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https://www.readbyqxmd.com/read/29351573/multicenter-french-harmonization-study-for-pd-l1-ihc-testing-in-non-small-cell-lung-cancer
#1
J Adam, N Le Stang, I Rouquette, A Cazes, C Badoual, H Pinot-Roussel, L Tixier, C Danel, F Damiola, D Damotte, F Penault-Llorca, S Lantuéjoul
Background: Various PD-L1 immunohistochemistry (IHC) assays have been developed and used in clinical trials in association with different drugs. In order to harmonize and make PD-L1 testing in non-small cell lung cancer (NSCLC) widely available, we conducted a multicenter study comparing PD-L1 standardized assays and laboratory-developed tests (LDT). Methods: IHC with five anti-PD-L1 monoclonal antibodies (28-8, 22C3, E1L3N, SP142 and SP263) was performed concomitantly on 41 NSCLC surgical specimens in 7 centers using Dako Autostainer Link 48 (3 centers), Leica Bond (2 centers) or Ventana BenchMark Ultra (2 centers), platforms...
January 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29351505/helping-mediating-and-gaining-recognition-the-everyday-identity-work-of-romanian-health-social-workers
#2
Alexandra Ciocănel, Florin Lazăr, Shari Munch, Cara Harmon, Georgiana-Cristina Rentea, Daniela Gaba, Anca Mihai
Health social work is a field with challenges, opportunities, and ways of professing social work that may vary between different national contexts. In this article, we look at how Romanian health social workers construct their professional identity through their everyday identity work. Drawing on a qualitative study based on interviews with 21 health social workers working in various organizational contexts, we analyze what health social workers say they do and how this shapes their self-conception as professionals...
January 19, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29351373/a-facile-space-confined-solid-phase-sulfurization-strategy-for-growth-of-high-quality-ultrathin-molybdenum-disulfide-single-crystals
#3
Dawei Li, Zhiyong Xiao, Sai Mu, Fei Wang, Ying Liu, Jingfeng Song, Xi Huang, Lijia Jiang, Jun Xiao, Lei Liu, Stephen Ducharme, Bai Cui, Xia Hong, Lan Jiang, Jean-Francois Silvain, Yongfeng Lu
Single-crystal transition metal dichalcogenides (TMDs) and TMD-based hetero-junctions have recently attracted significant research and industrial interest owing to their intriguing optical and electrical properties. However, the lack of a simple, low-cost, environmentally friendly, synthetic method and a poor understanding of the growth mechanism post a huge challenge to implementing TMDs in practical applications. In this work, we developed a novel approach for direct formation of high-quality, monolayer and few-layer MoS2 single crystal domains via a single-step rapid thermal processing of a sandwiched reactor with sulfur and molybdenum (Mo) film in a confined reaction space...
January 19, 2018: Nano Letters
https://www.readbyqxmd.com/read/29351326/increased-natural-reproduction-and-genetic-diversity-one-generation-after-cessation-of-a-steelhead-trout-oncorhynchus-mykiss-conservation-hatchery-program
#4
Barry A Berejikian, Donald M Van Doornik
Spatial and temporal fluctuations in productivity and abundance confound assessments of captive propagation programs aimed at recovery of Threatened and Endangered populations. We conducted a 17 year before-after-control-impact experiment to determine the effects of a captive rearing program for anadromous steelhead trout (Oncorhynchus mykiss) on a key indicator of natural spawner abundance (naturally produced nests or 'redds'). The supplemented population exhibited a significant (2.6-fold) increase in redd abundance in the generation following supplementation...
2018: PloS One
https://www.readbyqxmd.com/read/29351289/the-rumour-spectrum
#5
Nicolas Turenne
Rumour is an old social phenomenon used in politics and other public spaces. It has been studied for only hundred years by sociologists and psychologists by qualitative means. Social media platforms open new opportunities to improve quantitative analyses. We scanned all scientific literature to find relevant features. We made a quantitative screening of some specific rumours (in French and in English). Firstly, we identified some sources of information to find them. Secondly, we compiled different reference, rumouring and event datasets...
