functional parameters assessed at 11-14 weeks. MATERIALS AND METHODS: We have retrospectively selected 128 pregnant women that presented for the first trimester screening for aneuploidies between 11(+0) and 13(+6) weeks of gestation and received low-dose aspirin before 14 weeks...
October 16, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28917612/thyroid-stimulating-hormone-anti-thyroid-antibodies-and-pregnancy-outcomes
#10
Torie C Plowden, Enrique F Schisterman, Lindsey A Sjaarda, Neil J Perkins, Robert Silver, Rose Radin, Keewan Kim, Noya Galai, Alan H DeCherney, Sunni L Mumford
BACKGROUND: Overt thyroid dysfunction has been associated with adverse obstetric outcomes. However, less is known regarding subclinical hypothyroidism or thyroid autoimmunity and their relationship to pregnancy complications. OBJECTIVE: The purpose of this study was to examine the association between prepregnancy anti-thyroid antibodies and subclinical hypothyroidism and preterm delivery, gestational diabetes mellitus, and preeclampsia. STUDY DESIGN: We conducted a secondary analysis of a prospective cohort of 18- to 40-year-old women with 1-2 previous pregnancy losses (n=1193) who participated in a multicenter randomized, placebo-controlled trial of low-dose aspirin...
September 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28915160/current-insights-in-obstetric-antiphospholipid-syndrome
#11
Karen Schreiber, Massimo Radin, Savino Sciascia
PURPOSE OF REVIEW: Antiphospholipid syndrome (APS) is defined as the association of thrombotic events and/or obstetric morbidity in patients persistently positive for antiphospholipid antibodies (aPL). In this review, we will highlight the most important clinical presentations of APS with a focus on the obstetric morbidity, the current management strategies and the outlook for the future. RECENT FINDINGS: The use of aspirin and heparin has improved the pregnancy outcome in obstetric APS and approximately 70% of pregnant women with APS have a successful pregnancy outcome...
December 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28888591/aspirin-for-evidence-based-preeclampsia-prevention-trial-influence-of-compliance-on-beneficial-effect-of-aspirin-in-prevention-of-preterm-preeclampsia
#12
David Wright, Liona C Poon, Daniel L Rolnik, Argyro Syngelaki, Juan Luis Delgado, Denisa Vojtassakova, Mercedes de Alvarado, Evgenia Kapeti, Anoop Rehal, Andrea Pazos, Ilma Floriana Carbone, Vivien Dutemeyer, Walter Plasencia, Nikos Papantoniou, Kypros H Nicolaides
BACKGROUND: The Aspirin for Evidence-Based Preeclampsia Prevention trial was a multicenter study in women with singleton pregnancies. Screening was carried out at 11-13 weeks' gestation with an algorithm that combines maternal factors and biomarkers (mean arterial pressure, uterine artery pulsatility index, and maternal serum pregnancy-associated plasma protein A and placental growth factor). Those with an estimated risk for preterm preeclampsia of >1 in 100 were invited to participate in a double-blind trial of aspirin (150 mg/d) vs placebo from 11-14 until 36 weeks' gestation...
September 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28887883/early-screening-and-prevention-of-preterm-pre-eclampsia-with-aspirin-time-for-clinical-implementation
#13
EDITORIAL
D L Rolnik, N O'Gorman, S Roberge, E Bujold, J Hyett, S Uzan, M Beaufils, F da Silva Costa
No abstract text is available yet for this article.
November 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28851242/evaluation-of-agreement-of-placental-growth-factor-plgf-tests-and-the-soluble-fms-like-tyrosine-kinase-1-sflt-1-plgf-ratio-comparison-of-predictive-accuracy-for-pre-eclampsia-and-relation-to-uterine-artery-doppler-and-response-to-aspirin
#14
Kate Navaratnam, Patricia Abreu, Helen Clarke, Andrea Jorgensen, Ana Alfirevic, Zarko Alfirevic
OBJECTIVES: The objective of this study is to evaluate agreement between PlGF and sFlt-1/PlGF ratio tests and compare their predictive accuracy for pre-eclampsia in high-risk women. Also, to examine for associations of abnormal PlGF or sFlt-1/PlGF ratio with abnormal uterine artery Doppler and platelet response to aspirin. METHODS: Prospective cohort study, 150 pregnant women at high risk of pre-eclampsia prescribed 75 mg aspirin daily. Uterine artery Dopplers were assessed at 20(+0)-23(+6) weeks...
