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https://www.readbyqxmd.com/read/29917280/protective-effects-of-cinnamon-bark-extract-against-ischemia-reperfusion-injury-and-arrhythmias-in-rat
#1
Mehrnoosh Sedighi, Afshin Nazari, Mahdieh Faghihi, Mahmoud Rafieian-Kopaei, Arash Karimi, Maryam Moghimian, Seyyed Ali Mozaffarpur, Marzieh Rashidipour, Mehrdad Namdari, Mostafa Cheraghi, Bahram Rasoulian
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion...
June 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29916725/prognostic-value-of-neutrophil-gelatinase-associated-lipocalin-in-patients-with-acute-st-segment-elevation-myocardial-infarction-a-meta-analysis
#2
Yu Fan, Chen Zou
No abstract text is available yet for this article.
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29915211/prognostic-value-of-culprit-artery-double-stranded-dna-in-st-segment-elevated-myocardial-infarction
#3
Xiqiang Wang, Dandan Yang, Jing Liu, Xiude Fan, Aiqun Ma, Ping Liu
The double-stranded DNA (dsDNA) which is scaffold of neutrophil extracellular traps (NETs) has been reported to be associated with the occurrence of major adverse cardiovascular events (MACEs) in patients with coronary atherosclerosis. However, the relationship between the dsDNA and the occurrence of MACEs in patients with ST-segment elevated myocardial infarction (STEMI) remains unclear. In this study, 142 consecutive STEMI patients were admitted to medical institutions. Blood from the infarct-related coronary artery (ICA) and peripheral artery (PA) were obtained during percutaneous coronary intervention...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914695/sensitivity-analysis-of-st-segment-epicardial-potentials-arising-from-changes-in-ischaemic-region-conductivities-in-early-and-late-stage-ischaemia
#4
Barbara M Johnston, Peter R Johnston
Although computational studies are increasingly used to gain insight into diseases such as myocardial ischaemia, there is still considerable uncertainty about the values for many of the parameters in these studies. This is particularly true for the bidomain conductivity values that are used in normal tissue and, even more so, in ischaemic tissue, when modelling ischaemia. In this work, we extended a previous study that used a half-ellipsoidal model and a realistic model to study subendocardial ischaemia during the ST segment, so that we could simulate both early and late stage ischaemia...
June 15, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29913478/lipid-biomarkers-in-acute-myocardial-infarction-before-and-after-percutaneous-coronary-intervention-by-lipidomics-analysis
#5
Limin Feng, Jianzhou Yang, Wennan Liu, Qing Wang, Huijie Wang, Le Shi, Liyan Fu, Qiang Xu, Baohe Wang, Tian Li
BACKGROUND Reperfusion injury is one of the leading causes of myocardial cell death and heart failure. This study was performed to identify new candidate lipid biomarkers for the purpose of optimizing the diagnosis of myocardial ischemia reperfusion (I/R) injury, assessing the severity of myocardial I/R injury and trying to find the novel mechanism related to lipids. MATERIAL AND METHODS Forty patients who were diagnosed with ST-segment elevation myocardial infarction (STEMI) were randomly selected for this study...
June 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29912782/a-randomized-triple-blind-trial-of-cardiac-shock-wave-therapy-on-exercise-tolerance-and-symptoms-in-patients-with-stable-angina-pectoris
#6
Evgeny Shkolnik, Greta Burneikaite, Gabrielius Jakutis, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Yury Vasyuk, Aleksandras Laucevicius, Jelena Celutkiene
BACKGROUND: Despite major advances in managing coronary artery disease and continuous research on alternative techniques to enhance myocardial perfusion and reduce symptoms, coronary artery disease is still one of the leading causes of adult disability worldwide. Cardiac shock-wave therapy (CSWT) has shown promising results in the amelioration of myocardial ischemia in experimental studies; however, clinical results are limited to single-center, mostly uncontrolled and underpowered trials...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29911657/swimming-performance-of-a-bio-inspired-robotic-vessel-with-undulating-fin-propulsion
#7
Hanlin Liu, Oscar M Curet
Undulatory fin propulsion exhibits high degree of maneuver control -- an ideal for underwater vessels exploring complex environments. In this work, we developed and tested a self-contained, free-swimming robot with a single undulating fin running along the length of the robot, which controls both forward motion and directional maneuvers. We successfully replicated several maneuvers including forward swimming, reversed motion, diving, station-keeping and vertical swimming. For each maneuver, a series of experiments were performed as a function of fin frequency, wavelength and traveling wave direction to measure swimming velocities, orientation angles and mean power consumption...
