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Jayraj V Vaghasiya, Keval K Sonigara, Thomas Beuvier, Alain Gibaud, Saurabh S Soni
A novel saturated heterocyclic organic ionic crystal, piperidinium iodide (PiHI), is synthesized by a facile route and applied as a solid electrolyte in Dye Sensitized Solar Cells (ss-DSSCs). Upon addition of a small quantity of iodine, PiHI self-assembles into a 1D lamellar micro crystalline structure that shows anisotropic conductivity. The two-component PiHI was characterized by using electrochemical impedance spectroscopy, cyclic voltammetry, steady state voltammetry, FT-IR, and Raman spectroscopy. Wide angle X-ray diffraction (XRD) measurement confirms the presence of long range 1D lamellar channels that pave the way for the diffusion of the redox couple I(-)/I3(-) and exhibit high anisotropic conductivity...
October 26, 2017: Nanoscale
Xuan Ding, Man M Nguyen, Isaac B James, Kacey G Marra, J Peter Rubin, Steven A Leers, Kang Kim
Thermal (temporal) strain imaging (TSI) is being developed to detect the lipid-rich core of atherosclerotic plaques and presence of fatty liver disease. However, the effects of ultrasonic clutter on TSI have not been considered. In this study, we evaluated whether pulse inversion harmonic imaging (PIHI) could be used to improve estimates of thermal (temporal) strain. Using mixed castor oil-gelatin phantoms of different concentrations and artificially introduced clutter, we found that PIHI improved the signal-to-noise ratio of TSI by an average of 213% or 52...
May 2016: Ultrasound in Medicine & Biology
Flemming Forsberg, Raymond J Ro, Andrew Marshall, Ji-Bin Liu, See-Ying Chiou, Daniel A Merton, Priscilla Machado, Adam P Dicker, Levon N Nazarian
The development of antiangiogenic therapies has stimulated interest in noninvasive imaging methods to monitor response. We investigated whether the effects of a vascular endothelial growth factor decoy receptor (VEGF Trap, Regeneron Pharmaceuticals, Tarrytown, NY) could be monitored in vivo using contrast-enhanced ultrasonography (CEUS). Twenty nude mice (in two groups) were implanted with a human melanoma cell line (DB-1). The active group received VEGF Trap (4 × 25 mg/kg over 2 weeks), whereas the control group received an inactive protein...
2014: Molecular Imaging
Robert Green, Brian Hutton, Jason Lorette, Dominique Bleskie, Lauralyn McIntyre, Dean Fergusson
OBJECTIVE: Hemodynamic instability following emergent endotracheal intubation (EETI) is a potentially life-threatening adverse event. The objectives of this systematic literature review were to document the incidence of postintubation hemodynamic instability (PIHI), to determine the definitions for PIHI used in the available literature, and to examine factors associated with PIHI in adult patients who require EETI. DATA SOURCE: Articles published in Medline (1966-August 2012)...
January 2014: CJEM
Robert S Green, Janet Edwards, Elham Sabri, Dean Fergusson
OBJECTIVES: Postintubation hemodynamic instability (PIHI) is a potentially life-threatening adverse event of emergent endotracheal intubation. The objectives of this study were to determine the incidence, risk factors, and impact on patient outcomes associated with PIHI in intubations performed in emergency medicine. METHODS: A structured chart audit was performed of all consecutive adult patients requiring emergent endotracheal intubations over a 16-month period at a tertiary care emergency department (ED)...
March 2012: CJEM
Azimahtol Hawariah Lope Pihie, Zainul Amiruddin Zakaria, Fezah Othman
The present study was to determine the anticancer potential of Labisia pumila in in vitro models. Results from the study revealed that ethanol extract of L. pumila was more cytotoxic against HM3KO cells while having reduced effects on nonmalignant cells as compared to aqueous and hexane extracts. Thus, ethanol extract was selected to be further separated by using the bioassay-guided fractionation method to give an active fraction, SF2Lp. Results obtained from the flow cytometry analysis showed that SF2Lp was able to arrest the HM3KO cell cycle at the G1 phase, while morphological findings from AO-EB nuclear staining assays along with the Apoptotic Index confirmed the induction of apoptosis by SF2Lp in HM3KO cells...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
Thiam-Tsui Tee, Yew-Hoong Cheah, Nallappan Meenakshii, Mohd Yusof Mohd Sharom, Lope Pihie Azimahtol Hawariah
Xanthorrhizol is a plant-derived pharmacologically active sesquiterpenoid compound isolated from Curcuma xanthorrhiza. Previously, we have reported that xanthorrhizol inhibited the proliferation of HepG2 human hepatoma cells by inducing apoptotic cell death via caspase activation. Here, we attempt to further elucidate the mode of action of xanthorrhizol. Apoptosis in xanthorrhizol-treated HepG2 cells as observed by scanning electron microscopy was accompanied by truncation of BID; reduction of both anti-apoptotic Bcl-2 and Bcl-X(L) expression; cleavage of PARP and DFF45/ICAD proteins and DNA fragmentation...
