keyword
MENU ▼
Read by QxMD icon Read
search

uterin cancer

keyword
https://www.readbyqxmd.com/read/29454147/factors-associated-with-malignancy-in-hysteroscopically-resected-endometrial-polyps-a-systematic-review-and-meta-analysis
#1
Lizandra M Paravidine Sasaki, Keitty R C Andrade, Ana Claudia Morais Godoy Figueiredo, Miriam da S Wanderley, Maurício G Pereira
The objective of our study was to estimate the frequency of pre-malignant and malignant lesions in endometrial polyps and to evaluate associated clinical and demographic factors. A literature search was performed in major databases and the gray literature using the terms polyps OR endometrial polyp AND endometrial neoplasms OR endometrial cancer OR endometrial hyperplasia OR malignan*. Studies describing the frequency of pre-malignant and malignant lesions in endometrial polyps and any clinical or demographic factors associated with malignant lesions extracted using hysteroscopy were considered eligible...
February 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29451900/the-arid1a-p53-and-%C3%A3-catenin-statuses-are-strong-prognosticators-in-clear-cell-and-endometrioid-carcinoma-of-the-ovary-and-the-endometrium
#2
Marlene Heckl, Elisa Schmoeckel, Linda Hertlein, Miriam Rottmann, Udo Jeschke, Doris Mayr
AIM: The objective of this study was to evaluate the prognostic value of ARID1A, p53, p21, p16 and ß-Catenin in endometrioid and clear cell ovarian and endometrial carcinomas. MATERIALS AND METHODS: 97 tumors were available for analysis of ARID1A, p53, p21, p16 and ß-Catenin with the techniques of tissue microarray and immunohistochemistry. 32 were ovarian carcinomas and 65 were endometrial carcinomas. RESULTS: Endometrioid ovarian carcinomas showed negative staining for ARID1A (a) and p21 (b), aberrant expression of p53 (c) and p16 (d) and ß-Catenin positive nuclear expression (e) respectively in 19% (a), 100% (b), 28...
2018: PloS One
https://www.readbyqxmd.com/read/29449731/mixed-malignant-mullerian-tumor-with-neuroendocrine-features-in-an-irradiated-uterus-for-cervical-carcinoma-a-unique-association-a-morphological-immunohistochemisty-and-ultrastructural-study
#3
V G Vellone, B Spina, F Grillo, P Calamaro, F Sarocchi, P Sala, S Ferrero, E Fulcheri
Chemo-radiation represents an effective therapy for carcinoma of the uterine cervix. The endometrium may however receive a consistent dose of mutagenic radiations and patients may have an increased risk of secondary malignancies. Endometrial mixed malignant mullerian tumor (MMMT) is a rare, highly aggressive disease, and neuroendocrine features are even rarer. A 68 years old woman underwent radio-chemotherapy for a squamous cell carcinoma of the cervix. Follow up was uneventful until, eight years after radio-chemotherapy, imaging exams detected a diffuse enlargement of the uterine body...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29448806/endovascular-treatment-for-the-control-of-active-vaginal-bleeding-from-uterine-cervical-cancer-treated-with-radiotherapy
#4
Cheng Shi Chen, Sohee Park, Ji Hoon Shin, Yasir Nouri, Jong-Woo Kim, Hyun-Ki Yoon, Gi-Young Ko
Background Endovascular treatment has become a significant therapeutic option for the management of intractable bleeding in gynecologic malignancies. However, the endovascular treatment types were almost never mentioned when active bleeding from different arteries was identified. Purpose To present angiographic details and evaluate clinical efficacy of endovascular treatments to control active vaginal bleeding in uterine cervical cancer patients treated with radiotherapy. Material and Methods In this retrospective study, six, consecutive cervical cancer patients treated with radiotherapy who underwent endovascular treatment for active vaginal bleeding were included...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29442399/clinicopathologic-characteristics-of-double-primary-endometrial-and-colorectal-cancers-in-a-single-institution
#5
Hyun J Lee, Min C Choi, Ja-Hyun Jang, Sang G Jung, Hyun Park, Won D Joo, Tae H Kim, Chan Lee, Je H Lee
AIM: To investigate the clinicopathologic and genetic correlations between double primary endometrial and colorectal cancer related to Lynch syndrome and to analyze germline mutations in mismatch repair genes in endometrial cancer patients in Korea. METHODS: Thirteen patients diagnosed with pathologically endometrial and colorectal cancer between January 2005 and November 2016 in a single institution were enrolled in the study. The medical records were retrospectively analyzed...