June 18, 2018: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/29911392/remote-ischaemic-conditioning-for-myocardial-infarction-or-elective-pci-systematic-review-and-meta-analyses-of-randomised-trials
#8
Paul M Haller, Kris G Vargas, Maria C Haller, Edita Piackova, Johann Wojta, Mariann Gyöngyösi, Bernard J Gersh, Attila Kiss, Bruno K Podesser, Kurt Huber
BACKGROUND: The efficacy of remote ischaemic conditioning in clinical trials of ST-segment elevation myocardial infarction (STEMI) or elective percutaneous coronary intervention is controversial. We aimed to systematically review and meta-analyse whether remote ischaemic conditioning reduces myocardial damage in those patients. METHODS: We searched PubMed, Embase and Web of Science from inception until December 2017 for randomised clinical trials evaluating remote ischaemic conditioning versus a control group...
June 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29910588/nonsymptomatic-myocardial-bridge-causing-systolic-total-narrowing-of-circumflex-artery
#9
Fatih Aksoy, Hasan Aydın Baş, Ahmet Altınbaş
Myocardial bridge is defined as the narrowing of any coronary artery segment in systole but a normal diameter in diastole. It is most frequently seen on left anterior descending (LAD) artery. Left circumflex artery (LCx) is very rare. A 62 year-old male patient presented with severe, squeezing chest pain. The electrocardiogram showed T wave inversion in V1-V4 and ST depression in DII, DIII, aVF. Coronary angiography showed complicated lesion on after S2 branches of LAD and myocardial bridge causing 100% systolic narrowing of fourth obtus marginal branch of LCx...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29910059/bivalirudin-versus-heparin-with-primary-percutaneous-coronary-intervention
#10
Dimitrios Venetsanos, Sofia Sederholm Lawesson, Stefan James, Sasha Koul, David Erlinge, Eva Swahn, Joakim Alfredsson
BACKGROUND: Optimal adjunctive therapy in ST-segment elevation myocardial infarction (STEMI) patients treated with primary PCI (PPCI) remains a matter of debate. Our aim was to compare the efficacy and safety of bivalirudin to unfractionated heparin (UFH), with or without glycoprotein IIb/IIIa inhibitors (GPI) in a large real-world population, using data from the Swedish national registry, SWEDEHEART. METHOD: From 2008 to 2014 we identified 23,800 STEMI patients presenting within 12 hours from symptom onset treated with PPCI and UFH ± GPI or bivalirudin±GPI...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29910048/discharge-timing-and-outcomes-after-uncomplicated-non-st-segment-elevation-acute-myocardial-infarction
#11
Jennifer A Rymer, Michael W Tempelhof, Robert M Clare, Karen S Pieper, Christopher B Granger, Frans Van de Werf, David J Moliterno, Robert A Harrington, Harvey D White, Paul W Armstrong, Renato D Lopes, Kenneth W Mahaffey, L Kristin Newby
BACKGROUND: Length of stay after non-ST-segment elevation myocardial infarction (NSTEMI) continues to decrease, but information to guide duration of hospitalization is limited. METHODS: We used landmark analyses, in which the landmark defined potential days of discharge, to estimate complication rates on the first day the patient would have been out of the hospital, and estimated associations between timing of discharge and 30-day and 1-year event-free survival after discharge among NSTEMI patients...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29906667/the-high-cost-of-critical-care-unit-over-utilization-for-patients-with-nste-acs
#12
Sean van Diepen, Dat T Tran, Justin A Ezekowitz, David A Zygun, Jason N Katz, Renato D Lopes, L Kristin Newby, Finlay A McAlister, Padma Kaul
BACKGROUND: There is substantial variability among hospitals in critical care unit (CCU) utilization for patients admitted with non-ST-Segment Elevation Acute Coronary Syndromes (NSTE ACS). We estimated the potential cost saving if all hospitals adopted low CCU utilization practices for patients with NSTE ACS. METHODS: National hospital claims data were used to identify all patients with a primary diagnosis of NSTE ACS initially admitted to an acute care hospital between 2007 and 2013...
