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Cytokines and Angiogenesis

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https://www.readbyqxmd.com/read/28337277/effect-and-mechanism-of-shed-on-ulcer-wound-healing-in-sprague-dawley-rat-models-with-diabetic-ulcer
#1
Yue Lv, Lihong Ge, Yuming Zhao
To evaluate the effect of stem cells from human exfoliated deciduous teeth (SHED) upon the ulcer wound healing and evaluate the mechanism underlying the role of SHED in Sprague-Dawley rat models with diabetic foot ulcer. The rats with diabetic ulcer were established and treated with SHED, mesenchymal stem cell (MSC) and PBS, respectively. The expression of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), matrix metalloproteinase-2 (MMP-2) and MMP9 at both protein and RNA levels was quantitatively measured...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28335793/thrombus-leukocytes-exhibit-more-endothelial-cell-specific-angiogenic-markers-than-peripheral-blood-leukocytes-do-in-acute-coronary-syndrome-patients-suggesting-a-possibility-of-trans-differentiation-a-comprehensive-database-mining-study
#2
Hangfei Fu, Nish Vadalia, Eric R Xue, Candice Johnson, Luqiao Wang, William Y Yang, Claudette Sanchez, Jun Nelson, Qian Chen, Eric T Choi, Jian-Xing Ma, Jun Yu, Hong Wang, Xiaofeng Yang
BACKGROUND: Current angiogenic therapies for cancers and cardiovascular diseases have not yet achieved expected benefits, which reflects the need for improved understanding of angiogenesis. In this study, we focused on solving the problem of whether tissues have different angiogenic potentials (APs) in physiological conditions and how angiogenesis is regulated in various disease conditions. METHODS: In healthy and diseased human and mouse tissues, we profiled the expression of 163 angiogenic genes, including transcription regulators (TRs), growth factors and receptors (GF/Rs), cytokines and chemokines (C/Cs), and proteases and inhibitors (P/Is)...
March 23, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28325212/chemokine-receptor-signaling-and-the-hallmarks-of-cancer
#3
R A Lacalle, R Blanco, L Carmona-Rodríguez, A Martín-Leal, E Mira, S Mañes
The chemokines are a family of chemotactic cytokines that mediate their activity by acting on seven-transmembrane-spanning G protein-coupled receptors. Both the ability of the chemokines and their receptors to form homo- and heterodimers and the promiscuity of the chemokine-chemokine receptor interaction endow this protein family with enormous signaling plasticity and complexity that are not fully understood at present. Chemokines were initially identified as essential regulators of homeostatic and inflammatory trafficking of innate and adaptive leucocytes from lymphoid organs to tissues...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28323906/flt-1-gene-polymorphisms-and-protein-expression-profile-in-rheumatoid-arthritis
#4
Agnieszka Paradowska-Gorycka, Anna Sowinska, Andrzej Pawlik, Damian Malinowski, Barbara Stypinska, Ewa Haladyj, Katarzyna Romanowska-Prochnicka, Marzena Olesinska
OBJECTIVES: Inflammation and angiogenesis are a significant element of pathogenesis in rheumatoid arthritis (RA). The FLT-1- triggering factor for production of proinflammatory cytokines-might contributes to inflammation in patients with RA. Association of the FLT-1 polymorphisms with different "angiogenic diseases" suggests that it may be a novel genetic risk factor also for RA. The aim of the study was to identify FLT-1 genetic variants and their possible association with sFLT-1 levels, susceptibility to and severity of RA...
2017: PloS One
https://www.readbyqxmd.com/read/28319086/cytochrome-p450-cyp-epoxygenases-as-potential-targets-in-the-management-of-impaired-diabetic-wound-healing
#5
Huichen Zhao, Jicui Chen, Jiachao Chai, Yuchao Zhang, Cong Yu, Zhe Pan, Peng Gao, Chen Zong, Qingbo Guan, Yuqin Fu, Yuantao Liu
Epoxyeicosatrienoic acids (EETs) are the epoxidation products of arachidonic acid catalyzed by cytochrome P450 (CYP) epoxygenases, which possess multiple biological activities. In the present study, we aimed to explore the role and effects of CYP epoxygenases/EETs in wound healing in ob/ob mice. Full-thickness skin dorsal wounds were made on ob/ob mice and C57BL/6 control mice. The mRNA and protein expression of CYP epoxygenases were determined in granulation tissues of wounds. Effects of EETs on wound healing were evaluated...
