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Cytokines Promote Angiogenesis

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https://www.readbyqxmd.com/read/29768965/the-therapeutic-potential-of-the-mesenchymal-stem-cell-secretome-in-ischaemic-stroke
#1
Catriona J Cunningham, Elena Redondo-Castro, Stuart M Allan
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called "bystander" effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29764837/il22-promotes-kras-mutant-lung-cancer-by-induction-of-a-pro-tumor-immune-response-and-protection-of-stemness-properties
#2
Nasim Khosravi, Mauricio S Caetano, Amber M Cumpian, Nese Unver, Cynthia De la Garza Ramos, Oscar Noble, Soudabeh Daliri, Belinda J Hernandez, Berenice A Gutierrez, Scott E Evans, Samir Hanash, Andrei M Alekseev, Yi Yang, Seon Hee Chang, Roza Nurieva, Humam Kadara, Jichao Chen, Edwin J Ostrin, Seyed Javad Moghaddam
Somatic KRAS mutations are the most common oncogenic variants in lung cancer and are associated with poor prognosis. Using a Kras-induced lung cancer mouse model, CC-LR, we previously showed a role for inflammation in lung tumorigenesis through activation of the NF-kB pathway, along with induction of interleukin 6 (IL6) and an IL17-producing CD4+ T-helper cell response. IL22 is an effector molecule secreted by CD4+ and γδ T cells that we previously found to be expressed in CC-LR mice. IL22 mostly signals through the STAT3 pathway and is thought to act exclusively on non-hematopoietic cells with basal IL22 receptor (IL22R) expression on epithelial cells...
May 15, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29763904/treatment-of-cutaneous-ulcers-with-multilayered-mixed-sheets-of-autologous-fibroblasts-and-peripheral-blood-mononuclear-cells
#3
Takahiro Mizoguchi, Koji Ueno, Yuriko Takeuchi, Makoto Samura, Ryo Suzuki, Tomoaki Murata, Tohru Hosoyama, Noriyasu Morikage, Kimikazu Hamano
BACKGROUND/AIMS: We have developed a mixed-cell sheet consisting of autologous fibroblasts and peripheral blood mononuclear cells with a high potency for angiogenesis and wound healing against refractory cutaneous ulcers in mouse and rabbit models. To increase the effectiveness of the mixed sheet, we developed a multilayered mixed sheet. METHODS: We assessed the therapeutic effects of multilayered sheets on cutaneous ulcers in mice. Growth factors and chemokines were assessed by enzyme-linked immunosorbent assay...
May 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29759563/targeting-the-tumor-promoting-effects-of-adenosine-in-chronic-lymphocytic-leukemia
#4
REVIEW
Yiqing Cai, Lili Feng, Xin Wang
Chronic lymphocytic leukemia (CLL) is a hematological malignancy which is characterized by progressive accumulation of functionally deficient B cells in blood, bone marrow, and lymphatic tissue. The tumor microenvironment (TME) appears to play a critical role in genesis and progression of CLL. High levels of extracellular adenosine (ADO) are detected in CLL as a consequence of expression of ecto-enzymes, such as CD39 and CD73. Extracellular ADO exhibits a broad range of effects on cell cycle control, immunoregulation, angiogenesis and cytokine regulation through both direct and indirect mechanisms...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29748897/myeloid-derived-suppressor-cells-mdscs-in-patients-with-solid-tumors-considerations-for-granulocyte-colony-stimulating-factor-treatment
#5
REVIEW
Katerina Pilatova, Beatrix Bencsikova, Regina Demlova, Dalibor Valik, Lenka Zdrazilova-Dubska
Myeloid-derived suppressor cells (MDSCs) have been shown to contribute to tumor escape from host immune surveillance and to cancer progression by production of tumor-promoting soluble factors. Granulocyte colony-stimulating factor (G-CSF) is a principle cytokine controlling granulocyte number. Recombinant human G-CSF (rhG-CSF) has become the main therapeutic agent for the treatment of neutropenia and prophylaxis of febrile neutropenia in cancer patients. However, we show here that rhG-CSF triggers accumulation of granulocytic and monocytic subsets...
