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Aspirin in pregnancy

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https://www.readbyqxmd.com/read/29674206/using-extended-theory-of-planned-behavior-to-understand-aspirin-adherence-in-pregnant-women
#1
Chung-Ying Lin, Anders Broström, Per Nilsen, Amir H Pakpour
OBJECTIVE: To use the Theory of Planned Behavior (TPB) combined with action and coping planning plus global relationship with husband to explain the aspirin adherence in a sample of women with high-risk pregnancy. METHODS: A total of 535 Iranian women (mean age = 32.29 ± 4.98; year of marriage = 6.89 ± 3.61) completed the study. Each participant filled out several questionnaires on TPB (i.e., a widely applied theory describing how behaviors are influenced by beliefs, attitudes, perceived behavioral control and behavioral intentions), action planning, coping planning and relationship with husband at baseline...
April 6, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29656983/prophylaxis-and-treatment-of-foetal-growth-restriction
#2
REVIEW
Aamod Nawathe, Anna L David
Foetal growth restriction (FGR) and associated placental pathologies such as pre-eclampsia and stillbirth arise in early pregnancy when inadequate remodelling of maternal spiral arteries leads to persistent high-resistance low-flow uteroplacental circulation. Current interventions concentrate on targeting the placental ischaemia-reperfusion injury and oxidative stress associated with an imbalance in angiogenic/anti-angiogenic factors. Recent meta-analyses confirm that aspirin modestly reduces the risk for small-for-gestational-age pregnancy in high-risk women...
February 23, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29648647/a-prospective-study-of-physical-activity-and-fecundability-in-women-with-a-history-of-pregnancy-loss
#3
Lindsey M Russo, Brian W Whitcomb, Sunni L Mumford, Marquis Hawkins, Rose G Radin, Karen C Schliep, Robert M Silver, Neil J Perkins, Keewan Kim, Ukpebo R Omosigho, Daniel L Kuhr, Tiffany L Holland, Lindsey A Sjaarda, Enrique F Schisterman
STUDY QUESTION: Is physical activity (PA) associated with fecundability in women with a history of prior pregnancy loss? SUMMARY ANSWER: Higher fecundability was related to walking among overweight/obese women and to vigorous PA in women overall. WHAT IS KNOWN ALREADY: PA may influence fecundability through altered endocrine function. Studies evaluating this association have primarily utilized Internet-based recruitment and self-report for pregnancy assessment and have yielded conflicting results...
April 10, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29610265/preconception-blood-pressure-levels-and-reproductive-outcomes-in-a-prospective-cohort-of-women-attempting-pregnancy
#4
Carrie J Nobles, Pauline Mendola, Sunni L Mumford, Ashley I Naimi, Edwina H Yeung, Keewan Kim, Hyojun Park, Brian Wilcox, Robert M Silver, Neil J Perkins, Lindsey Sjaarda, Enrique F Schisterman
Elevated blood pressure in young adulthood is an early risk marker for cardiovascular disease. Despite a strong biological rationale, little research has evaluated whether incremental increases in preconception blood pressure have early consequences for reproductive health. We evaluated preconception blood pressure and fecundability, pregnancy loss, and live birth in the EAGeR trial (Effects of Aspirin on Gestational and Reproduction; 2007-2011), a randomized clinical trial of aspirin and reproductive outcomes among 1228 women attempting pregnancy with a history of pregnancy loss...
April 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29559482/giant-coronary-artery-aneurysm-at-autopsy
#5
Alicia Blackman, Wayne Mohammed
This case presents a woman in her early 20s who died after the sudden onset of chest pain. Five years earlier, she was investigated for a cardiac murmur during pregnancy and an echocardiogram revealed a 6.0×3.0 cm blood-filled sac compressing the left atrium and anterolateral aspect of the left ventricle with communication to the aortic root. She later had a CT scan of the chest with contrast, which showed aneurysmal dilatation of the left main coronary artery. She was placed on aspirin but defaulted from clinic 11 months post partum...