March 20, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28316997/sildenafil-can-affect-innate-and-adaptive-immune-system-in-both-experimental-animals-and-patients
#6
REVIEW
Monika Kniotek, Agnieszka Boguska
Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. cGMP is a secondary messenger activating protein kinases and a common regulator of ion channel conductance, glycogenolysis, and cellular apoptosis. PDE5 inhibitors (PDE-Is) found application in cardiology, nephrology, urology, dermatology, oncology, and gynecology. Positive result of sildenafil treatment is closely connected with its immunomodulatory effects...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28315704/interleukin-6-and-prostate-cancer-current-developments-and-unsolved-questions
#7
Zoran Culig, Martin Puhr
Interleukin (IL)-6 is a pro-inflammatory cytokine that is expressed in prostate tumors and in the stromal tumor micro-enviroment. It is known to regulate proliferation, apoptosis, angiogenesis, and differentiation. The signaling pathway of Janus kinase and signal transducer and activator of transcription (STAT)3, which is activated by IL-6, is in the focus of scientific investigations for improved treatment approaches. Different effects of IL-6 and/or STAT3 on tumor cell growth have been observed in human and murine prostate cancer (PCa) models...
March 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28302404/mesenchymal-stem-cells-derived-mfg-e8-accelerates-diabetic-cutaneous-wound-healing
#8
Akihiko Uchiyama, Sei-Ichiro Motegi, Akiko Sekiguchi, Chisako Fujiwara, Buddhini Perera, Sachiko Ogino, Yoko Yokoyama, Osamu Ishikawa
BACKGROUND: Diabetic wounds are intractable due to complex factors, such as the inhibition of angiogenesis, dysfunction of phagocytosis by macrophages and abnormal inflammatory responses. It is recognized that mesenchymal stem cells (MSCs) promote wound healing in diabetic mice. We previously demonstrated that MSCs produce large amounts of MFG-E8. OBJECT: The objective was to ascertain the role of MSCs-derived MFG-E8 in murine diabetic wounds. METHODS: MFG-E8 WT/KO MSCs or rMFG-E8 were subcutaneously injected around the wound in diabetic db/db mice, and wound areas were analyzed...
March 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28300714/biomarkers-and-immunotherapeutic-targets-in-glioblastoma
#9
REVIEW
Alice L Hung, Tomas Garzon-Muvdi, Michael Lim
Glioblastoma (GBM) is an aggressive central nervous system (CNS) cancer with poor prognosis despite maximal therapy. The recent advent of immunotherapy holds great promise for improving GBM survival and has already made great strides towards changing current management strategies. A diverse set of biomarkers has been implicated as immunotherapeutic targets and prognostic indicators in other cancers. Some of the more extensively studied examples include cytokines (IL-4, IL-13, and TGF-ß), checkpoint molecules (PD-1, CTLA-4, TIM-3, LAG-3, CD137, GITR, OX40), and growth/angiogenesis proteins (endoglin and EGFR)...
March 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28295901/high-aldehyde-dehydrogenase-activity-identifies-a-subset-of-human-mesenchymal-stromal-cells-with-vascular-regenerative-potential
#10
Stephen E Sherman, Miljan Kuljanin, Tyler T Cooper, David M Putman, Gilles A Lajoie, David A Hess
During culture expansion, multipotent mesenchymal stromal cells (MSC) differentially express aldehyde dehydrogenase (ALDH), an intracellular detoxification enzyme that protects long-lived cells against oxidative stress. Thus, MSC selection based on ALDH-activity may be used to reduce heterogeneity and distinguish MSC subsets with improved regenerative potency. After expansion of human bone marrow-derived MSC, cell progeny were purified based on low versus high ALDH-activity by fluorescence activated cell sorting, and each subset was compared for multipotent stromal and pro-vascular regenerative functions...
