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https://www.readbyqxmd.com/read/28816389/clinical-indications-for-hysteroscopic-removal-of-uterine-masses-time-age-at-diagnosis-and-mass-size
#1
Hyun-Woong Cho, Yu-Jin Koo, Jin-Hwa Hong, Jae-Kwan Lee
AIM: The aim of this study was to investigate clinical factors associated with abnormal pathologies of uterine masses resected via hysteroscopy. METHODS: Women who underwent hysteroscopic surgery for presumptive diagnoses of abnormal endometrial or endocervical masses, such as polyps or leiomyomas on ultrasonography, between January 2012 and April 2015, were enrolled. Clinical and pathologic data were retrospectively reviewed. RESULTS: Among 189 patients, pathologic diagnoses of the uterine mass were abnormal in 172 (91...
August 17, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28813112/what-do-cochrane-systematic-reviews-say-about-the-clinical-effectiveness-of-screening-and-diagnostic-tests-for-cancer
#2
André Tito Pereira Bueno, Vladimir Lisboa Capelasso, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca, Tiago Biachi de Castria, Daniela Vianna Pachito, Rachel Riera
CONTEXT AND OBJECTIVE: The purpose of screening tests for cancer is to detect it at an early stage in order to increase the chances of treatment. However, their unrestrained use may lead to unnecessary examinations, overdiagnosis and higher costs. It is thus necessary to evaluate their clinical effects in terms of benefits and harm. DESIGN AND SETTING: Review of Cochrane systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28812010/the-diagnostic-accuracy-of-ultrasound-in-assessment-of-myometrial-invasion-in-endometrial-cancer-subjective-assessment-versus-objective-techniques
#3
Filip Frühauf, Michal Zikan, Ivana Semeradova, Pavel Dundr, Kristyna Nemejcova, Ladislav Dusek, David Cibula, Daniela Fischerova
The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical staging between January 2009 and December 2011, were prospectively enrolled. Myometrial invasion was evaluated by subjective assessment using ultrasound (<50% or ≥50%) and calculated as deepest invasion/normal myometrium ratio (Gordon's ratio) and as tumor/uterine anteroposterior diameter ratio (Karlsson's ratio)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28805599/nationwide-trends-and-in-hospital-complications-of-trachelectomy-for-surgically-resectable-cervical-cancer-in-taiwanese-women-a%C3%A2-population-based-study-1998-2013
#4
Jerry Cheng-Yen Lai, Hung-Hui Chen, Kuei-Hui Chu, Chia-Sui Weng, Yiing-Jenq Chou, Nicole Huang, Yu-Ju Chien, Kung-Liahng Wang
OBJECTIVE: To describe the nationwide trends in the utilization of trachelectomy among Taiwanese women with surgically resectable cervical cancer over the past decade, and to compare associated demographic characteristics, in-hospital complications and related outcomes using a population-based dataset from 1998 to 2013. MATERIALS AND METHODS: We conducted a population-based, cohort study using inpatient admission claims data of Taiwan's National Health Insurance program...
August 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28803257/synthesis-and-biological-evaluation-of-4-o-acetyl-isoxanthohumol-and-its-analogues-as-antioxidant-and-antiproliferative-agents
#5
Monika Stompor, Marta Świtalska, Rafał Podgórski, Łukasz Uram, David Aebisher, Joanna Wietrzyk
Isoxanthohumol (2) and its 4'-O-monoacylated (3) and 7,4'-O-diacetylated (4) derivatives were synthesized and evaluated in vitro for their cytotoxic activity against several cancer cell lines of various origins: MCF-7 (breast), A549 (lung), MESSA (uterine sarcoma), LoVo (colon), drug-resistant human cancer cells (MESSA/DX and LoVo/DX), glioblastoma (U-118 MG), and also towards the non-cancerous cell line MCF-10A (normal breast cells). An antiproliferative assay indicates that 7,4'-di-O-acylisoxanthohumol (4) has similar cytotoxicity to its precursor, isoxanthohumol (2), against selected cell lines (A549, MES-SA, MES-SA/5DX, and U-118 MG)...
