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Diffusion Tensor MRI

Esther M C van Leijsen, H Bea Kuiperij, Iris Kersten, Mayra I Bergkamp, Ingeborg W M van Uden, Hugo Vanderstichele, Erik Stoops, Jurgen A H R Claassen, Ewoud J van Dijk, Frank-Erik de Leeuw, Marcel M Verbeek
BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) is a frequent pathology in aging and contributor to the development of dementia. Plasma Aβ (amyloid β) levels may be useful as early biomarker, but the role of plasma Aβ in SVD remains to be elucidated. We investigated the association of plasma Aβ levels with severity and progression of SVD markers. METHODS: We studied 487 participants from the RUN DMC study (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort) of whom 258 participants underwent 3 MRI assessments during 9 years...
March 14, 2018: Stroke; a Journal of Cerebral Circulation
Vishwesh Nath, Kurt G Schilling, Prasanna Parvathaneni, Justin Blaber, Allison E Hainline, Zhaohua Ding, Adam Anderson, Bennett A Landman
The diffusion tensor model is nonspecific in regions where micrometer structural patterns are inconsistent at the millimeter scale (i.e., brain regions with pathways that cross, bend, branch, fan, etc.). Numerous models have been proposed to represent crossing fibers and complex intravoxel structure from in vivo diffusion weighted magnetic resonance imaging (e.g., high angular resolution diffusion imaging-HARDI). Here, we present an empirical comparison of two HARDI approaches-persistent angular structure MRI (PAS-MRI) and Q-ball-using a newly acquired reproducibility dataset...
January 2018: Journal of Medical Imaging
Panlong Li, Han Shan, Shengxiang Liang, Binbin Nie, Shaofeng Duan, Qi Huang, Tianhao Zhang, Xi Sun, Ting Feng, Lin Ma, Baoci Shan, Demin Li, Hua Liu
Retrosplenial cortex (RSC) plays a key role in various cognitive functions. The fiber connectivity of RSC had been reported in rodent and primate studies by tracer injection methods To explore structural and functional connectivity of two sub-regions of RSC, Brodmann area (BA)29 and BA30, we constructed fiber connectivity networks of two sub-regions by diffusion tensor imaging (DTI) tractography based on diffusion magnetic resonance imaging (MRI) and functional connectivity networks by resting-state functional MRI...
March 9, 2018: Neuroscience Letters
Evangelia Tsolaki, Angela Downes, William Speier, W Jeff Elias, Nader Pouratian
Magnetic Resonance-guided Focused UltraSound (MRgFUS) offers an incisionless approach to treat essential tremor (ET). Due to lack of evident internal anatomy on traditional structural imaging, indirect targeting must still be used to localize the lesion. Here, we investigate the potential predictive value of probabilistic tractography guided thalamic targeting by defining how tractography-defined targets, lesion size and location, and clinical outcomes interrelate. MR imaging and clinical outcomes from 12 ET patients that underwent MRgFUS thalamotomy in a pilot study at the University of Virginia were evaluated in this analysis...
2018: NeuroImage: Clinical
Alexandre Lewalle, Sander Land, Eric Carruth, Lawrence R Frank, Pablo Lamata, Jeffrey H Omens, Andrew D McCulloch, Steven A Niederer, Nicolas P Smith
The cardiac system compensates for variations in physiological and pathophysiological conditions through a dynamic remodeling at the organ, tissue, and intracellular levels in order to maintain function. However, on longer time scales following the onset of ventricular pressure overload, such remodeling may begin to inhibit physiological function and ultimately lead to heart failure. This progression from compensatory to decompensatory behavior is poorly understood, in particular owing to the absence of a unified perspective of the concomitantly remodeling subsystems...
2018: Frontiers in Physiology
Eero Rissanen, Jouni Tuisku, Tero Vahlberg, Marcus Sucksdorff, Teemu Paavilainen, Riitta Parkkola, Johanna Rokka, Alexander Gerhard, Rainer Hinz, Peter S Talbot, Juha O Rinne, Laura Airas
Objective: To investigate the relationship of in vivo microglial activation to clinical and MRI parameters in MS. Methods: Patients with secondary progressive MS (n = 10) or relapsing-remitting MS (n = 10) and age-matched healthy controls (n = 17) were studied. Microglial activation was measured using PET and radioligand [11 C]( R )-PK11195. Clinical assessment and structural and quantitative MRI including diffusion tensor imaging (DTI) were performed for comparison...
May 2018: Neurology® Neuroimmunology & Neuroinflammation
Fuyu Wang, Jiashu Zhang, Peng Wang, Tao Zhou, Xianghui Meng, Jinli Jiang
The preservation of pituitary stalk during surgery is very important for neurosurgeons. Sometimes, it is hard to identify the pituitary stalk in the operation. The hypothalamo-hypophyseal tract (HHT) projects through the pituitary stalk to the posterior pituitary gland. If the HHT can be identified, the position of pituitary stalk will be visualized. The diffusion tensor imaging (DTI) fiber tracking technique has been widely used for the quantitative assessment of the white matter integrity and thus may be suitable for the evaluation of the HHT...