2018: PloS One
https://www.readbyqxmd.com/read/29350956/negative-mass-instability-of-the-spin-and-motion-of-an-atomic-gas-driven-by-optical-cavity-backaction
#6
Jonathan Kohler, Justin A Gerber, Emma Dowd, Dan M Stamper-Kurn
We realize a spin-orbit interaction between the collective spin precession and center-of-mass motion of a trapped ultracold atomic gas, mediated by spin- and position-dependent dispersive coupling to a driven optical cavity. The collective spin, precessing near its highest-energy state in an applied magnetic field, can be approximated as a negative-mass harmonic oscillator. When the Larmor precession and mechanical motion are nearly resonant, cavity mediated coupling leads to a negative-mass instability, driving exponential growth of a correlated mode of the hybrid system...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29350940/experimental-verification-of-a-jarzynski-related-information-theoretic-equality-by-a-single-trapped-ion
#7
T P Xiong, L L Yan, F Zhou, K Rehan, D F Liang, L Chen, W L Yang, Z H Ma, M Feng, V Vedral
Most nonequilibrium processes in thermodynamics are quantified only by inequalities; however, the Jarzynski relation presents a remarkably simple and general equality relating nonequilibrium quantities with the equilibrium free energy, and this equality holds in both the classical and quantum regimes. We report a single-spin test and confirmation of the Jarzynski relation in the quantum regime using a single ultracold ^{40}Ca^{+} ion trapped in a harmonic potential, based on a general information-theoretic equality for a temporal evolution of the system sandwiched between two projective measurements...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29350620/trions-in-bulk-and-monolayer-materials-faddeev-equations-and-hyperspherical-harmonics
#8
I Filikhin, Roman Ya Kezerashvili, Shalva M Tsiklauri, Bravislav Vlahovic
The negatively T<sup>- </sup>and positively T<sup>+</sup> charged trions in bulk and monolayer semiconductors are studied in the effective mass approximation within the framework of a potential model. The binding energies of trions in various semiconductors are calculated by employing Faddeev equation with the Coulomb potential in three-dimensional (3D) configuration space. Results of calculations of the binding energies for T<sup>-</sup> are consistent with previous computational studies while the T<sup>+</sup> is unbound for all considered cases...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29350538/express-potential-second-harmonic-ghost-bands-in-the-fourier-transform-infrared-ft-ir-difference-spectroscopy-of-proteins
#9
Shota Ito, Hideki Kandori, Victor A Lorenz Fonfria
No abstract text is available yet for this article.
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29348086/pharmaceutical-equivalent-dissertation-of-metformin-hydrochloride-brands
#10
Safila Naveed, Huma Dilshad, Maheen Nafees, Muhammad Ibrar Shinwari, Khan Usmanghani, Ghulam Sarwar
The aim of study is to establish pharmaceutical equivalence of different brands of Metformin tablets available in Karachi, Pakistan. The quality control parameters which are studied are weight variation test, hardness test, thickness, friability, disintegration and dissolution specified by BP/USP (British and United State Pharmacopoeia). Weight variation and hardness value requirement was complied by all brands. Disintegration time for all brands was within range i.e. 15 minutes and also complies with the BP/USP recommendation...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29347775/mode-locking-in-systems-of-globally-coupled-phase-oscillators
#11
Sebastian Eydam, Matthias Wolfrum
We investigate the dynamics of a Kuramoto-type system of globally coupled phase oscillators with equidistant natural frequencies and a coupling strength below the synchronization threshold. It turns out that in such cases one can observe a stable regime of sharp pulses in the mean field amplitude with a pulsation frequency given by spacing of the natural frequencies. This resembles a process known as mode locking in lasers and relies on the emergence of a phase relation induced by the nonlinear coupling. We discuss the role of the first and second harmonics in the phase-interaction function for the stability of the pulsations and present various bifurcating dynamical regimes such as periodically and chaotically modulated mode locking, transitions to phase turbulence, and intermittency...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347704/recurrence-due-to-periodic-multisoliton-fission-in-the-defocusing-nonlinear-schr%C3%A3-dinger-equation
#12
Guo Deng, Sitai Li, Gino Biondini, Stefano Trillo
We address the degree of universality of the Fermi-Pasta-Ulam recurrence induced by multisoliton fission from a harmonic excitation by analyzing the case of the semiclassical defocusing nonlinear Schrödinger equation, which models nonlinear wave propagation in a variety of physical settings. Using a suitable Wentzel-Kramers-Brillouin approach to the solution of the associated scattering problem we accurately predict, in a fully analytical way, the number and the features (amplitude and velocity) of solitonlike excitations emerging post-breaking, as a function of the dispersion smallness parameter...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347640/thermodynamic-cost-for-classical-counterdiabatic-driving
#13
Alessandro Bravetti, Diego Tapias
Motivated by the recent growing interest about the thermodynamic cost of shortcuts to adiabaticity, we consider the cost of driving a classical system by the so-called counterdiabatic driving (CD). To do so, we proceed in three steps: first we review a general definition recently put forward in the literature for the thermodynamic cost of driving a Hamiltonian system; then we provide a new complementary definition of cost, which is of particular relevance for cases where the average excess work vanishes; finally, we apply our general framework to the case of CD...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347605/classical-many-particle-systems-with-unique-disordered-ground-states