August 12, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28802955/hysterscopic-resection-of-premalignant-and-malignant-endometrial-polyps-is-it-a-safe-alternative-to-hysterectomy
#6
Osnat Elyashiv, Ron Sagiv, Ram Kerner, Ran Keidar, Joseph Menczer, Tally Levy
STUDY OBJECTIVE: The standard treatment of endometrial cancer (EC) and complex atypical hyperplasia (CAH) is hysterectomy with or without adnexectomy. In the last decade, several centers have attempted to perform hysteroscopic resection of malignant and pre-malignant polyps as an alternative to hysterectomy. In the present study, we evaluated the safety of this procedure in regard to residual uterine pathology. DESIGN: Retrospective chart review DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING: University hospital PATIENTS: 1766 women who underwent hysteroscopic polypectomy during the years 1998-2016 MEASUREMENTS: Patients with CAH and endometrioid type EC in the removed polyps who underwent hysterectomy were included in the study...
August 9, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28802188/risk-of-uterine-cancer-for-brca1-and-brca2-mutation-carriers
#7
Y C Lee, R L Milne, S Lheureux, M Friedlander, S A McLachlan, K L Martin, M Q Bernardini, C Smith, S Picken, S Nesci, J L Hopper, K A Phillips
BACKGROUND: Whether BRCA1 and BRCA2 mutation carriers have a clinically relevant elevated risk of uterine cancer has implications for risk-reducing surgery. AIM: This multicentre, prospective cohort study assessed uterine cancer risk for mutation carriers compared with the general population. METHODS: Eligible mutation carriers were enrolled in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) cohort study, had a uterus present and no history of uterine cancer at cohort entry...
August 9, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28801511/paraneoplastic-mucous-membrane-pemphigoid-with-ocular-and-laryngeal-involvement
#8
Silvia Lambiel, Pavel Dulguerov, Emmanuel Laffitte, Igor Leuchter
A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. A diagnosis of anti-laminin 5 mucous membrane pemphigoid was retained, based on skin biopsy, direct immunofluorescence and immunoprecipitation...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28797156/-expression-and-significance-of-ikk%C3%AE%C2%B5-in-the-specimens-and-cells-of-epithelial-ovarian-cancer
#9
L Pang, J C Gao, P X Zhang, Q Sun, W J Qi, H L Gao, H W Guan, H Shi
Objective: To examine the expressions of IKKε protein in the specimens and cells of epithelial ovarian cancer and investigate the effect of IKKε inhibitor on cell proliferation and apoptosis. Methods: (1) A total of 118 cases of patients with the median age of 59 who have accepted surgical treatment due to ovarian cancer in the First Affiliated Hospital of Dalian Medical University from January 2006 to April 2013 were selected. Twenty cases of patients with the median age of 55 who have accepted hysterectomy and salpingo-oophorectomy due to uterine leiomyoma during the same period were selected as the control...
July 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28796747/morphologic-and-immunohistochemical-study-of-clear-cell-carcinoma-of-the-uterine-endometrium-and-cervix-in-comparison-to-ovarian-clear-cell-carcinoma
#10
Baohui Ju, Jianmei Wang, Bo Yang, Lin Sun, Yuhong Guo, Quan Hao, Jianghua Wu
Endometrial clear cell carcinoma (ECCC) and clear cell adenocarcinoma of the cervix (CCAC) are uncommon gynecologic cancers that have morphologic and phenotypic features similar to ovarian clear cell carcinoma (OCCC), but the 3 entities may not be completely identical. This study identified the morphologic and phenotypic characteristics and the differences between ECCC and CCAC in Comparison to OCCC. The morphologic features of 16 ECCCs, 7 CCACs, and 22 OCCCs are described. The immunoprofiles of hepatocyte nuclear factor (HNF) 1β, napsin A, estrogen, progesterone, p53, and Ki-67 were assessed...
