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https://www.readbyqxmd.com/read/27911328/the-clinical-use-of-cerebrospinal-fluid-biomarkers-for-alzheimer-s-disease-diagnosis-the-italian-selfie
#1
Giulia M Sancesario, Sofia Toniolo, Davide Chiasserini, Simona G Di Santo, Josh Zegeer, Gaetano Bernardi, Massimo Musicco, Carlo Caltagirone, Lucilla Parnetti, Sergio Bernardini
Although the use of cerebrospinal fluid (CSF) amyloid β1-42 (Aβ42), tau (T-tau), and phosphorylated tau (p-tau181) gives added diagnostic and prognostic values, the diffusion is still limited in clinical practice and only a restricted number of patients receive an integrated clinico-biological diagnosis. By a survey, we aimed to do a "selfie" of the use and diffusion of CSF biomarkers of dementia in Italy, the standardization of pre-analytical procedures, the harmonization of ranges, and the participation to Quality Control programs...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27910938/modulated-switching-current-density-and-spin-orbit-torques-in-mnga-ta-films-with-inserting-ferromagnetic-layers
#2
Kangkang Meng, Jun Miao, Xiaoguang Xu, Yong Wu, Jiaxing Xiao, Jianhua Zhao, Yong Jiang
We report modulated switching current density and spin-orbit torques (SOT) in MnGa/Ta films with inserting very thin Co2FeAl and Co layers. Ferromagnetic coupling has been found in MnGa/Co2FeAl/Ta, resulting in a decreased effective anisotropy field. On the contrary, in MnGa/Co/Ta, antiferromagnetic coupling plays a dominant role. The switching current density Jc in MnGa/Ta is 8.5 × 10(7) A/cm(2). After inserting 0.8-nm-thick Co2FeAl and Co, theJc becomes 5 × 10(7) A/cm(2) and 9 × 10(7) A/cm(2), respectively...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910715/how-do-we-measure-adherence-to-anti-tuberculosis-treatment
#3
Salomé Valencia, Montserrat León, Irene Losada, Victor G Sequera, Manuel Fernandez Quevedo, Alberto L García-Basteiro
Completion of anti-tuberculosis (TB) treatment is of paramount importance for TB patients, as well as for the global efforts of TB control. However, there is neither a gold-standard measure to monitor adherence to TB treatment nor a widely used definition for different levels of adherence. Areas covered: in this review we aim to describe the different methods used to measure patients' adherence to anti-TB treatment, identifying their main strengths and limitations, with a focus on low resource settings. Expert commentary: there is a need for continuing the quest for a low cost, reliable and acceptable measure of adherence to TB treatment...
December 2, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27910703/co-calibration-of-two-self-reported-measures-of-adherence-to-antiretroviral-therapy
#4
Robin M Nance, J A Chris Delaney, Carol E Golin, Wendee M Wechsberg, Chinazo Cunningham, Frederick Altice, Katerina Christopoulos, Kevin Knight, Vu Quan, Michael S Gordon, Sandra Springer, Jeremy Young, Paul K Crane, Kenneth H Mayer, Michael J Mugavero, Carlos Del Rio, Richard A Kronmal, Heidi M Crane
Adherence to antiretroviral therapy (ART) is an important determinant of clinical success assessed in many HIV studies. Harmonizing adherence data from studies that use different measures is difficult without a co-calibration equation to convert between validated instruments. Our purpose was to co-calibrate two commonly used adherence measures: the AIDS Clinical Trials Group (ACTG) questionnaire and the Visual Analog Scale (VAS). We used robust linear regression to develop a co-calibration equation in a clinical care cohort...