April 20, 2012: Biochemical and Biophysical Research Communications
Hasmah Abdullah, Azimahtol Hawariah Lope Pihie, Judit Hohmann, Joseph Molnár
BACKGROUND: Hydnophytum formicarium Jack is an epyphytic shrub that belongs to the family of Rubiaceae and is native to the tropical rain forests of the Asean region, which includes Malaysia. A flavanoid derivative, 7, 3', 5'-trihydroxyflavanone (3HFD), isolated from H. formicarium has been reported to have cytotoxic effects on the human breast carcinoma cell line MCF-7. The aim of the current study was to investigate the mode of cell death in MCF-7 cells treated with 3HFD. A DNA fragmentation assay was conducted on isolated genomic DNA, a TUNEL assay was used to determine the mode of cell death and Western blotting was used to evaluate the expression levels of Bax and Bcl-2...
May 4, 2010: Cancer Cell International
Yusmazura Zakaria, Asmah Rahmat, Azimahtol Hawariah Lope Pihie, Noor Rain Abdullah, Peter J Houghton
BACKGROUND: Eurycomanone is a cytotoxic compound found in Eurycoma longifolia Jack. Previous studies had noted the cytotoxic effect against various cancer cell lines. The aim of this study is to investigate the cytotoxicity against human hepato carcinoma cell in vitro and the mode of action. The cytotoxicity of eurycomanone was evaluated using MTT assay and the mode of cell death was detected by Hoechst 33258 nuclear staining and flow cytometry with Annexin-V/propidium iodide double staining...
2009: Cancer Cell International
F Forsberg, R J Ro, J B Liu, K J Lipcan, M Potoczek, L N Nazarian
The potential for noninvasive monitoring and quantification of tumor angiogenesis with contrast-enhanced ultrasound imaging has been investigated in a murine cancer model. Seventy athymic nude mice were implanted with the human melanoma cell line DB-1 but only 30 of these were available for the final study. The 30 mice were divided into three groups (10 mice/group), which were studied with contrast-enhanced ultrasound imaging 4, 5 or 6 weeks post-implantation. Power Doppler and pulse inversion harmonic imaging (PIHI) were performed (in real time and intermittently) with a Sonoline Elegra scanner (Siemens Medical Solutions, Issaquah, WA) following injection of Optison (dose: 0...
October 2008: Ultrasonic Imaging
Hannes Platzgummer, Gerd Schueller, Johannes Grisar, Michael Weber, Claudia Schueller-Weidekamm
OBJECTIVE: The quantification of synovitis is of great significance for adequate therapy management and follow-up in patients with Rheumatoid Arthritis (RA). The purpose of this study was to validate a semi-quantitative Power Doppler (PD) scoring system by comparing the PD scores to the objective measurement of the synovial inflammation using dynamic contrast-enhanced Pulse-Inversion Harmonic Imaging (PIHI). MATERIALS AND METHODS: In 27 patients with RA, two radiologists performed semi-quantitative scoring of a PD examination, using a four-point scale from 0 to 3, in the metacarpophalangeal joints, proximal interphalangeal joints, and the wrists...
August 2009: European Journal of Radiology
Biagio Valentino, Giuseppe Caruso, Elvira Farina Lipari, Diego Lipari, Antonella Campisi, Giuseppe Salvaggio, Roberto Lagalla
Aim of the present study was to evaluate by transmission electron microscope (TEM) modifications in rabbit kidney-parenchyma after submission to ultrasound contrast agent (UCA) with Pulse Inversion Harmonic Imaging (PIHI). Seven inbred male albino rabbits were divided into three groups: 1) control group (n = 1 animal); 2) sonicated group (n = 3 animals); 3) sonicated group with UCA injection (CEUS) (n = 3 animals). The first group was not exposed to ultrasonography (US) and/or UCA. The second and third groups underwent baseline US and later to US with PIHI with a high mechanical index; in the third group UCA was simultaneously administered...
July 2008: Italian Journal of Anatomy and Embryology, Archivio Italiano di Anatomia Ed Embriologia
Yew Hoong Cheah, Fariza Juliana Nordin, Thiam Tsui Tee, Hawariah Lope Pihie Azimahtol, Noor Rain Abdullah, Zakiah Ismail
Xanthorrhizol is a natural sesquiterpenoid compound isolated from the rhizome of Curcuma xanthorrhizza Roxb (Zingerberaceae). Recent studies of xanthorrhizol in cell cultures strongly support the role of xanthorrhizol as an antiproliferative agent. In our study, we tested the antiproliferative effect of xanthorrhizol using different breast cancer cell lines. The invasive breast cancer cell line, MDA-MB-231, was then selected for further investigations. Treatment with xanthorrhizol caused 50% growth inhibition on MDA-MB-231 cells at 8...