March 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29536574/comparison-of-diagnostic-accuracy-of-early-screening-for-pre-eclampsia-by-nice-guidelines-and-a-method-combining-maternal-factors-and-biomarkers-results-of-spree
#6
M Y Tan, D Wright, A Syngelaki, R Akolekar, S Cicero, D Janga, M Singh, E Greco, A Wright, K Maclagan, L C Poon, K H Nicolaides
OBJECTIVE: To test the hypothesis that the performance of first-trimester screening for pre-eclampsia (PE) by a method that uses Bayes' theorem to combine maternal factors with biomarkers is superior to that defined by current National Institute for Health and Care Excellence (NICE) guidelines. METHODS: This was a prospective multicenter study (screening program for pre-eclampsia (SPREE)) in seven National Health Service maternity hospitals in England, of women recruited between April and December 2016...
March 14, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29512784/transdermal-estrogen-gel-and-oral-aspirin-combination-therapy-improves-fertility-prognosis-via-the-promotion-of-endometrial-receptivity-in-moderate-to-severe-intrauterine-adhesion
#7
Yugang Chi, Ping He, Li Lei, Yi Lan, Jianguo Hu, Ying Meng, Lina Hu
Intrauterine adhesion (IUA) is one of the most common gynecological diseases in women of reproductive age. IUA, particularlyin moderate to severe forms, accounts for a large percentage of infertility cases. Clinically, the first‑line treatment strategy for IUA is transcervical resection of adhesion (TCRA), followed by adjuvant postoperative treatment. Estrogen is one of the classic chemotherapies used following TCRA and contributes to preventing re‑adhesion following surgery. However, estrogen has limited effects in promoting pregnancy, which is the ultimate goal for IUA management...
March 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29505771/aspirin-for-evidence-based-preeclampsia-prevention-trial-effect-of-aspirin-on-length-of-stay-in-the-neonatal-intensive-care-unit
#8
David Wright, Daniel L Rolnik, Argyro Syngelaki, Catalina de Paco Matallana, Mirian Machuca, Mercedes de Alvarado, Sofia Mastrodima, Min Yi Tan, Siobhan Shearing, Nicola Persico, Jacques C Jani, Walter Plasencia, George Papaioannou, Francisca S Molina, Liona C Poon, Kypros H Nicolaides
BACKGROUND: Preeclampsia is a major pregnancy complication with adverse short- and long-term implications for both the mother and baby. Screening for preeclampsia at 11-13 weeks' gestation by a combination of maternal demographic characteristics and medical history with measurements of biomarkers can identify about 75% of women that develop preterm-preeclampsia with delivery at <37 weeks' gestation and 90% of those with early-preeclampsia at <32 weeks, at a screen positive rate of 10%...
March 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29465714/preeclampsia-induced-by-storkhead-box-1-overexpression-in-mice-induces-intrauterine-growth-restriction-abnormal-ultrasonography-and-blood-oxygenation-level-dependent-mri-signatures
#9
Hélène Collinot, Carmen Marchiol, Isabelle Lagoutte, Franck Lager, Nathalie Siauve, Gwennhael Autret, Daniel Balvay, Gilles Renault, Laurent J Salomon, Daniel Vaiman
BACKGROUND: Preeclampsia is a major hypertensive disease caused by pregnancy, inducing proteinuria and increased blood pressure starting from the second half of pregnancy (early preeclampsia) or near the end of pregnancy (late preeclampsia). Pre-symptomatic diagnosis would allow for therapeutic interventions, such as with low-dose aspirin. Among non-invasive methods to explore organ physiology, Doppler ultrasonography (US) and functional blood oxygenation level-dependent (BOLD) MRI (which do not need radioactive contrast agents such as gadolinium) can be used in pregnant women...
February 20, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29447091/obesity-in-pregnancy-a-comparison-of-four-national-guidelines
#10
Dana Vitner, Kristin Harris, Cynthia Maxwell, Dan Farine
BACKGROUND: Obesity in pregnancy has become one of the most important challenges in obstetrical care given its prevalence and potential adverse impact on both mother and fetus. The primary objective of this descriptive review is to identify common themes and distinctions within the current recommendations for maternal obesity in the most updated version of four published national guidelines. METHODS: We reviewed the following guidelines for obesity in pregnancy: American College of Obstetricians and Gynecologists (ACOG) 2015, Royal Australian and New Zealand College of Obstetricians and Gynecologists (RANZCOG) 2013, Royal College of Obstetrics and Gynecology (RCOG) 2010, and Society of Obstetrics and Gynecologists of Canada (SOGC) 2010...