March 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/28295786/stat3-potentiates-the-ability-of-airway-smooth-muscle-cells-to-promote-angiogenesis-by-regulating-vegf-signaling
#11
Jing Lv, Baohua Sun, Zhitao Mai, Mingming Jiang, Junfeng Du
Airway angiogenesis indicates the specific vascular structure remodeling that occurs in asthma. Airway smooth muscle (ASM) cells have been reported to be capable of promoting airway angiogenesis; however, the potential mechanism is yet not fully defined. Herein, we investigated the role of signal transducer and activator of transcription 3 (STAT3), in the progress of airway angiogenesis. Western blot analysis showed that STAT3 activation was aberrantly up-regulated in ASM tissues of patients with asthma and ASM cells that were exposed to cytokines to imitate the airway conditions in patients with asthma...
March 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28288823/cadmium-induced-il-6-and-il-8-expression-and-release-from-astrocytes-are-mediated-by-mapk-and-nf-%C3%AE%C2%BAb-pathways
#12
Suttinee Phuagkhaopong, Dusadee Ospondpant, Thitima Kasemsuk, Nathawut Sibmooh, Sunhapas Soodvilai, Christopher Power, Pornpun Vivithanaporn
Chronic exposure to cadmium has been linked to brain cancers, learning disabilities and memory deficits. Previous studies of cadmium toxicity in the central nervous system report cadmium induces oxidative stress in neurons and astrocytes. In the peripheral system, cadmium promotes interleukin-6 (IL-6) and IL-8 production and release. Elevation of IL-6 expression is linked to the pathogenesis of neurodegenerative diseases and astrogliosis. IL-8 plays a role in angiogenesis of gliomas and neurodegenerative diseases...
March 10, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28287533/isolation-of-endothelial-progenitor-cells-from-healthy-volunteers-and-their-migratory-potential-influenced-by-serum-samples-after-cardiac-surgery
#13
Christoph Emontzpohl, David Simons, Sandra Kraemer, Andreas Goetzenich, Gernot Marx, Jürgen Bernhagen, Christian Stoppe
Endothelial progenitor cells (EPCs) are recruited from the bone marrow under pathological conditions like hypoxia and are crucially involved in the neovascularization of ischemic tissues. The origin, classification and characterization of EPCs are complex; notwithstanding, two prominent sub-types of EPCs have been established: so-called "early" EPCs (subsequently referred to as early-EPCs) and late-outgrowth EPCs (late-EPCs). They can be classified by biological properties as well as by their appearance during in vitro culture...
February 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28284455/uterine-nk-cells-and-macrophages-in-pregnancy
#14
Marijke M Faas, Paul de Vos
The presence of immune cells in the placental bed is important for both mother and child. Although various immune cells can be found in the placental bed, such as regulatory T cells and dendritic cells, uterine NK cells and macrophages are the most prominent immune cells in the placental bed in early pregnancy. uNK cell and macrophage numbers in the placental bed decrease in the third trimester. These cells seem to be specifically adapted for their function and environment. uNK cells do not show cytotoxic activity, but are producers of cytokines, growth factors and many other factors...
March 2, 2017: Placenta
https://www.readbyqxmd.com/read/28275390/dual-role-of-inflammatory-mediators-in-cancer
#15
REVIEW
T G Shrihari
Inflammation is the body's response to noxious stimuli such as infectious, physiological or chemical agents, it releases various inflammatory mediators via immune cells such as neutrophils, macrophages, and lymphocytes. These inflammatory mediators are growth factors, chemokines, and cytokines. Reactive oxygen species (ROS) and nitrogen species (RNS) activate transcriptional factors (NF-KB, STAT-3) and bring about cellular proliferation, genomic instability, angiogenesis, resistance to apoptosis, invasion, and metastasis...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28274269/mesenchymal-stem-cell-derived-angiogenin-promotes-primodial-follicle-survival-and-angiogenesis-in-transplanted-human-ovarian-tissue
#16
Yaoyao Zhang, Xi Xia, Jie Yan, Liying Yan, Cuilin Lu, Xiaohui Zhu, Tianren Wang, Tailang Yin, Rong Li, Hsun-Ming Chang, Jie Qiao
BACKGROUND: We have recently reported that human bone marrow-derived mesenchymal stem cells (MSCs) facilitate angiogenesis and prevent follicle loss in xenografted human ovarian tissues. However, the mechanism underlying this effect remains to be elucidated. Thus, determining the paracrine profiles and identifying the key secreted factors in MSCs co-transplanted with ovarian grafts are essential for the future application of MSCs. METHODS: In this study, we used cytokine microarrays to identify differentially expressed proteins associated with angiogenesis in frozen-thawed ovarian tissues co-transplanted with MSCs...
