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https://www.readbyqxmd.com/read/30233406/key-role-of-the-membrane-trafficking-of-nav1-5-channel-protein-in-antidepressant-induced-brugada-syndrome
#1
Xi Chen, Chao Zhu, Hao Zhou, Yu Zhang, Zhongqi Cai, Honglin Wu, Xiaomeng Ren, Lei Gao, Jiancheng Zhang, Yang Li
Anti-depressant treatment has been found to be associated with the development of Brugada syndrome (BrS) through poorly defined mechanisms. Herein, this study aimed to explore the molecular basis for amitriptyline-induced BrS. The effects of long-term treatments of amitriptyline on Nav1.5 were investigated using neonatal rat ventricular myocytes. The electrophysiological properties, expression and distribution of Nav1.5 were studied using the patch clamp, Western blot and confocal laser microscopy assays. Interactions between Nav1...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30233201/evaluation-of-maternal-and-newborn-health-services-in-jordan
#2
Yousef S Khader, Mohammad S Alyahya, Nihaya A Al-Sheyab, Khulood K Shattnawi, Hind Rajeh Saqer, Anwar Batieha
Objectives: This study aimed to assess the maternal and newborn services in Jordanian hospitals to provide policymakers, health professionals, and researchers with a clear picture about the current status of maternal and newborn health services. Methods: A total of 32 main hospitals that provide maternity services in Jordan were assessed. The study involved direct observations of these hospitals and interviews with basic health and hospital staff, with the purpose of assessing and evaluating the availability of various services for mothers and newborns, availability of resources, equipment and supplies, documentation and staff training, and provision of the health care services...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/30233075/cognitive-deficits-and-alzheimer-like-neuropathological-impairments-during-adolescence-in-a-rat-model-of-type-2-diabetes-mellitus
#3
Li Jin, Yi-Pei Li, Qiong Feng, Li Ren, Fang Wang, Guo-Jia Bo, Li Wang
Numerous studies have shown that many patients who suffer from type 2 diabetes mellitus exhibit cognitive dysfunction and neuronal synaptic impairments. Therefore, growing evidence suggests that type 2 diabetes mellitus has a close relationship with occurrence and progression of neurodegeneration and neural impairment in Alzheimer's disease. However, the relationship between metabolic disorders caused by type 2 diabetes mellitus and neurodegeneration and neural impairments in Alzheimer's disease is still not fully determined...
November 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/30232967/incidence-of-congenital-anomalies-in-a-rural-population-of-jammu-a-prospective-study
#4
Anjum Ara, Dinesh Kumar, Deepika Dewan, Nasib C Digra
Background: Congenital anomalies (CAs) are a major cause of stillbirths and neonatal mortality in India. Its magnitude and pattern reportedly vary over time and across geographical locations. Objectives: The objective of the study is to estimate the incidence of CAs in community development block RS Pura of District Jammu. Methods: The present study is a community-based prospective study. The field workers were trained with the help of "Birth Defect Surveillance" Atlas issued by WHO and ICBDMS (International Clearinghouse for Birth Defects Monitoring Systems) 2014...
July 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/30232931/cell-type-specific-dna-methylation-in-neonatal-cord-tissue-and-cord-blood-a-850k-reference-panel-and-comparison-of-cell-types
#5
Xinyi Lin, Jane Yi Lin Tan, Ai Ling Teh, Ives Yubin Lim, Samantha J Liew, Julia L MacIsaac, Yap Seng Chong, Peter D Gluckman, Michael S Kobor, Clara Yujing Cheong, Neerja Karnani
No abstract text is available yet for this article.
September 20, 2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/30232728/neonatal-calf-meningitis-associated-with-streptococcus-gallolyticus-subsp-gallolyticus
#6
Fuat Aydın, Vehbi Güneş, Latife Çakır Bayram, Seçil Abay, Emre Karakaya, Kemal Varol, Gencay Ekinci, Kadir Semih Gümüşsoy, Hamit Kaan Müştak, Kadir Serdar Diker
Here, we report a case of neonatal calf meningitis due to Streptococcus gallolyticus subsp. gallolyticus (SGG). Clinical, pathological and microbiological findings were evaluated. API Strep, 16S rRNA gene sequencing, rpoB gene sequencing and sodA gene sequencing were used for the complete identification of SGG. This is the first documented report of neonatal calf meningitis due to SGG in veterinary medicine.
September 19, 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/30232594/transient-neonatal-hyperinsulinaemic-hypoglycaemia-perinatal-predictors-of-length-and-cost-of-stay
#7
Kazune Kozen, Theodore Dassios, Nick Kametas, Ritika R Kapoor, Anne Greenough
Admission to neonatal care causes separation of infants from their parents, can adversely affect breast-feeding and is associated with painful procedures. Our aim was to identify perinatal factors and cost of care associated with transient neonatal hyperinsulinaemic hypoglycaemia (HH). Infants born after 35 weeks of gestation admitted because of hypoglycaemia were studied. The neonates were divided into two groups (HH and non-HH), and their length and cost of care were compared and perinatal factors predicting those outcomes explored...
