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https://www.readbyqxmd.com/read/29667174/impact-of-prior-cancer-history-on-the-overall-survival-of-patients-newly-diagnosed-with-cancer-a-pan-cancer-analysis-of-the-seer-database
#1
Huaqiang Zhou, Yan Huang, Zeting Qiu, Hongyun Zhao, Wenfeng Fang, Yunpeng Yang, Yuanyuan Zhao, Xue Hou, Yuxiang Ma, Shaodong Hong, Ting Zhou, Yaxiong Zhang, Li Zhang
The population of cancer survivors with prior cancer is rapidly growing. Whether a prior cancer diagnosis interferes with outcome is unknown. We conducted a pan-cancer analysis to determine the impact of prior cancer history for patients newly diagnosed with cancer. We identified 20 types of primary solid tumors between 2004 to 2008 in the Surveillance, Epidemiology, and End Results (SEER) database. Demographic and clinicopathologic variables were compared by chi-squared test and t-test as appropriate. The propensity score-adjusted Kaplan-Meier method and Cox proportional hazards models were used to evaluate the impact of prior cancer on overall survival (OS)...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29666266/dna-methylation-and-transcriptome-aberrations-mediated-by-er%C3%AE-in-mouse-seminal-vesicles-following-developmental-des-exposure
#2
Yin Li, Katherine J Hamilton, Tianyuan Wang, Laurel A Coons, Wendy N Jefferson, Ruifang Li, Yu Wang, Sara A Grimm, J Tyler Ramsey, Liwen Liu, Kevin E Gerrish, Carmen J Williams, Paul A Wade, Kenneth S Korach
Early transient developmental exposure to an endocrine active compound, diethylstilbestrol (DES), a synthetic estrogen, causes late-stage effects in the reproductive tract of adult mice. Estrogen receptor alpha (ERα) plays a role in mediating these developmental effects. However, the developmental mechanism is not well known in male tissues. Here, we present genome-wide transcriptome and DNA methylation profiling of the seminal vesicles (SVs) during normal development and after DES exposure. ERα mediates aberrations of the mRNA transcriptome in SVs of adult mice following neonatal DES exposure...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665574/diagnostic-methods-to-detect-uterus-illnesses-in-mares
#3
Miguel Alejandro Silva Rua, Celia Raquel Quirino, Rachel Bittencourt Ribeiro, Eulogio Carlos Queiroz Carvalho, Maria de Lourdes Amaral Bernadino, Aylton Bartholazzi Junior, Luisa Fernanda Cipagalta, Marcus Antônio Pessanha Barreto
Uterine illnesses are the major problem in horse reproductive programs. The diagnosis of these pathologies is often neglected or does not provide enough information about the cause. The aim of this study was to evaluate different diagnoses to provide more accurate information about endometritis and the real endometrial profile at the beginning of a breeding season. Fifty-one mares with reproductive failure were evaluated. Two different uterine cytology diagnoses, culture of uterine flush material and biopsy assay, were performed...