May 19, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29902264/association-of-electrocardiogram-alterations-of-rescuers-and-performance-during-a-simulated-cardiac-arrest-a-prospective-simulation-study
#13
Lucas Tramèr, Christoph Becker, Seraina Hochstrasser, Stephan Marsch, Sabina Hunziker
BACKGROUND: Performance of cardiopulmonary resuscitation (CPR) causes significant mental stress for rescuers, especially if performed by inexperienced individuals. Our aim was to study electrocardiogram (ECG) alterations in rescuers and its association with gender and CPR performance. METHODS: We included 126 medical students in this prospective, observational simulator study. Each student was equipped with a 3-lead continuous ECG device tracking the individual electrocardiographic output before, during and after CPR...
2018: PloS One
https://www.readbyqxmd.com/read/29901579/electrocardiogram-criteria-of-limb-leads-predicting-right-coronary-artery-as-culprit-artery-in-inferior-wall-myocardial-infarction-a-meta-analysis
#14
Hao Liang, Lan Wu, Yingchen Li, Yidi Zeng, Zhixi Hu, Xinchun Li, Xiang Sun, Qiuyan Zhang, Xiaoqing Zhou
BACKGROUND: Prior studies have proposed several electrocardiogram (ECG) criteria in limb leads for identifying the culprit coronary artery (CCA) in patients with acute inferior wall myocardial infarction (IWMI). The aim of our study was to conduct an evidence-based evaluation and test accuracy comparison of these criteria. METHODS: We searched the PubMed, Embase, and Ovid. Eligible studies to assess the diagnostic performance of ECG criteria predicting CCA in IWMI were reviewed for inclusion...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899463/the-cami-score-a-novel-tool-derived-from-cami-registry-to-predict-in-hospital-death-among-acute-myocardial-infarction-patients
#15
Chenxi Song, Rui Fu, Kefei Dou, Jingang Yang, Haiyan Xu, Xiaojin Gao, Wei Li, Guofeng Gao, Zhiyong Zhao, Jia Liu, Yuejin Yang
Risk stratification of patients with acute myocardial infarction (AMI) is of clinical significance. Although there are many existing risk scores, periodic update is required to reflect contemporary patient profile and management. The present study aims to develop a risk model to predict in-hospital death among contemporary AMI patients as soon as possible after admission. We included 23417 AMI patients from China Acute Myocardial Infarction (CAMI) registry from January 2013 to September 2014 and extracted relevant data...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898017/cohort-of-patients-referred-for-brugada-syndrome-investigation-in-an-electrophysiology-service-19-year-registry
#16
Stefan Warpechowski Neto, Tiago Luiz Luz Leiria, Laura Lessa Gaudie Ley, Antonio Lessa Gaudie Ley, Luiza Zwan Dutra, Leonardo Martins Pires, Marcelo Lapa Kruse, Gustavo Glotz de Lima
BACKGROUND: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. OBJECTIVE: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center...
