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plant-based and coronary artery disease

Moslem Najafi, Elham Noroozi, Aniseh Javadi, Reza Badalzadeh
INTRODUCTION: Medicinal plants are increasingly used in the treatment of cardiovascular diseases due to their multifaceted properties. This study was designed to investigate anti-arrhythmic and anti-inflammatory potentials of the natural bioflavonoid, troxerutin (TXR) in myocardial ischemia/reperfusion (I/R) injury in diabetic rats. METHODS: Male Wistar rats were randomly divided into 4 groups (control, control + TXR [150 mg/kg, daily], diabetic, and diabetic + TXR)...
March 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yi Zhun Zhu, Weijun Wu, Qing Zhu, Xinhua Liu
Despite several advances in percutaneous coronary intervention and the discovery of new drugs, the incidence of myocardial infarction and deaths due to cardiovascular diseases (CVD) has not decreased markedly in China. The quality of life is affected seriously, which further results in great social and family burden. Many drugs, from the century-old aspirin to the newly FDA-approved Byvalson, have been proven to be effective in the treatment and prevention of CVD. As clinically reported, those life-saving drugs still have their side effects in regards to the narrow therapeutic indexes influenced by individual genetic variations...
March 8, 2018: Pharmacology & Therapeutics
Hweemin Chung, Kanwoo Youn, Kyuyeon Kim, Kyunggeun Park
Background: In Korea, Carbon disulfide (CS2 ) toxicity was an important social problem from the late 1980s to the early 1990s but there have been few large-scale studies examining the prevalence of diseases after CS2 exposure discontinuance. So we investigated past working exposure to CS2 characteristics from surviving ex-workers of a rayon manufacturing plant including cumulative CS2 exposure index. Furthermore, we studied the prevalence of their chronic diseases recently after many years...
2017: Annals of Occupational and Environmental Medicine
Feng Liu, Kai Xu, Zhijue Xu, Matilde de Las Rivas, Congrong Wang, Xing Li, Jishun Lu, Yueyang Zhou, Ignacio Delso, Pedro Merino, Ramon Hurtado-Guerrero, Yan Zhang, Fang Wu
Mucin-type O -glycosylation is the most abundant type of O -glycosylation. It is initiated by the members of the polypeptide N -acetyl-α-galactosaminyltransferase (ppGalNAc-T) family and closely associated with both physiological and pathological conditions, such as coronary artery disease or Alzheimer's disease. The lack of direct and selective inhibitors of ppGalNAc-Ts has largely impeded research progress in understanding the molecular events in mucin-type O -glycosylation. Here, we report that a small molecule, the plant flavonoid luteolin, selectively inhibits ppGalNAc-Ts in vitro and in cells...
December 29, 2017: Journal of Biological Chemistry
Caldwell B Esselstyn
No abstract text is available yet for this article.
May 2017: Journal of Geriatric Cardiology: JGC
Ruifeng Bai, Xu Yin, Xiao Feng, Yuan Cao, Yan Wu, Zhixiang Zhu, Chun Li, Pengfei Tu, Xingyun Chai
ETHNOPHARMACOLOGICAL RELEVANCE: Corydalis hendersonii Hemsl. (CH) with heat clearing and detoxifying effects are well described in Tibetan folk medicine. It has been used for centuries in China largely for the treatment of high altitude polycythemia, a pathophysiological condition referred to "plethora" in Tibetan medicine, hypertension, hepatitis, edema, gastritis, and other infectious diseases. AIM OF THE STUDY: To investigate the cardioprotective effects of Corydalis hendersonii extract in an ICR mouse model of myocardial ischemic injury...
July 31, 2017: Journal of Ethnopharmacology
Nana Zhang, Zeqin Lian, Xueying Peng, Zijian Li, Haibo Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: Aconitum has been used as local and traditional medicines in many asian regions for the treatment of various diseases such as collapse, syncope, painful joints, oedema, bronchial asthma et al. Higenamine, a plant-based alkaloid, was initially isolated from Aconitum and identified as the active cardiotonic component of Aconitum. It has been tested as a candidate of pharmacologic stress agent in the detection of coronary artery diseases (CADs) and now researchers have just accomplished the phase III clinical studies successfully in China...