April 9, 2018: Theriogenology
https://www.readbyqxmd.com/read/29663372/regulatory-t-and-t-helper-17-cells-their-roles-in-preeclampsia
#4
REVIEW
Arezoo Hosseini, Sanam Dolati, Vida Hashemi, Meghdad Abdollahpour-Alitappeh, Mehdi Yousefi
Regulatory T (Treg) cells have been identified as key immune regulators and are important to fetal survival within the maternal uterus. T helper 17 (Th17) cells have also emerged as a new subset of effector helper T cells and play significant roles in host defense against extracellular pathogens, autoimmune conditions, and inflammatory chronic diseases. Recent findings have provided strong support for the contribution of Th17 and Treg cells to successful pregnancy. Disorders of pregnancy such as preeclampsia (PE) and recurrent spontaneous abortion (RSA) are associated with low frequencies of Treg cells and high levels of Th17 cells...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29662714/post-cesarean-scar-endometriosis
#5
Doğan Yıldırım, Cihad Tatar, Ozan Doğan, Adnan Hut, Turgut Dönmez, Muzaffer Akıncı, Mehmet Toptaş, Rahime Nida Bayık
Objective: Endometriosis is seen in women during their reproductive period, where stromal tissue and functional endometrial glands of the uterus are observed outside the uterine cavity. In this study, we aimed to identify the clinical characteristics of our patients who underwent surgery with scar endometriosis and to discuss the surgical results in light of the literature. Materials and Methods: A total of 24 patients who underwent surgery and diagnosed as having endometriosis as the result of a pathologic examination were retrospectively evaluated...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29662713/are-the-skin-scar-characteristics-and-closure-of-the-parietal-peritoneum-associated-with-pelvic-adhesions
#6
Numan Çim, Erkan Elçi, Gülhan Güneş Elçi, Necat Almalı, Recep Yıldızhan
Objective: To assess whether the abdominal scar characteristics and closure of the peritoneum were associated with pelvic adhesions. Materials and Methods: Patients who had undergone cesarean section between December 2015 and February 2016 were assessed prospectively in terms of age, gravida, body mass index, number of living children, number of cesarean sections, time passed since the last cesarean section, closure status of the peritoneum in the last cesarean section, presence of other diseases, smoking status, location of incision in the abdomen (medial, pfannenstiel) scar dimensions (length, width), scar status with respect to skin (hypertrophic, flat, depressive), scar color [color change/no color change (hyperpigmented/hypopigmented)], adhesion of bowel-omentum-uterus, omentum-anterior abdominal wall, uterus-anterior abdominal wall, uterus-bladder, bladder-anterior abdominal wall, fixed uterus, and uterus-omentum-anterior abdominal wall in abdominal exploration...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29662708/emergency-peripartum-hysterectomy-in-the-dubai-health-system-a-fifteen-year-experience
#7
Muna Abdulrazzaq Tahlak, Mahera Abdulrahman, Nawal Mahmood Hubaishi, Mushtaq Omar, Fatima Cherifi, Shazia Magray, Frederick Robert Carrick
Objective: To determine the incidence, demographic data, risk factors, indications, outcome and complications of emergency peripartum hysterectomy (EPH) performed in two major tertiary care hospitals in Dubai, and to compare the results with the literature. Materials and Methods: The records of all women who underwent EPH from January 2000 to December 2015 in two major tertiary care hospitals in Dubai were accessed and reviewed. Maternal characteristics, hysterectomy indications, outcomes, and postoperative complications were recorded using descriptive statistics to describe the cohort...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29661501/mechanical-strain-induced-phospho-proteomic-signaling-in-uterine-smooth-muscle-cells
#8
Christian Copley Salem, Craig Ulrich, David Quilici, Karen Schlauch, Iain L O Buxton, Heather Burkin
Mechanical strain associated with the expanding uterus correlates with increased preterm birth rates. Mechanical signals result in a cascading network of protein phosphorylation events. These signals direct cellular activities and may lead to changes in contractile phenotype and calcium signaling. In this study, the complete phospho-proteome of uterine smooth muscle cells subjected to mechanical strain for 5 min was compared to un-strained controls. Statistically significant, differential phosphorylation events were annotated by Ingenuity Pathway Analysis to elucidate mechanically induced phosphorylation networks...
March 30, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29661120/uterine-tumors-resembling-ovarian-sex-cord-tumors-in-four-baboons-papio-spp
#9
Sara Mangosing, Ekaterina Perminov, Olga Gonzalez, Erica K Barkei, Emily M Corbin, Shyamesh Kumar, Edward J Dick
Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare uterine neoplasms that exhibit prominent sex cord-like differentiation. The authors describe 4 cases of UTROSCTs that were identified as incidental lesions in female baboons. All baboons were in good body condition. One animal had a 2-mm-diameter yellow-tan mass in the uterine body along the attachment of the left broad ligament; the other 3 did not have any gross lesions in the uterus. Histologically, the myometrium contained multifocal well-demarcated neoplasms composed of cuboidal to columnar cells arranged in variable arrangements of sheets, nests, cords, trabecular, and retiform patterns that occasionally formed Call-Exner-like bodies...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29660629/fatty-acid-profile-of-blood-plasma-and-oviduct-and-uterine-fluid-during-early-and-late-luteal-phase-in-the-horse
#10
B Drews, V Milojevic, K Giller, S E Ulbrich
During early pregnancy, the secretome of both oviduct and uterus serves as exchange medium for signaling factors between embryo and mother and provides the embryo with nutrients. The preimplantation embryo can utilize the fatty acids (FA) therein via direct incorporation into cell membrane lipid bilayers and for energy production via β-oxidation. The FA concentration and composition of the oviduct (OF) and uterine fluid (UF) might be regulated by ovarian hormones to meet the changing needs of the growing embryo...