June 11, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29896993/prolonged-veno-arterial-extracorporeal-life-support-for-cardiac-failure
#17
Sabina Pw Guenther, Yasuhiro Shudo, William Hiesinger, Dipanjan Banerjee
OBJECTIVES: In intractable cardiogenic shock, extracorporeal life support frequently is the last treatment option. Outcomes of prolonged veno-arterial extracorporeal life support for cardiac failure are poorly defined. METHODS: We retrospectively analyzed 10 patients (4 females, age = 36 ± 16 years) who underwent prolonged extracorporeal life support (≥7 days) from December 2015 to March 2017 for cardiogenic shock. The primary endpoint was survival to hospital discharge...
June 1, 2018: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29896813/cardiovascular-benefits-of-reducing-personal-exposure-to-traffic-related-noise-and-particulate-air-pollution-a-randomized-crossover-study-in-the-beijing-subway-system
#18
Xuan Yang, Xu Jia, Wei Dong, Shaowei Wu, Mark R Miller, Dayu Hu, Hongyu Li, Lu Pan, Furong Deng, Xinbiao Guo
To assess the cardiovascular benefits of protecting against particulate air pollution and noise, we conducted a randomized crossover study with 40 young healthy college students from March to May 2017 in the underground subway, Beijing. Participants each received four treatments [no intervention phase (NIP), respirator intervention phase (RIP), headphone intervention phase (HIP), respirator plus headphone intervention phase (RHIP)] in a randomized order during four different study periods with two-week washout intervals...
June 13, 2018: Indoor Air
https://www.readbyqxmd.com/read/29895599/activated-clotting-time-to-guide-heparin-dosing-in-non-st-segment-elevation-acute-coronary-syndrome-patients-undergoing-percutaneous-coronary-intervention-and-treated-with-iib-iiia-inhibitors-impact-on-ischemic-and-bleeding-outcomes-insights-from-the-tao-trial
#19
Jean-Guillaume Dillinger, Gregory Ducrocq, Yedid Elbez, Marc Cohen, Christoph Bode, Charles Pollack, José C Nicolau, Patrick Henry, Sasko Kedev, Stephen D Wiviott, Marc S Sabatine, Shamir R Mehta, Philippe Gabriel Steg
BACKGROUND: Monitoring anticoagulation with activated clotting time (ACT) has been proposed to reduce ischemic or bleeding events. However, the value of using ACT to improve outcomes is uncertain. This study sought to determine the relationship between ACT and outcomes during percutaneous coronary intervention in patients with non-ST-segment-elevation acute coronary syndrome (NSTE-ACS) treated by unfractionated heparin with GPIs (glycoprotein IIb/IIIa inhibitors). METHODS AND RESULTS: From the randomized TAO trial (Treatment of Acute Coronary Syndromes With Otamixaban), we analyzed the value of ACT to predict ischemic and bleeding outcomes in the 3275 patients receiving unfractionated heparin plus eptifibatide...
June 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29895484/coping-and-cardiac-troponin-t-a-risk-for-hypertension-and-sub-clinical-ecg-left-ventricular-hypertrophy-the-sabpa-study
#20
Catharina Elizabeth Myburgh, Leoné Malan, Annemarie Wentzel, Jacobus De Wet Scheepers, Nicolaas Theodor Malan
BACKGROUND: Defensive coping (DefS) was associated with cardiovascular disease (CVD) susceptibility in Blacks. Whether coping strategies will associate with sub-clinical left ventricular hypertrophy (electrocardiographic-left ventricular hypertrophy [ECG-LVH] or Cornell product), cardiomyocyte injury and blood pressure (BP), is unclear. Therefore, we assessed relationships between ECG-LVH, cardiac troponin T (cTnT) and 24-hour BP in bi-ethnic groups when habitually utilising a certain coping style, and these groups when having a stress-related cTnT cut-point of 4...
May 31, 2018: Heart, Lung & Circulation
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