March 2018: Medicine (Baltimore)
Anwar S Shatil, Md Nasir Uddin, Kant M Matsuda, Chase R Figley
Purpose: Postmortem MRI can be used to reveal important pathologies and establish radiology-pathology correlations. However, quantitative MRI values are altered by tissue fixation. Therefore, the purpose of this study was to investigate time-dependent effects of formalin fixation on MRI relaxometry (T1 and T2 ), diffusion tensor imaging (fractional anisotropy, FA; and mean diffusivity, MD), and myelin water fraction (MWF) measurements throughout intact human brain specimens. Methods: Two whole, neurologically-healthy human brains were immersed in 10% formalin solution and scanned at 13 time points between 0 and 1,032 h...
2018: Frontiers in Medicine
Ilaria Boscolo Galazzo, Lorenza Brusini, Silvia Obertino, Mauro Zucchelli, Cristina Granziera, Gloria Menegaz
Recent tract-based analyses provided evidence for the exploitability of 3D-SHORE microstructural descriptors derived from diffusion MRI (dMRI) in revealing white matter (WM) plasticity. In this work, we focused on the main open issues left: (1) the comparative analysis with respect to classical tensor-derived indices, i.e., Fractional Anisotropy (FA) and Mean Diffusivity (MD); and (2) the ability to detect plasticity processes in gray matter (GM). Although signal modeling in GM is still largely unexplored, we investigated their sensibility to stroke-induced microstructural modifications occurring in the contralateral hemisphere...
2018: Frontiers in Neuroscience
H B Stolp, G Ball, P-W So, J-D Tournier, M Jones, C Thornton, A D Edwards
A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology. We present a new technique, 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND), for registering medical images with 3D histology to overcome these limitations. Ex vivo 120 × 120 × 200 μm resolution diffusion-MRI (dMRI) data was acquired at 7 T from adult C57Bl/6 mouse hippocampus...
March 5, 2018: Scientific Reports
Raluca Pascalau, Roxana Popa Stănilă, Silviu Sfrângeu, Bianca Szabo
BACKGROUND: The limbic tracts are involved in crucial cerebral functions such as memory, emotion and behavior. The complex architecture of the limbic circuit makes it harder to approach compared to other white matter networks. Our study aims to describe the three-dimensional anatomy of the limbic white matter by use of two complementary study methods, namely ex vivo fiber dissection and in vivo MRI based tractography. METHODS: Three fiber dissection protocols were performed using blunt wooden instruments and a surgical microscope on formalin fixed brains prepared according to the Klingler method...
February 28, 2018: World Neurosurgery
Lionel Velly, Vincent Perlbarg, Thomas Boulier, Nicolas Adam, Sebastien Delphine, Charles-Edouard Luyt, Valentine Battisti, Gregory Torkomian, Charlotte Arbelot, Russell Chabanne, Betty Jean, Carol Di Perri, Steven Laureys, Giuseppe Citerio, Alessia Vargiolu, Benjamin Rohaut, Nicolas Bruder, Nadine Girard, Stein Silva, Vincent Cottenceau, Thomas Tourdias, Olivier Coulon, Bruno Riou, Lionel Naccache, Rajiv Gupta, Habib Benali, Damien Galanaud, Louis Puybasset
BACKGROUND: Prediction of neurological outcome after cardiac arrest is a major challenge. The aim of this study was to assess whether quantitative whole-brain white matter fractional anisotropy (WWM-FA) measured by diffusion tensor imaging between day 7 and day 28 after cardiac arrest can predict long-term neurological outcome. METHODS: This prospective, observational, cohort study (part of the MRI-COMA study) was done in 14 centres in France, Italy, and Belgium...
February 27, 2018: Lancet Neurology
Rossana Ganzola, Andrew M McIntosh, Thomas Nickson, Emma Sprooten, Mark E Bastin, Stephen Giles, Alix Macdonald, Jessika Sussmann, Simon Duchesne, Heather C Whalley
BACKGROUND: Mood disorders are familial psychiatric diseases, in which patients show reduced white matter (WM) integrity. We sought to determine whether WM integrity was affected in young offspring at high-familial risk of mood disorder before they go on to develop major depressive disorder (MDD). METHODS: The Bipolar Family study is a prospective longitudinal study examining young individuals (age 16-25 years) at familial risk of mood disorder on three occasions 2 years apart...
February 28, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Changbin Liu, Degang Yang, Jianjun Li, Dapeng Li, Mingliang Yang, Wei Sun, Qianru Meng, Wenhao Zhang, Chang Cai, Liangjie Du, Jun Li, Feng Gao, Rui Gu, Yutong Feng, Xuechao Dong, Qi Miao, Xinghua Yang, Zhentao Zuo
This study aimed to explore the dynamic diffusion tensor imaging (DTI) of changes in spinal cord contusion using a canine model of injury involving rostral and caudal levels. In this study, a spinal cord contusion model was established in female dogs using a custom-made weight-drop lesion device. DTI was performed on dogs with injured spinal cords (n=7) using a Siemens 3.0T MRI scanner at pre-contusion and at 3 h, 24 h, 6 weeks and 12 weeks post-injury. The tissue sections were stained for immunohistochemical analysis...
