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renal clear cell cancer

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https://www.readbyqxmd.com/read/29912290/accounting-for-differential-variability-in-detecting-differentially-methylated-regions
#1
Ya Wang, Andrew E Teschendorff, Martin Widschwendter, Shuang Wang
DNA methylation plays an essential role in cancer. Differential variability (DV) in cancer was recently observed that contributes to cancer heterogeneity and has been shown to be crucial in detecting epigenetic field defects, DNA methylation alterations happening early in carcinogenesis. As neighboring CpG sites are highly correlated, here, we present a new method to detect differentially methylated regions (DMRs) that uses combined signals from differential methylation and DV between sample groups. We demonstrated in simulation studies the superior performance of the new method than existing methods that use only one type of signals when true DMRs have both...
August 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29911113/survival-outcomes-for-advanced-kidney-cancer-patients-in-the-era-of-targeted-therapies
#2
Arpit Rao, Charles Wiggins, Richard C Lauer
Background: Advanced renal cell carcinoma (RCC) results in over 14,000 deaths each year in the United States alone. The therapeutic landscape for advanced RCC changed dramatically with the approval of tyrosine kinase inhibitors (TKI) between 2006 and 2012. A large-scale analysis of survival trends has not been performed in the TKI era to determine their impact on outcomes for advanced RCC patients. Methods: The Surveillance, Epidemiology and End-Results (SEER) database was queried for adult patients with advanced RCC diagnosed between 2000 and 2013...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29905933/the-classification-of-pediatric-and-young-adult-renal-cell-carcinomas-registered-on-the-children-s-oncology-group-cog-protocol-aren03b2-after-focused-genetic-testing
#3
Mariana M Cajaiba, Lisa M Dyer, James I Geller, Lawrence J Jennings, David George, Dawn Kirschmann, Stephen M Rohan, Nicholas G Cost, Geetika Khanna, Elizabeth A Mullen, Jeffrey S Dome, Conrad V Fernandez, Elizabeth J Perlman
BACKGROUND: Renal cell carcinomas (RCCs) are rare in young patients. Knowledge of their pathologic and molecular spectrum remains limited, and no prospective studies have been performed to date in this population. This study analyzes patients diagnosed with RCC who were prospectively enrolled in the AREN03B2 Children's Oncology Group (COG). The objective was to classify these tumors with the aid of focused genetic testing and to characterize their features. METHODS: All tumors registered as RCC by central review were retrospectively re-reviewed and underwent additional ancillary studies...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29902078/leukemia-inhibitory-factor-receptor-suppresses-the-metastasis-of-clear-cell-renal-cell-carcinoma-through-negative-regulation-of-the-yes-associated-protein
#4
Chengyong Lei, Shidong Lv, Hongyi Wang, Chuan Liu, Qiliang Zhai, Shanci Wang, Guixing Cai, Dingheng Lu, Zhen Sun, Qiang Wei
The role of leukemia inhibitory factor receptor (LIFR), which is important in the signal transduction of the interleukin-6 cytokine family, is still undefined in clear cell renal cell carcinoma (ccRCC). Thus, we examined the function and mechanism of LIFR in ccRCC. Low LIFR expression correlated with a poor prognosis and an aggressive tumor phenotype. Moreover, integrated LIFR DNA and mRNA analysis revealed that promoter methylation and copy number variation contributed to the reduced LIFR expression. LIFR knockdown increased 786-O and Caki-2 cell invasion and migration...
June 14, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29901172/dkc1-serves-as-a-potential-prognostic-biomarker-for-human-clear-cell-renal-cell-carcinoma-and-promotes-its-proliferation-migration-and-invasion-via-the-nf%C3%A2-%C3%AE%C2%BAb-pathway
#5
Meng Zhang, Yu Pan, Ranran Jiang, Pingfu Hou, Haixia Shan, Fang Chen, Tao Jiang, Jin Bai, Junnian Zheng
DKC1, an X‑linked gene encoding dyskerin at Xq28, is a crucial component of the telomerase complex and is indispensable for normal telomere function and the post‑-transcriptional modification of precursor rRNA. It has been revealed to exert diverse biological functions and prognostic values in numerous types of cancers. Our present study was aimed at examining DKC1 expression in normal renal tissues and clear cell renal cell carcinoma (ccRCC) samples and the prognostic value of DKC1 in ccRCC. We examined DKC1 protein expression levels in tissue microarrays including 307 cases of ccRCC tissues and in 75 pairs of ccRCC and paracancerous tissues with immunohistochemistry...
