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https://www.readbyqxmd.com/read/29051816/eptifibatide-is-associated-with-significant-cost-savings-and-similar-clinical-outcomes-to-abciximab-when-used-during-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction-an-observational-cohort-study-of-3863-patients
#1
K S Rathod, S Antoniou, P Avari, N Ding, P Wright, C Knight, A K Jain, A Mathur, E J Smith, R Weerackody, A Wragg, D A Jones
INTRODUCTION: Glycoprotein IIb/IIIa inhibitors are recommended by guidelines in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention. There are few studies directly comparing these agents. The aim of this study was to assess whether eptifibatide is a safe and cost-effective alternative to abciximab in the treatment of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. METHODS: This was an observational cohort study of 3863 patients who received a GPIIb/IIIa inhibitor whilst undergoing primary percutaneous coronary intervention from 2007 to 2014...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/29051544/estimating-prognosis-in-patients-with-acute-myocardial-infarction-using-personalized-computational-heart-models
#2
Hao Gao, Kenneth Mangion, David Carrick, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Biomechanical computational models have potential prognostic utility in patients after an acute ST-segment-elevation myocardial infarction (STEMI). In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n = 6, 83% male, age 54 ± 12 years) complicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control group (n = 6, 83% male, age 46 ± 14 years), no prior history of cardiovascular disease and normal systolic blood pressure (SBP < 130 mmHg)...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29049164/electrocardiogram-in-patients-with-acute-inferior-myocardial-infarction-due-to-occlusion-of-circumflex-artery
#3
Qun Li, De-Zhao Wang, Bu-Xing Chen
To investigate the diagnostic value of electrocardiographic (ECG) ST-segment in acute inferior myocardial infarction (AIMI) caused by the left circumflex branch (LCX).A total of 240 clinical cases with AIMI in our hospital were retrospectively analyzed. All of them had received percutaneous coronary intervention (PCI) within 12 hours after symptom onset. The clinical features, ECG manifestations, and coronary artery lesion characteristics of the patients were collected.The right coronary artery (RCA) was shown to be the infarct-related artery (IRA) in 177 patients, while LCX was responsible for AIMI in 63 cases...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048110/morphometric-and-morphologic-parameters-of-the-heart-in-healthy-alouatta-guariba-clamitans-cabrera-1940
#4
Murilo Gomes de Soutello Charlier, Maurício Gianfrancesco Filippi, Carolina Hagy Girotto, Vanessa Lanes Ribeiro, Carlos Roberto Teixeira, Maria Lúcia Gomes Lourenço, Luiz Carlos Vulcano
BACKGROUND: This study aimed at assessing the heart function of one neotropical primate (Alouatta guariba clamitans) kept in captivity using radiography, electrocardiogram (ECG) and Doppler echocardiography. METHODS: Ten adult healthy howler monkeys (A. g. clamitans) were evaluated under general anaesthesia. Vertebral Heart Scores (VHS) were obtained from radiographic studies. Ejection fraction, shortening fraction of left ventricle, left atrial/aortic root ratio, ascending aortic diameter, peak velocity of pulmonary, mitral, tricuspid and aortic blood flow and other values were measured by Doppler echocardiography...
October 19, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/29047360/comparison-of-circulating-dendritic-cell-and-monocyte-subsets-at-different-stages-of-atherosclerosis-insights-from-optical-coherence-tomography
#5
Jianhui Zhuang, Yang Han, Dachun Xu, Guofu Zhu, Shekhar Singh, Luoman Chen, Mengyun Zhu, Wei Chen, Yawei Xu, Xiankai Li
BACKGROUND: While specific patterns of circulating dendritic cells (DCs) and monocytes are associated with the incidence of coronary artery disease, the characterization of circulating DC and monocyte subsets in patients with different stages of atherosclerosis remains unclear. METHODS: Forty-eight patients with unstable angina pectoris (UAP) diagnosed by angiography were enrolled. Likewise, 31 patients with ST-segment elevation myocardial infarction (STEMI) were enrolled and confirmed with the presence of thrombosis by angiography...
