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https://www.readbyqxmd.com/read/28723271/development-of-three-orthogonal-assays-suitable-for-the-identification-and-qualification-of-pikfyve-inhibitors
#1
Kylie Fogarty, Mohammed Kashem, Andras Bauer, Alexandra Bernardino, Debra Brennan, Brian Cook, Neil Farrow, Teresa Molinaro, Richard Nelson
FYVE-type zinc finger-containing phosphoinositide kinase (PIKfyve) catalyzes the formation of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) from phosphatidylinositol 3-phosphate (PI(3)P). PIKfyve has been implicated in multiple cellular processes, and its role in the regulation of toll-like receptor (TLR) pathways and the production of proinflammatory cytokines has sparked interest in developing small-molecule PIKfyve inhibitors as potential therapeutics to treat autoimmune and inflammatory diseases. We developed three orthogonal assays to identify and qualify small-molecule inhibitors of PIKfyve: (1) a purified component microfluidic enzyme assay that measures the conversion of fluorescently labeled PI(3)P to PI(3,5)P2 by purified recombinant full-length human 6His-PIKfyve (rPIKfyve); (2) an intracellular protein stabilization assay using the kinase domain of PIKfyve expressed in HEK293 cells; and (3) a cell-based functional assay that measures the production of interleukin (IL)-12p70 in human peripheral blood mononuclear cells stimulated with TLR agonists lipopolysaccharide and R848...
July 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/28723093/plasmonic-aerogels-as-a-3d-nanoscale-platform-for-solar-fuels-photocatalysis
#2
Paul A DeSario, Jeremy J Pietron, Adam Dunkelberger, Todd H Brintlinger, Olga Baturina, Rhonda M Stroud, Jeffrey C Owrutsky, Debra R Rolison
We use plasmonic Au-TiO2 aerogels as a platform in which to marry synthetically thickened particle-particle junctions in TiO2 aerogel networks and Au||TiO2 interfaces and then investigate their cooperative influence on photocatalytic hydrogen (H2) generation under both broadband (i.e., UV + visible light) and visible-only excitation. In doing so, we elucidate the dual functions that incorporated Au can play as a water reduction/H2 generation co-catalyst and as a plasmonic sensitizer. We also introduce non-plasmonic Pt co-catalyst nanoparticles into our composite aerogels in order to leverage the catalytic water-reducing abilities of Pt...
July 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28720927/report-of-the-2016-17-academic-affairs-standing-committee-entrustable-professional-activities-implementation-roadmap
#3
Amy L Pittenger, Debra A Copeland, Matthew M Lacroix, Quamrun N Masuda, Peter Mbi, Melissa S Medina, Susan M Miller, Scott K Stolte, Cecilia M Plaza
The purpose of this report is to: 1) Identify linkages across the EPA statements, Center for the Advancement of Pharmacy Education 2013 Educational Outcomes (CAPE 2013) and the Joint Commission of Pharmacy Practitioners' Pharmacist Patient Care Process (PPCP); 2) Provide ways EPA statements can be used to communicate core skills that are part of the entry-level pharmacist identity; 3) Suggest a potential roadmap for AACP members on how to implement EPA statements.