December 2, 2016: AIDS Care
https://www.readbyqxmd.com/read/27910589/improved-cross-calibration-of-thomson-scattering-and-electron-cyclotron-emission-with-ech-on-diii-d
#5
M W Brookman, M E Austin, A G McLean, T N Carlstrom, A W Hyatt, J Lohr
Thomson scattering produces ne profiles from measurement of scattered laser beam intensity. Rayleigh scattering provides a first calibration of the relation ne ∝ ITS, which depends on many factors (e.g., laser alignment and power, optics, and measurement systems). On DIII-D, the ne calibration is adjusted against an absolute ne from the density-driven cutoff of the 48 channel 2nd harmonic X-mode electron cyclotron emission system. This method has been used to calibrate Thomson ne from the edge to near the core (r/a > 0...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910551/x-ray-analysis-of-electron-bernstein-wave-heating-in-mst
#6
A H Seltzman, J K Anderson, A M DuBois, A Almagri, C B Forest
A pulse height analyzing x-ray tomography system has been developed to detect x-rays from electron Bernstein wave heated electrons in the Madison symmetric torus reversed field pinch (RFP). Cadmium zinc telluride detectors are arranged in a parallel beam array with two orthogonal multi-chord detectors that may be used for tomography. In addition a repositionable 16 channel fan beam camera with a 55° field of view is used to augment data collected with the Hard X-ray array. The chord integrated signals identify target emission from RF heated electrons striking a limiter located 12° toroidally away from the RF injection port...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910542/design-and-first-plasma-measurements-of-the-iter-ece-prototype-radiometer
#7
M E Austin, M W Brookman, W L Rowan, S Danani, E W Bryerton, P Dougherty
On ITER, second harmonic optically thick electron cyclotron emission (ECE) in the range of 220-340 GHz will supply the electron temperature (Te). To investigate the requirements and capabilities prescribed for the ITER system, a prototype radiometer covering this frequency range has been developed by Virginia Diodes, Inc. The first plasma measurements with this instrument have been carried out on the DIII-D tokamak, with lab bench tests and measurements of third through fifth harmonic ECE from high Te plasmas...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910444/synthetic-diagnostics-platform-for-fusion-plasmas-invited
#8
L Shi, E J Valeo, B J Tobias, G J Kramer, L Hausammann, W M Tang, M Chen
A Synthetic Diagnostics Platform (SDP) for fusion plasmas has been developed which provides state of the art synthetic reflectometry, beam emission spectroscopy, and Electron Cyclotron Emission (ECE) diagnostics. Interfaces to the plasma simulation codes GTC, XGC-1, GTS, and M3D-C(1) are provided, enabling detailed validation of these codes. In this paper, we give an overview of SDP's capabilities, and introduce the synthetic diagnostic modules. A recently developed synthetic ECE Imaging module which self-consistently includes refraction, diffraction, emission, and absorption effects is discussed in detail...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910350/optimization-and-application-of-cooled-avalanche-photodiodes-for-spectroscopic-fluctuation-measurements-with-ultra-fast-charge-exchange-recombination-spectroscopy
#9
D D Truong, R J Fonck, G R McKee
The Ultra-Fast Charge Exchange Recombination Spectroscopy (UF-CHERS) diagnostic is a highly specialized spectroscopic instrument with 2 spatial channels consisting of 8 spectral channels each and a resolution of ∼0.25 nm deployed at DIII-D to measure turbulent ion temperature fluctuations. Charge exchange emissions are obtained between 528 and 530 nm with 1 μs time resolution to study plasma instabilities. A primary challenge of extracting fluctuation measurements from raw UF-CHERS signals is photon and electronic noise...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910304/highly-compact-fiber-fabry-perot-interferometer-a-new-instrument-design
#10
B K Nowakowski, D T Smith, S T Smith
This paper presents the design, construction, and characterization of a new optical-fiber-based, low-finesse Fabry-Perot interferometer with a simple cavity formed by two reflecting surfaces (the end of a cleaved optical fiber and a plane, reflecting counter-surface), for the continuous measurement of displacements of several nanometers to several tens of millimeters. No beam collimation or focusing optics are required, resulting in a displacement sensor that is extremely compact (optical fiber diameter 125 μm), is surprisingly tolerant of misalignment (more than 5°), and can be used over a very wide range of temperatures and environmental conditions, including ultra-high-vacuum...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910225/two-new-non-centrosymmetric-selenides-azn4in5se12-a-rb-cs-synthesis-characterization-and-nonlinear-optical-properties
#11
Liming Wu, Hua Lin, Yu-Jun Zheng, Xiao-Ning Hu, Hong Chen, Ju-Song Yu
Two new non-centrosymmetric polar quaternary selenides, namely, RbZn4In5Se12 and CsZn4In5Se12, have been synthesized and structurally characterized. They exhibit 3D diamond-like framework (DLF) consisting of corner shared MSe4 (M = Zn/In) tetrahedra, in which the A+ ions are located. Both compounds are thermally stable up to 1300 K and exhibit large transmittance in the infrared region (0.65-25 μm) with measured optical band gaps of 2.06 eV for RbZn4In5Se12 and 2.11 eV for CsZn4In5Se12. Inspiringly, they exhibit good balance between strong second harmonic generation (SHG) efficiency (3...
