Xiqian Zhou, Junyong Zhao, Tao Yan, Danrong Ye, Yuying Wang, Bai'an Zhou, Diya Liu, Xuehui Wang, Wenfang Zheng, Bowen Zheng, Fengyuan Qian, Yating Li, Dengfeng Li, Lin Fang
Breast cancer has the highest global incidence and mortality rates among all cancer types. Abnormal expression of the Annexin family has been observed in different malignant tumors, including upregulated ANXA9 in breast cancer. We found highly expressed ANXA9 in metastatic breast cancer tissues, which is correlated with breast cancer progression. In vitro, the functional experiments indicated ANXA9 influenced breast cancer proliferation, motility, invasion, and apoptosis; in vivo, downregulation of ANXA9 suppressed breast cancer xenograft tumor growth and lung metastasis...
April 12, 2024: Cell Death & Disease