September 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30232591/changes-in-bilirubin-in-infants-with-hypoxic-ischemic-encephalopathy
#8
Carlo Dani, Chiara Poggi, Claudia Fancelli, Simone Pratesi
Antioxidant properties of bilirubin have been reported in many studies. We hypothesized that bilirubin might be involved in neuroprotection mechanisms against oxidative stress in infants with hypoxic-ischemic encephalopathy (HIE) and that total serum bilirubin (TSB) might increase in these patients. We retrospectively studied infants with gestational age ≥ 35 weeks and birth weight ≥ 1800 g who were admitted to the neonatal intensive care unit (NICU) with a diagnosis of moderate-to-severe HIE and received or did not receive therapeutic hypothermia...
September 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30232412/reticulocyte-hemoglobin-content-as-an-early-predictive-biomarker-of-brain-iron-deficiency
#9
Kathleen M Ennis, Laura V Dahl, Raghavendra B Rao, Michael K Georgieff
BACKGROUND: Fetal and neonatal brain iron content is compromised at the time of anemia, suggesting that screening for iron deficiency by measuring hemoglobin is inadequate to protect the brain. Reticulocyte hemoglobin (Ret-He) reflects iron-deficient (ID) erythropoiesis prior to anemia. METHODS: At postnatal day (P), 10 and 20 iron-sufficient rat pups were fostered to ID dams to produce a postnatal ID (PNID) group, which was compared to 20 iron-sufficient (IS) pups fostered by IS dams...
September 13, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30232392/light-cured-polymer-electrodes-for-non-invasive-eeg-recordings
#10
Nora Vanessa de Camp, Gerhard Kalinka, Jürgen Bergeler
We invented the first non-metallic, self-adhesive and dry biosignalling electrode. The PEDOT polymer electrode changes its aggregate state and conductivity by a light curing procedure. The electrode can be applied as a gel underneath hair without shaving. With the aid of blue light, the electrode can be hardened within a few seconds at the desired location on the scalp. The cured polymer electrode is highly conductive and can be applied on a very small location. Unlike other EEG electrodes, our electrode does not lose conductivity upon drying...
September 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30232377/analysis-of-peak-inflating-pressure-and-inflating-pressure-limit-during-neonatal-volume-guaranteed-ventilation
#11
Eniko Szakmar, Colin J Morley, Gusztav Belteki
OBJECTIVES: To report how peak inflating pressure (PIP), tidal volume (VT) and low-tidal volume alarms are affected by maximum allowed inflating pressure (Pmax ) during volume guarantee (VG) ventilation. STUDY DESIGN: Ventilation data were analysed with 1 Hz sampling rate from 25 neonates receiving synchronised intermittent positive pressure ventilation with VG for >12 h. RESULTS: The difference between Pmax and PIP (Pdiff ) ranged between 5 and 20 mbar (median = 11 mbar) despite a protocol to keep Pmax 5 mbar above the "working PIP"...
September 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30232376/correction-neonatal-resuscitation-and-adaptation-score-vs-apgar-newborn-assessment-and-predictive-ability
#12
Teresa J Witcher, Shadi Jurdi, Vidhya Kumar, Aditi Gupta, Russell R Moores, Joseph Khoury, Henry J Rozycki
Since the publication of the above article, the authors have noted that the name of the first Item in the NRAS scoring system in Figure 1 was omitted. It is Heart Rate (C1). The authors apologise for any inconvenience caused by this error. The html and online pdf versions have now been rectified and carry the corrected Figure.
September 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/30232359/association-between-subcortical-morphology-and-cerebral-white-matter-energy-metabolism-in-neonates-with-congenital-heart-disease
#13
Nina Gertsvolf, Jodie K Votava-Smith, Rafael Ceschin, Sylvia Del Castillo, Vince Lee, Hollie A Lai, Stefan Bluml, Lisa Paquette, Ashok Panigrahy
Complex congenital heart disease (CHD) is associated with neurodevelopmental impairment, the mechanism of which is unknown. Cerebral cortical dysmaturation in CHD is linked to white matter abnormalities, including developmental vulnerability of the subplate, in relation to oxygen delivery and metabolism deficits. In this study, we report associations between subcortical morphology and white matter metabolism in neonates with CHD using quantitative magnetic resonance imaging (MRI) and spectroscopy (MRS). Multi-modal brain imaging was performed in three groups of neonates close to term-equivalent age: (1) term CHD (n = 56); (2) preterm CHD (n = 37) and (3) preterm control group (n = 22)...
September 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30232357/maternally-inherited-133kb-deletion-of-14q32-causing-kagami-ogata-syndrome
#14
Hou-Sung Jung, Stephanie E Vallee, Mary Beth Dinulos, Gregory J Tsongalis, Joel A Lefferts
We present a case of a newborn female with multiple anomalies demonstrating that the causes of imprinting disorders rely not only on the parent-of-origin of the chromosomal aberrations, but also the scope of genes contained in the imprinted region. The newborn female presented with prenatal polyhydramnios, neonatal respiratory distress, distal contractures, abdominal hernia, bell-shaped thorax, and abnormal ribs. The neonate required mechanical ventilation due to apnea, underwent surgery for laryngomalacia, and showed development delay by age 11 months...