December 1, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27909273/-minimally-invasive-coronary-artery-bypass-grafting-using-bilateral-in-situ-internal-thoracic-arteries
#12
Akihiko Yamauchi, Masaki Tabuchi, Shinya Terada, Keita Kikuchi
A 73-year-old male with diabetes mellitius was referred to our hospital for coronary artery bypass grafting (CABG). Preoperative coronary angiography revealed three-vessel coronary disease. Minimally invasive coronary artery grafting (MICS CABG) via left thoracotomy was selected to decrease surgical site infection due to severe diabetes. In situ bilateral internal thoracic arteries (BITA) were harvested using a long type Harmonic scalpel. In situ right internal thorac artery( RITA)-left anterior descending artery (LAD), in situ left internal thorac artery( LITA)-high lateral branch (HL), and aorta-saphenous vein graft (SVG)-#4 posterior descending artery were performed...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27908103/non-equilibrium-dynamics-from-rpmd-and-cmd
#13
Ralph Welsch, Kai Song, Qiang Shi, Stuart C Althorpe, Thomas F Miller
We investigate the calculation of approximate non-equilibrium quantum time correlation functions (TCFs) using two popular path-integral-based molecular dynamics methods, ring-polymer molecular dynamics (RPMD) and centroid molecular dynamics (CMD). It is shown that for the cases of a sudden vertical excitation and an initial momentum impulse, both RPMD and CMD yield non-equilibrium TCFs for linear operators that are exact for high temperatures, in the t = 0 limit, and for harmonic potentials; the subset of these conditions that are preserved for non-equilibrium TCFs of non-linear operators is also discussed...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27908092/the-effect-of-cubic-material-nonlinearity-on-the-propagation-of-torsional-wave-modes-in-a-pipe
#14
Yanzheng Wang, Jan D Achenbach
The effect of cubic material nonlinearity on the propagation in a pipe of the lowest axially symmetric torsional wave mode has been investigated in this paper. Two cases, one that the material of the whole pipe is nonlinear, and the second that a small segment of the pipe is nonlinear, have been considered. For the first case, a first and a third harmonic have been obtained by the perturbation method. Analytical expressions for the two cumulative harmonics have been derived. The second case leads to a scattering problem...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27908086/identification-of-the-rayleigh-surface-waves-for-estimation-of-viscoelasticity-using-the-surface-wave-elastography-technique
#15
Xiaoming Zhang
The purpose of this Letter to the Editor is to demonstrate an effective method for estimating viscoelasticity based on measurements of the Rayleigh surface wave speed. It is important to identify the surface wave mode for measuring surface wave speed. A concept of start frequency of surface waves is proposed. The surface wave speeds above the start frequency should be used to estimate the viscoelasticity of tissue. The motivation was to develop a noninvasive surface wave elastography (SWE) technique for assessing skin disease by measuring skin viscoelastic properties...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27908022/sampled-data-based-consensus-and-containment-control-of-multiple-harmonic-oscillators-a-motion-planning-approach
#16
Yongfang Liu, Yu Zhao, Guanrong Chen
This paper studies the distributed consensus and containment problems for a group of harmonic oscillators with a directed communication topology. First, for consensus without a leader, a class of distributed consensus protocols is designed by using motion planning and Pontryagin's principle. The proposed protocol only requires relative information measurements at the sampling instants, without requiring information exchange over the sampled interval. By using stability theory and the properties of stochastic matrices, it is proved that the distributed consensus problem can be solved in the motion planning framework...