February 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29442407/prediction-and-prevention-of-pre-eclampsia-in-asian-subpopulation
#11
REVIEW
Tuangsit Wataganara, Jarunee Leetheeragul, Suchittra Pongprasobchai, Anuwat Sutantawibul, Chayawat Phatihattakorn, Surasak Angsuwathana
The benefit of the early administration of aspirin to reduce preterm pre-eclampsia among screened positive European women from multivariate algorithmic approach (ASPRE trial) has opened an intense debate on the feasibility of universal screening. This review aims to assess the new perspectives in the combined screening of pre-eclampsia in the first trimester of pregnancy and the chances for prevention using low-dose aspirin with special emphasis on the particularities of the Asian population. PubMed, CENTRAL and Embase databases were searched from inception until 15 November 2017 using combinations of the search terms: preeclampsia, Asian, prenatal screening, early prediction, ultrasonography, pregnancy, biomarker, mean arterial pressure, soluble fms-like tyrosine kinase-1, placental growth factor, pregnancy-associated plasma protein-A and pulsatility index...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29439623/aspirin-ameliorates-preeclampsia-induced-by-a-peroxisome-proliferator-activated-receptor-antagonist
#12
Chunhua Zhang, Yong Zhu, Yan Shen, Changting Zuo
Reduced expression of peroxisome proliferator-activated receptor γ (PPARγ) in the placenta was found in women with severe preeclampsia. Aspirin is currently used as the only recommended intervention in pregnancies for prevention of preeclampsia. In this study, we aimed to investigate whether aspirin could attenuate PPARγ inhibitor (T0070907)-induced preeclampsia and its impact on expression of PPARγ. Sixty Sprague-Dawley rats were used and treated with different doses of aspirin (0, 1, and 1.5 mg/kg) in presence or absence of PPARγ antagonist, T0070907...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29433703/low-dose-aspirin-for-the-prevention-of-preeclampsia
#13
Heidi Collins Fantasia
Preeclampsia is a hypertensive disorder specific to pregnancy that remains a significant cause of maternal and neonatal morbidity and mortality. Identification of women who are most at risk for preeclampsia is imprecise. Because of the potential negative health consequences of preeclampsia for women and newborns and the lack of effective screening mechanisms preventing preeclampsia is an important component of prenatal care. Researchers have documented that low-dose aspirin, taken daily after the first trimester, can decrease the development of preeclampsia and reduce the incidence of preterm birth and birth of small-for-gestational-age infants...
February 2018: Nursing for Women's Health
https://www.readbyqxmd.com/read/29428315/association-of-testosterone-and-antim%C3%A3-llerian-hormone-with-time-to-pregnancy-and-pregnancy-loss-in-fecund-women-attempting-pregnancy
#14
Lindsey A Sjaarda, Sunni L Mumford, Daniel L Kuhr, Tiffany L Holland, Robert M Silver, Torie C Plowden, Neil J Perkins, Enrique F Schisterman
OBJECTIVE: To examine whether higher T and/or antimüllerian hormone (AMH) was associated with anovulation, time to pregnancy (TTP), or pregnancy loss risk among healthy, fecund women without diagnosed polycystic ovary syndrome. DESIGN: Prospective cohort study conducted as a secondary analysis from the Effects of Aspirin in Gestation and Reproduction randomized trial. SETTING: University medical centers. PATIENT(S): A total of 1,198 healthy, eumenorrheic women aged 18-40 years attempting spontaneous pregnancy with one to two prior pregnancy losses were included...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29422214/evidence-based-national-guidelines-for-the-management-of-suspected-fetal-growth-restriction-comparison-consensus-and-controversy
#15
REVIEW
Lesley M McCowan, Francesc Figueras, Ngaire H Anderson
Small for gestational age is usually defined as an infant with a birthweight <10th centile for a population or customized standard. Fetal growth restriction refers to a fetus that has failed to reach its biological growth potential because of placental dysfunction. Small-for-gestational-age babies make up 28-45% of nonanomalous stillbirths, and have a higher chance of neurodevelopmental delay, childhood and adult obesity, and metabolic disease. The majority of small-for-gestational-age babies are not recognized before birth...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29387829/the-effect-of-vitamin-e-and-aspirin-on-the-uterine-artery-blood-flow-in-women-with-recurrent-abortion-a-single-blind-randomized-controlled-trial
#16
Elaheh Mesdaghinia, Behnaz Mohammad-Ebrahimi, Fatemeh Foroozanfard, Hamid Reza Banafshe
Background: Recurrent spontaneous abortion has high incidence rate. The etiology is unknown in 30-40%. However high uterine artery resistance is accounted as one of the recurrent abortion reasons. Objective: The objective of the current study was to determine the impacts of vitamin E and aspirin on the uterine artery blood flow in women having recurrent abortions due to impaired uterine blood flow. Materials and Methods: This randomized clinical trial was conducted on 99 women having uterine pulsatility index (PI) more than 2...