May 10, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29710813/decellularized-diaphragmatic-muscle-drives-a-constructive-angiogenic-response-in-vivo
#6
Mario Enrique Alvarèz Fallas, Martina Piccoli, Chiara Franzin, Alberto Sgrò, Arben Dedja, Luca Urbani, Enrica Bertin, Caterina Trevisan, Piergiorgio Gamba, Alan J Burns, Paolo De Coppi, Michela Pozzobon
Skeletal muscle tissue engineering (TE) aims to efficiently repair large congenital and acquired defects. Biological acellular scaffolds are considered a good tool for TE, as decellularization allows structural preservation of tissue extracellular matrix (ECM) and conservation of its unique cytokine reservoir and the ability to support angiogenesis, cell viability, and proliferation. This represents a major advantage compared to synthetic scaffolds, which can acquire these features only after modification and show limited biocompatibility...
April 28, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29707160/pathogenic-role-for-macrophage-migration-inhibitory-factor-in-glioblastoma-and-its-targeting-with-specific-inhibitors-as-novel-tailored-therapeutic-approach
#7
REVIEW
Katia Mangano, Emanuela Mazzon, Maria Sofia Basile, Roberto Di Marco, Placido Bramanti, Santa Mammana, Maria Cristina Petralia, Paolo Fagone, Ferdinando Nicoletti
Macrophage Migration Inhibitory Factor (MIF) is a pro-inflammatory cytokine expressed by a variety of cell types. Although MIF has been primarily studied for its role in the pathogenesis of autoimmune diseases, it has also been shown to promote tumorigenesis and it is over expressed in various malignant tumors. MIF is able to induce angiogenesis, cell cycle progression, and to block apoptosis. As tailored therapeutic approaches for the inhibition of endogenous MIF are being developed, it is important to evaluate the role of MIF in individual neoplastic conditions that may benefit from specific MIF inhibitors...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29687874/effects-of-platelet-rich-plasma-on-angiogenesis-and-osteogenesis-associated-factors-in-rabbits-with-avascular-necrosis-of-the-femoral-head
#8
X-L Zhang, K-Q Shi, P-T Jia, L-H Jiang, Y-H Liu, X Chen, Z-Y Zhou, Y-X Li, L-S Wang
OBJECTIVE: Platelet-rich plasma (PRP) contains various growth factors and cytokines that can enhance the recovery of the damaged tissues. The present study aimed to examine the effects of PRP on the recovery of avascular necrosis of the femoral head (ANFH), and to provide novel insights into the clinical treatment of this disease. MATERIALS AND METHODS: A total of 24 New Zealand white rabbits were randomly divided into the normal control group, ANFH model and PRP-treated groups (n =1 2 each)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29675018/contribution-to-tumor-angiogenesis-from-innate-immune-cells-within-the-tumor-microenvironment-implications-for-immunotherapy
#9
REVIEW
Adriana Albini, Antonino Bruno, Douglas M Noonan, Lorenzo Mortara
The critical role of angiogenesis in promoting tumor growth and metastasis is strongly established. However, tumors show considerable variation in angiogenic characteristics and in their sensitivity to antiangiogenic therapy. Tumor angiogenesis involves not only cancer cells but also various tumor-associated leukocytes (TALs) and stromal cells. TALs produce chemokines, cytokines, proteases, structural proteins, and microvescicles. Vascular endothelial growth factor (VEGF) and inflammatory chemokines are not only major proangiogenic factors but are also immune modulators, which increase angiogenesis and lead to immune suppression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670296/paracrine-roles-of-cellular-senescence-in-promoting-tumourigenesis
#10
REVIEW
Jose Mario Gonzalez-Meljem, John Richard Apps, Helen Christina Fraser, Juan Pedro Martinez-Barbera
Senescent cells activate genetic programmes that irreversibly inhibit cellular proliferation, but also endow these cells with distinctive metabolic and signalling phenotypes. Although senescence has historically been considered a protective mechanism against tumourigenesis, the activities of senescent cells are increasingly being associated with age-related diseases, including cancer. An important feature of senescent cells is the secretion of a vast array of pro-inflammatory cytokines, chemokines, and growth factors collectively known as the senescence-associated secretory phenotype (SASP)...