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28720918/perceived-motivating-factors-and-barriers-for-the-completion-of-postgraduate-training-among-american-pharmacy-students-prior-to-beginning-advanced-pharmacy-practice-experiences
#4
Drayton A Hammond, Douglas R Oyler, John W Devlin, Jacob T Painter, Scott Bolesta, Joseph M Swanson, Brett J Bailey, Trisha Branan, Jeffrey F Barletta, Brianne Dunn, Jason S Haney, Paul Juang, Sandra L Kane-Gill, Tyree H Kiser, Hira Shafeeq, Debra Skaar, Pamela Smithburger, Jodi Taylor
Objective. To examine perceived motivating factors and barriers (MFB) to postgraduate training (PGT) pursuit among pharmacy students. Methods. Third-year pharmacy students at 13 schools of pharmacy provided demographics and their plan and perceived MFBs for pursuing PGT. Responses were characterized using descriptive statistics. Kruskal-Wallis equality-of-proportions rank tests determined if differences in perceived MFBs existed between students based on plan to pursue PGT. Results. Among 1218 (69.5%) respondents, 37...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28719499/a-retrospective-cohort-study-of-the-incidence-healthcare-resource-utilization-and-costs-of-icd-9-diagnosed-influenza-and-related-complications-in-us-children
#5
Philip O Buck, David M Smith, Rahul Shenolikar, Debra E Irwin
BACKGROUND: There is a paucity of data on the clinical and economic impact of seasonal influenza in children. This study estimated the incidence of diagnosed influenza and related complications, and associated healthcare resource utilization (HRU) and costs in US children. METHODS: Children ≥6 months and <18 years old diagnosed with influenza using ICD-9 codes and enrolled in a health plan during at least one influenza season between 2010-2014 were matched to similar patients without diagnosed influenza (GSK study identifier: HO-15-15728)...
July 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28717657/medical-genetics-and-genomic-medicine-in-the-united-states-of-america-part-1-history-demographics-legislation-and-burden-of-disease
#6
Carlos R Ferreira, Debra S Regier, Donald W Hadley, P Suzanne Hart, Maximilian Muenke
Medical genetics and genomic medicine in the United States of America. Part 1: history, demographics, legislation, and burden of disease.
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28716699/bridge-to-success-a-better-method-of-cryoablation-for-atrioventricular-nodal-reentrant-tachycardia-in-children
#7
Charitha D Reddy, Scott R Ceresnak, Kara S Motonaga, Kishor Avasarala, Christine Feller, Anthony Trela, Debra Hanisch, Anne M Dubin
BACKGROUND: Cryoablation for AVNRT is associated with higher recurrence rates than radiofrequency ablation(RF). Junctional tachycardia marks procedural success with RF, but no such indicator exists for cryoablation. OBJECTIVE: To determine the impact of voltage mapping plus longer ablation lesions on mid-term success of cryoablation for children with AVNRT. METHODS: A single-center retrospective analysis was performed of pediatric patients with AVNRT who underwent cryoablation from 2011-2015...
July 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28716687/measures-of-ventricular-arterial-coupling-and-incident-heart-failure-preserved-ejection-fraction-hfpef-a-matched-case-control-analysis
#8
Carolyn L Lekavich, Debra J Barksdale, Jia-Rong Wu, Virginia Neelon, Jamie Crandell, Eric J Velazquez
OBJECTIVES: This study was designed to detect differences in markers associated with incident heart failure preserved ejection fraction (HFpEF) when comparing matched case-control groups. BACKGROUND: Evidence continues to demonstrate increasing prevalence, cost and mortality implications of HFpEF, but clearly defined parameters that distinguish between controls and HFpEF have not been established. METHODS: A study cohort of case (incident patients with HFpEF, n=155) and matched control (patients with no prior HF, n=155) groups was retrospectively identified...
July 14, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28716023/retraction-note-to-extranuclear-er%C3%AE-is-associated-with-regression-of-t47d-pkc%C3%AE-overexpressing-tamoxifen-resistant-breast-cancer
#9
Bethany Perez White, Mary Ellen Molloy, Huiping Zhao, Yiyun Zhang, Debra A Tonetti
No abstract text is available yet for this article.
July 17, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28714439/psychometric-properties-of-the-brief-symptom-inventory-hostility-subscale-in-patients-with-heart-failure
#10
Lynn P Roser, Lynne A Hall, Debra A Moser
BACKGROUND AND PURPOSE: Patients with heart failure (HF) often have increased hostility. The Brief Symptom Inventory (BSI) Hostility subscale has not been evaluated in this population. The purpose of this study was to explore dimensionality, internal consistency, and construct validity of BSI Hostility subscale in HF. METHOD: Measures examined were BSI Hostility, Depression, and Anxiety subscales; Patient Health Questionnaire-9 (PHQ-9); and Multidimensional Scale of Perceived Social Support (MSPSS)...