August 7, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28795770/a-national-prospective-observational-study-of-first-recurrence-after-primary-treatment-for-gynecological-cancer-in-norway
#11
Ingvild Vistad, Line Bjørge, Olesya Solheim, Bent Fiane, Kurt Sachse, Jostein Tjugum, Siri Skrøppa, Anne Gry Bentzen, Trine Stokstad, Grete A Iversen, Helga B Salvesen, Gunnar B Kristensen, Anne Dørum
INTRODUCTION: Gynecological cancer patients are routinely followed up for 5 years after primary treatment. However, the value of such follow-up has been debated, as retrospective studies indicate that first recurrence is often symptomatic and occurs within 2-3 years of primary treatment. We prospectively investigated time to first recurrence, symptoms at recurrence, diagnostic procedures, and recurrence treatment in gynecological cancer patients after primary curative treatment. MATERIAL AND METHODS: Clinicians from 21 hospitals in Norway interviewed 680 patients with first recurrence of gynecological cancer (409 ovarian, 213 uterine, and 58 cervical cancer patients) between 2012 and 2016...
August 10, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28790116/targeted-proteomics-identifies-proteomic-signatures-in-liquid-biopsies-of-the-endometrium-to-diagnose-endometrial-cancer-and-assist-in-the-prediction-of-the-optimal-surgical-treatment
#12
Elena Martinez, Antoine Lesur, Laura Devis, Silvia Cabrera, Xavier Matias-Guiu, Marc Hirschfeld, Jasmin Asberger, Jan van Oostrum, María de Los Ángeles Casares de Cal, Antonio Gómez-Tato, Jaume Reventos, Bruno Domon, Eva Colas, Antonio Gil-Moreno
PURPOSE: Endometrial cancer (EC) diagnosis relies on the observation of tumor cells in endometrial biopsies obtained by aspiration i.e., uterine aspirates), but it is associated with 22% undiagnosed patients and up to 50% of incorrectly assigned EC histotype and grade. We aimed to identify biomarker signatures in the fluid fraction of these biopsies to overcome these limitations. EXPERIMENTAL DESIGN: The levels of 52 proteins were measured in the fluid fraction of uterine aspirates from 116 patients by LC-PRM, the latest generation of targeted mass-spectrometry acquisition...
August 8, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28782618/updates-on-conservative-management-of-endometrial-cancer
#13
REVIEW
Camila Corzo, Natalia Barrientos Santillan, Shannon N Westin, Pedro T Ramirez
Endometrial cancer is the most common gynecologic cancer in the United States. It is typically diagnosed in postmenopausal women. However, given the increasing incidence of risk factors such as obesity and diabetes in younger women, it is becoming a more prevalent problem in this age group. When endometrial cancer is diagnosed in patients of reproductive age, the standard surgical option of hysterectomy and bilateral salpingo-oophorectomy may not be ideal for women interested in future fertility. Hence, conservative options for select patients should be discussed along with the associated outcomes of each approach...
August 3, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28778083/the-prognostic-impact-of-overall-treatment-time-on-disease-outcome-in-uterine-cervical-cancer-patients-treated-primarily-with-concomitant-chemoradiotherapy-a-nationwide-taiwanese-cohort-study
#14
Shih-Min Lin, Hsiu-Ying Ku, Ting-Chang Chang, Tsang-Wu Liu, Ji-Hong Hong
The importance of the overall treatment time (OTT) has a paradoxical status in the current era of concomitant chemoradiotherapy. The main objective of this nationwide study was to evaluate the correlation between overall treatment duration and clinical outcome in cervical cancer patients treated primarily with curative concurrent chemoradiotherapy (CCRT). In this population-based cohort study, 2,594 patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I-IVA uterine cervical cancer were studied...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28777141/cytologic-histologic-discrepancies-in-pathology-of-the-uterine-cervix-analysis-of-the-clinical-and-pathologic-factors
#15
Fadi W Abdul-Karim, Bin Yang
Cytologic-histologic correlation (CHC) represents a documented effort to obtain and compare, when available, gynecologic cytology reports with an interpretation of high-grade squamous intraepithelial lesion or malignancy, with the subsequent histopathology report, and to determine the possible cause of any discrepancy. The correlation is influenced by multiple closely interdependent clinical and pathologic factors. Many of these factors including the sensitivity and accuracy of colposcopy-directed biopsy, the diligence of the colposcopist, and the attributes of the cervical lesion represent "preanalytical" factors which can significantly affect the CHC outcome, but are often less emphasized during CHC process...