#14
G Zhang, F H Stillinger, S Torquato
Classical ground states (global energy-minimizing configurations) of many-particle systems are typically unique crystalline structures, implying zero enumeration entropy of distinct patterns (aside from trivial symmetry operations). By contrast, the few previously known disordered classical ground states of many-particle systems are all high-entropy (highly degenerate) states. Here we show computationally that our recently proposed "perfect-glass" many-particle model [Sci. Rep. 6, 36963 (2016)10.1038/srep36963] possesses disordered classical ground states with a zero entropy: a highly counterintuitive situation ...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347528/quantum-work-fluctuations-in-connection-with-the-jarzynski-equality
#15
Juan D Jaramillo, Jiawen Deng, Jiangbin Gong
A result of great theoretical and experimental interest, the Jarzynski equality predicts a free energy change ΔF of a system at inverse temperature β from an ensemble average of nonequilibrium exponential work, i.e., 〈e^{-βW}〉=e^{-βΔF}. The number of experimental work values needed to reach a given accuracy of ΔF is determined by the variance of e^{-βW}, denoted var(e^{-βW}). We discover in this work that var(e^{-βW}) in both harmonic and anharmonic Hamiltonian systems can systematically diverge in nonadiabatic work protocols, even when the adiabatic protocols do not suffer from such divergence...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347519/environmental-rocking-ratchet-environmental-rectification-by-a-harmonically-driven-avoided-crossing
#16
P Nalbach, N Klinkenberg, T Palm, N Müller
We propose a rocking ratchet designed as a symmetric quantum two-state system driven by a single periodic harmonic force and influenced symmetrically by thermal fluctuations. We show that the necessary broken symmetry can dynamically be achieved by a thermal environment that couples to the energy difference between the two states and the tunnel coupling between them. The quantum two-state system is driven by the harmonic periodic drive through its avoided crossing. The correspondingly driven dissipative quantum dynamics results on average in a finite population difference between both states...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347469/quantum-adiabatic-protocols-using-emergent-local-hamiltonians
#17
Ranjan Modak, Lev Vidmar, Marcos Rigol
We present two applications of emergent local Hamiltonians to speed up quantum adiabatic protocols for isolated noninteracting and weakly interacting fermionic systems in one-dimensional lattices. We demonstrate how to extract maximal work from initial band-insulating states, and how to adiabatically transfer systems from linear and harmonic traps into box traps. Our protocols consist of two stages. The first one involves a free expansion followed by a quench to an emergent local Hamiltonian. In the second stage, the emergent local Hamiltonian is "turned off" quasistatically...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347462/underdamped-stochastic-harmonic-oscillator-driven-by-l%C3%A3-vy-noise
#18
Bartłomiej Dybiec, Ewa Gudowska-Nowak, Igor M Sokolov
We investigate the distribution of potential and kinetic energy in stationary states of the linearly damped stochastic oscillator driven by Lévy noises. In the long time limit distributions of kinetic and potential energies of the oscillator follow the power-law asymptotics and do not fulfill the equipartition theorem. The partition of the mechanical energy is controlled by the damping coefficient. In the limit of vanishing damping a stochastic analog of the equipartition theorem can be proposed, namely, the statistical properties of potential and kinetic energies attain distributions characterized by the same widths...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347392/two-dimensional-dynamics-of-a-trapped-active-brownian-particle-in-a-shear-flow
#19
Yunyun Li, Fabio Marchesoni, Tanwi Debnath, Pulak K Ghosh
We model the two-dimensional dynamics of a pointlike artificial microswimmer diffusing in a harmonic trap subject to the shear flow of a highly viscous medium. The particle is driven simultaneously by the linear restoring force of the trap, the drag force exerted by the flow, and the torque due to the shear gradient. For a Couette flow, elliptical orbits in the noiseless regime, and the correlation functions between the particle's displacements parallel and orthogonal to the flow are computed analytically. The effects of thermal fluctuations (translational) and self-propulsion fluctuations (angular) are treated separately...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347387/anomalous-interfacial-temperature-profile-induced-by-phonon-localization
#20
Yue Liu, Dahai He
Through the integration of the power spectral density, we obtain temperature profiles of both multisegment harmonic and anharmonic systems, showing the presence of an anomalous negative temperature gradient inside the interfacial segment. Via investigating patterns of the power spectral density, we found that the counterintuitive phenomenon comes from the presence of interfacial localized phonon modes. Two out-band localized modes of the harmonic model, which make no contributions to local temperature due to the absence of phonon interactions, result in the concave temperature profile and overcooling effect...
December 2017: Physical Review. E
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