December 1, 2016: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28713852/the-role-of-context-in-the-implementation-of-trauma-focused-treatments-effectiveness-research-and-implementation-in-higher-and-lower-income-settings
#11
Jessica A Chen, Cecilia C Olin, Shannon Wiltsey Stirman, Debra Kaysen
In recent years, the implementation of trauma-focused treatments has expanded across settings that vary widely in the availability of resources, infrastructure, and personnel. The present review aims to inform researchers, policy makers, trainers, and administrators about this diverse range of research. Taking a global health perspective, this review of effectiveness trials and implementation studies compares strategies used in high-income countries to those in low- and medium-income countries. A primary difference between studies in high-income and low- and medium-income countries is the relative emphasis placed on fidelity or adaptation...
April 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28712950/predictors-of-laparoscopic-simulation-performance-among-practicing-obstetrician-gynecologists
#12
Shyama Mathews, Michael Brodman, Debra D'Angelo, Scott Chudnoff, Peter Mcgovern, Tamara Kolev, Giti Bensinger, Santosh Mudiraj, Andreea Nemes, David Feldman, Patricia Kischak, Charles Ascher-Walsh
BACKGROUND: To determine if parameters of performance for validated laparoscopic virtual simulation tasks correlate with surgical volume and characteristics of practicing obstetricians and gynecologists. STUDY DESIGN: All gynecologists with laparoscopic privileges (n= 347) from five academic medical centers in New York City were required to complete a laparoscopic surgery simulation assessment. The physicians took a pre-simulation survey gathering physician self-reported characteristics and then performed 3 basic skills tasks (enforced peg transfer (PT), lifting & grasping (LG), and cutting (CT)) on the Surgical Science LapSim(®)virtual reality laparoscopic simulator...
July 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28710943/survival-after-recurrence-of-stage-i-iii-breast-colorectal-or-lung-cancer
#13
Michael J Hassett, Hajime Uno, Angel M Cronin, Nikki M Carroll, Mark C Hornbrook, Paul Fishman, Debra P Ritzwoller
BACKGROUND: The experiences of patients with recurrent cancer are assumed to reflect those of patients with de novo stage IV disease; yet, little is truly known because most registries lack recurrence status. Using two databases with excellent recurrence and death information, we examined determinants of survival duration after recurrence of breast (BC), colorectal (CRC), and lung cancers (LC). METHODS: Recurrence status was abstracted from the medical records of patients who participated in the Cancer Care Outcomes Research and Surveillance study and who received care at two Cancer Research Network sites-the Colorado and Northwest regions of Kaiser Permanente...
July 12, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28710350/environmental-surveillance-identifies-multiple-introductions-of-mrsa-cc398-in-an-equine-veterinary-hospital-in-the-uk-2011-2016
#14
Alessio Bortolami, Nicola J Williams, Catherine M McGowan, Padraig G Kelly, Debra C Archer, Michela Corrò, Gina Pinchbeck, Christine J Saunders, Dorina Timofte
Bacterial environmental and surgical site infection (SSI) surveillance was implemented from 2011-2016 in a UK Equine Referral Veterinary Hospital and identified 81 methicillin-resistant Staphylococcus aureus (MRSA) isolates. A cluster of MRSA SSIs occurred in early 2016 with the isolates confirmed as ST398 by multilocus sequence typing (MLST), which prompted retrospective analysis of all MRSA isolates obtained from the environment (n = 62), SSIs (n = 13) and hand plates (n = 6) in the past five years...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710026/systematic-review-of-the-impact-of-osteoarthritis-on-health-outcomes-for-comorbid-disease-in-older-people
#15
REVIEW
Lynne Parkinson, Debra L Waters, Linѐl Franck
OBJECTIVE: A systematic review was undertaken examining the impact of comorbid osteoarthritis on health outcomes for people aged 50 years or older with cardiovascular disease, diabetes or obesity. DESIGN: The protocol is registered in PROSPERO (CRD42015023417). Relevant electronic databases and grey literature were systematically searched for studies published in English between January 2005 and December 2016. Two reviewers independently screened studies for selection using predetermined inclusion and exclusion criteria, and independently completed methodological quality review...