October 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29042400/thrombus-aspiration-for-st-segment-elevation-myocardial-infarction-in-modern-era-still-an-issue-of-debate
#6
REVIEW
Junhua Ge, Andreas Schäfer, Georg Ertl, Peter Nordbeck
The role of manual thrombus aspiration (TA) during primary percutaneous coronary intervention (PPCI) for acute ST-segment-elevation myocardial infarction has been a matter of intense research and debate now. Although recent randomized controlled clinical trials (notably TASTE [Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia] and TOTAL [Trial of Routine Aspiration Thrombectomy With PCI Versus PCI Alone in Patients With STEMI]) do not supply evidence supporting the routine use of TA in patients with ST-segment-elevation myocardial infarction, manual TA remains a therapeutic option for interventional cardiologists when treating patients with substantial thrombus burden during PPCI...
October 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29041910/takotsubo-cardiomyopathy-in-a-patient-with-ileus-a-case-report
#7
Chen-Yu C Guo, Nan-Sung Chou
BACKGROUND: Takotsubo cardiomyopathy (TCM) is a form of stress-induced cardiomyopathy featured by the dilatation of the apex of the left ventricle during systole. Whereas the pathogenesis of this disorder is not well understood, it usually occurs after an emotional or physical stress such as acute asthma, surgery, chemotherapy, and stroke. However, its occurrence in ileus patients is rarely reported. We hereby report probably the first case of TCM after ileus in the literature and discuss its implications...
October 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29041896/-recommendations-of-the-society-of-specialists-in-urgent-cardiology-diagnosis-and-treatment-of-patients-with-non-st-segment-elevation-acute-coronary-syndrome-part-1
#8
S I YAvelov, Y M Ruda, V O Averkov, P E Panchenko
No abstract text is available yet for this article.
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29041001/hmgb1-expression-level-in-circulating-platelets-is-not-significantly-associated-with-outcomes-in-symptomatic-coronary-artery-disease
#9
Dominik Rath, Tobias Geisler, Meinrad Gawaz, Sebastian Vogel
BACKGROUND/AIMS: Platelets express high-mobility group box 1 (HMGB1), a damage-associated molecular pattern molecule (DAMP) that triggers thrombosis and inflammation when present in extracellular space. The role of platelet-derived HMGB1 in coronary artery disease (CAD) remains unexplored. METHODS: In a cohort study, we measured the expression of HMGB1 on the surface of circulating platelets in 183 patients with symptomatic CAD (stable CAD: n=80, acute coronary syndrome, ACS: n=103) at the time of percutaneous coronary intervention...
October 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29039827/-impact-of-hyperglycemia-on-the-results-of-percutaneous-coronary-interventions-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#10
I S Bessonov, V A Kuznetsov, Yu V Potolinskaya, I P Zyrianov, S S Sapozhnikov
AIM: To investigate the impact of hyperglycemia on the results of percutaneous coronary interventions (PCIs) in patients with acute ST-segment elevation myocardial infarction (ASTEMI). SUBJECTS AND METHODS: A study group consisted of 511 patients with hyperglycemia (blood glucose level (BGL) ≥7.77 mmol/L) who underwent primary PCIs in the period from 2005 to 2015. A comparison group included 579 patients (BGL ≥7.77 mmol/L). RESULTS: Assessment of the results of hospital interventions revealed that the mortality rates in patients with hyperglycemia proved to be higher than in those with normal BGL (6...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29038197/obstructive-coronary-artery-disease-in-patient-with-acute-thrombotic-thrombocytopenic-purpura
#11
Szymon L Wiernek, Xuming Dai
Thrombotic thrombocytopenic purpura (TTP) affects essentially all organ systems. Myocardial injury in TTP is often attributed to microthrombi formation. We present the first case report in the literature of an acute TTP patient with concomitant obstructive coronary artery disease (CAD) and acute myocardial infarction who underwent successful percutaneous coronary intervention (PCI). A 70-year-old female patient who was diagnosed with acute TTP required plasma exchange. The patient also experienced episodes of angina pectoris, elevated cardiac enzymes and global ST segment depressions on ECG...