June 11, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29897139/pathologic-staging-of-renal-cell-carcinoma-a-review-of-300-consecutive-cases-with-emphasis-on-retrograde-venous-invasion
#6
Kanika Taneja, Sohrab Arora, Craig G Rogers, Nilesh S Gupta, Sean R Williamson
AIMS: Pathologic staging of renal cell carcinoma (RCC) can be challenging compared to other cancer types, as invasion often manifests as finger-like protrusions into vascular spaces or renal sinus tissue. Although prior studies have shown larger tumour size to be highly correlated with renal sinus invasion, prospective data on evaluating pathologic stage are limited. We evaluated a large series reported by a single urologic pathologist. METHODS AND RESULTS: Three hundred consecutive specimens were reviewed...
June 13, 2018: Histopathology
https://www.readbyqxmd.com/read/29896907/modulating-atp-binding-cassette-abc-transporters-in-papillary-renal-cell-carcinoma-type-2-enhances-its-response-to-targeted-molecular-therapy
#7
Rola M Saleeb, Mina Farag, Zsuzsanna Lichner, Fadi Brimo, Jenni Bartlett, Georg Bjarnason, Antonio Finelli, Fabio Rontondo, Michelle R Downes, George M Yousef
Papillary renal cell carcinoma (PRCC) is the most common non-clear cell RCCs and is known to comprise two histological subtypes. PRCC2 is more aggressive and is molecularly distinct from the other subtypes. Despite this PRCCs are treated together as one entity, and they show poor response to the current therapies that do not target pathways implicated in their pathogenesis. We have previously detected ABCC2 (an ABC transporter), VEGF and mTOR pathways to be enriched in PRCC2. In this study, we assess the therapeutic potential of targeting these pathways in PRCC2...
June 13, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29896402/oral-metastasis-of-renal-cell-carcinoma-mimicking-recurrence-of-excised-malignant-myoepithelioma-a-case-report
#8
Yoshihiro Morita, Takaki Iwagami, Chisato Kawakita, Yukiko Kusuyama, Atsuko Niki-Yonekawa, Nobuo Morita
Following breast and lung cancers, renal cell carcinoma (RCC) is the third most frequent cancer to metastasize to the head and neck region, though such cases are rarely reported. Distinguishing between malignant tumors of salivary gland origin and metastatic RCC is very important. The case of a 75-year-old man with an oral cavity lesion in the left buccal submucosa measuring 40×30 mm that had grown substantially over several weeks is presented. His medical history included left kidney cancer 26 years earlier and a malignant myoepithelioma of the left buccal region 7 years earlier...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29894497/imaging-c-met-expression-using-18f-labeled-binding-peptide-in-human-cancer-xenografts
#9
Weihua Li, Hongqun Zheng, Jiankai Xu, Shaodong Cao, Xiuan Xu, Peng Xiao
OBJECTIVES: c-Met is a receptor tyrosine kinase shown inappropriate expression and actively involved in progression and metastasis in most types of human cancer. Development of c-Met-targeted imaging and therapeutic agents would be extremely useful. Previous studies reported that c-Met-binding peptide (Met-pep1, YLFSVHWPPLKA) specifically targets c-Met receptor. Here, we evaluated 18F-labeled Met-pep1 for PET imaging of c-Met positive tumor in human head and neck squamous cell carcinoma (HNSCC) xenografted mice...
2018: PloS One
https://www.readbyqxmd.com/read/29891694/impairment-of-gamma-glutamyl-transferase-1-activity-in-the-metabolic-pathogenesis-of-chromophobe-renal-cell-carcinoma
#10
Carmen Priolo, Damir Khabibullin, Ed Reznik, Harilaos Filippakis, Barbara Ogórek, Taylor R Kavanagh, Julie Nijmeh, Zachary T Herbert, John M Asara, David J Kwiatkowski, Chin-Lee Wu, Elizabeth P Henske
Chromophobe renal cell carcinoma (ChRCC) accounts for 5% of all sporadic renal cancers and can also occur in genetic syndromes including Birt-Hogg-Dube (BHD) and tuberous sclerosis complex (TSC). ChRCC has a distinct accumulation of abnormal mitochondria, accompanied by characteristic chromosomal imbalances and relatively few "driver" mutations. Metabolomic profiling of ChRCC and oncocytomas (benign renal tumors that share pathological features with ChRCC) revealed both similarities and differences between these tumor types, with principal component analysis (PCA) showing a distinct separation...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29889037/-kidney-cancer-stage-pt3a-fat-invasion-versus-renal-vein-invasion
#11
Alfredo Aguilera Bazán, José María Alonso Dorrego, Estefanía Linares, Jesús Díez, Luis Miguel Quintana, Luis Martínez-Piñeiro
OBJECTIVE: We discuss the influence that involvement of fat (perirenal, sinus) and vascular structures (renal vein, segmental veins) have on cancer-specific mortality (CSM) rates in renal cancer. METHODS: We conducted a retrospective analysis of 140 stage pT3a kidney tumors (114 clear cell, 9 type I papillary, 6 type II papillary, 11 chromophobe) surgically treated between 1997 and 2015. We conducted a cancer-specific survival study (Kaplan Meier) and a univariate and multivariate analysis of the variables: perirenal fat invasion, sinus fat invasion, renal vein invasion, segmental vein invasion and Fuhrman grade...