April 7, 2018: Theriogenology
https://www.readbyqxmd.com/read/29658476/-microbiota-establishment-an-in-utero-colonization-decisive-for-future-health
#11
Rémi Gschwind, Thierry Fournier, Marie-José Butel, Sandra Wydau-Dematteis
Some diseases seem to have a developmental origin. Today, the microbiota is recognized as a determinant in health and diseases and one important step is its establishment in the neonate. Some variations in its composition including an imbalance (also called dysbiosis) have been associated to several pathologies. Recent studies suggest a bacterial colonization in the non-pregnant uterus, in the amniotic fluid and in the placenta, which were previously thought sterile. So, during deve-lopmental phases, the fetus could have encounter bacteria in utero...
April 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29657689/successful-management-of-abdominal-pregnancy-two-case-reports
#12
Shabnam Saquib, Wafa Elhussein Mohammed Talha
Abdominal pregnancy is a rare, life-threatening condition defined as pregnancy in the peritoneal cavity exclusive of tubal, ovarian, or intraligamentary locations. It can be primarily located in the peritoneal cavity or secondary to a ruptured ectopic pregnancy or tubal abortion. We present two cases of abdominal pregnancy, one primary and another secondary, both diagnosed and successfully managed in our institution. The first patient, a para 2 at 14 weeks gestation, presented with abdominal pain, distension, and dizziness, which had started four days prior...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29656984/corrigendum-to-benign-and-malignant-pathology-of-the-uterus-best-pract-res-clin-obstet-gynaecol-46-2018-12-30
#13
V Tanos, K E Berry
No abstract text is available yet for this article.
March 14, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29656953/-cesarean-after-labor-induction-risk-factors-and-prediction-score
#14
B Branger, V Dochez, S Gervier, N Winer
OBJECTIVES: The objective of the study is to determine the risk factors for caesarean section at the time of labor induction, to establish a prediction algorithm, to evaluate its relevance and to compare the results with observation. METHODS: A retrospective study was carried out over a year at Nantes University Hospital with 941 cervical ripening and labor inductions (24.1%) terminated by 167 caesarean sections (17.8%). Within the cohort, a case-control study was conducted with 147 caesarean sections and 148 vaginal deliveries...
April 12, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29656535/uterine-and-eggshell-modifications-associated-with-the-evolution-of-viviparity-in-south-american-water-snakes-helicops-spp
#15
Henrique B Braz, Selma M Almeida-Santos, Christopher R Murphy, Michael B Thompson
The evolution of viviparity requires eggshell thinning to bring together the maternal uterus and extraembryonic membranes to form placentae for physiological exchanges. Eggshell thinning likely involves reduced activity of the uterine glands that secrete it. We tested these hypotheses by comparing the uterine and eggshell structure and histochemistry among oviparous and viviparous water snakes (Helicops) using phylogenetic methods. Eggshell thinning occurred convergently in all three origins of viviparity in Helicops and was accomplished by the loss of the mineral layer and thinning of the shell membrane...