September 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28776178/protocols-for-rat-uterus-isolation-and-decellularization-applications-for-uterus-tissue-engineering-and-3d-cell-culturing
#16
Arvind Manikantan Padma, Tom Tristan Tiemann, Ahmed Baker Alshaikh, Randa Akouri, Min Jong Song, Mats Hellström
Sophisticated culturing conditions are required to grow cells in a three-dimensional (3D) environment. Cells then require a type of scaffold rich in proteins, growth factors, and signaling molecules that simulates their natural environment. Tissues from all species of animals have an organ-specific extracellular matrix (ECM) structure that plays a key role in cell proliferation and migration. Hence, the scaffold composition plays a significant role for any successful 3D cell culturing system. We developed a whole rat uterus ECM scaffold by the perfusion of detergents and ionic solutions through the vascular system of an isolated normal rat uterus in a process termed "decellularization...
August 4, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28770968/lncrna-malat1-promotes-proliferation-and-metastasis-in-epithelial-ovarian-cancer-via-the-pi3k-akt-pathway
#17
Y Jin, S-J Feng, S Qiu, N Shao, J-H Zheng
OBJECTIVE: The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that plays a key role in the malignant phenotype of tumors. Although abnormal regulation of lncRNA MALAT1 impacts clinical prognostic and tumor metastasis, its function remains unclear in ovarian cancer. PATIENTS AND METHODS: We collected 64 samples of surgical EOC tissues and 30 samples of normal ovarian tissues at the Department of Gynecology of Harbin Medical University (Harbin, China)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28768676/role-of-metastasectomy-and-chemotherapy-in-carcinoma-of-uterine-cervix
#18
Nasir Ali, Muhammad Atif Mansha, Ahmed Nadeem Abbasi, Bilal Mazhar Qureshi
Squamous cell carcinoma of uterine cervix is potentially a curable disease; however, many patients treated with definitive chemoradiotherapy develop distant metastases, with few of them having a single metastatic deposit. There are no guidelines for the treatment of patients with oligometastatic cervical cancer.We present a case of a patient with International Federation of Gynecology and Obstetrics (FIGO) Stage IIB squamous cell carcinoma of uterine cervix. She was successfully treated with concurrent chemoradiotherapy with definitive intent...
August 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28768532/estrogen-like-and-tissue-selective-effects-of-7-methoxycoumarin-from-ficus-umbellata-moraceae-an-in-vitro-and-in-vivo-study
#19
Stéphane Zingue, Thomas Michel, Chantal Beatrice Magne Nde, Amstrong Nang Njuh, Julia Cisilotto, Derek Tantoh Ndinteh, Colin Clyne, Xavier Fernandez, Tânia Beatriz Creczynski-Pasa, Dieudonné Njamen
BACKGROUND: Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory activity, which is of particular interest in the treatment of estrogen-dependent cancers. The present work aimed at evaluating the estrogenic/antiestrogenic effects of MC in vitro and in vivo. METHODS: To do so, in vitro assays using E-screen and reporter gene were done...
August 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28763739/risk-of-malignancy-on-suspicion-of-polyps-in-menopausal-women
#20
Sandra Bel, Camille Billard, Julien Godet, Victor Viviani, Cherif Akladios, Aline Host, Emilie Faller, Thomas Boisrame, Michel Hummel, Jean-Jacques Baldauf, Lise Lecointre, Olivier Garbin
Improved performances in gynaecological ultrasonography have enabled an increasing number of often asymptomatic endometrial polyps to be detected. Most of these polyps are removed surgically, as a precautionary measure, so as not to miss a case of endometrial cancer. Nonetheless, this management strategy is based solely on the sonographer's judgement and a number of these operations, which are probably of no benefit, could be avoided. In order to do so, risk factors for malignancy need to be identified. OBJECTIVE: Estimate the prevalence of lesions in menopausal patients with a pre-operative diagnosis of endometrial polyp...
July 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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