January 20, 2017: Journal of Ethnopharmacology
Kevin Phan, Cheryl Au, Paul Mitchell, Gerald Liew, Adam J H Plant, Sarah B Wang, Joseph Chiha, Aravinda Thiagalingam, George Burlutsky, Bamini Gopinath
BACKGROUND: Prior studies have suggested the association between incidence of coronary artery disease (CAD) with chronic kidney disease (CKD) and poor glomerular filtration function. However to the best of our knowledge, few studies have specifically assessed this relationship based on the severity of CAD as quantified using Extent and Gensini scores. METHODS: Between June 2009 and January 2012, data were collected from 1,680 participants as part of the Australian Heart Eye Study (AHES) cohort...
August 2016: Journal of Thoracic Disease
Daniele Massera, Tarique Zaman, Grace E Farren, Robert J Ostfeld
A 60-year-old man presented with typical angina and had a positive stress test. He declined both drug therapy and invasive testing. Instead, he chose to adopt a whole-food plant-based diet, which consisted primarily of vegetables, fruits, whole grains, potatoes, beans, legumes, and nuts. His symptoms improved rapidly, as well as his weight, blood pressure, and cholesterol levels. Plant-based diets have been associated with improved plasma lipids, diabetes control, coronary artery disease and with a reduction in mortality...
2015: Case Reports in Cardiology
Phillip Tuso, Scott R Stoll, William W Li
A plant-based diet is increasingly becoming recognized as a healthier alternative to a diet laden with meat. Atherosclerosis associated with high dietary intake of meat, fat, and carbohydrates remains the leading cause of mortality in the US. This condition results from progressive damage to the endothelial cells lining the vascular system, including the heart, leading to endothelial dysfunction. In addition to genetic factors associated with endothelial dysfunction, many dietary and other lifestyle factors, such as tobacco use, high meat and fat intake, and oxidative stress, are implicated in atherogenesis...
2015: Permanente Journal
Caldwell B Esselstyn, Gina Gendy, Jonathan Doyle, Mladen Golubic, Michael F Roizen
PURPOSE: Plant-based nutrition achieved coronary artery disease (CAD) arrest and reversal in a small study. However, there was skepticism that this approach could succeed in a larger group of patients. The purpose of our follow-up study was to define the degree of adherence and outcomes of 198 consecutive patient volunteers who received counseling to convert from a usual diet to plant-based nutrition. METHODS: We followed 198 consecutive patients counseled in plant-based nutrition...
July 2014: Journal of Family Practice
Xidan Zhou, Liying Tang, Yilong Xu, Guohong Zhou, Zhuju Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Carthamus tinctorius L. (Compositae), a widely used traditional Chinese medicine, was known as Hong hua (Chinese: ), safflower. Safflower with a wide spectrum of pharmacological effects has been used to treat dysmenorrhea, amenorrhea, postpartum abdominal pain and mass, trauma and pain of joints, etc. The present paper reviews the advancements in investigation of botany and ethnopharmacology, phytochemistry, pharmacology and toxicology of safflower. Finally, the possible tendency and perspective for future investigation of this plant are discussed, too...
2014: Journal of Ethnopharmacology
Harvinder S Dod, Ravindra Bhardwaj, Venu Sajja, Gerdi Weidner, Gerald R Hobbs, Gregory W Konat, Shanthi Manivannan, Wissam Gharib, Bradford E Warden, Navin C Nanda, Robert J Beto, Dean Ornish, Abnash C Jain
Intensive lifestyle changes have been shown to regress atherosclerosis, improve cardiovascular risk profiles, and decrease angina pectoris and cardiac events. We evaluated the influence of the Multisite Cardiac Lifestyle Intervention Program, an ongoing health insurance-covered lifestyle intervention conducted at our site, on endothelial function and inflammatory markers of atherosclerosis in this pilot study. Twenty-seven participants with coronary artery disease (CAD) and/or risk factors for CAD (nonsmokers, 14 men; mean age 56 years) were enrolled in the experimental group and asked to make changes in diet (10% calories from fat, plant based), engage in moderate exercise (3 hours/week), and practice stress management (1 hour/day)...
February 1, 2010: American Journal of Cardiology
Hope R Ferdowsian, Neal D Barnard
Dyslipidemia is a primary risk factor for cardiovascular disease, peripheral vascular disease, and stroke. Current guidelines recommend diet as first-line therapy for patients with elevated plasma cholesterol concentrations. However, what constitutes an optimal dietary regimen remains a matter of controversy. Large prospective trials have demonstrated that populations following plant-based diets, particularly vegetarian and vegan diets, are at lower risk for ischemic heart disease mortality. The investigators therefore reviewed the published scientific research to determine the effectiveness of plant-based diets in modifying plasma lipid concentrations...