November 2016: Chaos
https://www.readbyqxmd.com/read/27906368/euv-scatterometer-with-a-high-harmonic-generation-euv-source
#17
Yi-Sha Ku, Chia-Liang Yeh, Yi-Chang Chen, Chun-Wei Lo, Wei-Ting Wang, Ming-Chang Chen
We have developed an extreme ultraviolet (EUV) scatterometer based on the analysis of coherent EUV light diffracted from a periodic array with nano-scale features. We discuss the choice of appropriate orders of the high harmonics generated coaxially along with the intense Ti:sapphire laser pulses for high resolution spatial performance. We describe an inverse-problem methodology for determining the structural parameters, and present preliminary measurement results confirming the functionality of the scatterometer...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906360/large-amplitude-wavelength-modulation-spectroscopy-for-sensitive-measurements-of-broad-absorbers
#18
Torrey R S Hayden, Gregory B Rieker
We demonstrate large amplitude wavelength modulation spectroscopy (WMS) with a MEMS-tunable vertical cavity surface-emitting laser (MEMS-VCSEL) to measure high-density gases. WMS enables sensitive measurements of gas phase thermodynamic properties in harsh environments, but has been limited to moderate pressure and density conditions because of the narrow tuning range of traditional DFB lasers. The MEMS-tunable laser is able to rapidly modulate across the broadened features of high-density gas mixtures to produce the harmonic signals in the detected light intensity typical of WMS...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906354/anticrossing-double-fano-resonances-generated-in-metallic-dielectric-hybrid-nanostructures-using-nonradiative-anapole-modes-for-enhanced-nonlinear-optical-effects
#19
Wu-Chao Zhai, Tie-Zhu Qiao, Dong-Jin Cai, Wen-Jie Wang, Jing-Dong Chen, Zhi-Hui Chen, Shao-Ding Liu
Third-harmonic generation with metallic or dielectric nanoparticles often suffer from, respectively, small modal volumes and weak near-field enhancements. This study propose and demonstrate that a metallic/dielectric hybrid nanostructure composed of a silver double rectangular nanoring and a silicon square nanoplate can be used to overcome these obstacles for enhanced third-harmonic generation. It is shown that the nonradiative anapole mode of the Si plate can be used as a localized source to excite the dark subradiant octupole mode of the Ag ring, and the mode hybridization leads to the formation of an antibonding and a bonding subradiant collective mode, thereby forming anticrossing double Fano resonances...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906339/shaping-of-ultraviolet-femtosecond-laser-pulses-by-fourier-domain-harmonic-generation
#20
E Hertz, F Billard, G Karras, P Béjot, B Lavorel, O Faucher
We present a method to finely tailor ultraviolet femtosecond laser pulses using a pulse shaper with ability in the infrared/visible spectral range. We have developed to that end a frequency doubling module in which the up-conversion mechanism is carried out in the Fourier plane of a 4 f -line. The pulse shaper is used to imprint a spectral phase and/or amplitude onto the fundamental pulse. The shaped pulse is then frequency doubled through the module which transfers the applied spectral shaping to the second harmonic field in a predictable manner...
November 28, 2016: Optics Express
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