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https://www.readbyqxmd.com/read/28738234/m1-homeopathic-complex-trigger-effective-responses-against-leishmania-l-amazonensis-in-vivo-and-in-vitro
#1
Katia Fialho Nascimento, Fabiana Rodrigues de Santana, Cleber Rafael Vieira da Costa, Vanessa Kaplum, Helito Volpato, Celso Vaturo Nakamura, Leoni Villano Bonamin, Dorly de Freitas Buchi
Leishmaniasis is a term referring to a range of clinical conditions caused by protozoan parasites of the genus Leishmania, Trypanosomatidae family, Kinetoplastida order that is transmitted by the bite of certain species of mosquitoes Phlebotominae subfamily. These parasites infect hosts wild and domestic mammals, considered as natural reservoirs and can also infect humans. Leishmania are obligate intramacrophage protozoa that have exclusively intracellular life style. This suggests that the amastigotes possess mechanisms to avoid killing by host cells...
July 21, 2017: Cytokine
https://www.readbyqxmd.com/read/28737936/a-ii-geteo6-a-mn-cd-pb-non-centrosymmetric-layered-tellurates-with-pbsb2o6-related-structure
#2
Sun Woo Kim, Zheng Deng, Shuang Yu, Haricharan Padmanabhan, Weiguo Zhang, Venkatraman Gopalan, Changqing Jin, Martha Greenblatt
A(II)GeTeO6 (A = Mn, Cd, Pb), new non-centrosymmetric (NCS) honeycomb-layered tellurates, were synthesized and characterized. A(II)GeTeO6 (A = Mn, Cd, Pb) crystallize in trigonal space group P312 (No. 149) of edge-sharing Ge(4+)O6 and Te(6+)O6 octahedra, which form honeycomb-like-layers in the ab-plane with A(II) (A = Mn, Cd, Pb) cations located between the layers. Their crystal structures are PbSb2O6-related, and the ordering of Ge(4+) and Te(6+) in octahedral environment breaks the inversion symmetry of the parent PbSb2O6 structure...
July 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28737123/development-and-validation-of-eco-friendly-liquid-chromatographic-and-spectrophotometric-methods-for-simultaneous-determination-of-coformulated-drugs-phenylephrine-hydrochloride-and-prednisolone-acetate
#3
Nadia M Mostafa, Ghada M Elsayed, Nagiba Y Hassan, Dina A El Mously
Five simple, sensitive, and eco-friendly LC and UV spectrophotometric methods have been developed for the simultaneous determination of phenylephrine hydrochloride (PHE) and prednisolone acetate (PRD) in their combined dosage form. The first method was reversed-phase (RP) LC using methanol–water–heptane-1-sulfonic acid sodium salt (75 + 25 + 0.1, v/v/w) as a mobile phase. Separation was achieved using an XSelect HSS reversed-phase C18 analytical column (250 × 4.6 mm, 5µm). The flow rate was 1...
July 24, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28736572/an-index-to-characterize-female-career-promotion-in-academic-medicine
#4
Dörthe Brüggmann, David A Groneberg
BACKGROUND: Imbalances in female career promotion are a key factor of gender disparities at the workplace. They may lead to stress and stress-related diseases including burnout, depression or cardiovascular diseases. Since this problem cannot be generalized and varies between different fields, new approaches are needed to assess and describe the magnitude of the problem in single fields of work. METHODS: To construct a new index, operating figures of female and male medical students were collected for Germany in a period over 15 years and their progression throughout their studies towards specialization and academic chair positions...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28736467/stability-of-gradient-field-corrections-for-quantitative-diffusion-mri
#5
Baxter P Rogers, Justin Blaber, E Brian Welch, Zhaohua Ding, Adam W Anderson, Bennett A Landman
In magnetic resonance diffusion imaging, gradient nonlinearity causes significant bias in the estimation of quantitative diffusion parameters such as diffusivity, anisotropy, and diffusion direction in areas away from the magnet isocenter. This bias can be substantially reduced if the scanner- and coil-specific gradient field nonlinearities are known. Using a set of field map calibration scans on a large (29 cm diameter) phantom combined with a solid harmonic approximation of the gradient fields, we predicted the obtained b-values and applied gradient directions throughout a typical field of view for brain imaging for a typical 32-direction diffusion imaging sequence...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28736466/spatiotemporal-aggregation-for-temporally-extensive-international-microdata
#6
Tracy A Kugler, Steven M Manson, Joshua R Donato
We describe a strategy for regionalizing subnational administrative units in conjunction with harmonizing changes in unit boundaries over time that can be applied to provide small-area geographic identifiers for census microdata. The availability of small-area identifiers blends the flexibility of individual microdata with the spatial specificity of aggregate data. Regionalizing microdata by administrative units poses a number of challenges, such as the need to aggregate individual scale data in a way that ensures confidentiality and issues arising from changing spatial boundaries over time...