October 1, 2009: American Journal of Cardiology
Patrick J Smith, James A Blumenthal, Michael A Babyak, Anastasia Georgiades, Andrew Sherwood, Michael H Sketch, Lana L Watkins
BACKGROUND: n-3 (omega-3) Fatty acids are associated with a reduced risk of cardiovascular disease; however, the relation between dietary intake of n-3 fatty acids and ventricular arrhythmias has not been investigated among acute post-myocardial infarction (AMI) patients-a group at elevated risk of malignant arrhythmias. OBJECTIVE: The objective was to examine the association between n-3 fatty acid consumption and ventricular ectopy among AMI patients. DESIGN: In 260 AMI patients, dietary intake of n-3 fatty acids was assessed by using the Harvard food-frequency questionnaire, and ventricular ectopy was estimated from 24-h electrocardiograph recordings...
May 2009: American Journal of Clinical Nutrition
Joanne Frattaroli, Gerdi Weidner, Terri A Merritt-Worden, Steven Frenda, Dean Ornish
Cardiovascular symptom relief is a major indicator for revascularization procedures. To examine the effects of intensive lifestyle modification on symptom relief, we investigated changes in angina pectoris, coronary risk factors, quality of life, and lifestyle behaviors in patients with stable coronary artery disease enrolled in the multisite cardiac lifestyle intervention program, an ongoing health insurance-covered lifestyle intervention conducted at 22 sites in the united states. Patients with coronary artery disease (nonsmokers; 757 men, 395 women; mean age 61 years) were asked to make changes in diet (10% calories from fat, plant based), engage in moderate exercise (3 hours/week), and practice stress management (1 hour/day)...
April 1, 2008: American Journal of Cardiology
Linda Van Horn, Mikelle McCoin, Penny M Kris-Etherton, Frances Burke, Jo Ann S Carson, Catherine M Champagne, Wahida Karmally, Geeta Sikand
During the past few decades numerous studies have reported the atherogenic potential of saturated fatty acids, trans-fatty acids, and cholesterol, and beneficial effects of fiber, phytostanols/phytosterols, n-3 fatty acids, a Mediterranean diet, and other plant-based approaches. The purpose of this article is to provide a comprehensive and systematic review of the evidence associated with key dietary factors and risk of cardiovascular disease-an umbrella term encompassing diseases that affect the heart and blood vessels, including coronary heart disease, coronary artery disease, dyslipidemia, and hypertension-in conjunction with the work of the American Dietetic Association Evidence Analysis Library review on diet and lipids, updated with new evidence from the past 2 years...
February 2008: Journal of the American Dietetic Association
James H O'Keefe, Neil M Gheewala, Joan O O'Keefe
The highly processed, calorie-dense, nutrient-depleted diet favored in the current American culture frequently leads to exaggerated supraphysiological post-prandial spikes in blood glucose and lipids. This state, called post-prandial dysmetabolism, induces immediate oxidant stress, which increases in direct proportion to the increases in glucose and triglycerides after a meal. The transient increase in free radicals acutely triggers atherogenic changes including inflammation, endothelial dysfunction, hypercoagulability, and sympathetic hyperactivity...
January 22, 2008: Journal of the American College of Cardiology
Christine M Albert
Based upon the data from observational epidemiologic studies and randomized clinical trials that are summarized in this article, as well as plausible mechanisms for benefit, the American Heart Association and several international health agencies recommend that all adults eat fish, particularly fatty fish, at least two times per week to lower risk of coronary heart disease (CHD). Patients with established CHD are advised to consume 1 g/d of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) combined...
February 2007: Current Treatment Options in Cardiovascular Medicine
Claudia R Pischke, Gerdi Weidner, Melanie Elliott-Eller, Larry Scherwitz, Terri A Merritt-Worden, Ruth Marlin, Lee Lipsenthal, Robert Finkel, Donald Saunders, Patty McCormac, Judith M Scheer, Richard E Collins, Erminia M Guarneri, Dean Ornish
It is unclear whether patients with coronary artery disease (CAD) and diabetes mellitus (DM) can make comprehensive lifestyle changes that produce similar changes in coronary risk factors and quality of life compared with patients with CAD and without DM. We examined medical characteristics, lifestyle, and quality of life by diabetic status and gender in the Multicenter Lifestyle Demonstration Project (MLDP), a study of 440 nonsmoking patients with CAD (347 men, 55 with DM; 15.9%; 93 women, 36 with DM; 38.7%)...
May 1, 2006: American Journal of Cardiology
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