September 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28846803/comprehensive-primary-prevention-of-cardiovascular-disease-in-women
#15
REVIEW
Suegene K Lee, Jay Khambhati, Tina Varghese, Eric P Stahl, Sonali Kumar, Pratik B Sandesara, Nanette K Wenger, Laurence S Sperling
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of mortality in women. Historically, medical research has focused on male patients, and subsequently, there has been decreased awareness of the burden of ASCVD in females until recent years. The biological differences between sexes and differences in societal expectations defined by gender roles contribute to gender differences in ASCVD risk factors. With these differing risk profiles, risk assessment, risk stratification, and primary preventive measures of ASCVD are different in women and men...
August 28, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28793357/preeclampsia
#16
José Geraldo Lopes Ramos, Nelson Sass, Sérgio Hofmeister Martins Costa
The authors review hypertensive disease during pregnancy with an academic and practical view, and using the best evidence available. This disease, which is the most important clinical disease in Brazilian pregnant women, may have its incidence reduced with prevention through the use of calcium and aspirin in pregnant women at risk. Previously, it was a disease that presented with hypertension with proteinuria, but it has now been classified with new clinical parameters besides proteinuria. Morbidity and mortality should be reduced in a continental country such as Brazil using protocols for the early treatment of complications by calculating severe outcomes in preeclampsia...
September 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28741785/aspre-trial-performance-of-screening-for-preterm-pre-eclampsia
#17
D L Rolnik, D Wright, L C Y Poon, A Syngelaki, N O'Gorman, C de Paco Matallana, R Akolekar, S Cicero, D Janga, M Singh, F S Molina, N Persico, J C Jani, W Plasencia, G Papaioannou, K Tenenbaum-Gavish, K H Nicolaides
OBJECTIVE: To examine the performance of screening for preterm and term pre-eclampsia (PE) in the study population participating in the ASPRE (Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention) trial. METHODS: This was a prospective first-trimester multicenter study on screening for preterm PE in 26 941 singleton pregnancies by means of an algorithm that combines maternal factors, mean arterial pressure, uterine artery pulsatility index and maternal serum pregnancy-associated plasma protein-A and placental growth factor at 11-13 weeks' gestation...
October 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28657417/aspirin-versus-placebo-in-pregnancies-at-high-risk-for-preterm-preeclampsia
#18
RANDOMIZED CONTROLLED TRIAL
Daniel L Rolnik, David Wright, Liona C Poon, Neil O'Gorman, Argyro Syngelaki, Catalina de Paco Matallana, Ranjit Akolekar, Simona Cicero, Deepa Janga, Mandeep Singh, Francisca S Molina, Nicola Persico, Jacques C Jani, Walter Plasencia, George Papaioannou, Kinneret Tenenbaum-Gavish, Hamutal Meiri, Sveinbjorn Gizurarson, Kate Maclagan, Kypros H Nicolaides
BACKGROUND: Preterm preeclampsia is an important cause of maternal and perinatal death and complications. It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia. METHODS: In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with singleton pregnancies who were at high risk for preterm preeclampsia to receive aspirin, at a dose of 150 mg per day, or placebo from 11 to 14 weeks of gestation until 36 weeks of gestation...
August 17, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28651448/adverse-pregnancy-outcomes-in-deliveries-prior-to-at-and-beyond-39-weeks-low-and-high-risk-women
#19
Hind N Moussa, Susan Hosseini Nasab, Farah H Amro, Jennifer Hoayek, Ziad A Haidar, Sean C Blackwell, Baha M Sibai
BACKGROUND: Hypertensive disorders are associated with maternal and neonatal complications. Though they are more common in women with history of prior preeclampsia, they can occur in uncomplicated pregnancies. OBJECTIVE: To determine the proportion of adverse pregnancy outcomes in deliveries prior to or at ≥39 weeks, in uncomplicated singleton nulliparous women (low-risk), as well as women with history of preeclampsia in a prior gestation (high-risk). STUDY DESIGN: This was a secondary analysis from the multicenter trials of low dose aspirin for preeclampsia prevention in low and high-risk pregnancies...
July 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28599894/impact-of-aspirin-on-fetal-growth-in-diabetic-pregnancies-according-to-white-classification
#20
RANDOMIZED CONTROLLED TRIAL
Katlynn Adkins, Amanda A Allshouse, Torri D Metz, Kent D Heyborne
BACKGROUND: Current US Preventive Services Task Force and other guidelines recommend low-dose aspirin for all pregnant women with pregestational diabetes mellitus to prevent preeclampsia and small-for-gestational-age birth. The Maternal-Fetal Medicine Units High-Risk Aspirin trial did not show a reduction in either preeclampsia or small-for-gestational-age birth in diabetic women. OBJECTIVE: Our objective was to reassess the impact of aspirin on fetal growth in diabetic pregnancies overall and according to White classification...
October 2017: American Journal of Obstetrics and Gynecology
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