April 19, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29666270/mk2-contributes-to-tumor-progression-by-promoting-m2-macrophage-polarization-and-tumor-angiogenesis
#11
Lucia Suarez-Lopez, Ganapathy Sriram, Yi Wen Kong, Sandra Morandell, Karl A Merrick, Yuliana Hernandez, Kevin M Haigis, Michael B Yaffe
Chronic inflammation is a major risk factor for colorectal cancer. The p38/MAPKAP Kinase 2 (MK2) kinase axis controls the synthesis of proinflammatory cytokines that mediate both chronic inflammation and tumor progression. Blockade of this pathway has been previously reported to suppress inflammation and to prevent colorectal tumorigenesis in a mouse model of inflammation-driven colorectal cancer, by mechanisms that are still unclear. Here, using whole-animal and tissue-specific MK2 KO mice, we show that MK2 activity in the myeloid compartment promotes tumor progression by supporting tumor neoangiogenesis in vivo...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29663878/role-of-angiogenenic-growth-factors-in-psoriasis-a-review
#12
Tahseena Akhtar, Willayat Yousuf Wani, Mohammad A Kamal, Rajinder Kaur
BACKGROUND: Psoriasis is a chronic inflammatory disease, involving autoimmune mechanism wherein immune system, autoantigens and various environmental triggers all interact to create the systemically diseased state. It is a multifactorial skin disease of complex nature characterized by infiltration of multiple immune cells, kerationcyte proliferation, and increased dermal vascularity. Among all factors, vascular alterations present a significant feature of the disease and angiogenesis seems to have an important role in giving rise to psoriasis phenotype...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29643458/pro-inflammatory-cytokines-activate-hypoxia-inducible-factor-3%C3%AE-via-epigenetic-changes-in-mesenchymal-stromal-stem-cells
#13
Francesca Cuomo, Antonietta Coppola, Chiara Botti, Ciro Maione, Amalia Forte, Lucia Scisciola, Giuseppina Liguori, Ilaria Caiafa, Matilde Valeria Ursini, Umberto Galderisi, Marilena Cipollaro, Lucia Altucci, Gilda Cobellis
Human mesenchymal stromal/stem cells (hMSCs) emerged as a promising therapeutic tool for ischemic disorders, due to their ability to regenerate damaged tissues, promote angiogenesis and reduce inflammation, leading to encouraging, but still limited results. The outcomes in clinical trials exploring hMSC therapy are influenced by low cell retention and survival in affected tissues, partially influenced by lesion's microenvironment, where low oxygen conditions (i.e. hypoxia) and inflammation coexist. Hypoxia and inflammation are pathophysiological stresses, sharing common activators, such as hypoxia-inducible factors (HIFs) and NF-κB...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29627179/a-prostacyclin-agonist-and-an-omental-flap-increased-myocardial-blood-flow-in-a-porcine-chronic-ischemia-model
#14
Shin Yajima, Shigeru Miyagawa, Satsuki Fukushima, Yoshiki Sakai, Kayako Isohashi, Tadashi Watabe, Hayato Ikeda, Genki Horitsugi, Akima Harada, Ryoto Sakaniwa, Jun Hatazawa, Yoshiki Sawa
OBJECTIVE: We hypothesized that therapeutic efficacy may be augmented by a combination of placing a sheet immersed in ONO-1301SR, a slow-release synthetic prostacyclin agonist-inducing multiproangiogenic cytokines, over the left ventricle and a pedicled omental flap in a chronic myocardial infarct heart. METHODS: A minipig chronic myocardial infarction was generated by placing an ameroid constrictor ring around the left anterior descending artery for 4 weeks. The minipigs were then assigned into 4 groups of 6 each: sham, omental flap only, ONO-1301SR only, and ONO-1301SR combined with an omental flap (combined)...
March 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29625858/m2-polarization-of-macrophages-by-oncostatin-m-in-hypoxic-tumor-microenvironment-is-mediated-by-mtorc2-and-promotes-tumor-growth-and-metastasis
#15
Richa Shrivastava, Mohammad Asif, Varsha Singh, Parul Dubey, Showkat Ahmad Malik, Mehraj-U-Din Lone, Brij Nath Tewari, Khemraj Singh Baghel, Subhashis Pal, Geet Kumar Nagar, Naibedya Chattopadhyay, Smrati Bhadauria
Oncostatin M (OSM), an inflammatory cytokine belonging to the interleukin-6 (IL-6) superfamily, plays a vital role in multitude of physiological and pathological processes. Its role in breast tumor progression and metastasis to distant organs is well documented. Recent reports implicate OSM in macrophage M2 polarization, a key pro-tumoral phenomenon. M2 polarization of macrophages is believed to promote tumor progression by potentiating metastasis and angiogenesis. In the current study, we delineated the mechanism underlying OSM induced macrophage M2 polarization...
