Georgina Perez Garcia, Gissel M Perez, Rita De Gasperi, Miguel A Gama Sosa, Alena Otero-Pagan, Rania Abutarboush, Usmah Kawoos, Jonathan K Statz, Jacob Patterson, Carolyn W Zhu, Patrick R Hof, David G Cook, Stephen T Ahlers, Gregory A Elder
Many military veterans who experienced blast-related traumatic brain injuries (TBIs) in the conflicts in Iraq and Afghanistan suffer from chronic cognitive and mental health problems, including post-traumatic stress disorder (PTSD). Male rats subjected to repetitive low-level blast exposure develop chronic cognitive and PTSD-related traits that develop in a delayed manner. Ketamine has received attention as a treatment for refractory depression and PTSD. (2R,6R)-hydroxynorketamine [(2R,6R)-HNK] is a ketamine metabolite that exerts rapid antidepressant actions...
2023: Neurotrauma reports