April 14, 2018: Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
https://www.readbyqxmd.com/read/29655696/syringin-prevents-bone-loss-in-ovariectomized-mice-via-traf6-mediated-inhibition-of-nf-%C3%AE%C2%BAb-and-stimulation-of-pi3k-akt
#16
Jingjing Liu, Zhuanzhuan Zhang, Qi Guo, Yanhong Dong, Qipeng Zhao, Xueqin Ma
BACKGROUND: Syringin, also called eleutheroside B, is a main bioactive phenolic glycoside in Acanthopanax senticosus (Rupr. et Maxim.) Harms. Based on the "kidney dominates bone" theory of TCM, A. senticosus can strengthen bone and Syringin may be one of the responsibilities. PURPOSE: The objectives of this study were to estimate the osteoporotic activity of Syringin and reveal the possible molecular mechanisms in vivo. METHODS: Sixty female ICR mice were randomly assigned into sham operated group (SHAM, treated with vehicle) and five ovariectomized subgroups (n = 10 each), treated with vehicle as OVX group, estradiol valerate (EV, 1 mg/kg/day) as positive group, and Syringin (10, 20 and 40 mg/kg/day) as low, moderate and high dosage groups...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29653387/bovine-uterus-derived-exosomes-improve-developmental-competence-of-somatic-cell-nuclear-transfer-embryos
#17
Fang Qiao, Hui Ge, Xiaonan Ma, Ying Zhang, Zhenzi Zuo, Mengyun Wang, Yong Zhang, Yongsheng Wang
Exosomes widely exist in various tissues and body fluids, including blood, tissue fluid, and urine. In the present study, exosomes were first isolated from the early luteal phase uterus and confirmed through morphological examination, immunofluorescence (IF) staining of special membrane antigen, and Western blot. The effects of exosomes on the developmental competence of somatic cell nuclear transfer (SCNT) embryos were investigated. Transmission electron microscopy results showed that the isolated exsomes were spherical particles with a 50 nm-150 nm diameter...
March 22, 2018: Theriogenology
https://www.readbyqxmd.com/read/29652817/selenium-in-radiation-oncology-15-years-of-experiences-in-germany
#18
REVIEW
Ralph Muecke, Oliver Micke, Lutz Schomburg, Jens Buentzel, Klaus Kisters, Irenaeus A Adamietz
Introduction: Se measurement and supplementation in radiation oncology is a controversial issue. The German Working Group Trace Elements and Electrolytes in Oncology (AKTE) has conducted a number of studies on this issue, which are summarized in this review. Strategies have been tested and developed, aiming to stratify the patients with a potential need for supplemental Se and how best to monitor Se supplementation with respect to health effects and risks. Methods: We analyzed blood and tissue Se-levels of different tumor patients ( n = 512)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29652725/therapeutic-strategies-involving-uterine-stem-cells-in-reproductive-medicine
#19
Michael Simoni, Hugh S Taylor
PURPOSE OF REVIEW: The current review provides an update on recent advances in stem cell biology relevant to female reproduction. RECENT FINDINGS: Stem cells are undifferentiated cells that often serve as a reservoir of cells to regenerate tissue in settings or injury or cell loss. The endometrium has progenitor stem cells that can replace all of the endometrium during each menstrual cycle. In addition, multipotent endometrial cells replace these progenitor cells when depleted...
April 12, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29650317/monte-carlo-based-assessment-of-magic-magicaug-pagatug-and-pagataug-polymer-gel-dosimeters-for-ovaries-and-uterus-organ-dosimetry-in-brachytherapy-nuclear-medicine-and-tele-therapy
#20
Karim Adinehvand, Fereidoun Nowshiravan Rahatabad
BACKGROUND AND OBJECTIVES: Calculation of 3D dose distribution during radiotherapy and nuclear medicine helps us for better treatment of sensitive organs such as ovaries and uterus. In this research, we investigate two groups of normoxic dosimeters based on meta-acrylic acid (MAGIC and MAGICAUG) and polyacrylamide (PAGATUG and PAGATAUG) for brachytherapy, nuclear medicine and Tele-therapy in their sensitive and critical role as organ dosimeters. METHODS: These polymer gel dosimeters are compared with soft tissue while irradiated by different energy photons in therapeutic applications...
June 2018: Computer Methods and Programs in Biomedicine
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