November 2008: Anticancer Research
Yew Hoong Cheah, Fariza Juliana Nordin, Rozie Sarip, Thiam Tsui Tee, Hawariah Lope Pihie Azimahtol, Hasnah M Sirat, Badrul Amini Abd Rashid, Noor Rain Abdullah, Zakiah Ismail
BACKGROUND: It has been suggested that combined effect of natural products may improve the treatment effectiveness in combating proliferation of cancer cells. The present study was undertaken to evaluate the possibility that the combination of xanthorrhizol and curcumin might show synergistic growth inhibitory effect towards MDA-MB-231 human breast cancer cells via apoptosis induction. The effective dose that produced 50% growth inhibition (GI50) was calculated from the log dose-response curve of fixed-combinations of xanthorrhizol and curcumin generated from the sulforhodamine B (SRB) assay...
January 2, 2009: Cancer Cell International
Tsutomu Nakaoka, Hidehiko Shoji, Hideyuki Tabeta, Hiroaki Ikeshima, Tamao Uchida, Kenjirou Itou
We usually check stenosis rate in patients through the limited directions of angiography. This can result in insufficient evaluation. The importance of the condition of the carotid artery wall in fully accpted nowadays, and ultrasound sonography is being used as a means to study it. Neovascularization in the plaque is one of the pathological factors inducing plaque hemorrhage and rupture, and this is suspected of causing carotid artery stenosis, occlusion and artery-to-artery embolism. Harmonic image is a contrast specific imaging modality, which uses the nonlinear properties of ultrasound contrast agents by transmitting at the fundamental frequency and receiving at multiples of these frequencies...
November 2008: No Shinkei Geka. Neurological Surgery
C H Nolte, J Gruss, J Steinbrink, G J Jungehulsing, P Brunecker, A M Hopt, S J Schreiber
PURPOSE: Ultrasound (US) perfusion imaging of ischemic stroke has mainly been applied to large middle cerebral artery infarction. We investigated whether small stroke involving the thalamus can also be detected. MATERIALS AND METHODS: Phase inversion harmonic imaging (PIHI) was applied to patients with small infarctions involving the thalamus (maximal longitudinal infarct diameter less than 3 cm). PIHI was performed from both the left and right side in axial diencephalic planes...
October 2009: Ultraschall in der Medizin
Thiam Tsui Tee, Yew Hoong Cheah, Lope Pihie Azimahtol Hawariah
F16 is a plant-derived pharmacologically active fraction extracted from Eurycoma longifolia Jack. Previously, we have reported that F16 inhibited the proliferation of MCF-7 human breast cancer cells by inducing apoptotic cell death while having some degree of cytoselectivity on a normal human breast cell line, MCF-10A. In this study, we attempted to further elucidate the mode of action of F16. We found that the intrinsic apoptotic pathway was invoked, with the reduction of Bcl-2 protein. Then, executioner caspase-7 was cleaved and activated in response to F16 treatment...
September 2007: Anticancer Research
Hüseyin Ozdemir, Mustafa Kemal Demir, Osman Temizöz, Hakan Genchellac, Ercument Unlu
PURPOSE: To compare phase inversion harmonic imaging (PIHI) with fundamental imaging (FI) in the evaluation of renal calculi. METHODS: Thirty adult patients with renal calculi (17 men, 13 women; mean age 44 years [range, 25-71]) underwent transabdominal sonographic examination of the urinary system. Both kidneys and renal calculi were examined with PIHI and FI. Overall renal conspicuity, calculus visibility, and clarity of posterior shadowing were assessed subjectively using a 4-point scale (0 being the worst, 3 being the best)...
January 2008: Journal of Clinical Ultrasound: JCU
Gerhard J Jungehulsing, Peter Brunecker, Christian H Nolte, Jochen B Fiebach, Claudia Kunze, Florian Doepp, Arno Villringer, Stephan J Schreiber
The purpose was to assess whether standard ultrasound (US) perfusion-imaging by means of contrast-enhanced transcranial color-coded sonography (TCCS) affects the blood-brain barrier (BBB) in patients with small-vessel disease (SVD). One week after a screening MRI to exclude a preexisting BBB disruption, unilateral TCCS phase inversion harmonic imaging (PIHI) was performed in an axial diencephalic plane after intravenous bolus application of 2.5 mL SonoVue (IGEA, Bracco, Italy). Magnetic resonance imaging (MRI) was performed immediately after US...
January 2008: Ultrasound in Medicine & Biology
Tri Handayani, Sharifah Sakinah, Meenakshii Nallappan, Azimahtol Hawariah Lope Pihie
Xanthorrhizol is a sesquiterpenoid compound extracted from the rhizome of Curcuma xanthorrhiza. This study investigated the antiproliferative effect and the mechanism of action of xanthorrhizol on human hepatoma cells, HepG2, and the mode of cell death. An antiproliferative assay using methylene blue staining revealed that xanthorrhizol inhibited the proliferation of the HepG2 cells with a 50% inhibition of cell growth (IC50) value of 4.17 +/- 0.053 microg/ml. The antiproliferative activity of xanthorrhizol was due to apoptosis induced in the HepG2 cells and not necrosis, which was confirmed by the Tdt-mediated dUTP nick end labeling (TUNEL) assay...
March 2007: Anticancer Research
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