May 2017: Computers, Environment and Urban Systems
https://www.readbyqxmd.com/read/28736221/scaffold-curvature-mediated-novel-biomineralization-process-originates-a-continuous-soft-tissue-to-bone-interface
#7
Michael Paris, Andreas Götz, Inga Hettrich, Cécile M Bidan, John W C Dunlop, Hajar Razi, Ivo Zizak, Dietmar W Hutmacher, Peter Fratzl, Georg N Duda, Wolfgang Wagermaier, Amaia Cipitria
A myriad of shapes are found in biological tissues, often naturally evolved to fulfill a particular function. In the field of tissue engineering, substrate geometry influences cell behavior and tissue formation in-vitro, yet little is known how this translates to an in-vivo scenario. Here we investigate scaffold curvature-induced tissue growth, without additional growth factors or cells, in an ovine animal model. We show that soft tissue formation follows a curvature-driven tissue growth model. The highly organized endogenous soft matrix, potentially under mechanical strain, leads to a non-standard form of biomineralization, whereby the pre-existing organic matrix is mineralized without collagen remodeling and without an intermediate cartilage ossification phase...
July 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28734783/dementia-prevalence-and-incidence-in-a-federation-of-european-electronic-health-record-databases-the-european-medical-informatics-framework-resource
#8
Gayan Perera, Lars Pedersen, David Ansel, Myriam Alexander, H Michael Arrighi, Paul Avillach, Nadia Foskett, Rosa Gini, Mark F Gordon, Usha Gungabissoon, Miguel-Angel Mayer, Gerald Novak, Peter Rijnbeek, Gianluca Trifirò, Johan van der Lei, Pieter J Visser, Robert Stewart
INTRODUCTION: The European Medical Information Framework consortium has assembled electronic health record (EHR) databases for dementia research. We calculated dementia prevalence and incidence in 25 million persons from 2004 to 2012. METHODS: Six EHR databases (three primary care and three secondary care) from five countries were interrogated. Dementia was ascertained by consensus harmonization of clinical/diagnostic codes. Annual period prevalences and incidences by age and gender were calculated and meta-analyzed...