June 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29880274/treatment-facility-volume-and-survival-in-patients-with-metastatic-renal-cell-carcinoma-a-registry-based-analysis
#12
Shreyas S Joshi, Elizabeth A Handorf, Matthew Zibelman, Elizabeth R Plimack, Robert G Uzzo, Alexander Kutikov, Marc C Smaldone, Daniel M Geynisman
BACKGROUND: Higher treatment facility (TF) volume has been linked with improved oncologic treatment outcomes. OBJECTIVE: To determine the association between TF volume and overall survival in patients with metastatic renal cell carcinoma (mRCC). DESIGN, SETTING, AND PARTICIPANTS: The National Cancer Database (NCDB) was queried for all patients with mRCC with survival data available (2004-2013, cohort A). Overall survival was assessed based on TF volumes, and increasingly narrow inclusion criteria were used to confirm the cohort A association: cohort B=mRCC patients with active treatment; cohort C=mRCC patients with systemic therapy; cohort D=mRCC patients with systemic therapy at the reporting institution; and cohort E=mRCC patients with systemic therapy at the reporting institution with known liver and lung metastatic status...
June 4, 2018: European Urology
https://www.readbyqxmd.com/read/29873849/assessment-of-cellular-adequacy-of-fna-biopsy-for-small-solid-renal-tumors
#13
Jin Wen, Guorong Li, Sid Ali Berremila, Jean-Philippe Klein, Michel Péoc'h, Michèle Cottier, Nicolas Mottet
OBJECTIVE: Our aim was to evaluate the performance of fine needle aspiration (FNA) as a method for obtaining cellular material for the tissue diagnosis of small solid renal tumors. METHODS: 55 patients with a small solid renal tumor (≤4 cm) underwent a FNA biopsy under CT guidance. Direct smears and rinse of needle with Cytolyt were prepared. The cellular adequacy was divided into three groups: satisfactory cellular material, scant cellular material and non-cellular material...
June 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29872221/the-glutathione-redox-system-is-essential-to-prevent-ferroptosis-caused-by-impaired-lipid-metabolism-in-clear-cell-renal-cell-carcinoma
#14
Heike Miess, Beatrice Dankworth, Arvin M Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W Felsher, Barrie Peck, Almut Schulze
Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient depletion, functional RNAi screening and inhibitor treatment. We found that ccRCC cells are highly sensitive to the depletion of glutamine or cystine, two amino acids required for glutathione (GSH) synthesis. Moreover, silencing of enzymes of the GSH biosynthesis pathway or glutathione peroxidases, which depend on GSH for the removal of cellular hydroperoxides, selectively reduced viability of ccRCC cells but did not affect the growth of non-malignant renal epithelial cells...
June 5, 2018: Oncogene
https://www.readbyqxmd.com/read/29869165/polycystic-kidney-features-of-the-renal-pathology-in-glycogen-storage-disease-type-i-possible-evolution-to-renal-neoplasia
#15
Monika Gjorgjieva, Laure Monteillet, Julien Calderaro, Gilles Mithieux, Fabienne Rajas
Glycogen storage disease type I (GSDI) is a rare genetic pathology characterized by glucose-6 phosphatase (G6Pase) deficiency, translating in hypoglycemia during short fasts. Besides metabolic perturbations, GSDI patients develop long-term complications, especially chronic kidney disease (CKD). In GSDI patients, CKD is characterized by an accumulation of glycogen and lipids in kidneys, leading to a gradual decline in renal function. At a molecular level, the activation of the renin-angiotensin system is responsible for the development of renal fibrosis, eventually leading to renal failure...