February 14, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29441675/uterine-adenosarcoma-in-japan-clinicopathologic-features-diagnosis-and-management
#6
Keisei Tate, Reiko Watanabe, Hiroshi Yoshida, Hanako Shimizu, Takashi Uehara, Mitsuya Ishikawa, Shun-Ichi Ikeda, Nobuyoshi Hiraoka, Tomoyasu Kato
AIM: Uterine adenosarcoma is a rare malignancy with limited cohort data in Asian countries. This study evaluated the clinicopathologic features of Japanese patients with uterine adenosarcoma and their potential treatment challenges. METHODS: A retrospective chart review was performed at the National Cancer Center Hospital, Japan from 2000 to 2016. A literature search for Japanese cases of uterine adenosarcoma was conducted using PubMed, Japanese Central Review of Medicine, and the Annual of Pathological Autopsy Cases in Japan...
February 14, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29441095/off-line-magnetic-resonance-imaging-navigation-of-cervix-cancer-brachytherapy-in-patients-with-risk-factors-for-uterine-perforation
#7
Noora Mohammed Al-Hammadi, Suparna Halsnad Chandramouli, Rabih Hammoud, Primoz Petric
Purpose: There are no reports on pre-insertion identification of cervix cancer patients at risk for uterine perforation during brachytherapy (BT). Our aim was to assess the incidence of risk factors in our patient cohort, and assess feasibility of a novel technique of magnetic resonance imaging (MRI)-guided navigation for applicator insertion (NAI) in high-risk cases. Material and methods: All patients with locally advanced cervical cancer, treated with image guided adaptive BT at our department between October 2013 and June 2017 were considered for analysis...
December 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29440396/oncogenic-exon-2-mutations-in-mediator-subunit-med12-disrupt-allosteric-activation-of-cyclin-c-cdk8-19
#8
Min Ju Park, Hailian Shen, Jason M Spaeth, Jaana H Tolvanen, Courtney Failor, Jennifer F Knudtson, Jessica McLaughlin, Sunil K Halder, Qiwei Yang, Serdar E Bulun, Ayman Al-Hendy, Robert S Schenken, Lauri A Aaltonen, Thomas G Boyer
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at high frequency in uterine fibroids (UFs) and breast fibroepithelial tumors as well as recurrently, albeit less frequently, in malignant uterine leimyosarcomas, chronic lymphocytic leukemias, and colorectal cancers. Previously, we reported that UF-linked mutations in MED12 disrupt its ability to activate CycC-dependent kinase 8 (CDK8), implicating impaired Mediator-associated CDK8 activity in the pathogenesis of these clinically significant lesions...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29440294/in-vitro-and-in-vivo-activity-of-imgn853-an-antibody-drug-conjugate-targeting-folate-receptor-alpha-linked-to-dm4-in-biologically-aggressive-endometrial-cancers
#9
Gary Altwerger, Elena Bonazzoli, Stefania Bellone, Tomomi Egawa-Takata, Gulden Menderes, Francesca Pettinella, Anna Bianchi, Francesco Riccio, Jacqueline Feinberg, Luca Zammataro, Chanhee Han, Ghanshyam Yadav, Katherine Dugan, Ashley Morneault, Jose F Ponte, Natalia Buza, Pei Hui, Serena Wong, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Gloria S Huang, Masoud Azodi, Peter E Schwartz, Alessandro D Santin
Grade 3 endometrioid and uterine serous carcinomas (USC) account for the vast majority of endometrial cancer deaths. The purpose of this study was to determine folic acid receptor alpha (FR⍺) expression in these biologically aggressive (Type II) endometrial cancers,and evaluate FR⍺ as a targetable receptor for IMGN853 (Mirvetuximab soravtansine). The expression of FR⍺ was evaluated by immunohistochemistry (IHC) and flow cytometry in 90 endometrioid and USC samples. The in vitro cytotoxic activity and bystander effect were studied in primary uterine cancer cell lines expressing differential levels of FR⍺...