July 20, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28734296/spherical-harmonics-analysis-of-surface-density-fluctuations-of-spherical-ionic-sds-and-nonionic-c12e8-micelles-a-molecular-dynamics-study
#9
Noriyuki Yoshii, Yuki Nimura, Kazushi Fujimoto, Susumu Okazaki
The surface structure and its fluctuation of spherical micelles were investigated using a series of density correlation functions newly defined by spherical harmonics and Legendre polynomials based on the molecular dynamics calculations. To investigate the influence of head-group charges on the micelle surface structure, ionic sodium dodecyl sulfate and nonionic octaethyleneglycol monododecylether (C12E8) micelles were investigated as model systems. Large-scale density fluctuations were observed for both micelles in the calculated surface static structure factor...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734295/estimating-the-intrinsic-limit-of-the-feller-peterson-dixon-composite-approach-when-applied-to-adiabatic-ionization-potentials-in-atoms-and-small-molecules
#10
David Feller
Benchmark adiabatic ionization potentials were obtained with the Feller-Peterson-Dixon (FPD) theoretical method for a collection of 48 atoms and small molecules. In previous studies, the FPD method demonstrated an ability to predict atomization energies (heats of formation) and electron affinities well within a 95% confidence level of ±1 kcal/mol. Large 1-particle expansions involving correlation consistent basis sets (up to aug-cc-pV8Z in many cases and aug-cc-pV9Z for some atoms) were chosen for the valence CCSD(T) starting point calculations...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734284/cage-model-of-polar-fluids-finite-cage-inertia-generalization
#11
W T Coffey, M Zarifakis, Y P Kalmykov, S V Titov, W J Dowling, A S Titov
The itinerant oscillator model describing rotation of a dipole about a fixed axis inside a cage formed by its surrounding polar molecules is revisited in the context of modeling the dielectric relaxation of a polar fluid via the Langevin equation. The dynamical properties of the model are studied by averaging the Langevin equations describing the complex orientational dynamics of two bodies (molecule-cage) over their realizations in phase space so that the problem reduces to solving a system of three index linear differential-recurrence relations for the statistical moments...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28733862/recommendations-for-systematic-statistical-computation-of-immunogenicity-cut-points
#12
Viswanath Devanarayan, Wendell C Smith, Rocco L Brunelle, Mary E Seger, Kim Krug, Ronald R Bowsher
Today, the assessment of immunogenicity is integral in nonclinical and clinical testing of new biotherapeutics and biosimilars. A key component in the risk-based evaluation of immunogenicity involves the detection and characterization of anti-drug antibodies (ADA). Over the past couple of decades, much progress has been made in standardizing the generalized approach for ADA testing with a three-tiered testing paradigm involving screening, confirmation, and quasi-quantitative titer assessment representing the typical harmonized scheme...
July 21, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28733803/vocoder-simulations-explain-complex-pitch-perception-limitations-experienced-by-cochlear-implant-users
#13
Anahita H Mehta, Andrew J Oxenham
Pitch plays a crucial role in speech and music, but is highly degraded for people with cochlear implants, leading to severe communication challenges in noisy environments. Pitch is determined primarily by the first few spectrally resolved harmonics of a tone. In implants, access to this pitch is limited by poor spectral resolution, due to the limited number of channels and interactions between adjacent channels. Here we used noise-vocoder simulations to explore how many channels, and how little channel interaction, are required to elicit pitch...
July 21, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28733068/effects-of-eu-harmonization-policies-on-national-public-supervision-of-clinical-trials-a-dynamic-cycle-of-institutional-change-and-institutional-work
#14
Jacqueline C F van Oijen, Kor J Grit, Hester M van de Bovenkamp, Roland A Bal
BACKGROUND: The EU Clinical Trials Directive (EUCTD) and the EU Clinical Trials Regulation aim to harmonize good clinical practice (GCP) of clinical trials across Member States. Using the Netherlands as a case study, this paper analyzes how endeavours to implement the EUCTD set in motion a dynamic process of institutional change and institutional work. This process lead to substantial differences between policy and actual practice; therefore, it is important to learn more about the implementation of harmonization policies...