March 9, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28269759/effects-of-different-concentrations-of-platelet-rich-plasma-and-platelet-poor-plasma-on-vitality-and-differentiation-of-autologous-adipose-tissue-derived-stem-cells
#17
Oliver Felthaus, Lukas Prantl, Mona Skaff-Schwarze, Silvan Klein, Alexandra Anker, Marco Ranieri, Britta Kühlmann
BACKGROUND: Autologous fat grafts and adipose-derived stem cells (ASCs) can be used to treat soft tissue defects. However, the results are inconsistent and sometimes comprise tissue resorption and necrosis. This might be due to insufficient vascularization. Platelet-rich plasma (PRP) is a source of concentrated autologous platelets. The growth factors and cytokines released by platelets can facilitate angiogenesis. The simultaneous use of PRP might improve the regeneration potential of fat grafts...
February 28, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28268243/immunomodulatory-glc-man-directed-dolichos-lablab-lectin-dll-evokes-anti-tumor-response-in-vivo-by-counteracting-angiogenic-gene-expressions
#18
V Vigneshwaran, Prabhu Thirusangu, Vijay Avin Br, V Krishna, Siddanakoppalu N Pramod, B T Prabhakar
Neovascularization and jeopardized immunity has been critically emphasized for the establishment of malignant progression. Lectins are the diverse class of carbohydrate interacting proteins having great potential as immunopotentiating and anticancer agents. The present investigation sought to demonstrate the antiproliferative activity of Dolichos lablab lectin (DLL) encompassing immunomodulatory attribute. DLL specific to glucose and mannose carbohydrate moieties has been purified to homogeneity from the common dietary legume Dolichos lablab...
March 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28267633/sclerostin-stimulates-angiogenesis-in-human-endothelial-cells
#19
Angela Oranger, Giacomina Brunetti, Graziana Colaianni, Roberto Tamma, Claudia Carbone, Luciana Lippo, Giorgio Mori, Paolo Pignataro, Nunzio Cirulli, Roberta Zerlotin, Biagio Moretti, Angela Notarnicola, Domenico Ribatti, Maria Grano, Silvia Colucci
Sclerostin, negative regulator of bone formation, has been originally known as an osteocyte product. Recently, it has been also detected in hypertrophic chondrocytes, distinctive cells of avascular cartilage which is invaded by capillaries and then replaced by vascularized bone. Thus, we hypothesized that sclerostin, in addition to its role already known, may exert an angiogenic activity. We first proved that sclerostin increased the proliferation of human umbilical vein endothelial cells (HUVECs), and next, by using the chicken chorioallantoic membrane (CAM) in vivo assay, we demonstrated that it exerts an angiogenic activity similar to that of vascular endothelial growth factor (VEGF)...
March 3, 2017: Bone
https://www.readbyqxmd.com/read/28267621/targeting-hepatic-macrophages-to-treat-liver-diseases
#20
REVIEW
Frank Tacke
Our view on liver macrophages in the context of health and disease has been reformed by the recognition of a remarkable heterogeneity of phagocytes in the liver. Liver macrophages consist of ontogenically distinct populations termed Kupffer cells and monocyte-derived macrophages. Kupffer cells are self-renewing, resident and principally non-migratory phagocytes, serving as sentinels for liver homeostasis. Liver injury triggers Kupffer cell activation, leading to inflammatory cytokine and chemokine release. This fosters the infiltration of monocytes into liver that give rise to large numbers of inflammatory monocyte-derived macrophages...
March 3, 2017: Journal of Hepatology
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