February 13, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29439178/uterine-neoplasms-version-1-2018-nccn-clinical-practice-guidelines-in-oncology
#10
Wui-Jin Koh, Nadeem R Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M Campos, Kathleen R Cho, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J Eifel, Christine M Fisher, Peter Frederick, David K Gaffney, Suzanne George, Ernest Han, Susan Higgins, Warner K Huh, John R Lurain, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W Remmenga, R Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M Yashar, Nicole R McMillian, Jillian L Scavone
Endometrial carcinoma is a malignant epithelial tumor that forms in the inner lining, or endometrium, of the uterus. Endometrial carcinoma is the most common gynecologic malignancy. Approximately two-thirds of endometrial carcinoma cases are diagnosed with disease confined to the uterus. The complete NCCN Guidelines for Uterine Neoplasms provide recommendations for the diagnosis, evaluation, and treatment of endometrial cancer and uterine sarcoma. This manuscript discusses guiding principles for the diagnosis, staging, and treatment of early-stage endometrial carcinoma as well as evidence for these recommendations...
February 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29435288/a-post-recurrence-survival-predicting-indicator-for-cervical-cancer-from-the-analysis-of-165-patients-who-developed-recurrence
#11
Kosuke Yoshida, Hiroaki Kajiyama, Fumi Utsumi, Kaoru Niimi, Jun Sakata, Shiro Suzuki, Kiyosumi Shibata, Fumitaka Kikkawa
The aim of the present study was to estimate the post-recurrence survival (PRS) of patients with relapsed uterine cervical cancer (RUCC). In addition, clinicopathological indicators that influenced PRS were investigated. Between 1998 and 2014, of 740 patients with cervical cancer, 165 patients experienced recurrence (recurrence rate, 22.3%), and 83 patients succumbed to the disease within a median follow-up of 34.3 months. A total of 151 stage Ib-IV patients who experienced recurrence after initial treatment for cervical cancer at our institute were analyzed...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29434755/anti-tumour-effects-of-polysaccharide-extracted-from-acanthopanax-senticosus-and-cell-mediated-immunity
#12
Qinglong Meng, Jingzhi Pan, Yajing Liu, Li Chen, Yueying Ren
Acanthopanax senticosus, also known as Siberian ginseng, is widely distributed throughout northern Asia and used in traditional Chinese medicine; it has been reported to prevent a number of diseases. However, the association between the antitumour and immunostimulatory activities of polysaccharide extracted from A. senticosus (ASPS) remains to be elucidated. The aim of the present study was to investigate the anti-tumour and immunomodulatory effects of polysaccharide extracted from ASPS on Crocker sarcoma S180, hepatic carcinoma H22 and uterine cervical carcinoma U14 tumour cell lines implanted in mice...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433465/strengthening-health-data-on-a-rare-and-heterogeneous-disease-sarcoma-incidence-and-histological-subtypes-in-germany
#13
Meike Ressing, Eva Wardelmann, Peter Hohenberger, Jens Jakob, Bernd Kasper, Katharina Emrich, Andrea Eberle, Maria Blettner, Sylke Ruth Zeissig
BACKGROUND: The population-based incidence of sarcoma and its histological subtypes in Germany is unknown. Up-to-date information on a disease with an incidence comparable to other cancer entities is of high public health relevance. The aim of this study was to determine this incidence and to detect significant changes in incidence trends using data from German epidemiological cancer registries. METHODS: Pooled data from the German Centre for Cancer Registry Data with a primary diagnosis occurring in 2013 were used...
February 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29428270/-ten-years-of-human-papilloma-virus-vaccination-from-dermatology-to-oncology-via-the-infectious-diseases-department
#14
Fernando A Moraga-Llop
Human papilloma virus (HPV) was first identified in dermatology, and it was subsequently demonstrated that is was required for the development of uterine cervical cancer and other tumours, after a persistent infection by any of its oncogenic genotypes. Ten years ago, the most common infections and cancers associated with HPV could be prevented by immunisation with 2vaccines, one bivalent, and another tetravalent, and having just marketed a nonavalent one. During the period 2007-2008, the HPV vaccine was included in the Autonomous Communities vaccination calendar, and it is the second vaccine, after that of Hepatitis B, that prevents cancer...
February 7, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29423582/a-retrospective-review-of-48-individuals-including-12-families-molecularly-diagnosed-with-hereditary-leiomyomatosis-and-renal-cell-cancer-hlrcc
#15
Priya T Bhola, Cathy Gilpin, Amanda Smith, Gail E Graham
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is caused by autosomal dominant germline mutations in the fumarate hydratase (FH) gene and is characterized by cutaneous leiomyomas, uterine leiomyomas and aggressive renal malignancies. We conducted a retrospective chart review to characterize the patients referred to our Regional Genetics Program for assessment of HLRCC from 2004 to mid-2016. Forty-eight of 69 (69.5%) referred individuals were positive for a pathogenic or likely pathogenic variant in FH; they had an average age of 39...