June 30, 2017: Health Policy
https://www.readbyqxmd.com/read/28732985/numerical-models-for-the-study-of-the-nonlinear-frequency-mixing-in-two-and-three-dimensional-resonant-cavities-filled-with-a-bubbly-liquid
#15
María Teresa Tejedor Sastre, Christian Vanhille
The objective of this work is to develop versatile numerical models to study the nonlinear distortion of ultrasounds and the generation of low-ultrasonic frequency signals by nonlinear frequency mixing in two and three-dimensional resonators filled with bubbly liquids. The interaction of the acoustic field and the bubble vibrations is modeled through a coupled differential system formed by the multi-dimensional wave equation and a Rayleigh-Plesset equation. The numerical models we develop are based on multi-dimensional finite-volume techniques and a time discretization carried out by finite differences...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732949/dependence-of-cavitation-chemical-effect-and-mechanical-effect-thresholds-on-ultrasonic-frequency
#16
Tam Thanh Nguyen, Yoshiyuki Asakura, Shinobu Koda, Keiji Yasuda
Cavitation, chemical effect, and mechanical effect thresholds were investigated in wide frequency ranges from 22 to 4880kHz. Each threshold was measured in terms of sound pressure at fundamental frequency. Broadband noise emitted from acoustic cavitation bubbles was detected by a hydrophone to determine the cavitation threshold. Potassium iodide oxidation caused by acoustic cavitation was used to quantify the chemical effect threshold. The ultrasonic erosion of aluminum foil was conducted to estimate the mechanical effect threshold...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28731774/femtosecond-spin-current-pulses-generated-by-the-nonthermal-spin-dependent-seebeck-effect-and-interacting-with-ferromagnets-in-spin-valves
#17
Alexandr Alekhin, Ilya Razdolski, Nikita Ilin, Jan P Meyburg, Detlef Diesing, Vladimir Roddatis, Ivan Rungger, Maria Stamenova, Stefano Sanvito, Uwe Bovensiepen, Alexey Melnikov
Using the sensitivity of optical second harmonic generation to currents, we demonstrate the generation of 250-fs long spin current pulses in Fe/Au/Fe/MgO(001) spin valves. The temporal profile of these pulses indicates ballistic transport of hot electrons across a sub-100 nm Au layer. The pulse duration is primarily determined by the thermalization time of laser-excited hot carriers in Fe. Considering the calculated spin-dependent Fe/Au interface transmittance we conclude that a nonthermal spin-dependent Seebeck effect is responsible for the generation of ultrashort spin current pulses...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731696/tuning-nonradiative-lifetimes-via-molecular-aggregation
#18
Alan Celestino, Alexander Eisfeld
We show that molecular aggregation can strongly influence the nonradiative decay (NRD) lifetime of an electronic excitation. As a demonstrative example, we consider a transition-dipole-dipole-interacting dimer whose monomers have harmonic potential energy surfaces (PESs). Depending on the position of the NRD channel ($q_{\rm nr}$), we find that the NRD lifetime ($\tau_{\rm nr}^{\rm dim}$) can exhibit a completely different dependence on the intermolecular-interaction strength. We observe that (i) for $q_{\rm nr}$ near the Franck-Condon region, $\tau_{\rm nr}^{\rm dim}$ increases with the interaction strength; (ii) for $q_{\rm nr}$ near the minimum of the monomer excited PES, the intermolecular interaction has little influence on $\tau_{\rm nr}^{\rm dim}$; (iii) for $q_{\rm nr}$ near the classical turning point of the monomer nuclear dynamics, on the other side of the minimum, $\tau_{\rm nr}^{\rm dim}$ decreases with the interaction strength...
July 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28731212/cross-validation-of-commercial-enzyme-linked-immunosorbent-assay-and-radioimmunoassay-for-porcine-c-peptide-concentration-measurements-in-non-human-primate-serum
#19
Sarah C Gresch, Lucas A Mutch, Jody L Janecek, Rebecca L Hegstad-Davies, Melanie L Graham
BACKGROUND: C-peptide concentration is widely used as a marker of insulin secretion and is especially relevant in evaluating islet graft function following transplantation, because its measurement is not confounded by the presence of exogenous insulin. To address the shortage of human islet donors, the use of porcine islets has been proposed as a possible solution and the stringent pig-to-non-human primate (NHP) model is often the most relevant for pre-clinical evaluation of the potential for diabetes reversal resulting from an islet xenograft...
July 21, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28731095/polarization-driven-conductance-variations-at-charged-ferroelectric-domain-walls
#20
A-S Pawlik, T Kämpfe, A Haußmann, T Woike, U Treske, M Knupfer, B Büchner, E Soergel, R Streubel, A Koitzsch, L M Eng
Conducting domain walls (CDWs) in ferroelectric materials are promising candidates for applications in a manifold of nanoscale, optoelectronic devices. Characterization of their microscopic properties, however, remains challenging due to their small dimension and highly insulating environment. Here, we inspect individual CDWs in single-crystalline LiNbO3 by the combination of photoemission electron microscopy (PEEM) and second harmonic generation (SHG) microscopy. While SHG unveils the overall domain wall inclination angle α, PEEM is sensitive to local conductance variations, both at and away from the domain wall...
July 21, 2017: Nanoscale
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