Yuriko Katsumata, David W Fardo, Lincoln M P Shade, Xian Wu, Shama D Karanth, Timothy J Hohman, Julie A Schneider, David A Bennett, Jose M Farfel, Kathryn Gauthreaux, Charles Mock, Walter A Kukull, Erin L Abner, Peter T Nelson
INTRODUCTION: Although dementia-related proteinopathy has a strong negative impact on public health, and is highly heritable, understanding of the related genetic architecture is incomplete. METHODS: We applied multidimensional generalized partial credit modeling (GPCM) to test genetic associations with dementia-related proteinopathies. Data were analyzed to identify candidate single nucleotide variants for the following proteinopathies: Aβ, tau, α-synuclein, and TDP-43...
March 9, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association