July 11, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28708462/heterogeneous-enhancement-patterns-of-tumor-adjacent-parenchyma-at-mr-imaging-are-associated-with-dysregulated-signaling-pathways-and-poor-survival-in-breast-cancer
#16
Jia Wu, Bailiang Li, Xiaoli Sun, Guohong Cao, Daniel L Rubin, Sandy Napel, Debra M Ikeda, Allison W Kurian, Ruijiang Li
Purpose To identify the molecular basis of quantitative imaging characteristics of tumor-adjacent parenchyma at dynamic contrast material-enhanced magnetic resonance (MR) imaging and to evaluate their prognostic value in breast cancer. Materials and Methods In this institutional review board-approved, HIPAA-compliant study, 10 quantitative imaging features depicting tumor-adjacent parenchymal enhancement patterns were extracted and screened for prognostic features in a discovery cohort of 60 patients. By using data from The Cancer Genome Atlas (TCGA), a radiogenomic map for the tumor-adjacent parenchymal tissue was created and molecular pathways associated with prognostic parenchymal imaging features were identified...
July 14, 2017: Radiology
https://www.readbyqxmd.com/read/28705660/prevalence-of-diagnosed-dry-eye-disease-in-the-united-states-among-adults-aged-18-years-and-older
#17
Kimberly F Farrand, Moshe Fridman, Ipek Özer Stillman, Debra A Schaumberg
PURPOSE: To provide current estimates of the prevalence of diagnosed dry eye disease (DED) and associated demographics among US adults aged ≥18 years. DESIGN: Cross-sectional, population-based survey. METHODS: Data were analyzed from 75,000 participants in the 2013 National Health and Wellness Survey to estimate prevalence/risk of diagnosed DED overall, and by age, sex, insurance, and other demographic factors. We weighted the observed DED prevalence to project estimates to the US adult population and examined associations between demographic factors and DED using multivariable logistic regression...
July 10, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28703328/insight-into-infection-mediated-prostate-damage-contrasting-patterns-of-c-reactive-protein-and-prostate-specific-antigen-levels-during-infection
#18
Melissa Milbrandt, Anke C Winter, Remington L Nevin, Ratna Pakpahan, Gary Bradwin, Angelo M De Marzo, Debra J Elliott, Charlotte A Gaydos, William B Isaacs, William G Nelson, Nader Rifai, Lori J Sokoll, Jonathan M Zenilman, Elizabeth A Platz, Siobhan Sutcliffe
BACKGROUND: To investigate mechanisms underlying our previous observation of a large rise in serum prostate-specific antigen, a marker of prostate pathology, during both sexually transmitted and systemic infections, we measured serum high-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, in our previous case-control study of young, male US military members and compared our findings to those for PSA. METHODS: We measured hsCRP before and during infection for 299 chlamydia, 112 gonorrhea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases; before and after infection for 55 infectious mononucleosis (IM) and 90 other systemic/non-genitourinary cases; and for 220-256 controls...
July 12, 2017: Prostate
https://www.readbyqxmd.com/read/28703079/insights-into-neuro-urology
#19
Debra Fromer, Michelle Kim
No abstract text is available yet for this article.
July 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28702877/absorption-distribution-metabolism-and-excretion-of-14-c-volixibat-in-healthy-men-phase-1-open-label-study
#20
Nicholas Siebers, Melissa Palmer, Debra G Silberg, Lee Jennings, Caleb Bliss, Patrick T Martin
BACKGROUND AND OBJECTIVES: Volixibat is a potent inhibitor of the apical sodium-dependent bile acid transporter in development for the treatment of nonalcoholic steatohepatitis. This phase 1, open-label study investigated the absorption, distribution, metabolism, and excretion of [(14)C]-volixibat in heathy men. METHODS: Eligible men (n = 8) aged 18-50 years (body mass index 18.0-30.0 kg/m(2); weight >50 kg) received a single oral dose of [(14)C]-volixibat 50 mg containing ~5...
July 12, 2017: European Journal of Drug Metabolism and Pharmacokinetics
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