April 3, 2018: Cytokine
https://www.readbyqxmd.com/read/29620150/lack-of-endogenous-parathyroid-hormone-delays-fracture-healing-by-inhibiting-vascular-endothelial-growth-factor%C3%A2-mediated-angiogenesis
#16
Qingfeng Ding, Peng Sun, Hao Zhou, Bowen Wan, Jian Yin, Yao Huang, Qingqing Li, Guoyong Yin, Jin Fan
Intermittent low‑dose injections of parathyroid hormone (PTH) have been reported to exert bone anabolic effects and to promote fracture healing. As an important proangiogenic cytokine, vascular endothelial growth factor (VEGF) is secreted by bone marrow mesenchymal stem cells (BMSCs) and osteoblasts, and serves a crucial regulatory role in the process of vascular development and regeneration. To investigate whether lack of endogenous PTH causes reduced angiogenic capacity and thereby delays the process of fracture healing by downregulating the VEGF signaling pathway, a PTH knockout (PTHKO) mouse fracture model was generated...
April 3, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29614426/plasticity-and-biological-diversity-of-myeloid-derived-suppressor-cells
#17
REVIEW
Kerem Ben-Meir, Nira Twaik, Michal Baniyash
Myeloid derived suppressor cells (MDSCs) are immature myeloid cells characterized by diverse phenotypes and functions. They impair effector functions of immune cells and promote tumor growth, angiogenesis, and tissue damage. In pathologies characterized by chronic inflammation, MDSCs are arrested in their immature state and migrate from the bone marrow to the periphery and to the site of inflammation, where they mediate immunosuppression. When reaching new environments, which exhibit a different array of cytokines, chemokines, and pro-inflammatory mediators, MDSCs sense and adapt to the altered micro-environment by virtue of acquiring different suppressive features/functions that involve changing their cell fate, surface receptors, metabolism and intracellular as well as secreted molecules...
March 31, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29607508/activation-of-autophagy-in-periodontal-ligament-mesenchymal-stem-cells-promotes-angiogenesis-in-periodontitis
#18
Wei Wei, Yulin An, Ying An, Dongdong Fei, Qintao Wang
BACKGROUND: Angiogenesis alteration in tooth support tissue plays an essential role in periodontitis. Mesenchymal stem cells (MSCs) can affect vessel formation by endothelial cells (ECs) through paracrine function. Autophagy is reported to be closely related to cell secretion. Here we investigated the angiogenesis-promoting ability of MSCs that reside in the periodontal ligament (known as periodontal ligament stem cells, PDLSCs) under inflammatory conditions in order to explore the mechanism of angiogenesis alteration in periodontitis...
April 1, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29578814/mechanisms-of-phytonutrient-modulation-of-cyclooxygenase-2-cox-2-and-inflammation-related-to-cancer
#19
Shreena J Desai, Ben Prickril, Avraham Rasooly
The link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism, is upregulated during both inflammation and cancer. COX-2 is induced by pro-inflammatory cytokines at the site of inflammation and enhanced COX-2-induced synthesis of prostaglandins stimulates cancer cell proliferation, promotes angiogenesis, inhibits apoptosis, and increases metastatic potential. As a result, COX-2 inhibitors are a subject of intense research interest toward potential clinical applications...
March 26, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29571248/anti-inflammatory-and-anti-tumor-effects-of-l-guluronic-acid-g2013-on-cancer-related-inflammation-in-a-murine-breast-cancer-model
#20
Fatemeh Hosseini, Ahmad Mahdian-Shakib, Farhad Jadidi-Niaragh, Seyed Ehsan Enderami, Hamed Mohammadi, Maryam Hemmatzadeh, Hussaini Alhassan Mohammed, Ali Anissian, Parviz Kokhaei, Abbas Mirshafiey, Hadi Hassannia
Cancer-related inflammation (CRI) is associated with the malignant progression of several cancer types. Targeting these pathways is a novel promising strategy for cancer prevention and treatment. In this present study, we evaluated the efficacy of ?-l-guluronic acid (ALG), a potent anti-inflammatory agent on breast cancer-related inflammation both in vitro and in vivo conditions. Our results indicated that ALG can effectively inhibit the CRI and tumor-promoting mediators (COX-2, MMP2, MMP9, VEGF and proinflammatory cytokines) without direct toxic effects on the cells...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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