February 8, 2018: Familial Cancer
https://www.readbyqxmd.com/read/29423555/second-malignancies-after-hematopoietic-stem-cell-transplantation
#16
REVIEW
Ivetta Danylesko, Avichai Shimoni
Second malignancies are a rare but well-defined late complication after autologous and allogeneic hematopoietic stem-cell transplantation (SCT). Solid malignancies occur in up to 15% of patients 15 years after SCT with myeloablative conditioning, with no plateau in the incidence rates. They are responsible for 5-10% of late deaths after SCT. The incidence is increased with advanced age at SCT. The major risk factors are the use of total body irradiation, which is associated with adenocarcinomas and with chronic graft-versus-host disease which is associated with squamous cell cancers...
February 8, 2018: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29423520/cisplatin-chemoradiotherapy-vs-radiotherapy-in-figo-stage-iiib-squamous-cell-carcinoma-of-the-uterine-cervix-a-randomized-clinical-trial
#17
Shyamkishore Shrivastava, Umesh Mahantshetty, Reena Engineer, Supriya Chopra, Rohini Hawaldar, Vinod Hande, Rajendra A Kerkar, Amita Maheshwari, T S Shylasree, Jaya Ghosh, Jyoti Bajpai, Lavanya Gurram, Seema Gulia, Sudeep Gupta
Importance: The evidence for concurrent chemoradiotherapy (CT-RT) in International Federation of Gynecology and Obstetrics (FIGO) stage IIIB squamous cell carcinoma of the uterine cervix is not robust. This study reports the final results of a randomized clinical trial of concurrent cisplatin-based CT-RT and radiotherapy alone (RT) in women with FIGO stage IIIB squamous cell carcinoma of the uterine cervix. Objective: To investigate the benefit of concurrent CT-RT in FIGO stage IIIB squamous cell carcinoma of the uterine cervix...
February 8, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29423040/systematic-analysis-of-gene-expression-alterations-and-clinical-outcomes-of-stat3-in-cancer
#18
Xiangrong Cui, Xuan Jing, Qin Yi, Chunlan Long, Bin Tan, Xin Li, Xueni Chen, Yue Huang, Zhongping Xiang, Jie Tian, Jing Zhu
Accumulated studies have provided controversial evidences of prognostic value for signal transducer and activator of transcription proteins 3 (STAT3) in cancers. To address this inconsistency, we performed a systematic analysis to determine whether STAT3 can serve as a prognostic marker in human cancers. STAT3 expression was assessed using Oncomine analysis. cBioPortal, Kaplan-Meier Plotter, and Prognoscan were performed to identify the prognostic roles of STAT3 in human cancers. The copy number alteration, mutation, interactive analysis, and visualize the altered networks were performed by cBioPortal...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29417283/depleted-lamin-b1-a-possible-marker-of-the-involvement-of-senescence-in-endometriosis
#19
Helena Malvezzi, Bruno Gallani Viana, Cristine Dobo, Renee Zon Filippi, Sérgio Podgaec, Carla Azevedo Piccinato
PROPOSE: Endometriosis is a benign disease characterized by implantation and the growth of endometrial tissue outside the uterine cavity and it shares similarities with cancer. Lamin B1, p16 and p21 play a role on cell cycle regulation, development, cell repair and its activities are related to cancers. Considering the similarities between endometriosis and cancer, the aim of the present cross-sectional study is to detect p16, p21 and Lamin B1 in the ectopic endometrium of patients with endometriosis (n = 8) with eutopic (n = 8) and control endometrium (n = 8) and relate them to the maintenance and development of endometriosis...
February 7, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29416287/hereditary-leiomyomatosis-and-renal-cell-carcinoma-case-report-and-review-of-the-literature
#20
Ferreira Natália, Oliveira Tiago, Oliveira Pedro, Gaspar Sandro
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare genetic disorder in which the affected individuals tend to develop cutaneous leiomyomas, uterine leiomyomas, and renal cell cancer (RCC). Within the spectrum of this syndromic disease, RCC is the most severe manifestation, occurring at a younger age compared to the sporadic form. Pathological suspicion or diagnosis of HLRCC is critical for appropriate clinical management and genetic counseling of the affected family members. In this study, we report the case of a 27-year-old misdiagnosed carrier of HLRCC phenotype, who presented with a large solitary Type II papillary RCC...
January 2018: Urology Annals
keyword
keyword
77806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"