October 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29037939/relationship-of-hospital-teaching-status-with-in-hospital-outcomes-for-st-segment-elevation-myocardial-infarction
#12
Tanush Gupta, Kavisha Patel, Dhaval Kolte, Sahil Khera, Pedro A Villablanca, Wilbert S Aronow, William H Frishman, Howard A Cooper, Anna E Bortnick, Gregg C Fonarow, Julio A Panza, Giora Weisz, Mark A Menegus, Mario J Garcia, Deepak L Bhatt
BACKGROUND: Prior analyses have largely shown a survival advantage with admission to a teaching hospital for acute myocardial infarction. However, most prior studies report data on patients hospitalized over a decade ago. It is important to re-examine the association of hospital teaching status with outcomes of acute myocardial infarction in the current era. METHODS: We queried the 2010 to 2014 National Inpatient Sample databases to identify all patients aged ≥18 years hospitalized with the principal diagnosis of ST-segment elevation myocardial infarction (STEMI)...
October 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29036457/feasibility-evaluation-of-long-term-use-of-beta-blockers-and-calcium-antagonists-in-patients-with-brugada-syndrome
#13
Tsukasa Kamakura, Mitsuru Wada, Kohei Ishibashi, Yuko Y Inoue, Koji Miyamoto, Hideo Okamura, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Satoshi Yasuda, Wataru Shimizu, Shiro Kamakura, Kengo Kusano
Aims: Beta-blockers (BBs) and calcium antagonists (CAs) are reported to aggravate ST-segment elevation in some patients with Brugada syndrome (BrS). The feasibility of their long-term use in BrS still remains unknown. We investigated the safety of long-term use of BB and CA in BrS patients. Methods and results: Of the 360 consecutive BrS patients, 29 [5: a history of ventricular fibrillation (VF), 17: syncope, 7: asymptomatic] took BB and/or CA (BB: 22, CA: 8) for more than 1 year for the treatment of co-morbidities such as atrial tachyarrhythmia, vasospastic angina, and neurally mediated syncope...
September 23, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29035225/a-review-of-automated-methods-for-detection-of-myocardial-ischemia-and-infarction-using-electrocardiogram-and-electronic-health-record
#14
Sardar Ansari, Negar Farzaneh, Marlena Duda, Kelsey Horan, Hedvig B Andersson
There is a growing body of research focusing on automatic detection of ischemia and myocardial infarction (MI) using computer algorithms. In clinical settings, ischemia and MI are diagnosed using ECG recordings as well as medical context including patient symptoms, medical history and risk factors, information that is often stored in the electronic health records. The ECG signal is inspected to identify changes in the morphology such as ST-segment deviation and T wave changes. Some of the proposed methods compute similar features automatically while others use non-conventional features such as wavelet coefficients...
October 16, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/29034073/unmet-goals-in-the-treatment-of-acute-myocardial-infarction-review
#15
REVIEW
Alejandro Farah, Alejandro Barbagelata
Reperfusion therapy decreases myocardium damage during an acute coronary event and consequently mortality. However, there are unmet needs in the treatment of acute myocardial infarction, consequently mortality and heart failure continue to occur in about 10% and 20% of cases, respectively. Different strategies could improve reperfusion. These strategies, like generation of warning sign recognition and being initially assisted and transferred by an emergency service, could reduce the time to reperfusion. If the first electrocardiogram is performed en route, it can be transmitted and interpreted in a timely manner by a specialist at the receiving center, bypassing community hospitals without percutaneous coronary intervention capabilities...