September 19, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/30232349/n-phenylquinazolin-2-amine-yhhu4952-as-a-novel-promotor-for-oligodendrocyte-differentiation-and-myelination
#15
Xueli Yu, Gang Cheng, Lei Zhang, Yu Zhang, Qing Wang, Mengxue Zhao, Limin Zeng, Youhong Hu, Linyin Feng
Oligodendrocytes are a type of glial cells that ensheath multiple neuronal axons and form myelin. Under pathological conditions, such as multiple sclerosis (MS), inflammatory damage to myelin and oligodendrocytes leads to demyelination. Although the demyelinated regions can partially resolve functional deficits through remyelination, however, as the disease progresses, remyelination typically becomes incomplete and ultimately fails. One possible explanation for this failure is the activation of the Notch pathway in MS lesions, which impedes oligodendrocyte precursor cells (OPCs) at maturation...
September 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30232242/multi-lag-tone-entropy-in-neonatal-stress
#16
Matej Šapina, Chandan Kumar Karmakar, Karolina Kramarić, Matthieu Garcin, P David Adelson, Krešimir Milas, Marko Pirić, Dario Brdarić, John Yearwood
Heart rate variability (HRV) has been analysed using linear and nonlinear methods. In the framework of a controlled neonatal stress model, we applied tone-entropy (T-E) analysis at multiple lags to understand the influence of external stressors on healthy term neonates. Forty term neonates were included in the study. HRV was analysed using multi-lag T-E at two resting and two stress phases (heel stimulation and a heel stick blood drawing phase). Higher mean entropy values and lower mean tone values when stressed showed a reduction in randomness with increased sympathetic and reduced parasympathetic activity...
September 19, 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/30232177/towards-a-combinatorial-approach-for-the-prediction-of-immunoglobulin-g-half-life-and-clearance
#17
Dennis R Goulet, Michael J Watson, Susan H Tam, Adam Zwolak, Mark L Chiu, William M Atkins, Abhinav Nath
The serum half-life and clearance of therapeutic monoclonal antibodies (mAbs) are critical factors that impact their efficacy and optimal dosing regimen. The pH-dependent binding of a mAb to the neonatal Fc receptor (FcRn) has long been recognized as an important determinant of its pharmacokinetics. However, FcRn affinity alone is not a reliable predictor of mAb half-life, suggesting that other biological or biophysical mechanisms must be accounted for. mAb thermal stability, which reflects its unfolding and aggregation propensities, may also relate to its pharmacokinetic properties...
September 19, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/30232094/targeting-glucose-control-in-preterm-infants-pilot-studies-of-continuous-glucose-monitoring
#18
Lynn Thomson, Daniela Elleri, Simon Bond, James Howlett, David B Dunger, Kathryn Beardsall
OBJECTIVE: Hyperglycaemia is common in very preterm infants and is associated with adverse outcomes. Preventing hyperglycaemia without increasing the risk of hypoglycaemia is difficult. Real time tracking with continuous glucose monitors (CGM) may improve glucose control. We assessed the feasibility and safety of CGM to target glucose control in preterm infants, to inform a randomised controlled trial (RCT). DESIGN: We performed a single centre study in very preterm infants during the first week of life...
September 19, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30232009/subtle-changes-in-the-levels-of-bcl-2-proteins-cause-severe-craniofacial-abnormalities
#19
Stephanie Grabow, Andrew J Kueh, Francine Ke, Hannah K Vanyai, Bilal N Sheikh, Michael A Dengler, William Chiang, Samantha Eccles, Ian M Smyth, Lynelle K Jones, Frederic J de Sauvage, Mark Scott, Lachlan Whitehead, Anne K Voss, Andreas Strasser
Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The regulation of apoptosis is thought to be crucial for normal embryonic development. Accordingly, complete loss of pro-survival MCL-1 or BCL-XL (BCL2L1) causes embryonic lethality. However, it is not known whether minor reductions in pro-survival proteins could cause developmental abnormalities. We explored the rate-limiting roles of MCL-1 and BCL-XL in development and show that combined loss of single alleles of Mcl-1 and Bcl-x causes neonatal lethality...
September 18, 2018: Cell Reports
https://www.readbyqxmd.com/read/30231873/maternal-socioeconomic-factors-and-the-risk-of-premature-birth-and-low-birth-weight-in-cyprus-a-case-control-study
#20
Paraskevi Stylianou-Riga, Panayiotis Kouis, Paraskevi Kinni, Angelos Rigas, Thalia Papadouri, Panayiotis K Yiallouros, Mamas Theodorou
BACKGROUND: Prematurity and low birth weight are significant predictors of perinatal morbidity and mortality and are influenced by the overall health and socioeconomic status of the pregnant mother. Although Cyprus is characterized by the highest prematurity rate in Europe (13.1% in 2014), the relationship between maternal health and socioeconomic characteristics with prematurity and low birth weight has never been investigated. We aimed to investigate the association of maternal demographic, clinical and socioeconomic characteristics with premature delivery and low neonatal birth weight in Cyprus...
September 19, 2018: Reproductive Health
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