October 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29381473/low-dose-aspirin-for-preventing-fetal-growth-restriction-a-randomised-trial
#17
Anca-Daniela Stanescu, Roxana Banica, Romina-Marina Sima, Liana Ples
The purpose of this study was to investigate when in pregnancy to stop the administration of low dose aspirin (150 mg/daily) so as to prevent fetal growth restriction (FGR) A randomised, placebo-controlled study was designed. The patients were all screened positive using the Fetal Medicine Foundation (FMF) early pregnancy screening test for preeclampsia (PE) and FGR prediction. One hundred and fifty patients were enrolled and divided equally into three groups: A - the controls who received placebo treatment; B - those who received aspirin till 32 weeks of gestation and C - those who received aspirin till 36 weeks of gestation...
January 30, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29371328/role-of-combined-prenatal-and-postnatal-paracetamol-exposure-on-asthma-development-the-czech-elspac-study
#18
Pavel Piler, Jan Švancara, Lubomír Kukla, Hynek Pikhart
BACKGROUND: Prenatal and postnatal paracetamol exposure has been previously associated with asthma development in childhood in Western populations. We explore the association between prenatal and postnatal paracetamol exposure and asthma development in a Central European sample of Czech children, suggesting possible additive effect of the both exposures. Furthermore, since aspirin had been used more widely during study data collection in Central Europe, we also compared asthma development for those exposed to paracetamol and aspirin...
January 25, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29367581/pre-eclampsia-and-eclampsia-an-update-on-the-pharmacological-treatment-applied-in-portugal
#19
REVIEW
Gonçalo Miguel Peres, Melissa Mariana, Elisa Cairrão
Pre-eclampsia and eclampsia are two hypertensive disorders of pregnancy, considered major causes of maternal and perinatal death worldwide. Pre-eclampsia is a multisystemic disease characterized by the development of hypertension after 20 weeks of gestation, with the presence of proteinuria or, in its absence, of signs or symptoms indicative of target organ injury. Eclampsia represents the consequence of brain injuries caused by pre-eclampsia. The correct diagnosis and classification of the disease are essential, since the therapies for the mild and severe forms of pre-eclampsia are different...
January 17, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29366353/effect-of-early-use-of-low-dose-aspirin-therapy-on-late-onset-preeclampsia
#20
Patrick G Lan, Adrian G Gillin, Marilena Pelosi, Jane Tooher, Puk Sandager, Jon Hyett
OBJECTIVE: Low-dose aspirin (LDA) therapy has been found to be effective in preventing the development of early-onset preeclampsia. However, its effect on late-onset preeclampsia has not been described. Our study was aimed at determining if LDA therapy prescribed from early in pregnancy modified the severity of late-onset preeclampsia. MATERIALS AND METHODS: A retrospective analysis of all women who were screened for early-onset preeclampsia at 11-13+6 weeks' gestation between April 2012 and October 2014 at our institution, and who subsequently developed late-onset preeclampsia...
January 24, 2018: Journal of Maternal-fetal & Neonatal Medicine
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