2017: F1000Research
https://www.readbyqxmd.com/read/29033507/syntax-score-of-infarct-related-artery-other-than-the-number-of-coronary-balloon-inflations-and-deflations-as-an-independent-predictor-of-contrast-induced-acute-kidney-injury-in-patients-with-st-segment-elevation-myocardial-infarction
#16
Cheng-Wei Liu, Pen-Chih Liao, Kuo-Chin Chen, Jung-Cheng Hsu, Chung-Ming Tu, Yen-Wen Wu, Ai-Hsien Li, Shin-Rong Ke, Jiunn-Lee Lin
BACKGROUND: Although remote ischemic post-conditioning (RIPC) has been shown to prevent contrast-induced acute kidney injury (CIAKI) in patients with acute coronary syndrome, its efficacy in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. We examined the relationship among balloon inflations and deflations (BID) times, SYNTAX score of infarction-related artery (SI), periprocedural complications, and CIAKI in STEMI patients undergoing primary percutaneous coronary intervention (pPCI)...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29033503/the-management-and-prognostic-factors-of-acute-coronary-syndrome-evidence-from-the-taiwan-acute-coronary-syndrome-full-spectrum-registry
#17
REVIEW
Chun-Yuan Chu, Tsung-Hsien Lin, Wen-Ter Lai
Cardiovascular disease (CVD) accounts for approximately one-third of all global deaths, and acute coronary syndrome (ACS) is the most severe form of CVD. It is of notable importance to develop ACS strategies for reducing major adverse cardiac events (MACE) and preventing complications. In the Taiwan ACS Full Spectrum Registry, 1-year mortality among patients with ST-segment elevation myocardial infarction, non ST-segment elevation myocardial infarction and unstable angina was 6.1%, 10.1%, and 6.2%, respectively...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29033367/stent-implantation-and-vascular-healing-of-a-spontaneous-coronary-artery-dissection-assessed-by-optical-coherence-tomography-in-a-patient-with-acute-coronary-syndrome
#18
Kirstine Nørregaard Hansen, Lisbeth Antonsen, Lisette Okkels Jensen
A 60-year old woman with non-ST-segment elevation myocardial infarction, underwent coronary angiogram combined with optical coherence tomography (OCT) revealing a long dissection in the right coronary artery. The patient experienced peri-procedural chest pain, the electrocardiogram showed ST-segment elevations, and compromised coronary blood flow, why mechanical revascularization with percutaneous coronary intervention (PCI) was indicated. At 1-month follow-up, OCT revealed early, competent vascular healing, and a distal stenosis was treated with PCI...
September 5, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29033340/nonepileptic-seizure-provoked-by-cardiac-dysrhythmia-a-case-of-st-elevation-myocardial-infarction
#19
A Pourmand, S Davis, K Yensen
Acute seizures represent 1% of all visits to emergency departments in the United States. While many acute seizures are correctly attributable to underlying epilepsy, approximately one-third of acute seizures are provoked by underlying and potentially life-threatening acute conditions. Many clinical syndromes associated with seizure-like activity are well-established and readily identified in the acute setting. Cardiac dysrhythmias are known causes of acute seizure-like activity and, if transient and not captured by electrocardiogram tracings during acute episodes, may be incorrectly diagnosed as epileptic seizures...
October 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29030902/the-prognostic-significance-of-early-and-late-right-precordial-lead-v4-r-st-segment-elevation-in-patients-with-acute-anterior-myocardial-infarction
#20
Muhammed Keskin, Ahmet Okan Uzun, Edibe Betül Börklü, Mert İlker Hayıroğlu, Ceyhan Türkkan, Ahmet İlker Tekkeşin, Ömer Kozan
BACKGROUND: The predictive significance of ST-segment elevation (STE) in lead V4 R in patients with anterior ST-segment elevation myocardial infarction (STEMI) has not been well-understood. In this study, we evaluated the prognostic value of early and late STE in lead V4 R in patients with anterior STEMI. METHODS: A total 451 patients with anterior STEMI who treated with primary percutaneous coronary intervention (PPCI) were prospectively enrolled in this study...
October 14, 2017: Annals of Noninvasive Electrocardiology
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