June 4, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29866440/ppar%C3%AE-is-dispensable-for-clear-cell-renal-cell-carcinoma-progression
#16
Danielle J Sanchez, David J Steger, Nicolas Skuli, Ankita Bansal, M Celeste Simon
OBJECTIVE: Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer defined by robust lipid accumulation, which prior studies have indicated plays an important role in tumor progression. We hypothesized that the peroxisome proliferator-activated receptor gamma (PPARγ), detected in both ccRCC tumors and cell lines, promotes lipid storage in ccRCC and contributes to tumorigenesis in this setting. PPARγ transcriptionally regulates a number of genes involved in lipid and glucose metabolism in adipocytes, yet its role in ccRCC has not been described...
May 21, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29860937/sunitinib-alone-or-after-nephrectomy-in-metastatic-renal-cell-carcinoma
#17
Arnaud Méjean, Alain Ravaud, Simon Thezenas, Sandra Colas, Jean-Baptiste Beauval, Karim Bensalah, Lionnel Geoffrois, Antoine Thiery-Vuillemin, Luc Cormier, Hervé Lang, Laurent Guy, Gwenaelle Gravis, Frederic Rolland, Claude Linassier, Eric Lechevallier, Christian Beisland, Michael Aitchison, Stephane Oudard, Jean-Jacques Patard, Christine Theodore, Christine Chevreau, Brigitte Laguerre, Jacques Hubert, Marine Gross-Goupil, Jean-Christophe Bernhard, Laurence Albiges, Marc-Olivier Timsit, Thierry Lebret, Bernard Escudier
Background Cytoreductive nephrectomy has been the standard of care in metastatic renal-cell carcinoma for 20 years, supported by randomized trials and large, retrospective studies. However, the efficacy of targeted therapies has challenged this standard. We assessed the role of nephrectomy in patients with metastatic renal-cell carcinoma who were receiving targeted therapies. Methods In this phase 3 trial, we randomly assigned, in a 1:1 ratio, patients with confirmed metastatic clear-cell renal-cell carcinoma at presentation who were suitable candidates for nephrectomy to undergo nephrectomy and then receive sunitinib (standard therapy) or to receive sunitinib alone...
June 3, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29850911/a-graph-embedded-deep-feedforward-network-for-disease-outcome-classification-and-feature-selection-using-gene-expression-data
#18
Yunchuan Kong, Tianwei Yu
Motivation: Gene expression data represents a unique challenge in predictive model building, because of the small number of samples (n) compared to the huge amount of features (p). This "n = p" property has hampered application of deep learning techniques for disease outcome classification. Sparse learning by incorporating external gene network information could be a potential solution to this issue. Still, the problem is very challenging because (1) there are tens of thousands of features and only hundreds of training samples, (2) the scale-free structure of the gene network is unfriendly to the setup of convolutional neural networks...
May 29, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29850494/the-immunoexpression-of-yap1-and-lats1-proteins-in-clear-cell-renal-cell-carcinoma-impact-on-patients-survival
#19
J Godlewski, J Kiezun, B E Krazinski, Z Kozielec, P M Wierzbicki, Z Kmiec
The aim of the study was to determine by immunohistochemistry cellular localization and immunoreactivity levels of YAP1 and LATS1 proteins in paired sections of tumor and unchanged renal tissues of 54 clear cell renal cell carcinoma (ccRCC) patients. Associations between clinical-pathological and overall survival (OS; median follow-up was 40.6 months) data of patients and YAP1 and LATS1 immunoreactivity were analyzed by uni- and multivariate Cox regression model and log-rank test. YAP1 immunoreactivity was found in the nuclei of tumor cells in 64...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29849797/expression-of-cold-inducible-rna-binding-protein-cirp-in-renal-cell-carcinoma-and-the-effect-of-cirp-downregulation-cell-proliferation-and-chemosensitivity-to-gemcitabine
#20
Ke-Wen Zhou, Kun Jiang, Weizhi Zhu, Guobin Weng
The aim of the present study was to investigate the expression of cold-inducible RNA-binding protein (CIRP) in renal cell carcinoma (RCC) and to determine the effects of downregulation of CIRP on cell proliferation and chemosensitivity to gemcitabine. The expression of CIRP was detected by western blot analysis, quantitative polymerase chain reaction and immunohistochemistry (IHC) in 17 RCC and peri-cancerous tissue samples. Subsequently, the RCC 786-0 cell line was selected in order to investigate the function of CIRP using RNA interference (RNAi) technology, which was able to inhibit the expression of CIRP in vitro ...
May 2018: Oncology Letters
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