February 27, 2018: Journal of Neuroscience Research
Katrin Parmar, Brenda L Banwell, Nadine Akbar, Sandra Bigi
Pediatric onset multiple sclerosis (POMS) is a rare disease with an incidence of 0.07 to 2.9/100'000 children per year. It follows a relapsing-remitting disease course and is characterized by rapid accrual of inflammatory lesions, high relapse frequency, and early cognitive impairment. Magnetic resonance imaging (MRI) plays a pivotal role in the diagnosis of POMS, and in the exclusion of other disorders mimicking POMS. Furthermore, MRI aids in disease monitoring, and in the evaluation of therapeutic efficacy in both clinical practice and clinical trials...
February 26, 2018: Neuropediatrics
Ae Ryoung Kim, Dae Hyun Kim, So Young Park, Sunghyon Kyeong, Yong Wook Kim, Seung Koo Lee, Deog Young Kim
This study aimed to investigate the long-term motor outcome according to early diffusion tensor tractography findings for the affected corticospinal tract (CST) in poststroke hemiplegic patients. A total of 48 supratentorial subacute patients after stroke were enrolled, who had a brain MRI scan within 6 weeks from onset, and no stroke recurrence reported within the 2-year follow-up period. Diffusion tensor images were obtained and CSTs were reconstructed. The participants were classified into three groups: type A, the CST originating from the primary motor cortex was preserved around the lesion area; type B, the CST was similar to type A, except that the fiber originated from the area adjacent to the primary motor cortex; and type C, the CST was interrupted or not shown...
February 23, 2018: Neuroreport
Cornelia Laule, Irene M Vavasour, Elham Shahinfard, Burkhard Mädler, Jing Zhang, David K B Li, Alex L MacKay, Sandra M Sirrs
BACKGROUND AND PURPOSE: Late-onset adult Krabbe disease is a very rare demyelinating leukodystrophy, affecting less than 1 in a million people. Hematopoietic stem cell transplantation (HSCT) strategies can stop the accumulation of toxic metabolites that damage myelin-producing cells. We used quantitative advanced imaging metrics to longitudinally assess the impact of HSCT on brain abnormalities in adult-onset Krabbe disease. METHODS: A 42-year-old female with late-onset Krabbe disease and an age/sex-matched healthy control underwent annual 3T MRI (baseline was immediately prior to HSCT for the Krabbe subject)...
February 26, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Dorothée Lulé, Sarah Böhm, Hans-Peter Müller, Helena Aho-Özhan, Jürgen Keller, Martin Gorges, Markus Loose, Jochen H Weishaupt, Ingo Uttner, Elmar Pinkhardt, Jan Kassubek, Kelly Del Tredici, Heiko Braak, Sharon Abrahams, Albert C Ludolph
Sequential spread of TDP-43 load in the brain may be a pathological characteristic of amyotrophic lateral sclerosis (ALS). Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) based marker of this pathological feature. Cognitive deficits known to be present in a subset of ALS patients might act as an additional in vivo clinical marker of disease spread. N = 139 patients with ALS were tested with the Edinburgh Cognitive and Behavioural ALS screen (ECAS) in addition to DTI brain measures of pathological spread...
January 31, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Mohammadreza Soltaninejad, Guang Yang, Tryphon Lambrou, Nigel Allinson, Timothy L Jones, Thomas R Barrick, Franklyn A Howe, Xujiong Ye
BACKGROUND: Accurate segmentation of brain tumour in magnetic resonance images (MRI) is a difficult task due to various tumour types. Using information and features from multimodal MRI including structural MRI and isotropic (p) and anisotropic (q) components derived from the diffusion tensor imaging (DTI) may result in a more accurate analysis of brain images. METHODS: We propose a novel 3D supervoxel based learning method for segmentation of tumour in multimodal MRI brain images (conventional MRI and DTI)...
April 2018: Computer Methods and Programs in Biomedicine
Patrice Péran, Gaetano Barbagallo, Federico Nemmi, Maria Sierra, Monique Galitzky, Anne Pavy-Le Traon, Pierre Payoux, Wassilios G Meissner, Olivier Rascol
BACKGROUND: Multimodal MRI approach is based on a combination of MRI parameters sensitive to different tissue characteristics (eg, volume atrophy, iron deposition, and microstructural damage). The main objective of the present study was to use a multimodal MRI approach to identify brain differences that could discriminate between matched groups of patients with multiple system atrophy, Parkinson's disease, and healthy controls. We assessed the 2 different MSA variants, namely, MSA-P, with predominant parkinsonism, and MSA-C, with more prominent cerebellar symptoms...
February 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
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